NO323376B1 - Umettede 14,15-syklopropanandrostaner, fremgangsmate for deres fremstilling, farmasoytiske preparater som inneholder disse forbindelsene, og anvendelse av forbindelsene til fremstilling av farmasoytiske preparater. - Google Patents
Umettede 14,15-syklopropanandrostaner, fremgangsmate for deres fremstilling, farmasoytiske preparater som inneholder disse forbindelsene, og anvendelse av forbindelsene til fremstilling av farmasoytiske preparater. Download PDFInfo
- Publication number
- NO323376B1 NO323376B1 NO20022712A NO20022712A NO323376B1 NO 323376 B1 NO323376 B1 NO 323376B1 NO 20022712 A NO20022712 A NO 20022712A NO 20022712 A NO20022712 A NO 20022712A NO 323376 B1 NO323376 B1 NO 323376B1
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- Prior art keywords
- methylene
- hydroxy
- androst
- group
- compounds
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 34
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title description 8
- -1 formyloxy group Chemical group 0.000 claims description 31
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 8
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- GQJCAQADCPTHKN-UHFFFAOYSA-N methyl 2,2-difluoro-2-fluorosulfonylacetate Chemical compound COC(=O)C(F)(F)S(F)(=O)=O GQJCAQADCPTHKN-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004432 carbon atom Chemical group C* 0.000 description 12
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- 125000000217 alkyl group Chemical group 0.000 description 10
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- 239000000243 solution Substances 0.000 description 9
- 125000003710 aryl alkyl group Chemical group 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 7
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- 125000004423 acyloxy group Chemical group 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
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- 239000008298 dragée Substances 0.000 description 2
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- 230000003054 hormonal effect Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
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- 238000009835 boiling Methods 0.000 description 1
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19959696A DE19959696A1 (de) | 1999-12-08 | 1999-12-08 | Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| PCT/EP2000/011557 WO2001042275A1 (de) | 1999-12-08 | 2000-11-21 | Ungesättigte 14,15-cyclopropano-androstane, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20022712L NO20022712L (no) | 2002-06-07 |
| NO20022712D0 NO20022712D0 (no) | 2002-06-07 |
| NO323376B1 true NO323376B1 (no) | 2007-04-16 |
Family
ID=7932216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20022712A NO323376B1 (no) | 1999-12-08 | 2002-06-07 | Umettede 14,15-syklopropanandrostaner, fremgangsmate for deres fremstilling, farmasoytiske preparater som inneholder disse forbindelsene, og anvendelse av forbindelsene til fremstilling av farmasoytiske preparater. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6710039B1 (cs) |
| EP (1) | EP1235850B1 (cs) |
| JP (1) | JP3793088B2 (cs) |
| KR (1) | KR100468341B1 (cs) |
| CN (1) | CN1205219C (cs) |
| AT (1) | ATE275576T1 (cs) |
| AU (1) | AU774384B2 (cs) |
| BG (1) | BG106861A (cs) |
| BR (1) | BR0016737A (cs) |
| CA (1) | CA2393758C (cs) |
| CZ (1) | CZ20022005A3 (cs) |
| DE (2) | DE19959696A1 (cs) |
| DK (1) | DK1235850T3 (cs) |
| EE (1) | EE200200302A (cs) |
| ES (1) | ES2226949T3 (cs) |
| HU (1) | HUP0203655A3 (cs) |
| IL (2) | IL150082A0 (cs) |
| MX (1) | MXPA02005644A (cs) |
| NO (1) | NO323376B1 (cs) |
| PL (1) | PL356061A1 (cs) |
| PT (1) | PT1235850E (cs) |
| RU (1) | RU2244718C2 (cs) |
| SI (1) | SI1235850T1 (cs) |
| SK (1) | SK8092002A3 (cs) |
| WO (1) | WO2001042275A1 (cs) |
| ZA (1) | ZA200205362B (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE31269C (de) * | B.GERVAIS in Montmorillon Vienne, Frankreich | Transportable Brauerei für Kleinbetrieb | ||
| DE33136C (de) * | J. KENDAL und M. LAVAL in London | Uhr mit zwei Zifferblättern und dazu gehörigem Zeigerstellwerk | ||
| NL215687A (cs) | 1956-03-26 | |||
| CH376097A (de) * | 1956-04-23 | 1964-03-31 | Farmaceutici Italia | Verfahren zur Herstellung von 4-Halogen-3-keto- 4-steroiden |
| US2895969A (en) | 1957-09-23 | 1959-07-21 | Syntex Sa | Cyclopentanophenanthrene derivatives |
| GB839908A (en) | 1957-12-24 | 1960-06-29 | Farmaceutici Italia | 4,17ª‡-dihydroxy progesterone and its esters and the preparation thereof |
| GB874572A (en) | 1959-02-18 | 1961-08-10 | Farmaceutici Italia | A method for the production of new ketosteroid compounds |
| GB928714A (en) | 1961-02-10 | 1963-06-12 | Farmaceutici Italia | Process for the preparation of 4-hydroxy-3-keto-í¸-steroids |
| GB991804A (en) | 1962-03-13 | 1965-05-12 | Piero Gomarasca | New derivatives of cyclopentanophenanthrene and processes for their preparation |
| US3239512A (en) | 1964-08-04 | 1966-03-08 | Syntex Corp | 17-tetrahydropyranylether of 4-chlorotestosterone |
| DE19537626A1 (de) * | 1995-10-10 | 1997-04-17 | Jenapharm Gmbh | Steroide mit einer 14, 15-Methylengruppe |
| DE19827523A1 (de) | 1998-06-22 | 1999-12-23 | Jenapharm Gmbh | Ungesättigte 14,15-Cyclopropano-Androstane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
-
1999
- 1999-12-08 DE DE19959696A patent/DE19959696A1/de not_active Ceased
-
2000
- 2000-11-21 BR BR0016737-1A patent/BR0016737A/pt not_active Application Discontinuation
- 2000-11-21 SK SK809-2002A patent/SK8092002A3/sk unknown
- 2000-11-21 US US10/148,157 patent/US6710039B1/en not_active Ceased
- 2000-11-21 CN CNB008188556A patent/CN1205219C/zh not_active Expired - Fee Related
- 2000-11-21 JP JP2001543572A patent/JP3793088B2/ja not_active Expired - Fee Related
- 2000-11-21 IL IL15008200A patent/IL150082A0/xx active IP Right Grant
- 2000-11-21 DK DK00979607T patent/DK1235850T3/da active
- 2000-11-21 WO PCT/EP2000/011557 patent/WO2001042275A1/de active IP Right Grant
- 2000-11-21 AT AT00979607T patent/ATE275576T1/de not_active IP Right Cessation
- 2000-11-21 ES ES00979607T patent/ES2226949T3/es not_active Expired - Lifetime
- 2000-11-21 KR KR10-2002-7007365A patent/KR100468341B1/ko not_active IP Right Cessation
- 2000-11-21 RU RU2002117425/04A patent/RU2244718C2/ru not_active IP Right Cessation
- 2000-11-21 US US11/008,758 patent/USRE39862E1/en not_active Expired - Fee Related
- 2000-11-21 DE DE50007708T patent/DE50007708D1/de not_active Expired - Fee Related
- 2000-11-21 EE EEP200200302A patent/EE200200302A/xx unknown
- 2000-11-21 AU AU17038/01A patent/AU774384B2/en not_active Ceased
- 2000-11-21 CZ CZ20022005A patent/CZ20022005A3/cs unknown
- 2000-11-21 MX MXPA02005644A patent/MXPA02005644A/es active IP Right Grant
- 2000-11-21 PL PL00356061A patent/PL356061A1/xx not_active Application Discontinuation
- 2000-11-21 SI SI200030553T patent/SI1235850T1/xx unknown
- 2000-11-21 EP EP00979607A patent/EP1235850B1/de not_active Expired - Lifetime
- 2000-11-21 PT PT00979607T patent/PT1235850E/pt unknown
- 2000-11-21 CA CA002393758A patent/CA2393758C/en not_active Expired - Fee Related
- 2000-11-21 HU HU0203655A patent/HUP0203655A3/hu unknown
-
2002
- 2002-06-06 IL IL150082A patent/IL150082A/en not_active IP Right Cessation
- 2002-06-07 NO NO20022712A patent/NO323376B1/no unknown
- 2002-06-24 BG BG106861A patent/BG106861A/bg unknown
- 2002-07-04 ZA ZA200205362A patent/ZA200205362B/xx unknown
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