ES307266A1 - A procedure for the preparation of 21-apocanfan-1-carboxylates of steroids. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of 21-apocanfan-1-carboxylates of steroids. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Sanofi Aventis France
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Roussel Uclaf SA
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Priority claimed from FR966962Aexternal-prioritypatent/FR1512324A/en
Application filed by Roussel Uclaf SAfiledCriticalRoussel Uclaf SA
Publication of ES307266A1publicationCriticalpatent/ES307266A1/en
A procedure for the preparation of spheroidal 21-apo-canphan-1-carboxylates, which correspond to the general formula ** (See formula) ** and especially: a) prednisolone apocanfan-1-carboxylate, b) apocanfan-1-carboxylate of cortisone, c) apocanfan-1-carboxylate of hydrocortisone, d) apocanfan-1-carboxylate of 9alpha-fluorohydrocortisone, e) apocanfan-1-carboxylate of prednisone, f) apocanfan-1-carboxylate of 9alpha-fluoro prednisone, g) apocanfan-1-carboxylate of 9alpha-fluoro prednisolone, h) apocanfan-1-carboxylate of dexamethasone, i) apocanfan-1-carboxylate of beta-methasone, j) apocanfan-1-carboxylate of parametasone, K) apocanfan-1-carboxylate of 6-methyl prednisolone, l) apocanfan-1-carboxylate of 9alfa-fluoro 16-alpha-hydroxy prednisolone, characterized in that apocanfan-1-carboxylic acid is transformed into a functional derivative, such as for example the acid chloride, and this is reacted on the chosen cortisonic derivative in the presence of a tertiary base such such as pyridine, dimethylaniline or triethylamine, in the presence or absence of an organic solvent. (Machine-translation by Google Translate, not legally binding)
ES0307266A1964-03-111964-12-18A procedure for the preparation of 21-apocanfan-1-carboxylates of steroids. (Machine-translation by Google Translate, not legally binding)
ExpiredES307266A1
(en)
A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)
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