SE318274B - - Google Patents

Info

Publication number
SE318274B
SE318274B SE1542164A SE1542164A SE318274B SE 318274 B SE318274 B SE 318274B SE 1542164 A SE1542164 A SE 1542164A SE 1542164 A SE1542164 A SE 1542164A SE 318274 B SE318274 B SE 318274B
Authority
SE
Sweden
Prior art keywords
apocamphane
oxo
steroid
carbonyloxy
ch2oh
Prior art date
Application number
SE1542164A
Inventor
A Allais
J Meier
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE318274B publication Critical patent/SE318274B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 21 - (apocamphane - 1 - carbonyloxy)-20 - oxo - steroids of the pregnane series are obtained in a process in which a functional derivative of apocamphane-1-carboxylic acid is reacted with a 21-hydroxy-20-oxo steroid of the partial general formula St-CO-CH2OH (wherein St represents a steroid nucleus), in the presence of a tertiary base, e.g. pyridine, N,N-dimethylaniline or triethylamine, to give the corresponding 21 - (apocamphane - 1 - carbonyloxy)-20-oxo-steroid Pharmaceutical compositions containing the above compounds and having anti-inflammatory activity are administered parenterally, topically or rectally.
SE1542164A 1964-01-02 1964-12-18 SE318274B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR959163A FR3316M (en) 1964-01-02 1964-01-02 New drug in particular for the treatment of inflammatory manifestations of rheumatic, arthritic or infectious origin.
FR966962A FR1512324A (en) 1964-01-02 1964-03-11 New esters in 21 of cortisone derivatives and method of preparation

Publications (1)

Publication Number Publication Date
SE318274B true SE318274B (en) 1969-12-08

Family

ID=26205184

Family Applications (1)

Application Number Title Priority Date Filing Date
SE1542164A SE318274B (en) 1964-01-02 1964-12-18

Country Status (10)

Country Link
BE (1) BE657319A (en)
BR (1) BR6465428D0 (en)
CH (1) CH436282A (en)
DE (1) DE1468892B1 (en)
DK (1) DK112236B (en)
FR (2) FR3316M (en)
GB (1) GB1087729A (en)
IL (1) IL22709A (en)
NL (2) NL6414704A (en)
SE (1) SE318274B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1439605A (en) * 1972-07-14 1976-06-16 Akzo Nv 2beta-hydroxy-3-alpha-amino-steroids and derivatives thereof and the processes for their preparation

Also Published As

Publication number Publication date
BR6465428D0 (en) 1973-08-07
FR3316M (en) 1965-05-17
FR1512324A (en) 1968-02-09
CH436282A (en) 1967-05-31
BE657319A (en)
NL122978C (en)
DE1468892B1 (en) 1970-03-12
GB1087729A (en) 1967-10-18
IL22709A (en) 1969-02-27
DK112236B (en) 1968-11-25
NL6414704A (en) 1965-07-05

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