DE214376C - - Google Patents
Info
- Publication number
- DE214376C DE214376C DENDAT214376D DE214376DA DE214376C DE 214376 C DE214376 C DE 214376C DE NDAT214376 D DENDAT214376 D DE NDAT214376D DE 214376D A DE214376D A DE 214376DA DE 214376 C DE214376 C DE 214376C
- Authority
- DE
- Germany
- Prior art keywords
- theophylline
- piperazine
- mol
- water
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 28
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 16
- 229960000278 theophylline Drugs 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- -1 carbonic acid Chemical class 0.000 claims 1
- 235000015250 liver sausages Nutrition 0.000 claims 1
- 230000005923 long-lasting effect Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 6
- 159000000000 sodium salts Chemical class 0.000 description 4
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 229940075420 xanthine Drugs 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 229960004559 theobromine Drugs 0.000 description 2
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000004027 organic amino compounds Chemical class 0.000 description 1
- 229960005222 phenazone Drugs 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE223695T |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE214376C true DE214376C (en:Method) |
Family
ID=33035725
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT224981D Active DE224981C (en:Method) | |||
| DENDAT223695D Active DE223695C (en:Method) | |||
| DENDAT214376D Active DE214376C (en:Method) | |||
| DENDAT217620D Active DE217620C (en:Method) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT224981D Active DE224981C (en:Method) | |||
| DENDAT223695D Active DE223695C (en:Method) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT217620D Active DE217620C (en:Method) |
Country Status (1)
| Country | Link |
|---|---|
| DE (4) | DE217620C (en:Method) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE748005C (de) * | 1939-12-15 | 1944-10-23 | Verfahren zur Herstellung von leicht wasserloeslichen Verbindungen des Theophyllins bzw. Coffeins | |
| DE762284C (de) * | 1940-07-15 | 1952-07-24 | Byk Guldenwerke Chem Fab A G | Verfahren zur Erhoehung der Wasserloeslichkeit der Dimethylxanthine und ihrer Verbindungen |
| DE908857C (de) * | 1951-05-28 | 1954-06-08 | Hoffmann La Roche | Verfahren zur Herstellung einer leicht loeslichen Verbindung aus Theophyllin und 3-Aminomethylpyridin |
| DE944518C (de) * | 1950-08-20 | 1956-06-14 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung von Loesungen von in 1, 3-Stellung substituierten Xanthinen |
| US6070295A (en) * | 1998-09-22 | 2000-06-06 | Bemis Manufacturing Company | Quick release toilet seat hinge with swivel |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1207936B (de) * | 1961-03-17 | 1965-12-30 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung wasserloeslicher Theophyllinverbindungen von bisquartaerenAmmoniumhydroxyden |
| DE2547916C2 (de) * | 1975-10-25 | 1986-06-05 | Zahnradfabrik Friedrichshafen Ag, 7990 Friedrichshafen | Endabschaltung für den Lenkmotor von hydraulischen Kraftfahrzeug-Servolenkanlagen |
-
0
- DE DENDAT224981D patent/DE224981C/de active Active
- DE DENDAT223695D patent/DE223695C/de active Active
- DE DENDAT214376D patent/DE214376C/de active Active
- DE DENDAT217620D patent/DE217620C/de active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE748005C (de) * | 1939-12-15 | 1944-10-23 | Verfahren zur Herstellung von leicht wasserloeslichen Verbindungen des Theophyllins bzw. Coffeins | |
| DE762284C (de) * | 1940-07-15 | 1952-07-24 | Byk Guldenwerke Chem Fab A G | Verfahren zur Erhoehung der Wasserloeslichkeit der Dimethylxanthine und ihrer Verbindungen |
| DE944518C (de) * | 1950-08-20 | 1956-06-14 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung von Loesungen von in 1, 3-Stellung substituierten Xanthinen |
| DE908857C (de) * | 1951-05-28 | 1954-06-08 | Hoffmann La Roche | Verfahren zur Herstellung einer leicht loeslichen Verbindung aus Theophyllin und 3-Aminomethylpyridin |
| US6070295A (en) * | 1998-09-22 | 2000-06-06 | Bemis Manufacturing Company | Quick release toilet seat hinge with swivel |
Also Published As
| Publication number | Publication date |
|---|---|
| DE223695C (en:Method) | |
| DE224981C (en:Method) | |
| DE217620C (en:Method) |
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