GB1317194A - 21,21-dichloro-steroids - Google Patents
21,21-dichloro-steroidsInfo
- Publication number
- GB1317194A GB1317194A GB3432470A GB3432470A GB1317194A GB 1317194 A GB1317194 A GB 1317194A GB 3432470 A GB3432470 A GB 3432470A GB 3432470 A GB3432470 A GB 3432470A GB 1317194 A GB1317194 A GB 1317194A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- formula
- dichloro
- july
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1317194 21,21-Dichloro-steroids SCHERING AG 15 July 1970 [24 July 1969] 34324/70 Heading C2U Novel steroids of the formula (wherein R 1 is H or Cl, R 2 is H, F or CH 3 , R 3 is H or CH 3 , R 4 is H, OH or O acyl, and C 2 =C 1 is single or double bond) are prepared by reacting steroids of the formula with HF and an agent capable of liberating a positively charged chlorine atom in a solvent for at least 3 hours. Steroids of the Formula (II) above are prepared from the corresponding 21-ols via their mesylates. The novel steroids are stated to be antiinflammatory agents, and they may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1938218A DE1938218C3 (en) | 1969-07-24 | 1969-07-24 | 9 a, 21,21-trichloro-ll ß-fluorine pregnene, process for their production and pharmaceuticals containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1317194A true GB1317194A (en) | 1973-05-16 |
Family
ID=5741103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3432470A Expired GB1317194A (en) | 1969-07-24 | 1970-07-15 | 21,21-dichloro-steroids |
Country Status (18)
Country | Link |
---|---|
US (1) | US3681405A (en) |
JP (1) | JPS4815290B1 (en) |
AT (1) | AT300217B (en) |
BE (1) | BE753874A (en) |
CH (1) | CH557339A (en) |
CS (1) | CS161757B2 (en) |
DE (1) | DE1938218C3 (en) |
DK (1) | DK122454B (en) |
ES (1) | ES381790A1 (en) |
FI (1) | FI46844C (en) |
FR (1) | FR2059554B1 (en) |
GB (1) | GB1317194A (en) |
IE (1) | IE34401B1 (en) |
IL (1) | IL34976A (en) |
NL (1) | NL7010876A (en) |
PL (1) | PL79781B1 (en) |
SE (1) | SE355578B (en) |
ZA (1) | ZA704574B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972922A (en) * | 1990-06-11 | 1999-10-26 | Alcon Laboratories, Inc. | Steroids which inhibit angiogenesis |
KR101591482B1 (en) * | 2008-05-28 | 2016-02-03 | 레베라겐 바이오파마 인코포레이티드 | - non-hormonal steroid modulators of nf-b for treatment of disease |
EP2556083A4 (en) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | Non-hormonal steroid modulators of nf- kappa b for treatment of disease |
US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236866A (en) * | 1959-04-08 | 1966-02-22 | Syntex Corp | 21, 21-difluoro pregnenes |
US3025312A (en) * | 1959-07-14 | 1962-03-13 | Olin Mathieson | 9alpha, 11beta-dichloro pregnanes |
US3038898A (en) * | 1960-11-10 | 1962-06-12 | Syntex Sa | 6-fluoromethyl-9alpha, 11beta-dichlorocortical hormones |
-
1969
- 1969-07-24 DE DE1938218A patent/DE1938218C3/en not_active Expired
-
1970
- 1970-06-16 FI FI701704A patent/FI46844C/en active
- 1970-06-18 CH CH927470A patent/CH557339A/en not_active IP Right Cessation
- 1970-06-24 DK DK327370AA patent/DK122454B/en unknown
- 1970-07-02 CS CS4621A patent/CS161757B2/cs unknown
- 1970-07-02 AT AT598070A patent/AT300217B/en not_active IP Right Cessation
- 1970-07-03 ZA ZA704574A patent/ZA704574B/en unknown
- 1970-07-15 GB GB3432470A patent/GB1317194A/en not_active Expired
- 1970-07-15 ES ES381790A patent/ES381790A1/en not_active Expired
- 1970-07-21 IE IE948/70A patent/IE34401B1/en unknown
- 1970-07-22 NL NL7010876A patent/NL7010876A/xx not_active Application Discontinuation
- 1970-07-22 US US57334A patent/US3681405A/en not_active Expired - Lifetime
- 1970-07-22 IL IL34976A patent/IL34976A/en unknown
- 1970-07-23 SE SE10206/70A patent/SE355578B/xx unknown
- 1970-07-23 PL PL1970142238A patent/PL79781B1/pl unknown
- 1970-07-23 FR FR707027250A patent/FR2059554B1/fr not_active Expired
- 1970-07-23 JP JP45064682A patent/JPS4815290B1/ja active Pending
- 1970-07-24 BE BE753874D patent/BE753874A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK122454B (en) | 1972-03-06 |
FR2059554B1 (en) | 1974-06-14 |
BE753874A (en) | 1971-01-25 |
NL7010876A (en) | 1971-01-26 |
DE1938218C3 (en) | 1978-10-19 |
DE1938218B2 (en) | 1978-01-26 |
ZA704574B (en) | 1971-03-31 |
IL34976A (en) | 1973-06-29 |
JPS4815290B1 (en) | 1973-05-14 |
IE34401L (en) | 1971-01-24 |
CS161757B2 (en) | 1975-06-10 |
PL79781B1 (en) | 1975-06-30 |
CH557339A (en) | 1974-12-31 |
IL34976A0 (en) | 1970-09-17 |
FI46844B (en) | 1973-04-02 |
SE355578B (en) | 1973-04-30 |
ES381790A1 (en) | 1972-12-01 |
AT300217B (en) | 1972-07-25 |
US3681405A (en) | 1972-08-01 |
FR2059554A1 (en) | 1971-06-04 |
FI46844C (en) | 1973-07-10 |
IE34401B1 (en) | 1975-04-30 |
DE1938218A1 (en) | 1971-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |