DE19959696A1 - Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen - Google Patents

Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Info

Publication number
DE19959696A1
DE19959696A1 DE19959696A DE19959696A DE19959696A1 DE 19959696 A1 DE19959696 A1 DE 19959696A1 DE 19959696 A DE19959696 A DE 19959696A DE 19959696 A DE19959696 A DE 19959696A DE 19959696 A1 DE19959696 A1 DE 19959696A1
Authority
DE
Germany
Prior art keywords
methylene
group
hydroxy
androst
androsta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19959696A
Other languages
German (de)
English (en)
Inventor
Sven Ring
Walter Elger
Guenter Kaufmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Priority to DE19959696A priority Critical patent/DE19959696A1/de
Priority to HU0203655A priority patent/HUP0203655A3/hu
Priority to EEP200200302A priority patent/EE200200302A/xx
Priority to PL00356061A priority patent/PL356061A1/xx
Priority to AT00979607T priority patent/ATE275576T1/de
Priority to DK00979607T priority patent/DK1235850T3/da
Priority to KR10-2002-7007365A priority patent/KR100468341B1/ko
Priority to US10/148,157 priority patent/US6710039B1/en
Priority to JP2001543572A priority patent/JP3793088B2/ja
Priority to ES00979607T priority patent/ES2226949T3/es
Priority to US11/008,758 priority patent/USRE39862E1/en
Priority to RU2002117425/04A priority patent/RU2244718C2/ru
Priority to CZ20022005A priority patent/CZ20022005A3/cs
Priority to IL15008200A priority patent/IL150082A0/xx
Priority to SI200030553T priority patent/SI1235850T1/xx
Priority to BR0016737-1A priority patent/BR0016737A/pt
Priority to SK809-2002A priority patent/SK8092002A3/sk
Priority to EP00979607A priority patent/EP1235850B1/de
Priority to DE50007708T priority patent/DE50007708D1/de
Priority to AU17038/01A priority patent/AU774384B2/en
Priority to CA002393758A priority patent/CA2393758C/en
Priority to PT00979607T priority patent/PT1235850E/pt
Priority to PCT/EP2000/011557 priority patent/WO2001042275A1/de
Priority to CNB008188556A priority patent/CN1205219C/zh
Priority to MXPA02005644A priority patent/MXPA02005644A/es
Publication of DE19959696A1 publication Critical patent/DE19959696A1/de
Priority to IL150082A priority patent/IL150082A/en
Priority to NO20022712A priority patent/NO323376B1/no
Priority to BG106861A priority patent/BG106861A/bg
Priority to ZA200205362A priority patent/ZA200205362B/xx
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE19959696A 1999-12-08 1999-12-08 Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen Ceased DE19959696A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE19959696A DE19959696A1 (de) 1999-12-08 1999-12-08 Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
BR0016737-1A BR0016737A (pt) 1999-12-08 2000-11-21 14,15-ciclopropano-androstanos insaturados, processos para a sua preparação e composições farmacêuticas contendo estes compostos
SK809-2002A SK8092002A3 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds
EEP200200302A EE200200302A (et) 1999-12-08 2000-11-21 Küllastumata 14,15-tsüklopropanoandrostaanid, nende valmistamise meetod ja neid ühendeid sisaldavadfarmatseutilised kompositsioonid
AT00979607T ATE275576T1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
DK00979607T DK1235850T3 (da) 1999-12-08 2000-11-21 Umættede 14,15-cyclopropano-androstaner, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
KR10-2002-7007365A KR100468341B1 (ko) 1999-12-08 2000-11-21 불포화 14,15-시클로프로판-안드로스탄, 이의 제조 방법및 이 화합물을 포함하는 제약 조성물
US10/148,157 US6710039B1 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharamceutical compositions containing these compounds
JP2001543572A JP3793088B2 (ja) 1999-12-08 2000-11-21 不飽和１４，１５−シクロプロパノ−アンドロスタン、その製造法および該化合物を含有する医薬組成物
ES00979607T ES2226949T3 (es) 1999-12-08 2000-11-21 14,15-ciclopropano-androstanos insaturados, un procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos.
US11/008,758 USRE39862E1 (en) 1999-12-08 2000-11-21 Unsaturated 14, 15-cyclopropanoandrostanes, a method for their production and pharmaceutical compositions containing these compounds
RU2002117425/04A RU2244718C2 (ru) 1999-12-08 2000-11-21 Ненасыщенные 14,15-циклопропаноандростаны, способ их получения, соединения, фармацевтическая композиция
CZ20022005A CZ20022005A3 (cs) 1999-12-08 2000-11-21 Nenasycené 14, 15-cyklopropano-androstany, způsob jejich přípravy a farmaceutické kompozice obsahující tyto sloučeniny
IL15008200A IL150082A0 (en) 1999-12-08 2000-11-21 Unsaturated 14, 15-cyclopropane-andostranes, a method for their production and pharmaceutical compositions containing these compounds
SI200030553T SI1235850T1 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds
HU0203655A HUP0203655A3 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds
PL00356061A PL356061A1 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds
EP00979607A EP1235850B1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
DE50007708T DE50007708D1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
AU17038/01A AU774384B2 (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds
CA002393758A CA2393758C (en) 1999-12-08 2000-11-21 Unsaturated 14,15-cyclopropano-androstanes
PT00979607T PT1235850E (pt) 1999-12-08 2000-11-21 14,15-ciclopropano-androstanos insaturados, processo para a sua preparacao e composicoes farmaceuticas contendo estes compostos
PCT/EP2000/011557 WO2001042275A1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
CNB008188556A CN1205219C (zh) 1999-12-08 2000-11-21 不饱和14,15－环丙烷并－雄烷,其制备方法以及包含该化合物的药物组合物
MXPA02005644A MXPA02005644A (es) 1999-12-08 2000-11-21 14,15-ciclopropano-androstanos insaturados, un metodo para su produccion y composiciones farmaceuticas que contienen estos compuestos.
IL150082A IL150082A (en) 1999-12-08 2002-06-06 Unsaturated 14,15 - cyclopropane
NO20022712A NO323376B1 (no) 1999-12-08 2002-06-07 Umettede 14,15-syklopropanandrostaner, fremgangsmate for deres fremstilling, farmasoytiske preparater som inneholder disse forbindelsene, og anvendelse av forbindelsene til fremstilling av farmasoytiske preparater.
BG106861A BG106861A (bg) 1999-12-08 2002-06-24 Ненаситени 14,15-циклопропано-андростани, метод за тяхното получаване и фармацевтични състави, които ги съдържат
ZA200205362A ZA200205362B (en) 1999-12-08 2002-07-04 Unsaturated 14, 15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19959696A DE19959696A1 (de) 1999-12-08 1999-12-08 Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
DE19959696A1 true DE19959696A1 (de) 2001-06-21

Family

ID=7932216

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19959696A Ceased DE19959696A1 (de) 1999-12-08 1999-12-08 Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE50007708T Expired - Fee Related DE50007708D1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50007708T Expired - Fee Related DE50007708D1 (de) 1999-12-08 2000-11-21 Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Country Status (26)

Country Link
US (2) US6710039B1 (cs)
EP (1) EP1235850B1 (cs)
JP (1) JP3793088B2 (cs)
KR (1) KR100468341B1 (cs)
CN (1) CN1205219C (cs)
AT (1) ATE275576T1 (cs)
AU (1) AU774384B2 (cs)
BG (1) BG106861A (cs)
BR (1) BR0016737A (cs)
CA (1) CA2393758C (cs)
CZ (1) CZ20022005A3 (cs)
DE (2) DE19959696A1 (cs)
DK (1) DK1235850T3 (cs)
EE (1) EE200200302A (cs)
ES (1) ES2226949T3 (cs)
HU (1) HUP0203655A3 (cs)
IL (2) IL150082A0 (cs)
MX (1) MXPA02005644A (cs)
NO (1) NO323376B1 (cs)
PL (1) PL356061A1 (cs)
PT (1) PT1235850E (cs)
RU (1) RU2244718C2 (cs)
SI (1) SI1235850T1 (cs)
SK (1) SK8092002A3 (cs)
WO (1) WO2001042275A1 (cs)
ZA (1) ZA200205362B (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE31269C (de) * B.GERVAIS in Montmorillon Vienne, Frankreich Transportable Brauerei für Kleinbetrieb
DE33136C (de) * J. KENDAL und M. LAVAL in London Uhr mit zwei Zifferblättern und dazu gehörigem Zeigerstellwerk
NL110102C (cs) 1956-03-26
CH376097A (de) * 1956-04-23 1964-03-31 Farmaceutici Italia Verfahren zur Herstellung von 4-Halogen-3-keto- 4-steroiden
US2895969A (en) 1957-09-23 1959-07-21 Syntex Sa Cyclopentanophenanthrene derivatives
GB839908A (en) 1957-12-24 1960-06-29 Farmaceutici Italia 4,17ª‡-dihydroxy progesterone and its esters and the preparation thereof
GB874572A (en) 1959-02-18 1961-08-10 Farmaceutici Italia A method for the production of new ketosteroid compounds
GB928714A (en) 1961-02-10 1963-06-12 Farmaceutici Italia Process for the preparation of 4-hydroxy-3-keto-í¸-steroids
GB991804A (en) 1962-03-13 1965-05-12 Piero Gomarasca New derivatives of cyclopentanophenanthrene and processes for their preparation
US3239512A (en) 1964-08-04 1966-03-08 Syntex Corp 17-tetrahydropyranylether of 4-chlorotestosterone
DE19537626A1 (de) * 1995-10-10 1997-04-17 Jenapharm Gmbh Steroide mit einer 14, 15-Methylengruppe
DE19827523A1 (de) 1998-06-22 1999-12-23 Jenapharm Gmbh Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
AU774384B2 (en) 2004-06-24
DE50007708D1 (de) 2004-10-14
CN1205219C (zh) 2005-06-08
NO20022712L (no) 2002-06-07
CA2393758A1 (en) 2001-06-14
JP3793088B2 (ja) 2006-07-05
USRE39862E1 (en) 2007-09-25
EP1235850B1 (de) 2004-09-08
SK8092002A3 (en) 2003-05-02
IL150082A0 (en) 2002-12-01
PL356061A1 (en) 2004-06-14
KR100468341B1 (ko) 2005-01-27
NO323376B1 (no) 2007-04-16
ATE275576T1 (de) 2004-09-15
CA2393758C (en) 2007-06-12
EP1235850A1 (de) 2002-09-04
CN1433425A (zh) 2003-07-30
EE200200302A (et) 2003-06-16
AU1703801A (en) 2001-06-18
KR20030028448A (ko) 2003-04-08
NO20022712D0 (no) 2002-06-07
DK1235850T3 (da) 2005-01-17
RU2244718C2 (ru) 2005-01-20
JP2003516416A (ja) 2003-05-13
BG106861A (bg) 2003-02-28
SI1235850T1 (en) 2005-04-30
MXPA02005644A (es) 2002-12-13
IL150082A (en) 2007-05-15
ES2226949T3 (es) 2005-04-01
HUP0203655A3 (en) 2004-07-28
PT1235850E (pt) 2005-01-31
BR0016737A (pt) 2002-11-05
HUP0203655A2 (hu) 2003-03-28
CZ20022005A3 (cs) 2002-10-16
ZA200205362B (en) 2003-10-06
WO2001042275A1 (de) 2001-06-14
US6710039B1 (en) 2004-03-23

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: SCHERING AG, 13353 BERLIN, DE

8131 Rejection