NL7600372A - Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids - Google Patents

Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Info

Publication number
NL7600372A
NL7600372A NL7600372A NL7600372A NL7600372A NL 7600372 A NL7600372 A NL 7600372A NL 7600372 A NL7600372 A NL 7600372A NL 7600372 A NL7600372 A NL 7600372A NL 7600372 A NL7600372 A NL 7600372A
Authority
NL
Netherlands
Prior art keywords
lactamase
cpd
beta
broad
4pethyl
Prior art date
Application number
NL7600372A
Other languages
Dutch (nl)
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to NL7600372A priority Critical patent/NL7600372A/en
Publication of NL7600372A publication Critical patent/NL7600372A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporins of formula (I): (where R1 = H, a cation or a blocking group and R2 = acetoxy (cpd. C) carbamyloxy (cpd. D), 5-methyl-1,3,4-thiazol-2-ylthio (cpd. B) or 1-methyl-1,2,3,4-tetrazol-5-ylthio (cpd. A)), are broad spectrum antibiotics effective against Gram-positive and Gram-negative bacteria (partic. Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus species) and stable to bacterial beta-lactamase. The cpds. have low toxicity, are well absorbed to give high blood levels and do not show hemolytic activity.
NL7600372A 1976-01-15 1976-01-15 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids NL7600372A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7600372A NL7600372A (en) 1976-01-15 1976-01-15 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7600372A NL7600372A (en) 1976-01-15 1976-01-15 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Publications (1)

Publication Number Publication Date
NL7600372A true NL7600372A (en) 1977-07-19

Family

ID=19825442

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7600372A NL7600372A (en) 1976-01-15 1976-01-15 Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

Country Status (1)

Country Link
NL (1) NL7600372A (en)

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