ES290864A1 - Novel steroid esters, their preparation and employment - Google Patents

Novel steroid esters, their preparation and employment

Info

Publication number
ES290864A1
ES290864A1 ES0290864A ES290864A ES290864A1 ES 290864 A1 ES290864 A1 ES 290864A1 ES 0290864 A ES0290864 A ES 0290864A ES 290864 A ES290864 A ES 290864A ES 290864 A1 ES290864 A1 ES 290864A1
Authority
ES
Spain
Prior art keywords
hexahydrobenzyloxycarbonyloxy
preparation
estra
triene
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0290864A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES290864A1 publication Critical patent/ES290864A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 3 - (hexahydrobenzyloxycarbonyloxy) - 17b - hydroxy-estra-1,3,5(10 - triene, 3b - (hexahydrobenzyloxycarbonyloxy) - androst - 5 - en - 17 - one, 17b - (hexa-hydrobenzyloxycarbonyloxy) - 19-nor - androst - 4 - en - 3 - one, 17b - (hexahydrobenzyloxycarbonyloxy) - 5a - androstan-3 - one, 3 - acetoxy - 17b - (hexahydrobenzyloxycarbonyloxy) - estra - 1,3,5(10) - triene, 17b - (hexahydrobenzyloxycarbonyloxy) - 3-hydroxy - estra - 1,3,5(10) - triene and processes for the preparation thereof in which an appropriate 3 - and/or 17 - hydroxy steroid is reacted with hexahydrobenzyl chloroformate in a basic medium to yield the desired compound. The basic medium may be provided by potassium hydroxide or pyridine. Pharmaceutical compositions having estrogenic activity and containing the above compounds are administered trancutaneously by intramuscular or subcutaneous injections or rectally as a suppository.
ES0290864A 1962-08-17 1963-08-16 Novel steroid esters, their preparation and employment Expired ES290864A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR907178A FR1421227A (en) 1962-08-17 1962-08-17 Hexahydrobenzyl carbonates steroids and method of preparation

Publications (1)

Publication Number Publication Date
ES290864A1 true ES290864A1 (en) 1963-11-16

Family

ID=8785329

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0290864A Expired ES290864A1 (en) 1962-08-17 1963-08-16 Novel steroid esters, their preparation and employment

Country Status (7)

Country Link
BE (1) BE636216A (en)
CA (1) CA745995A (en)
CH (1) CH405303A (en)
DE (1) DE1300110B (en)
ES (1) ES290864A1 (en)
FR (2) FR1421227A (en)
GB (1) GB985634A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531089B1 (en) * 1982-07-27 1986-03-21 Pharmascience Lab NOVEL OESTRANIC DERIVATIVES FOR TOPICAL PHARMACOLOGICAL APPLICATIONS AND THEIR PREPARATION METHOD
DE4322186A1 (en) * 1993-07-03 1995-01-12 Jenapharm Gmbh Oral estrogenic esters of 14alpha, 15alpha-methylene-estradiol
US6740646B2 (en) 2002-01-16 2004-05-25 Biotest Laboratories, Llc Bioavailable prodrugs of androgenic steroids and related method
US6818668B2 (en) 2002-04-12 2004-11-16 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester and related method

Also Published As

Publication number Publication date
CA745995A (en) 1966-11-08
FR2444M (en) 1964-05-08
DE1300110B (en) 1969-07-31
FR1421227A (en) 1965-12-17
GB985634A (en) 1965-03-10
BE636216A (en) 1964-02-14
CH405303A (en) 1966-01-15

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