GB928714A - Process for the preparation of 4-hydroxy-3-keto-í¸-steroids - Google Patents
Process for the preparation of 4-hydroxy-3-keto-í¸-steroidsInfo
- Publication number
- GB928714A GB928714A GB437662A GB437662A GB928714A GB 928714 A GB928714 A GB 928714A GB 437662 A GB437662 A GB 437662A GB 437662 A GB437662 A GB 437662A GB 928714 A GB928714 A GB 928714A
- Authority
- GB
- United Kingdom
- Prior art keywords
- keto
- hydroxy
- steroid
- chloro
- testosterone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
4-Hydroxy-3-keto-D 4-steroid is prepared by treating a 19-nor- or a 10b -methyl-4-halo-3-keto-D 4-steroi dissolved in a t-aliphatic alcohol with oxygen in the presence of an alkali metal salt of a t-aliphatic alcohol at from 10 DEG to 50 DEG C. and, in the case of 10b -methyl reactant, catalytically hydrogenating the resulting 4-hydroxy-3-keto-D 4,6-steroid produced until one mol of hydrogen is absorbed. The above process may be modified in that the resulting 4-hydroxy-3-keto-D 4-steroid is acylated to form the corresponding 4-acyloxy compound. The initial reactants used in the above process may be a 4-chloro-D 4-steroid of the androstane, 19-nor-androstane and 17a -hydroxy-pregnane series such as 4-chlorotestosterone acetate, 4-chloro-17a -methyl-testosterone and 19-nor-testosterone, 4-chloro-19-nor-testosterone and 4-chloro-4-pregnen-17a -ol-3,20-dione. Therapeutic compositions having anabolic, androgenic and progestative activity contain as the active ingredient a 4-hydroxy (or acyloxy)-3-keto-D 4-steroid and a pharmacologically acceptable carrier. Specifications 838,773, 839,908, 848,288, 864,608, 864,610, 864,611, 864,613, 867,721, 888,665 and 922,803 also are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT245761 | 1961-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB928714A true GB928714A (en) | 1963-06-12 |
Family
ID=11102880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB437662A Expired GB928714A (en) | 1961-02-10 | 1962-02-05 | Process for the preparation of 4-hydroxy-3-keto-í¸-steroids |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT240543B (en) |
| BE (1) | BE613713A (en) |
| ES (1) | ES274471A1 (en) |
| GB (1) | GB928714A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001042275A1 (en) * | 1999-12-08 | 2001-06-14 | Jenapharm Gmbh & Co. Kg | Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds |
-
1962
- 1962-02-05 GB GB437662A patent/GB928714A/en not_active Expired
- 1962-02-09 AT AT107862A patent/AT240543B/en active
- 1962-02-09 ES ES0274471A patent/ES274471A1/en not_active Expired
- 1962-02-09 BE BE613713A patent/BE613713A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001042275A1 (en) * | 1999-12-08 | 2001-06-14 | Jenapharm Gmbh & Co. Kg | Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds |
| US6710039B1 (en) | 1999-12-08 | 2004-03-23 | Schering Ag | Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharamceutical compositions containing these compounds |
| USRE39862E1 (en) * | 1999-12-08 | 2007-09-25 | Schering Ag | Unsaturated 14, 15-cyclopropanoandrostanes, a method for their production and pharmaceutical compositions containing these compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| ES274471A1 (en) | 1962-07-16 |
| BE613713A (en) | 1962-05-29 |
| AT240543B (en) | 1965-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1096762A (en) | Processes for preparing steroids compounds and the compounds when thus prepared | |
| GB928714A (en) | Process for the preparation of 4-hydroxy-3-keto-í¸-steroids | |
| GB1409239A (en) | Process for the preparation of 3alpha-hydroxy-5alpha-steroids | |
| GB928805A (en) | Steroid compounds | |
| GB1100443A (en) | 17ª‡-chloroethynyl-13ª‰-ethylgonenolone | |
| GB919565A (en) | 17 alpha-chlorethynyl steroids | |
| ES290864A1 (en) | Novel steroid esters, their preparation and employment | |
| GB937598A (en) | Process for the production of reserpic acid diesters | |
| US2952676A (en) | 17alpha-carboxyalkyl-17beta-hydroxyandros-tan-3-one lactones and nor compounds corresponding | |
| GB1067345A (en) | Novel steroid compounds, processes for preparing them and compositions containing them | |
| GB957541A (en) | 5ª‡-steroids | |
| GB1164705A (en) | Preparation of Delta<7>-Dehydro Steroids | |
| GB970898A (en) | Derivatives of 6ª-methyl-17ª-hydroxyprogesterone and method of preparing them | |
| GB1101791A (en) | New 1ª‡:7ª‡-dimethyl steroids and a process for their manufacture | |
| GB992148A (en) | Synthesis of steroids | |
| FR2115454A1 (en) | Hormonal delta-4-6, 7-dimethyl steroids - prepd by dehydration of 5-hydroxy cpds | |
| GB1214508A (en) | 03-alkyl-11-oxygenated-18,19-dinorpregnenes | |
| GB849072A (en) | Improvements in or relating to steroids and the manufacture thereof | |
| GB1231003A (en) | ||
| GB877024A (en) | Improvements in or relating to steroid derivatives | |
| GB884544A (en) | 6-methyl steroid compounds | |
| GB1066658A (en) | Oxido androstanes | |
| GB923736A (en) | Improvements in or relating to steroids | |
| GB1043156A (en) | 10-hydroxy-19-norandrostanes | |
| ES459520A1 (en) | D-homosteroids |