GB1551672A - Thienamycin derivatives - Google Patents

Thienamycin derivatives

Info

Publication number
GB1551672A
GB1551672A GB10479/77A GB1047977A GB1551672A GB 1551672 A GB1551672 A GB 1551672A GB 10479/77 A GB10479/77 A GB 10479/77A GB 1047977 A GB1047977 A GB 1047977A GB 1551672 A GB1551672 A GB 1551672A
Authority
GB
United Kingdom
Prior art keywords
thienamycin
toxic
pharmaceutically acceptable
acceptable salts
sulphoxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10479/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1551672A publication Critical patent/GB1551672A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Thienamycin sulphoxide of the structural formula I <IMAGE> and the non-toxic, pharmaceutically acceptable salts thereof are obtained by oxidising thienamycin and converting the resulting compound where appropriate into the non-toxic, pharmaceutically acceptable salts. Thienamycin sulphone and the non-toxic, pharmaceutically acceptable salts thereof are obtained by preparing thienamycin sulphoxide of the structural formula I, and further oxidising the resulting compound and converting the compound obtained in this way where appropriate into the non-toxic, pharmaceutically acceptable salts. The compounds which can be prepared according to the invention are generally valuable antibiotics which are active against various Gram-negative and Gram-positive bacteria.
GB10479/77A 1976-03-16 1977-03-11 Thienamycin derivatives Expired GB1551672A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66732376A 1976-03-16 1976-03-16

Publications (1)

Publication Number Publication Date
GB1551672A true GB1551672A (en) 1979-08-30

Family

ID=24677763

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10479/77A Expired GB1551672A (en) 1976-03-16 1977-03-11 Thienamycin derivatives

Country Status (8)

Country Link
JP (1) JPS52111591A (en)
CH (1) CH630086A5 (en)
DE (1) DE2711223A1 (en)
DK (1) DK90277A (en)
FR (1) FR2344558A1 (en)
GB (1) GB1551672A (en)
NL (1) NL7702183A (en)
SE (1) SE7702370L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1577725A (en) * 1976-06-30 1980-10-29 Beecham Group Ltd Azetidinone derivatives
EP0002564B1 (en) * 1977-11-12 1984-06-20 Beecham Group Plc Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates
JPS61236785A (en) * 1985-04-15 1986-10-22 Sankyo Co Ltd Azetidinone derivative

Also Published As

Publication number Publication date
FR2344558A1 (en) 1977-10-14
DE2711223A1 (en) 1977-10-27
SE7702370L (en) 1977-09-17
CH630086A5 (en) 1982-05-28
JPS52111591A (en) 1977-09-19
NL7702183A (en) 1977-09-20
DK90277A (en) 1977-09-17
FR2344558B1 (en) 1980-06-13

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee