GB1551672A - Thienamycin derivatives - Google Patents
Thienamycin derivativesInfo
- Publication number
- GB1551672A GB1551672A GB10479/77A GB1047977A GB1551672A GB 1551672 A GB1551672 A GB 1551672A GB 10479/77 A GB10479/77 A GB 10479/77A GB 1047977 A GB1047977 A GB 1047977A GB 1551672 A GB1551672 A GB 1551672A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thienamycin
- toxic
- pharmaceutically acceptable
- acceptable salts
- sulphoxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Thienamycin sulphoxide of the structural formula I <IMAGE> and the non-toxic, pharmaceutically acceptable salts thereof are obtained by oxidising thienamycin and converting the resulting compound where appropriate into the non-toxic, pharmaceutically acceptable salts. Thienamycin sulphone and the non-toxic, pharmaceutically acceptable salts thereof are obtained by preparing thienamycin sulphoxide of the structural formula I, and further oxidising the resulting compound and converting the compound obtained in this way where appropriate into the non-toxic, pharmaceutically acceptable salts. The compounds which can be prepared according to the invention are generally valuable antibiotics which are active against various Gram-negative and Gram-positive bacteria.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66732376A | 1976-03-16 | 1976-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1551672A true GB1551672A (en) | 1979-08-30 |
Family
ID=24677763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB10479/77A Expired GB1551672A (en) | 1976-03-16 | 1977-03-11 | Thienamycin derivatives |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS52111591A (en) |
CH (1) | CH630086A5 (en) |
DE (1) | DE2711223A1 (en) |
DK (1) | DK90277A (en) |
FR (1) | FR2344558A1 (en) |
GB (1) | GB1551672A (en) |
NL (1) | NL7702183A (en) |
SE (1) | SE7702370L (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1577725A (en) * | 1976-06-30 | 1980-10-29 | Beecham Group Ltd | Azetidinone derivatives |
EP0002564B1 (en) * | 1977-11-12 | 1984-06-20 | Beecham Group Plc | Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates |
JPS61236785A (en) * | 1985-04-15 | 1986-10-22 | Sankyo Co Ltd | Azetidinone derivative |
-
1977
- 1977-03-01 NL NL7702183A patent/NL7702183A/en not_active Application Discontinuation
- 1977-03-02 DK DK90277A patent/DK90277A/en unknown
- 1977-03-03 SE SE7702370A patent/SE7702370L/en not_active Application Discontinuation
- 1977-03-11 GB GB10479/77A patent/GB1551672A/en not_active Expired
- 1977-03-14 FR FR7707487A patent/FR2344558A1/en active Granted
- 1977-03-15 CH CH322877A patent/CH630086A5/en not_active IP Right Cessation
- 1977-03-15 DE DE19772711223 patent/DE2711223A1/en not_active Ceased
- 1977-03-16 JP JP2814677A patent/JPS52111591A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2344558A1 (en) | 1977-10-14 |
DE2711223A1 (en) | 1977-10-27 |
SE7702370L (en) | 1977-09-17 |
CH630086A5 (en) | 1982-05-28 |
JPS52111591A (en) | 1977-09-19 |
NL7702183A (en) | 1977-09-20 |
DK90277A (en) | 1977-09-17 |
FR2344558B1 (en) | 1980-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |