FR2457282A1 - Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament - Google Patents

Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament

Info

Publication number
FR2457282A1
FR2457282A1 FR7913118A FR7913118A FR2457282A1 FR 2457282 A1 FR2457282 A1 FR 2457282A1 FR 7913118 A FR7913118 A FR 7913118A FR 7913118 A FR7913118 A FR 7913118A FR 2457282 A1 FR2457282 A1 FR 2457282A1
Authority
FR
France
Prior art keywords
medicament
preparation
application
new derivative
dihydroxy cholecalciferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7913118A
Other languages
English (en)
Other versions
FR2457282B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7913118A priority Critical patent/FR2457282A1/fr
Priority to SE8002244A priority patent/SE445345B/sv
Priority to IL59857A priority patent/IL59857A/xx
Priority to ZA00802389A priority patent/ZA802389B/xx
Priority to US06/146,497 priority patent/US4435325A/en
Priority to HU801252A priority patent/HU182137B/hu
Priority to GR62007A priority patent/GR68548B/el
Priority to AU58627/80A priority patent/AU530140B2/en
Priority to PT71293A priority patent/PT71293B/fr
Priority to ES491732A priority patent/ES491732A0/es
Priority to CH402080A priority patent/CH646146A5/fr
Priority to IT48763/80A priority patent/IT1145684B/it
Priority to GB8016893A priority patent/GB2051818B/en
Priority to CA000352534A priority patent/CA1140155A/fr
Priority to BE0/200723A priority patent/BE883435A/fr
Priority to NL8003001A priority patent/NL8003001A/nl
Priority to DE19803019885 priority patent/DE3019885A1/de
Priority to AT0278780A priority patent/AT371434B/de
Priority to JP6798480A priority patent/JPS55160758A/ja
Publication of FR2457282A1 publication Critical patent/FR2457282A1/fr
Application granted granted Critical
Publication of FR2457282B1 publication Critical patent/FR2457282B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENTION A POUR OBJET LE MONOHYDRATE DE 1A,25 DIHYDROXY CHOLECALCIFEROL A (0,5 ETHANOL) 5348. LE PROCEDE DE PREPARATION DU MONOHYDRATE DE 1A,25 DIHYDROXY CHOLECALCIFEROL. A TITRE DE MEDICAMENT, LE MONOHYDRATE DE 1A,25 DIHYDROXY CHOLECALCIFEROL.
FR7913118A 1979-05-23 1979-05-23 Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament Granted FR2457282A1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR7913118A FR2457282A1 (fr) 1979-05-23 1979-05-23 Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament
SE8002244A SE445345B (sv) 1979-05-23 1980-03-24 Monohydratet av 1alfa,25-dihyroxi-cholekalciferol samt farmaceutiska kompositioner innehallande denna forening
IL59857A IL59857A (en) 1979-05-23 1980-04-17 Monohydrate of 1alpha,25-dihydroxycholecalciferol,process for preparing it and pharmaceutical compositions containing it
ZA00802389A ZA802389B (en) 1979-05-23 1980-04-21 New derivative of 1 alpha,25-dihydroxy-cholecalciferol,process for preparing it,its use as a medicament and the pharmaceutical compositions containing it
US06/146,497 US4435325A (en) 1979-05-23 1980-05-05 1α,25α-Dihydroxy-cholecalciferol and methods for the production thereof
HU801252A HU182137B (en) 1979-05-23 1980-05-20 Process for producing new derivatives of 1-alpha,25-dihydroxy-chloecalciferole
AU58627/80A AU530140B2 (en) 1979-05-23 1980-05-21 1alpha, 25-dihydroxycholecalciferol derivatives
GR62007A GR68548B (fr) 1979-05-23 1980-05-21
IT48763/80A IT1145684B (it) 1979-05-23 1980-05-22 Nuovi derivati di 1x25 diidrossi colecalciferolo dotati di attivita' farmacologica e procedimento per la loro preparazione
CH402080A CH646146A5 (fr) 1979-05-23 1980-05-22 Derive du 1alpha,25-dihydroxy cholecalciferol et son procede de preparation.
PT71293A PT71293B (fr) 1979-05-23 1980-05-22 Procede de preparation d'un nouveau derive du 1 alpha 25-dihydroxy cholecalciferol
GB8016893A GB2051818B (en) 1979-05-23 1980-05-22 Derivative of 1 ,25-dihydroxy-cholecalciferol
CA000352534A CA1140155A (fr) 1979-05-23 1980-05-22 PROCEDE DE PREPARATION D'UN NOUVEAU DERIVE DU 1.alpha.,25-DIHYDROXY CHOLECALCIFEROL
BE0/200723A BE883435A (fr) 1979-05-23 1980-05-22 Nouveau derive du 1alpha, 25-dihydroxy cholecalciferol, son procede de preparation, son application comme medicament et les compositions pharmaceutiques le renfermant
ES491732A ES491732A0 (es) 1979-05-23 1980-05-22 Procedimiento de preparacion de monohidrato de 1,25-dihidro-xi-colecalciferol
NL8003001A NL8003001A (nl) 1979-05-23 1980-05-23 Nieuw derivaat van 1 alfa, 25-dihydroxy-cholecalciferol en werkwijzen voor het bereiden en toepassen van dit derivaat.
DE19803019885 DE3019885A1 (de) 1979-05-23 1980-05-23 Neues 1 alpha ,25-dihydroxycholecalciferol-derivat, verfahren zu dessen herstellung, seine verwendung als arzneimittel und die sie enthaltenden pharmazeutischen zusammensetzungen
AT0278780A AT371434B (de) 1979-05-23 1980-05-23 Verfahren zur herstellung eines neuen derivates des 1alpha,25-dihydroxycholecalciferols
JP6798480A JPS55160758A (en) 1979-05-23 1980-05-23 Novel derivative of 1 alpha*255 dihydroxycholecalciferol* its manufacture* use as drug and pharmaceutic composition containing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7913118A FR2457282A1 (fr) 1979-05-23 1979-05-23 Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament

Publications (2)

Publication Number Publication Date
FR2457282A1 true FR2457282A1 (fr) 1980-12-19
FR2457282B1 FR2457282B1 (fr) 1983-10-28

Family

ID=9225772

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7913118A Granted FR2457282A1 (fr) 1979-05-23 1979-05-23 Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament

Country Status (19)

Country Link
US (1) US4435325A (fr)
JP (1) JPS55160758A (fr)
AT (1) AT371434B (fr)
AU (1) AU530140B2 (fr)
BE (1) BE883435A (fr)
CA (1) CA1140155A (fr)
CH (1) CH646146A5 (fr)
DE (1) DE3019885A1 (fr)
ES (1) ES491732A0 (fr)
FR (1) FR2457282A1 (fr)
GB (1) GB2051818B (fr)
GR (1) GR68548B (fr)
HU (1) HU182137B (fr)
IL (1) IL59857A (fr)
IT (1) IT1145684B (fr)
NL (1) NL8003001A (fr)
PT (1) PT71293B (fr)
SE (1) SE445345B (fr)
ZA (1) ZA802389B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
USRE33107E (en) * 1983-03-22 1989-11-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same
US4610978A (en) * 1983-03-22 1986-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
USRE39706E1 (en) * 1993-01-15 2007-06-26 Leo Pharma A/S Crystalline form of a vitamin D analogue

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2126414A1 (fr) * 1971-02-25 1972-10-06 Wisconsin Alumni Res Found
FR2213053A1 (fr) * 1973-01-10 1974-08-02 Res Inst Medicine Chemistry
FR2301503A1 (fr) * 1975-02-24 1976-09-17 Hoffmann La Roche Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol
US4022768A (en) * 1976-02-12 1977-05-10 Wisconsin Alumni Research Foundation Process for preparation of 1α,25-dihydroxycholecalciferol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
JPS4934980A (fr) * 1972-08-04 1974-03-30
JPS51100056A (en) * 1975-02-28 1976-09-03 Chugai Pharmaceutical Co Ltd 1 arufua 255 jihidorokishikorekarushifuerooruno seiho

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2126414A1 (fr) * 1971-02-25 1972-10-06 Wisconsin Alumni Res Found
FR2213053A1 (fr) * 1973-01-10 1974-08-02 Res Inst Medicine Chemistry
FR2301503A1 (fr) * 1975-02-24 1976-09-17 Hoffmann La Roche Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol
US4022768A (en) * 1976-02-12 1977-05-10 Wisconsin Alumni Research Foundation Process for preparation of 1α,25-dihydroxycholecalciferol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1975 *

Also Published As

Publication number Publication date
JPS55160758A (en) 1980-12-13
IT1145684B (it) 1986-11-05
US4435325A (en) 1984-03-06
SE8002244L (sv) 1980-11-24
FR2457282B1 (fr) 1983-10-28
GR68548B (fr) 1982-01-18
GB2051818B (en) 1983-06-29
ZA802389B (en) 1981-04-29
SE445345B (sv) 1986-06-16
ES8102092A1 (es) 1980-12-16
IT8048763A0 (it) 1980-05-22
ATA278780A (de) 1982-11-15
AU5862780A (en) 1980-11-27
ES491732A0 (es) 1980-12-16
IL59857A (en) 1983-12-30
DE3019885C2 (fr) 1990-04-05
AT371434B (de) 1983-06-27
NL8003001A (nl) 1980-11-25
PT71293A (fr) 1980-06-01
AU530140B2 (en) 1983-07-07
DE3019885A1 (de) 1980-11-27
HU182137B (en) 1983-12-28
IL59857A0 (en) 1980-06-30
BE883435A (fr) 1980-11-24
CA1140155A (fr) 1983-01-25
GB2051818A (en) 1981-01-21
CH646146A5 (fr) 1984-11-15
PT71293B (fr) 1981-09-21

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Legal Events

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CD Change of name or company name
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