GB1533413A - Penicillins - Google Patents

Penicillins

Info

Publication number
GB1533413A
GB1533413A GB37525/75A GB3752575A GB1533413A GB 1533413 A GB1533413 A GB 1533413A GB 37525/75 A GB37525/75 A GB 37525/75A GB 3752575 A GB3752575 A GB 3752575A GB 1533413 A GB1533413 A GB 1533413A
Authority
GB
United Kingdom
Prior art keywords
nhz
gram
hooc
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB37525/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to GB37525/75A priority Critical patent/GB1533413A/en
Priority to US05/711,858 priority patent/US4053609A/en
Priority to MX763675U priority patent/MX3970E/en
Priority to DE2638067A priority patent/DE2638067C2/en
Priority to AT640476A priority patent/AT344904B/en
Priority to PH18847A priority patent/PH13848A/en
Priority to JP51104509A priority patent/JPS5236689A/en
Priority to SU762393510A priority patent/SU633482A3/en
Priority to CS765796A priority patent/CS202564B2/en
Priority to SE7609909A priority patent/SE430337B/en
Priority to FI762576A priority patent/FI63413C/en
Priority to AR264648A priority patent/AR220887A1/en
Priority to PT65575A priority patent/PT65575B/en
Priority to BE170545A priority patent/BE846094A/en
Priority to ES451449A priority patent/ES451449A1/en
Priority to CH1155876A priority patent/CH622798A5/en
Priority to FR7627393A priority patent/FR2323384A1/en
Priority to CA260,920A priority patent/CA1081211A/en
Priority to HU76TA00001412A priority patent/HU171688B/en
Priority to DK411076A priority patent/DK144301C/en
Priority to EG550/76A priority patent/EG12522A/en
Priority to PL1976192334A priority patent/PL110862B1/en
Priority to NLAANVRAGE7610151,A priority patent/NL176677C/en
Priority to AU17697/76A priority patent/AU493313B2/en
Priority to GB5045476A priority patent/GB1533414A/en
Priority to JP52044008A priority patent/JPS6052125B2/en
Publication of GB1533413A publication Critical patent/GB1533413A/en
Priority to JP57170795A priority patent/JPS58116418A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds of the formula I, in which the substituents have the meaning mentioned in Claim 1, are obtained by condensaton of 6-(D-2-amino-2-phenylacetamido)penicillanic acid having an optionally protected acid group with an N-protected amino acid of the formula HOOC-CH(NHZ)-CH2COR<3'> or HOOC-CH2-CH(NHZ)-COR<3'>. The novel penicillins obtained in this manner are antibacterially active and are suitable as animal feed additives and for the control of infectious diseases caused by Gram-positive or Gram-negative bacteria. <IMAGE>
GB37525/75A 1975-09-12 1975-09-12 Penicillins Expired GB1533413A (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GB37525/75A GB1533413A (en) 1975-09-12 1975-09-12 Penicillins
US05/711,858 US4053609A (en) 1975-09-12 1976-08-05 Penicillins and processes for preparing the same
MX763675U MX3970E (en) 1975-09-12 1976-08-18 PROCEDURE FOR PREPARING ACID 6- (D-2-ACILAMIDO-2-FENILA-CETAMIDO) PENICILANICO
DE2638067A DE2638067C2 (en) 1975-09-12 1976-08-24 Penicillins and processes for their manufacture
AT640476A AT344904B (en) 1975-09-12 1976-08-30 METHOD FOR MANUFACTURING NEW PENICILLIN
PH18847A PH13848A (en) 1975-09-12 1976-08-30 Process for preparing new penicillins
JP51104509A JPS5236689A (en) 1975-09-12 1976-08-31 Novel synthetic penicillins and their preparation process
SU762393510A SU633482A3 (en) 1975-09-12 1976-09-06 Method of obtaining penicillanic acid derivatives or salts thereof
CS765796A CS202564B2 (en) 1975-09-12 1976-09-07 Process for preparing derivatives of 6-/d-2-amino-2-phenylacetamido/penicilanic acid
SE7609909A SE430337B (en) 1975-09-12 1976-09-08 PROCEDURE FOR PREPARING 6- (D-2-AMINO-2-PHENYL-ACETAMIDO) -PENICILLANIC ACID DERIVATIVES
FI762576A FI63413C (en) 1975-09-12 1976-09-08 FOERFARANDE FOER FRAMSTAELLNING AV ANTIMIKROBA 6- (D-2-AMINO-2-PHENYLACETAMIDO) PENICILLANSYRADERIVAT
AR264648A AR220887A1 (en) 1975-09-12 1976-09-09 NEW ACID DERIVATIVE 6- (D-2-ACILAMIDO-2-PHENYLACETAMIDE PENICILANICO, PARTICULARLY USEFUL AS A NON-PHARMACOLOGICAL INTERMEDIARY IN THE PRODUCTION OF NEW PENICILLINS; AND PROCEDURE FOR THE PREPARATION OF ACID COMPOUNDS 6- (2-ACID-2-ACID -PHENYL ACETAMIDE) PENICILANIC FROM THIS INTERMEDIARY
BE170545A BE846094A (en) 1975-09-12 1976-09-10 NEW PENICILLINS AND THEIR PREPARATION METHODS
PT65575A PT65575B (en) 1975-09-12 1976-09-10 Process for preparing new penicillins
ES451449A ES451449A1 (en) 1975-09-12 1976-09-10 Penicillins
CH1155876A CH622798A5 (en) 1975-09-12 1976-09-10 Process for the preparation of 6-(D-2-acylamido-2-phenylactamido)- penicillanic acids
FR7627393A FR2323384A1 (en) 1975-09-12 1976-09-10 NEW PENICILLINS AND METHODS FOR THEIR PREPARATION
CA260,920A CA1081211A (en) 1975-09-12 1976-09-10 Penicillins and processes for preparing the same
HU76TA00001412A HU171688B (en) 1975-09-12 1976-09-10 Process for producing new pename-3-carboxylic acid derivatives and pharmaceutical compositions containing them
DK411076A DK144301C (en) 1975-09-12 1976-09-10 ANALOGY PROCEDURE FOR PENICILLIN OR SALT PREPARATION
PL1976192334A PL110862B1 (en) 1975-09-12 1976-09-11 Preparation of novel 6-/d-2-acylamide-2-phenylacetamide/-penicillanic acid
EG550/76A EG12522A (en) 1975-09-12 1976-09-11 6-(d-2 acylamido-2 phenylacetamido)penicillanic acid
NLAANVRAGE7610151,A NL176677C (en) 1975-09-12 1976-09-13 METHOD FOR PREPARING OR MANUFACTURING A MEDICINAL PRODUCT WITH ANTIBACTERIAL ACTION AND METHOD FOR PREPARING AN ALPHA-AMINOBENZYL-PENICILLIN DERIVATIVE FURGED BY AN AMINOIC ACID
AU17697/76A AU493313B2 (en) 1976-09-13 6-(d-2-acylamido-2-phenylacetamido) penicillanic acids and their preparation
GB5045476A GB1533414A (en) 1975-09-12 1976-12-03 Process for preparing penicillins
JP52044008A JPS6052125B2 (en) 1975-09-12 1977-04-15 Antibacterial pharmaceutical composition
JP57170795A JPS58116418A (en) 1975-09-12 1982-09-28 Antimicrobial pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB37525/75A GB1533413A (en) 1975-09-12 1975-09-12 Penicillins

Publications (1)

Publication Number Publication Date
GB1533413A true GB1533413A (en) 1978-11-22

Family

ID=10397137

Family Applications (1)

Application Number Title Priority Date Filing Date
GB37525/75A Expired GB1533413A (en) 1975-09-12 1975-09-12 Penicillins

Country Status (14)

Country Link
JP (3) JPS5236689A (en)
AR (1) AR220887A1 (en)
AT (1) AT344904B (en)
CH (1) CH622798A5 (en)
CS (1) CS202564B2 (en)
EG (1) EG12522A (en)
ES (1) ES451449A1 (en)
GB (1) GB1533413A (en)
HU (1) HU171688B (en)
MX (1) MX3970E (en)
PH (1) PH13848A (en)
PL (1) PL110862B1 (en)
PT (1) PT65575B (en)
SU (1) SU633482A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104059087A (en) * 2014-07-08 2014-09-24 湖南尔康制药股份有限公司 Synthesis method of aspoxicillin
CN113999251A (en) * 2021-11-12 2022-02-01 海南海灵化学制药有限公司 Synthetic method of aspoxicillin sodium

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4839044B2 (en) * 2005-08-30 2011-12-14 富士機工株式会社 Shift lever range position display device

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104059087A (en) * 2014-07-08 2014-09-24 湖南尔康制药股份有限公司 Synthesis method of aspoxicillin
CN104059087B (en) * 2014-07-08 2016-02-17 湖南尔康制药股份有限公司 A kind of synthetic method of aspoxicillin
CN113999251A (en) * 2021-11-12 2022-02-01 海南海灵化学制药有限公司 Synthetic method of aspoxicillin sodium

Also Published As

Publication number Publication date
ES451449A1 (en) 1978-01-16
MX3970E (en) 1981-10-20
AR220887A1 (en) 1980-12-15
EG12522A (en) 1981-06-30
JPS6052125B2 (en) 1985-11-18
CS202564B2 (en) 1981-01-30
PT65575A (en) 1976-10-01
PT65575B (en) 1978-03-28
JPS5443519B2 (en) 1979-12-20
SU633482A3 (en) 1978-11-15
PL110862B1 (en) 1980-08-30
JPS58116418A (en) 1983-07-11
CH622798A5 (en) 1981-04-30
PL192334A1 (en) 1979-02-12
AT344904B (en) 1978-08-25
HU171688B (en) 1978-02-28
JPS5236689A (en) 1977-03-22
PH13848A (en) 1980-10-22
ATA640476A (en) 1977-12-15
JPS5332125A (en) 1978-03-27

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960815