JPS54125672A - Pseudomonic acid amide derivative, or its salt, and their preparation - Google Patents
Pseudomonic acid amide derivative, or its salt, and their preparationInfo
- Publication number
- JPS54125672A JPS54125672A JP3376278A JP3376278A JPS54125672A JP S54125672 A JPS54125672 A JP S54125672A JP 3376278 A JP3376278 A JP 3376278A JP 3376278 A JP3376278 A JP 3376278A JP S54125672 A JPS54125672 A JP S54125672A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- acid amide
- alkyl
- aryl
- pseudomonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:A pseudomonic acid amide derivative or its salt of formula I (R<1>,<2> are alkyl, substituted alkyl, alkenyl, alkynyl, aryl, substituted aryl, etc.; or one of the R<1> and R<2> is H and the other is alkyl, substituted alkyl, alkenyl, alkynyl, aryl, aralkyl, etc.). EXAMPLE:N-Hydroxy-N-methylpseudomonic acid amide. USE:Remedy for the infectious diseases of man and animal by bacteria. Strong antibacterial activity to Gram-positive bacteria such as Staphylococcus aureus, Streptococcus biogenes, etc., and effective to the penicillin-resistant or macrolide-resistant variant thereof. Long acting effectiveness. For oral or parenteral administration. PROCESS:The compound I is prepared by reacting the compound II with pseudomonic acid, its salt, or its reactive derivative in an inert solvent at -50 deg.C - room temp.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3376278A JPS54125672A (en) | 1978-03-23 | 1978-03-23 | Pseudomonic acid amide derivative, or its salt, and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3376278A JPS54125672A (en) | 1978-03-23 | 1978-03-23 | Pseudomonic acid amide derivative, or its salt, and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54125672A true JPS54125672A (en) | 1979-09-29 |
JPS6157313B2 JPS6157313B2 (en) | 1986-12-06 |
Family
ID=12395433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3376278A Granted JPS54125672A (en) | 1978-03-23 | 1978-03-23 | Pseudomonic acid amide derivative, or its salt, and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54125672A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292892A (en) * | 1991-05-07 | 1994-03-08 | Sankyo Company, Limited | Anti-bacterial compound and pharmaceutical compositions thereof |
US5380723A (en) * | 1991-10-07 | 1995-01-10 | Nisshin Flour Milling Co., Ltd. | Indole derivatives |
US5399711A (en) * | 1992-09-18 | 1995-03-21 | Sankyo Company, Limited | Thiomarinol compounds |
-
1978
- 1978-03-23 JP JP3376278A patent/JPS54125672A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292892A (en) * | 1991-05-07 | 1994-03-08 | Sankyo Company, Limited | Anti-bacterial compound and pharmaceutical compositions thereof |
US5405762A (en) * | 1991-05-07 | 1995-04-11 | Sankyo Company, Limited | Culture of alteromonas and process of using the same to produce an antibacterial compound |
US5380723A (en) * | 1991-10-07 | 1995-01-10 | Nisshin Flour Milling Co., Ltd. | Indole derivatives |
US5399711A (en) * | 1992-09-18 | 1995-03-21 | Sankyo Company, Limited | Thiomarinol compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS6157313B2 (en) | 1986-12-06 |
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