PH20534A - Novel cephalosporins having a mono or d-oxo-piperazino-carbonyl groups in the molecule and a pharmaceutical composition thereof - Google Patents

Novel cephalosporins having a mono or d-oxo-piperazino-carbonyl groups in the molecule and a pharmaceutical composition thereof

Info

Publication number
PH20534A
PH20534A PH18076A PH18076A PH20534A PH 20534 A PH20534 A PH 20534A PH 18076 A PH18076 A PH 18076A PH 18076 A PH18076 A PH 18076A PH 20534 A PH20534 A PH 20534A
Authority
PH
Philippines
Prior art keywords
piperazino
oxo
mono
molecule
pharmaceutical composition
Prior art date
Application number
PH18076A
Inventor
Isamu Saikawa
Shuntaru Takano
Okuta Takashima
Seietsu Kuroda
Yutaka Kodama
Chosaku Yoshida
Kaishu Momonoi
Miwako Komatsu
Takash Yasuda
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5066374A external-priority patent/JPS539238B2/ja
Priority claimed from JP5225474A external-priority patent/JPS539239B2/ja
Priority claimed from JP6078774A external-priority patent/JPS539240B2/ja
Priority claimed from JP9199674A external-priority patent/JPS5123284A/en
Priority claimed from JP10995474A external-priority patent/JPS5139687A/en
Priority claimed from JP14249974A external-priority patent/JPS5170788A/en
Priority claimed from JP50037207A external-priority patent/JPS51113890A/en
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of PH20534A publication Critical patent/PH20534A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1508064 N-Piperazinocarbonyl-amino acid derivatives TOYAMA CHEMICAL CO Ltd 28 April 1975 [13 Aug 1974 28 Oct 1974 17 Feb 1975] 15360/77 Divided out of 1508062 Heading C2C Novel compounds I and salts and carboxyl derivatives thereof (R is an amino acid residue; R<SP>2</SP> and R<SP>3</SP> are H or alkyl and R<SP>2</SP> and R<SP>3</SP> are both linked to the same carbon atom; and A is H or an optionally substituted alkyl, alkenyl, aryl or aralkyl group) are prepared by reaction of a compound II NH 2 RCOOR<SP>1</SP> (III) (R<SP>1</SP> is H or a cation) with a reactive derivative of a compound IV
PH18076A 1974-05-09 1976-02-10 Novel cephalosporins having a mono or d-oxo-piperazino-carbonyl groups in the molecule and a pharmaceutical composition thereof PH20534A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP5066374A JPS539238B2 (en) 1974-05-09 1974-05-09
JP5225474A JPS539239B2 (en) 1974-05-13 1974-05-13
JP6078774A JPS539240B2 (en) 1974-05-31 1974-05-31
JP9199674A JPS5123284A (en) 1974-08-13 1974-08-13 Shinkina penishirinruino seizoho
JP10995474A JPS5139687A (en) 1974-09-26 1974-09-26 SHINKINAPENISHIRINRUINOSEIZOHO
JP14249974A JPS5170788A (en) 1974-12-13 1974-12-13 Shinkina sefuarosuhorinruino seizoho
JP50037207A JPS51113890A (en) 1975-03-27 1975-03-27 Method for preparing novel cephalosporins

Publications (1)

Publication Number Publication Date
PH20534A true PH20534A (en) 1987-02-09

Family

ID=27564446

Family Applications (5)

Application Number Title Priority Date Filing Date
PH17137A PH21545A (en) 1974-05-09 1975-05-05 Novel penicillins and pharmaceutically acceptable salts thereof which contain a mono- or di- oxo piperazino (thio)-carbonyl amino group in molecule
PH18076A PH20534A (en) 1974-05-09 1976-02-10 Novel cephalosporins having a mono or d-oxo-piperazino-carbonyl groups in the molecule and a pharmaceutical composition thereof
PH19128A PH22346A (en) 1974-05-09 1976-11-15 2,3-dioxo-piperazino carbonylamino alkanoic acid
PH19129A PH22336A (en) 1974-05-09 1976-11-15 A reactive derivative of 2,3-dioxapiperazine derivative
PH19814A PH21987A (en) 1974-05-09 1977-05-25 Process for producing novel penicillins and cephalosporins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PH17137A PH21545A (en) 1974-05-09 1975-05-05 Novel penicillins and pharmaceutically acceptable salts thereof which contain a mono- or di- oxo piperazino (thio)-carbonyl amino group in molecule

Family Applications After (3)

Application Number Title Priority Date Filing Date
PH19128A PH22346A (en) 1974-05-09 1976-11-15 2,3-dioxo-piperazino carbonylamino alkanoic acid
PH19129A PH22336A (en) 1974-05-09 1976-11-15 A reactive derivative of 2,3-dioxapiperazine derivative
PH19814A PH21987A (en) 1974-05-09 1977-05-25 Process for producing novel penicillins and cephalosporins

Country Status (18)

Country Link
AR (1) AR209607A1 (en)
AT (1) AT344906B (en)
BE (1) BE828692A (en)
CH (1) CH605995A5 (en)
CY (1) CY1026A (en)
DD (1) DD117882A5 (en)
DE (2) DE2519400C3 (en)
DK (1) DK151338C (en)
FI (1) FI63760C (en)
FR (2) FR2269937B1 (en)
GB (2) GB1508064A (en)
HK (1) HK26279A (en)
HU (1) HU169633B (en)
IL (2) IL47168A (en)
KE (1) KE2923A (en)
NL (1) NL162386C (en)
PH (5) PH21545A (en)
SE (2) SE431457B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624958A5 (en) * 1975-06-24 1981-08-31 Bayer Ag Process for the preparation of beta-lactam compounds
DE2528079A1 (en) * 1975-06-24 1977-01-20 Bayer Ag PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT
FR2338046A2 (en) * 1976-01-19 1977-08-12 Toyama Chemical Co Ltd Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids
JPS6026800B2 (en) * 1976-01-22 1985-06-25 富山化学工業株式会社 Novel 7α-methoxycephalosporins and their production method
JPS52106883A (en) * 1976-02-13 1977-09-07 Toyama Chem Co Ltd Novel penicillins and cephalosporins
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
DE2831568C2 (en) * 1977-07-23 1985-01-10 Toyama Chemical Co. Ltd., Tokio / Tokyo 7 α-Methoxycephalosporins and methods for making the same
DE2810083A1 (en) * 1978-03-08 1979-09-20 Bayer Ag BETA-LACTAM COMPOUNDS
DE2813771A1 (en) * 1978-03-30 1979-10-11 Bayer Ag BETA-LACTAM COMPOUNDS
DE2817228A1 (en) * 1978-04-20 1979-10-31 Bayer Ag PROCESS FOR MANUFACTURING SEMI-SYNTHETIC BETA-LACTAMANTIBIOTICS
EP0015240A1 (en) * 1979-02-16 1980-09-03 Ciba-Geigy Ag Azacyclyl (thio) ureidoacetyl compounds and their preparation
CA1209477A (en) * 1981-03-26 1986-08-12 Bruce E. Haeger Composition of matter comprising a lyophilized preparation of a penicillin derivative
CA1200239A (en) * 1981-03-30 1986-02-04 Donald C. Boop Process for preparing 6-¬d-(-)-alpha-(4-c1-c4 alkyl- 2,3-dioxo-1-piperazinocarbonyl-amino)- phenylacetamido|penicillanic acid
JPS57118587A (en) * 1981-11-26 1982-07-23 Toyama Chem Co Ltd Novel penicillin
BG46664A1 (en) * 1985-08-16 1990-02-15 Druzhestven N Izsledovatelski Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid
DE3619562A1 (en) * 1986-06-11 1987-12-17 Basf Ag METHOD FOR PRODUCING 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES, NEW 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES AND THE USE THEREOF
US5859012A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
AU2002332640B2 (en) 2001-08-24 2007-11-08 University Of South Florida Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US7482365B2 (en) 2002-02-08 2009-01-27 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US20100063273A1 (en) * 2007-01-31 2010-03-11 Toyama Chemical Co., Ltd Novel crystal of piperacillin sodium
AU2009310959B2 (en) 2008-10-31 2015-05-07 Shionogi & Co., Ltd. Cephalosporin having catechol group
MX2012011521A (en) 2010-04-05 2013-03-08 Shionogi & Co Cephem compound having catechol group.
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
WO2011136268A1 (en) 2010-04-28 2011-11-03 塩野義製薬株式会社 Novel cephem derivative
CA2833121A1 (en) 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
WO2013002215A1 (en) 2011-06-27 2013-01-03 塩野義製薬株式会社 Cephem compound having pyridinium group
CN110746445B (en) * 2019-10-16 2021-03-16 深圳海关食品检验检疫技术中心 Preparation method of cefoperazone deuterated internal standard substance

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770620A1 (en) * 1968-06-12 1971-11-11 Bayer Ag New penicillins
DE2104580C3 (en) * 1971-02-01 1981-04-02 Bayer Ag, 5090 Leverkusen Acylureidopenicillins
DE2025415C3 (en) * 1970-05-25 1981-01-22 Bayer Ag, 5090 Leverkusen Process for the preparation of cyclic acylureido penicillins
US3741962A (en) 1971-05-21 1973-06-26 Squibb & Sons Inc Alpha-thioureidocephalosporanic acid compounds
BE790440A (en) * 1971-10-23 1973-04-24 Bayer Ag
BE794886A (en) * 1972-02-22 1973-08-02 Pfizer 6- (ALPHA- (OMEGA-GUANIDINOALCANOYLAMINO) ACYLAMINO) -PENICILLANIC ACIDS
CH570407A5 (en) * 1972-03-29 1975-12-15 Ciba Geigy Ag
AR204162A1 (en) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF AMPICILLIN DERIVATIVES
AR208171A1 (en) 1972-09-29 1976-12-09 Ciba Geigy Ag PROCEDURE FOR OBTAINING NEW DERIVATIVES OF CEF-3-EM-4-CARBOXYL ACID

Also Published As

Publication number Publication date
CH605995A5 (en) 1978-10-13
DE2519400B2 (en) 1981-05-21
DE2560239C2 (en) 1984-10-11
FI63760B (en) 1983-04-29
GB1508062A (en) 1978-04-19
KE2923A (en) 1979-04-06
AT344906B (en) 1978-08-25
FR2269937A1 (en) 1975-12-05
AR209607A1 (en) 1977-05-13
PH22336A (en) 1988-08-12
PH21545A (en) 1987-12-11
BE828692A (en) 1975-11-03
DD117882A5 (en) 1976-02-05
FI751340A (en) 1975-11-10
DE2519400C3 (en) 1982-02-11
NL7505375A (en) 1975-11-11
DE2519400A1 (en) 1976-03-04
FR2269937B1 (en) 1979-06-15
CY1026A (en) 1980-08-01
SE7505392L (en) 1975-12-23
PH22346A (en) 1988-08-12
NL162386B (en) 1979-12-17
SE435062B (en) 1984-09-03
GB1508064A (en) 1978-04-19
FR2320295A1 (en) 1977-03-04
HK26279A (en) 1979-05-04
SE431457B (en) 1984-02-06
IL47168A0 (en) 1975-06-25
DK151338C (en) 1988-07-18
IL47168A (en) 1979-07-25
SE7808204L (en) 1978-07-27
FR2320295B1 (en) 1980-11-07
AU8043175A (en) 1976-10-28
PH21987A (en) 1988-05-02
DK201975A (en) 1975-11-10
FI63760C (en) 1983-08-10
IL53485A0 (en) 1978-01-31
NL162386C (en) 1980-05-16
DK151338B (en) 1987-11-23
ATA828976A (en) 1977-12-15
HU169633B (en) 1976-12-28

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