DE2301317C2 - Alkylierte 3,20-Diketo-Δ↑4↑-steroide der Pregnanreihe und Verfahren zu deren Herstellung - Google Patents

Alkylierte 3,20-Diketo-Δ↑4↑-steroide der Pregnanreihe und Verfahren zu deren Herstellung

Info

Publication number
DE2301317C2
DE2301317C2 DE2301317A DE2301317A DE2301317C2 DE 2301317 C2 DE2301317 C2 DE 2301317C2 DE 2301317 A DE2301317 A DE 2301317A DE 2301317 A DE2301317 A DE 2301317A DE 2301317 C2 DE2301317 C2 DE 2301317C2
Authority
DE
Germany
Prior art keywords
dione
trimethyl
hydroxy
solution
pregnen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2301317A
Other languages
German (de)
English (en)
Other versions
DE2301317A1 (de
Inventor
James Cumbernauld Scotland Cairns
George Airdrie Scotland McGarry
Gilbert Frederick Glasgow Scotland Woods
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of DE2301317A1 publication Critical patent/DE2301317A1/de
Application granted granted Critical
Publication of DE2301317C2 publication Critical patent/DE2301317C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2301317A 1972-01-12 1973-01-11 Alkylierte 3,20-Diketo-Δ↑4↑-steroide der Pregnanreihe und Verfahren zu deren Herstellung Expired DE2301317C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB153472A GB1416427A (en) 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same

Publications (2)

Publication Number Publication Date
DE2301317A1 DE2301317A1 (de) 1973-07-26
DE2301317C2 true DE2301317C2 (de) 1983-11-03

Family

ID=9723658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2301317A Expired DE2301317C2 (de) 1972-01-12 1973-01-11 Alkylierte 3,20-Diketo-Δ↑4↑-steroide der Pregnanreihe und Verfahren zu deren Herstellung

Country Status (17)

Country Link
US (1) US3862194A (cs)
JP (1) JPS5614678B2 (cs)
AT (1) AT367068B (cs)
BE (1) BE793958A (cs)
CA (1) CA1022158A (cs)
CH (1) CH615934A5 (cs)
DE (1) DE2301317C2 (cs)
DK (1) DK139031B (cs)
FI (1) FI52587C (cs)
FR (1) FR2168006B1 (cs)
GB (1) GB1416427A (cs)
HU (1) HU167205B (cs)
IE (1) IE37048B1 (cs)
IL (1) IL41160A (cs)
NL (2) NL179287C (cs)
PH (1) PH9719A (cs)
SE (1) SE411213B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947478A (en) * 1972-01-12 1976-03-30 Akzona Incorporated Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
GB1436324A (en) * 1972-05-12 1976-05-19 Glaxo Lab Ltd Anaesthetic 3alpha-hydroxy pregnanes
US4031075A (en) * 1973-07-11 1977-06-21 Akzona Incorporated Alkylated pregnanes and process for obtaining same
GB1478968A (en) * 1973-07-11 1977-07-06 Akzo Nv Alkylated pregnanes
JPS5264666A (en) * 1975-11-25 1977-05-28 Sharp Kk Bothhside circuit substrate
EP0014005B1 (en) * 1979-01-24 1983-08-03 Akzo N.V. Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
JPS58194A (ja) * 1981-06-25 1983-01-05 北陸電気工業株式会社 Ｃｕ粉末導電塗料を用いた印刷抵抗回路基板の製造方法
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
EP0523132A1 (en) * 1990-03-27 1993-01-20 Schering Corporation PROCESS FOR 9$g(a)-HYDROXY STEROID DEHYDRATION
WO1997022616A1 (en) * 1995-12-20 1997-06-26 Schering Corporation PROCESS FOR PREPARATION OF 9,11β-EPOXIDE STEROIDS
US6040468A (en) * 1996-10-25 2000-03-21 Alcon Laboratories, Inc. Method of preparing 16α, 17α-dialkylated steroids
EP0882062A1 (en) * 1996-10-25 1998-12-09 Alcon Laboratories, Inc. Method of preparing 21-alkylated pregna-1,4,16-trien-3,20-diones
CN1336824A (zh) * 1997-06-04 2002-02-20 阿克佐诺贝尔公司 抗炎甾类化合物在治疗慢性感染性肠道疾病中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064017A (en) * 1962-11-13 Preparation viii
US3047594A (en) * 1960-05-11 1962-07-31 Pfizer & Co C Preparation of 21-methyl steroids and intermediates
US3114750A (en) * 1960-11-07 1963-12-17 British Drug Houses Ltd 3-enol ethers of 6-formyl-3-oxo-delta4-steroids and process for their preparation
US3166551A (en) * 1962-01-02 1965-01-19 British Drug Houses Ltd Process for the preparation of 3-oxo-delta4-6-methyl steroids
DE1167829B (de) * 1962-08-03 1964-04-16 Schering Ag Verfahren zur Herstellung von 21-Methyl-í¸-pregnen-11ª‰, 17ª‡-diol-3, 20-dion
US3594407A (en) * 1969-04-03 1971-07-20 American Home Prod 13,17-dialkyl-19-norpregn-4-ene,3,20-diones

Also Published As

Publication number Publication date
JPS504060A (cs) 1975-01-16
DK139031B (da) 1978-12-04
NL930031I1 (nl) 1993-07-01
IE37048L (en) 1973-07-12
ATA28373A (de) 1981-10-15
HU167205B (cs) 1975-09-27
AT367068B (de) 1982-05-25
NL179287C (nl) 1986-08-18
FR2168006A1 (cs) 1973-08-24
CH615934A5 (cs) 1980-02-29
FR2168006B1 (cs) 1976-09-03
CA1022158A (en) 1977-12-06
PH9719A (en) 1976-02-27
US3862194A (en) 1975-01-21
DK139031C (cs) 1979-05-14
FI52587C (fi) 1977-10-10
NL179287B (nl) 1986-03-17
GB1416427A (en) 1975-12-03
FI52587B (cs) 1977-06-30
IE37048B1 (en) 1977-04-27
IL41160A0 (en) 1973-02-28
NL7300313A (cs) 1973-07-16
SE411213B (sv) 1979-12-10
IL41160A (en) 1977-04-29
DE2301317A1 (de) 1973-07-26
BE793958A (fr) 1973-07-12
JPS5614678B2 (cs) 1981-04-06

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Legal Events

Date Code Title Description
OD Request for examination
8125 Change of the main classification

Ipc: C07J 9/00

D2 Grant after examination
8364 No opposition during term of opposition