GB1289020A - - Google Patents
Info
- Publication number
- GB1289020A GB1289020A GB1289020DA GB1289020A GB 1289020 A GB1289020 A GB 1289020A GB 1289020D A GB1289020D A GB 1289020DA GB 1289020 A GB1289020 A GB 1289020A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chloromethyl
- compounds
- formula
- iii
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1289020 Halopregnenes F HOFFMANN-LA ROCHE & CO AG 10 Dec 1970 [11 Dec 1969 (2)] 58718/70 Heading C2U The invention comprises (A) compounds of Formulµ III and IV (wherein R 1 , R 2 and R 4 are each Cl or Br and n is 0, 1, 2, 3, 4 or 5); and (B) a process for preparing compounds of Formula I (wherein R 3 is C 1-6 straight-chained alkylidene) from compounds of Formula II by converting the latter, either directly or via compounds of Formula IV, into compounds of Formula III which are then refluxed in an inert organic solvent with an alkali metal iodide in the presence of, or followed by the addition of, a C 1-6 alkenoic acid, to give the compounds of Formula I. The conversion of II to IV is effected with Cl 2 or Br 2 . The conversion of IV to III is effected with a dehydrohalogenating agent, and the direct conversion of II to III is effected with Cl 2 , or Br 2 in the presence of a dehydrohalogenating agent. 6 - Chloro - 16# - chloromethyl - 16α,17α- epoxypregna - 4,6 - diene - 3,20 - dione (VI) is prepared from 3# - acetoxy - 17α - hydroxy- 16 - methylenepregn - 5 - en - 20 - one (V) by the sequence: V # 3# - acetoxy - 5α,6#- dichloro 16# - chloromethyl - 16α,17α - epoxypregnan - 20 - one # 3# - hydroxy - 5α,6#- dichloro - 16# - chloromethyl - 16α,17α - epoxypregnan - 20 - one # 5α,6# - dichloro - 16#- chloromethyl - 16α,17α - epoxypregnane - 3,20- dione # 6# - chloro - 16# - chloromethyl- 16α,17α - epoxypregn - 4 - ene - 3,20 - dione # 3 - ethoxy - 6 - chloro - 16# - chloromethyl- 16α,17α - epoxypregna - 3,5 - dien - 20 - one # VI.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88432469A | 1969-12-11 | 1969-12-11 | |
US88432369A | 1969-12-11 | 1969-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1289020A true GB1289020A (en) | 1972-09-13 |
Family
ID=27128721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1289020D Expired GB1289020A (en) | 1969-12-11 | 1970-12-10 |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS504658B1 (en) |
BE (1) | BE760128A (en) |
CA (1) | CA933518A (en) |
CH (1) | CH548383A (en) |
DE (1) | DE2059839A1 (en) |
DK (1) | DK126937B (en) |
FR (1) | FR2073547A5 (en) |
GB (1) | GB1289020A (en) |
IL (1) | IL35598A (en) |
NL (1) | NL7017756A (en) |
SE (1) | SE368398B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113956133A (en) * | 2021-11-08 | 2022-01-21 | 湖南科瑞生物制药股份有限公司 | Synthesis method of 25-hydroxy steroid compound, preparation method of side chain thereof and preparation method of side chain intermediate |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5068651A (en) * | 1973-10-22 | 1975-06-09 |
-
1970
- 1970-11-06 IL IL35598A patent/IL35598A/en unknown
- 1970-11-17 CA CA098308A patent/CA933518A/en not_active Expired
- 1970-11-25 CH CH1746870A patent/CH548383A/en not_active IP Right Cessation
- 1970-11-27 JP JP45104725A patent/JPS504658B1/ja active Pending
- 1970-12-04 DE DE19702059839 patent/DE2059839A1/en active Pending
- 1970-12-04 NL NL7017756A patent/NL7017756A/xx unknown
- 1970-12-10 SE SE16753/70A patent/SE368398B/xx unknown
- 1970-12-10 FR FR7044522A patent/FR2073547A5/en not_active Expired
- 1970-12-10 BE BE760128A patent/BE760128A/en unknown
- 1970-12-10 GB GB1289020D patent/GB1289020A/en not_active Expired
- 1970-12-10 DK DK627570AA patent/DK126937B/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113956133A (en) * | 2021-11-08 | 2022-01-21 | 湖南科瑞生物制药股份有限公司 | Synthesis method of 25-hydroxy steroid compound, preparation method of side chain thereof and preparation method of side chain intermediate |
Also Published As
Publication number | Publication date |
---|---|
CH548383A (en) | 1974-04-30 |
IL35598A0 (en) | 1971-01-28 |
SE368398B (en) | 1974-07-01 |
DK126937B (en) | 1973-09-03 |
CA933518A (en) | 1973-09-11 |
BE760128A (en) | 1971-06-10 |
NL7017756A (en) | 1971-06-15 |
IL35598A (en) | 1974-11-29 |
DE2059839A1 (en) | 1971-06-16 |
JPS504658B1 (en) | 1975-02-22 |
FR2073547A5 (en) | 1971-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |