GB985634A - Novel steroid esters, their preparation and employment - Google Patents

Novel steroid esters, their preparation and employment

Info

Publication number
GB985634A
GB985634A GB31436/63A GB3143663A GB985634A GB 985634 A GB985634 A GB 985634A GB 31436/63 A GB31436/63 A GB 31436/63A GB 3143663 A GB3143663 A GB 3143663A GB 985634 A GB985634 A GB 985634A
Authority
GB
United Kingdom
Prior art keywords
hexahydrobenzyloxycarbonyloxy
preparation
estra
triene
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31436/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB985634A publication Critical patent/GB985634A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 3 - (hexahydrobenzyloxycarbonyloxy) - 17b - hydroxy-estra-1,3,5(10 - triene, 3b - (hexahydrobenzyloxycarbonyloxy) - androst - 5 - en - 17 - one, 17b - (hexa-hydrobenzyloxycarbonyloxy) - 19-nor - androst - 4 - en - 3 - one, 17b - (hexahydrobenzyloxycarbonyloxy) - 5a - androstan-3 - one, 3 - acetoxy - 17b - (hexahydrobenzyloxycarbonyloxy) - estra - 1,3,5(10) - triene, 17b - (hexahydrobenzyloxycarbonyloxy) - 3-hydroxy - estra - 1,3,5(10) - triene and processes for the preparation thereof in which an appropriate 3 - and/or 17 - hydroxy steroid is reacted with hexahydrobenzyl chloroformate in a basic medium to yield the desired compound. The basic medium may be provided by potassium hydroxide or pyridine. Pharmaceutical compositions having estrogenic activity and containing the above compounds are administered trancutaneously by intramuscular or subcutaneous injections or rectally as a suppository.
GB31436/63A 1962-08-17 1963-08-08 Novel steroid esters, their preparation and employment Expired GB985634A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR907178A FR1421227A (en) 1962-08-17 1962-08-17 Hexahydrobenzyl carbonates steroids and method of preparation

Publications (1)

Publication Number Publication Date
GB985634A true GB985634A (en) 1965-03-10

Family

ID=8785329

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31436/63A Expired GB985634A (en) 1962-08-17 1963-08-08 Novel steroid esters, their preparation and employment

Country Status (7)

Country Link
BE (1) BE636216A (en)
CA (1) CA745995A (en)
CH (1) CH405303A (en)
DE (1) DE1300110B (en)
ES (1) ES290864A1 (en)
FR (2) FR1421227A (en)
GB (1) GB985634A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531089A1 (en) * 1982-07-27 1984-02-03 Pharmascience Lab New oestrane derivatives intended for topical pharmacological application, and process for preparing them
WO1995001988A1 (en) * 1993-07-03 1995-01-19 Jenapharm Gmbh ORALLY ADMINISTERABLE ESTERS OF 14α,15α-METHYLENE-OESTRADIOL WITH AN OESTROGENIC ACTION

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740646B2 (en) 2002-01-16 2004-05-25 Biotest Laboratories, Llc Bioavailable prodrugs of androgenic steroids and related method
US6818668B2 (en) 2002-04-12 2004-11-16 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester and related method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531089A1 (en) * 1982-07-27 1984-02-03 Pharmascience Lab New oestrane derivatives intended for topical pharmacological application, and process for preparing them
WO1995001988A1 (en) * 1993-07-03 1995-01-19 Jenapharm Gmbh ORALLY ADMINISTERABLE ESTERS OF 14α,15α-METHYLENE-OESTRADIOL WITH AN OESTROGENIC ACTION

Also Published As

Publication number Publication date
BE636216A (en) 1964-02-14
ES290864A1 (en) 1963-11-16
CA745995A (en) 1966-11-08
DE1300110B (en) 1969-07-31
CH405303A (en) 1966-01-15
FR1421227A (en) 1965-12-17
FR2444M (en) 1964-05-08

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