DE2543870A1 - Verfahren zur herstellung von 5-fluor-2-methyl-1-(p-methyl-sulfinylbenzyliden)-indenyl-3-essigsaeure - Google Patents

Verfahren zur herstellung von 5-fluor-2-methyl-1-(p-methyl-sulfinylbenzyliden)-indenyl-3-essigsaeure

Info

Publication number
DE2543870A1
DE2543870A1 DE19752543870 DE2543870A DE2543870A1 DE 2543870 A1 DE2543870 A1 DE 2543870A1 DE 19752543870 DE19752543870 DE 19752543870 DE 2543870 A DE2543870 A DE 2543870A DE 2543870 A1 DE2543870 A1 DE 2543870A1
Authority
DE
Germany
Prior art keywords
acetic acid
valerolactone
acid
methyl
fluorobenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19752543870
Other languages
German (de)
English (en)
Inventor
David Gregory Melillo
Roger James Tull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2543870A1 publication Critical patent/DE2543870A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19752543870 1974-10-02 1975-10-01 Verfahren zur herstellung von 5-fluor-2-methyl-1-(p-methyl-sulfinylbenzyliden)-indenyl-3-essigsaeure Withdrawn DE2543870A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/511,349 US3998875A (en) 1974-10-02 1974-10-02 Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid

Publications (1)

Publication Number Publication Date
DE2543870A1 true DE2543870A1 (de) 1976-04-22

Family

ID=24034513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752543870 Withdrawn DE2543870A1 (de) 1974-10-02 1975-10-01 Verfahren zur herstellung von 5-fluor-2-methyl-1-(p-methyl-sulfinylbenzyliden)-indenyl-3-essigsaeure

Country Status (21)

Country Link
US (2) US3998875A (enExample)
JP (1) JPS51105049A (enExample)
AT (1) AT344154B (enExample)
BE (1) BE834080A (enExample)
CH (1) CH615158A5 (enExample)
CS (2) CS183850B2 (enExample)
DD (1) DD125639A5 (enExample)
DE (1) DE2543870A1 (enExample)
DK (1) DK416975A (enExample)
ES (1) ES441404A1 (enExample)
FI (1) FI61690C (enExample)
FR (1) FR2286817A1 (enExample)
GB (1) GB1483980A (enExample)
HU (1) HU171805B (enExample)
LU (1) LU73496A1 (enExample)
NL (1) NL7510944A (enExample)
NO (2) NO141050C (enExample)
PL (2) PL103093B1 (enExample)
SE (1) SE7510329L (enExample)
SU (3) SU860695A1 (enExample)
YU (2) YU239875A (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4368127A (en) * 1979-07-02 1983-01-11 Akzona Incorporated Fabric softening compounds and method
DE3266350D1 (en) * 1981-06-11 1985-10-24 Sumitomo Chemical Co Tetrahydronaphthalene derivatives and their production
IT1190371B (it) * 1985-06-19 1988-02-16 Zambon Spa Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
CN1110262C (zh) * 1996-07-01 2003-06-04 普罗克特和甘保尔公司 脱水马铃薯薄片
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
CN120965538A (zh) * 2025-10-21 2025-11-18 济南悟通生物科技有限公司 一种4-巯基-1-辛醇的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532752A (en) * 1965-12-30 1970-10-06 Merck & Co Inc 1-alkylidene-3-indenyl aliphatic amines
US3547923A (en) * 1968-03-25 1970-12-15 Bristol Myers Co Piperazyl ethyl 7h-benzocycloheptenes
US3654349A (en) * 1970-05-01 1972-04-04 Merck & Co Inc Substituted indenyl acetic acids
US3725548A (en) * 1970-05-01 1973-04-03 Merck & Co Inc Substituted indenyl acetic acids in the treatment of pain, fever or inflammation
US3766259A (en) * 1970-05-01 1973-10-16 Merck & Co Inc Preparation of 1-aryl-3-indenyl acetic acids
US3692825A (en) * 1970-05-01 1972-09-19 Merck & Co Inc Indanyl acetic acids
US3870753A (en) * 1973-12-20 1975-03-11 Merck & Co Inc Process for preparing indenyl acetic acids

Also Published As

Publication number Publication date
DD125639A5 (enExample) 1977-05-04
US4123457A (en) 1978-10-31
NL7510944A (nl) 1976-04-06
NO141050C (no) 1980-01-02
SU995705A3 (ru) 1983-02-07
CS183821B2 (en) 1978-07-31
SE7510329L (sv) 1976-04-05
US3998875A (en) 1976-12-21
LU73496A1 (enExample) 1976-08-19
HU171805B (hu) 1978-03-28
FR2286817B1 (enExample) 1979-01-05
ATA734575A (de) 1977-11-15
PL103093B1 (pl) 1979-05-31
PL103733B1 (pl) 1979-07-31
FI61690C (fi) 1982-09-10
ES441404A1 (es) 1977-03-01
AT344154B (de) 1978-07-10
NO791267L (no) 1976-04-05
YU239875A (en) 1982-06-30
FI752573A7 (enExample) 1976-04-03
YU141481A (en) 1982-02-28
CH615158A5 (enExample) 1980-01-15
SU860695A1 (ru) 1981-08-30
FI61690B (fi) 1982-05-31
JPS51105049A (en) 1976-09-17
BE834080A (fr) 1976-04-01
GB1483980A (en) 1977-08-24
NO141050B (no) 1979-09-24
NO753179L (enExample) 1976-04-05
DK416975A (da) 1976-04-03
FR2286817A1 (fr) 1976-04-30
SU957760A3 (ru) 1982-09-07
NO146198C (no) 1982-08-18
NO146198B (no) 1982-05-10
CS183850B2 (en) 1978-07-31

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination