DE2400931A1 - Derivate des vitamin d und verfahren zu ihrer herstellung - Google Patents

Derivate des vitamin d und verfahren zu ihrer herstellung

Info

Publication number
DE2400931A1
DE2400931A1 DE2400931A DE2400931A DE2400931A1 DE 2400931 A1 DE2400931 A1 DE 2400931A1 DE 2400931 A DE2400931 A DE 2400931A DE 2400931 A DE2400931 A DE 2400931A DE 2400931 A1 DE2400931 A1 DE 2400931A1
Authority
DE
Germany
Prior art keywords
vitamin
hydroxy
hydrogen
administered
previtamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2400931A
Other languages
German (de)
English (en)
Other versions
DE2400931C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Derk Harold Richard Pro Barton
Robert Henry Hesse
Ezzio Rizzardo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27348128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2400931(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Priority claimed from KR7401148A external-priority patent/KR790000218B1/ko
Publication of DE2400931A1 publication Critical patent/DE2400931A1/de
Application granted granted Critical
Publication of DE2400931C2 publication Critical patent/DE2400931C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
DE2400931A 1973-01-10 1974-01-09 Derivate des vitamin d und verfahren zu ihrer herstellung Granted DE2400931A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32246273A 1973-01-10 1973-01-10
US362339A US3901928A (en) 1973-01-10 1973-05-21 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
KR7401148A KR790000218B1 (en) 1973-01-10 1974-01-09 Process for preparation of 1 , 3 -dihy droxy steroid-5-enes

Publications (2)

Publication Number Publication Date
DE2400931A1 true DE2400931A1 (de) 1974-07-25
DE2400931C2 DE2400931C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-10-29

Family

ID=27348128

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2400931A Granted DE2400931A1 (de) 1973-01-10 1974-01-09 Derivate des vitamin d und verfahren zu ihrer herstellung
DE2463203A Expired DE2463203C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-01-10 1974-01-09

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2463203A Expired DE2463203C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-01-10 1974-01-09

Country Status (19)

Country Link
US (1) US3901928A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (4) JPS5745740B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR213608A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE809578A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1055011A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH603571A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE2400931A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK158786C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES422140A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2213053B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1463985A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK98589A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE40496B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU69133A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY104375A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL187010C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH14419A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE419981B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG68389G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2724994A1 (de) * 1976-06-03 1977-12-15 Res Inst Medicine Chem 5,6-cis- und 5,6-trans-10,19-dihydrovitamin d-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2945124A1 (de) * 1978-11-17 1980-06-04 Hoffmann La Roche Verfahren zur herstellung von 1 alpha, 3 beta -dihydroxy- delta hoch 5 -steroiden

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA74158B (en) * 1973-01-10 1975-03-26 Res Inst Medicine Chem Chemical process
US4022891A (en) * 1974-06-18 1977-05-10 Teijin Limited Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
US4004003A (en) * 1974-08-28 1977-01-18 The Upjohn Company 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
JPS5265262A (en) * 1975-11-27 1977-05-30 Teijin Ltd Synthesis of 1alpha acyloxy-provitamine d compounds
JPS5265261A (en) * 1975-11-27 1977-05-30 Teijin Ltd Synthesis of 1alpha-hyaroxy-provitamine d compounds
US4021423A (en) * 1976-03-08 1977-05-03 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholecalciferol
CH626336A5 (en) * 1976-03-08 1981-11-13 Hoffmann La Roche Process for the preparation of cholecalciferol derivatives
US4046760A (en) * 1976-07-01 1977-09-06 Merck & Co., Inc. Process for preparing 1-α-hydroxy cholesterol derivatives
IT1088094B (it) * 1976-10-14 1985-06-04 Hoffmann La Roche Derivati del pregnano
US4098801A (en) * 1977-01-26 1978-07-04 Hoffmann-La Roche Inc. Synthesis of 1α-hydroxylated derivatives of cholesterol
CH638215A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-derivate.
US4157984A (en) * 1977-06-08 1979-06-12 Z-L Limited Antioxidants, antioxidant compositions and methods of preparing and using same
US4218489A (en) * 1977-06-08 1980-08-19 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
JPS5452717A (en) * 1977-09-29 1979-04-25 Chugai Pharmaceut Co Ltd Stable oily pharmaceuticals containing 1alpha-hydroxyvitamin d
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
JPS557215A (en) * 1978-06-30 1980-01-19 Teijin Ltd Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
FR2457282A1 (fr) * 1979-05-23 1980-12-19 Roussel Uclaf Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament
DK160817C (da) * 1979-10-23 1991-10-07 Teijin Ltd Fremgangsmaade til fremstilling af vitamin d3 forbindelser
EP0070588B1 (en) * 1981-07-17 1986-05-07 Duphar International Research B.V Method of preparing 1-alpha-hydroxyvitamin d and 1-alpha-hydroxy-previtamin d compounds, and adduct of a previtamin d or tachysterol compound with a suitable dienophile
JPS5856646A (ja) * 1981-09-26 1983-04-04 Tatsuo Suda 産卵めんどりの初産促進方法、初産促進剤及びそのための飼料組成物
CA1272953A (en) 1984-10-08 1990-08-21 Yuji Makino Pharmaceutical composition for external use containing active-type vitamin d.sub.3
JPS61189229A (ja) * 1985-02-18 1986-08-22 Tokai Kapuseru Kk 安定な１α−ヒドロキシビタミンＤ類製剤
JPH0749435B2 (ja) * 1988-07-04 1995-05-31 帝人株式会社 １α，３β，２４−トリヒドロキシ−△▲上５▼−ステロイド類の製造方法
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
KR960013798B1 (ko) * 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
AU666529B2 (en) * 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
US5194431A (en) 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
WO2005077378A1 (ja) * 2004-02-18 2005-08-25 Mercian Corporation 家畜哺乳動物の低カルシウム血症の予防、治療および／または処置方法
CN115785182B (zh) * 2022-11-29 2024-06-21 浙江工业大学 一种1α-羟基胆固醇的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2259661B2 (de) * 1971-12-02 1975-05-15 Wisconsin Alumni Research Foundation, Madison, Wis. (V.St.A.) 1 alpha-Hydroxycholecalclferol Verfahren zu dessen Herstellung und dieses enthaltendes Geflügel- oder Tierfutter

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697559A (en) * 1971-02-25 1972-10-10 Wisconsin Alumni Res Found 1,25-dihydroxycholecalciferol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2259661B2 (de) * 1971-12-02 1975-05-15 Wisconsin Alumni Research Foundation, Madison, Wis. (V.St.A.) 1 alpha-Hydroxycholecalclferol Verfahren zu dessen Herstellung und dieses enthaltendes Geflügel- oder Tierfutter

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C. Djerassi, Steroid Reactions (1963), S. 596 u. 231 *
J. FRIED u. J.A. EDWARDS, Organic Reactions in Steroid Chemistry, Vol. 1, 1972, S.32 u. 38
Tetrahedron Letters 40 (1972), S. 4147-4150 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2724994A1 (de) * 1976-06-03 1977-12-15 Res Inst Medicine Chem 5,6-cis- und 5,6-trans-10,19-dihydrovitamin d-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2945124A1 (de) * 1978-11-17 1980-06-04 Hoffmann La Roche Verfahren zur herstellung von 1 alpha, 3 beta -dihydroxy- delta hoch 5 -steroiden
US4305881A (en) * 1978-11-17 1981-12-15 Hoffmann-La Roche Inc. Process for 1α,3β-dihydroxy-Δ5 -steroids

Also Published As

Publication number Publication date
JPS4995956A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-09-11
LU69133A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-04-02
DE2463203C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-06-04
ES422140A1 (es) 1976-08-01
BE809578A (fr) 1974-07-09
SG68389G (en) 1990-01-26
MY104375A (en) 1994-03-31
HK98589A (en) 1989-12-22
CA1055011A (en) 1979-05-22
IE40496B1 (en) 1979-06-20
NL187010C (nl) 1993-12-16
DE2400931C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-10-29
US3901928A (en) 1975-08-26
FR2213053B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-12-10
JPS50100216A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-08-08
IE40496L (en) 1974-07-10
SE419981B (sv) 1981-09-07
JPS50100045A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-08-08
JPS5854160B2 (ja) 1983-12-02
NL187010B (nl) 1990-12-03
CH603571A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-08-31
DK158786B (da) 1990-07-16
DK158786C (da) 1990-11-26
GB1463985A (en) 1977-02-09
PH14419A (en) 1981-07-10
NL7400282A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-07-12
AR213608A1 (es) 1979-02-28
JPS581116B2 (ja) 1983-01-10
JPS5745740B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1982-09-29
JPS51110554A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-09-30
FR2213053A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-08-02
AU6434974A (en) 1975-07-10

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