GB879100A - Improvements in or relating to cyclopentanophenanthrene compounds and process for the manufacture thereof - Google Patents

Improvements in or relating to cyclopentanophenanthrene compounds and process for the manufacture thereof

Info

Publication number
GB879100A
GB879100A GB39089/57A GB3908957A GB879100A GB 879100 A GB879100 A GB 879100A GB 39089/57 A GB39089/57 A GB 39089/57A GB 3908957 A GB3908957 A GB 3908957A GB 879100 A GB879100 A GB 879100A
Authority
GB
United Kingdom
Prior art keywords
lower alkyl
ethyl
methyl
compounds
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39089/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex SA
Original Assignee
Syntex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex SA filed Critical Syntex SA
Publication of GB879100A publication Critical patent/GB879100A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 2a -lower alkyl-19-nor-D 4-androstan-17b -o1-3-ones, their 17a -lower alkyl derivatives and also the corresponding 3-hydroxy compounds together with a process for the preparation of the corresponding D 4-androstene compounds by treating 19-nortesttosterone or a 17a -lower alkyl derivative thereof with ethyl formate to form the corresponding 2-hydroxymethylene derivative, reacting the latter with a lower alkyl iodide and then eliminating the carbon monoxide from the resulting 2-formyl-2-lower alkyl compound by means of activated alumina. Detailed examples illustrate the preparation of 2a -methyl-19-nor-D 4-androsten-17b -ol-3-one, its 2a -ethyl-, 2a ,17a -dimethyl-, 2a -methyl- 17a -ethyl-, 2a -ethyl- 17a -methyl-, and 2a ,17a -diethyl analogues and the corresponding 5a -androstanes and the 17-acetates, propionates, cyclopentylpropionates and benzoates of the 17a -unsubstituted compounds. Specifications 853,291, 854,407 and 879,102 are referred to. Reference has been directed by the Comptroller to Specification 809,485.
GB39089/57A 1956-12-17 1957-12-16 Improvements in or relating to cyclopentanophenanthrene compounds and process for the manufacture thereof Expired GB879100A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX879100X 1956-12-17

Publications (1)

Publication Number Publication Date
GB879100A true GB879100A (en) 1961-10-04

Family

ID=19743127

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39089/57A Expired GB879100A (en) 1956-12-17 1957-12-16 Improvements in or relating to cyclopentanophenanthrene compounds and process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB879100A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355495A (en) * 1965-03-02 1967-11-28 Smith Kline French Lab 2-substituted b-norandrostenes and estrenes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355495A (en) * 1965-03-02 1967-11-28 Smith Kline French Lab 2-substituted b-norandrostenes and estrenes

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