ES455933A1 - 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones - Google Patents

2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones

Info

Publication number
ES455933A1
ES455933A1 ES455933A ES455933A ES455933A1 ES 455933 A1 ES455933 A1 ES 455933A1 ES 455933 A ES455933 A ES 455933A ES 455933 A ES455933 A ES 455933A ES 455933 A1 ES455933 A1 ES 455933A1
Authority
ES
Spain
Prior art keywords
6beta
diene
bromo
fluoropregna
diones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455933A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PIENEL SpA
Original Assignee
PIENEL SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PIENEL SpA filed Critical PIENEL SpA
Publication of ES455933A1 publication Critical patent/ES455933A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Abstract

Procedure for the preparation of new steroids, such as 2-bromo-6beta-fluoro-9alfa-halo-11beta, 17,21-trihydroxy-pregna-1,4-diene-3-dione and its 17,21-esters and 2 -bromo-6beta-fluoride-9alpha, 11 beta-dihalo-17,21-dihydroxyregna-1,4-diene-3,20-dione and its 17,21-esters, 17,21-alkylortoesters and 17,21-acetals cyclics of formula (A). *** (Machine-translation by Google Translate, not legally binding)
ES455933A 1974-02-27 1977-02-15 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones Expired ES455933A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (1)

Publication Number Publication Date
ES455933A1 true ES455933A1 (en) 1978-05-01

Family

ID=27447687

Family Applications (3)

Application Number Title Priority Date Filing Date
ES435067A Expired ES435067A1 (en) 1974-02-27 1975-02-25 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
ES455934A Expired ES455934A1 (en) 1974-02-27 1977-02-15 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
ES455933A Expired ES455933A1 (en) 1974-02-27 1977-02-15 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES435067A Expired ES435067A1 (en) 1974-02-27 1975-02-25 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
ES455934A Expired ES455934A1 (en) 1974-02-27 1977-02-15 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones

Country Status (18)

Country Link
JP (1) JPS5614677B2 (en)
AR (1) AR218601A1 (en)
BE (1) BE826030A (en)
CA (1) CA1064476A (en)
CH (1) CH608243A5 (en)
DE (3) DE2508136C3 (en)
DK (1) DK144068C (en)
ES (3) ES435067A1 (en)
FI (1) FI56188C (en)
FR (1) FR2261776B1 (en)
GB (1) GB1499822A (en)
IE (1) IE42112B1 (en)
LU (1) LU71908A1 (en)
NO (1) NO144527C (en)
NZ (1) NZ176716A (en)
RO (1) RO78881A (en)
SE (1) SE410736B (en)
YU (3) YU108481A (en)

Also Published As

Publication number Publication date
FR2261776A1 (en) 1975-09-19
SE410736B (en) 1979-10-29
NO750633L (en) 1975-08-28
DE2533377C3 (en) 1979-08-02
DE2533377A1 (en) 1976-02-05
YU108381A (en) 1982-02-28
IE42112B1 (en) 1980-06-04
IE42112L (en) 1975-08-27
ES455934A1 (en) 1978-05-01
SE7502146L (en) 1975-08-28
NZ176716A (en) 1978-07-10
FI56188B (en) 1979-08-31
CA1064476A (en) 1979-10-16
LU71908A1 (en) 1975-06-24
DK144068C (en) 1982-05-03
FI56188C (en) 1979-12-10
CH608243A5 (en) 1978-12-29
YU108481A (en) 1982-02-28
FR2261776B1 (en) 1978-07-21
DE2508136C3 (en) 1979-06-21
DE2508136A1 (en) 1975-10-30
GB1499822A (en) 1978-02-01
YU108281A (en) 1982-02-28
DK61575A (en) 1975-10-27
ES435067A1 (en) 1977-07-01
AR218601A1 (en) 1980-06-30
NO144527B (en) 1981-06-09
DE2533323C3 (en) 1979-07-12
DE2508136B2 (en) 1978-11-02
FI750537A (en) 1975-08-28
BE826030A (en) 1975-06-16
JPS50126652A (en) 1975-10-04
DK144068B (en) 1981-11-30
RO78881A (en) 1982-07-06
DE2533323B2 (en) 1978-11-16
JPS5614677B2 (en) 1981-04-06
NO144527C (en) 1981-09-23
DE2533377B2 (en) 1978-11-16
DE2533323A1 (en) 1976-02-12

Similar Documents

Publication Publication Date Title
ES300814A1 (en) A procedure for the preparation of steroid compounds (Machine-translation by Google Translate, not legally binding)
AU2047276A (en) 9 21-dihalogeno-11 17 -dihydroxy-6 -fluro-16-methyl-pregna-1,4-diene-3,20-diones
ZA755553B (en) Anti-inflammatory steroids of the androstane series
ES455933A1 (en) 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
IL39821A0 (en) 21-esters of 11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione derivatives
DK129039B (en) Process for the preparation of 11β, 16α17α21-tetrahydroxy-pregna-1,4-diene-3,20-diones or the corresponding 16,17-acetonides.
GB1089945A (en) Steroidal-6-spirocyclopropyl-4-en-3-ones
GB1536875A (en) Process for the manufacture of oestrene-3,17-dione derivatives
CA1035351A (en) Process for producing cholestane type steroid
CA1034521A (en) PROCESS FOR THE PREPARATION OF 17-ACYL ESTERS OF 17.alpha.,21-DIHYDROXYSTEROIDS OF THE PREGNANE SERIES
ES316376A1 (en) A procedure for the preparation of 3-espiro-3-diazirinaesteroides. (Machine-translation by Google Translate, not legally binding)
ES444231A1 (en) Steroidal derivatives of bendazolic acid and process for the preparation of the same
ES465550A1 (en) Procedure for the obtaining of halogenopregnadienos. (Machine-translation by Google Translate, not legally binding)
GB1008273A (en)
NL7511830A (en) PROCESS FOR THE PREPARATION OF 13 (BETA) -ALKYL-4-GO-NO-3,17-DIONES.
ES306437A1 (en) A procedure for the preparation of 3-espiro-3-diazirinaesteroides or 3-espiro-3-diaziridina steroides. (Machine-translation by Google Translate, not legally binding)
ES319114A1 (en) A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)
IL51085A (en) 2,9 -dichloro-6 -fluoro-16 -methyl-11 ,17,21-trihydroxy-pregna-1,4-diene-3,20-dione compounds, process for the manufacture thereof and pharmalceutical compositions containing them
ES388784A1 (en) Novel preparation of pregnanes
AT272536B (en) Process for the preparation of androsta-1,4-diene-3,17-dione
GB1515664A (en) Derivatives of 17alpha-hydroxy-19-norpregn-4-ene-3,20-dione
DK140900B (en) Analogous process for the preparation of D-homopregna-1,4-diene-3,11,20-trions.
CA890901A (en) Process for the manufacture of 11-oxygenated steroids of the pregnane series
ES307266A1 (en) A procedure for the preparation of 21-apocanfan-1-carboxylates of steroids. (Machine-translation by Google Translate, not legally binding)
ES451299A1 (en) D-Homo-pregnene steroids

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001