DE19918325A1 - Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion - Google Patents

Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion

Info

Publication number
DE19918325A1
DE19918325A1 DE19918325A DE19918325A DE19918325A1 DE 19918325 A1 DE19918325 A1 DE 19918325A1 DE 19918325 A DE19918325 A DE 19918325A DE 19918325 A DE19918325 A DE 19918325A DE 19918325 A1 DE19918325 A1 DE 19918325A1
Authority
DE
Germany
Prior art keywords
matrix
dosage form
release
extrusion
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19918325A
Other languages
German (de)
English (en)
Inventor
Hubert Rein
Klaus-Juergen Steffens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Priority to DE19918325A priority Critical patent/DE19918325A1/de
Priority to EP07103714A priority patent/EP1839651A1/de
Priority to CA002372025A priority patent/CA2372025C/en
Priority to EP00927010A priority patent/EP1171101B1/de
Priority to AU45542/00A priority patent/AU763609B2/en
Priority to PT00927010T priority patent/PT1171101E/pt
Priority to AT00927010T priority patent/ATE356617T1/de
Priority to IL14575500A priority patent/IL145755A0/xx
Priority to HU0200843A priority patent/HU227001B1/hu
Priority to KR10-2001-7013353A priority patent/KR100511113B1/ko
Priority to CNB008064199A priority patent/CN1214783C/zh
Priority to ES00927010T priority patent/ES2284495T3/es
Priority to RU2001128233/14A priority patent/RU2208436C2/ru
Priority to US09/980,727 priority patent/US8557286B1/en
Priority to DK00927010T priority patent/DK1171101T3/da
Priority to DE50014164T priority patent/DE50014164D1/de
Priority to BRPI0009927-9A priority patent/BR0009927B1/pt
Priority to PCT/EP2000/003612 priority patent/WO2000064415A1/de
Priority to DE20022720U priority patent/DE20022720U1/de
Priority to JP2000613406A priority patent/JP4575599B2/ja
Publication of DE19918325A1 publication Critical patent/DE19918325A1/de
Priority to JP2007098734A priority patent/JP5022086B2/ja
Priority to CY20071100766T priority patent/CY1106478T1/el
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19918325A 1999-04-22 1999-04-22 Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion Withdrawn DE19918325A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19918325A DE19918325A1 (de) 1999-04-22 1999-04-22 Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
RU2001128233/14A RU2208436C2 (ru) 1999-04-22 2000-04-20 Способ изготовления фармацевтических лекарственных форм и их предшественников и фармацевтическая лекарственная форма
ES00927010T ES2284495T3 (es) 1999-04-22 2000-04-20 Procedimiento para la fabricacion de una matriz amorfa en insoluble en agua de accion prolongada.
EP00927010A EP1171101B1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
AU45542/00A AU763609B2 (en) 1999-04-22 2000-04-20 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
PT00927010T PT1171101E (pt) 1999-04-22 2000-04-20 Processo para a produção de uma matriz de libertação prolongada, amorfa ou parcialmente amorfa, insolúvel em água.
AT00927010T ATE356617T1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
IL14575500A IL145755A0 (en) 1999-04-22 2000-04-20 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
US09/980,727 US8557286B1 (en) 1999-04-22 2000-04-20 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
CA002372025A CA2372025C (en) 1999-04-22 2000-04-20 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
CNB008064199A CN1214783C (zh) 1999-04-22 2000-04-20 生产控释药物剂型或其前体的方法和药物剂型或其前体
EP07103714A EP1839651A1 (de) 1999-04-22 2000-04-20 Verfahren zur Herstellung einer Wasserunlösslichen amorphen oder teilamorphen Retardmatrix
KR10-2001-7013353A KR100511113B1 (ko) 1999-04-22 2000-04-20 비수용성 비정질 또는 부분비정질 서방성 매트릭스의 제조방법
HU0200843A HU227001B1 (en) 1999-04-22 2000-04-20 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
DK00927010T DK1171101T3 (da) 1999-04-22 2000-04-20 Fremgangsmåde til fremstilling af en vanduoplöselig amorf depotmatrix
DE50014164T DE50014164D1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
BRPI0009927-9A BR0009927B1 (pt) 1999-04-22 2000-04-20 mÉtodo para produzir uma matriz de liberaÇço controlada, amàrfica ou parcialmente amàrfica insolével em Água.
PCT/EP2000/003612 WO2000064415A1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen oder teilamorphen retardmatrix
DE20022720U DE20022720U1 (de) 1999-04-22 2000-04-20 Arzneiform
JP2000613406A JP4575599B2 (ja) 1999-04-22 2000-04-20 非水溶性の非晶質または部分的に非晶質の放出制御基材を製造する方法
JP2007098734A JP5022086B2 (ja) 1999-04-22 2007-04-04 医薬の剤形の使用方法
CY20071100766T CY1106478T1 (el) 1999-04-22 2007-06-11 Μεθοδος για την παραγωγη αμορφης επιβραδυντικης μητρας μη διαλυτης στο υδωρ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19918325A DE19918325A1 (de) 1999-04-22 1999-04-22 Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion

Publications (1)

Publication Number Publication Date
DE19918325A1 true DE19918325A1 (de) 2000-10-26

Family

ID=7905525

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19918325A Withdrawn DE19918325A1 (de) 1999-04-22 1999-04-22 Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DE50014164T Expired - Lifetime DE50014164D1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
DE20022720U Expired - Lifetime DE20022720U1 (de) 1999-04-22 2000-04-20 Arzneiform

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE50014164T Expired - Lifetime DE50014164D1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
DE20022720U Expired - Lifetime DE20022720U1 (de) 1999-04-22 2000-04-20 Arzneiform

Country Status (18)

Country Link
US (1) US8557286B1 (https=)
EP (2) EP1839651A1 (https=)
JP (2) JP4575599B2 (https=)
KR (1) KR100511113B1 (https=)
CN (1) CN1214783C (https=)
AT (1) ATE356617T1 (https=)
AU (1) AU763609B2 (https=)
BR (1) BR0009927B1 (https=)
CA (1) CA2372025C (https=)
CY (1) CY1106478T1 (https=)
DE (3) DE19918325A1 (https=)
DK (1) DK1171101T3 (https=)
ES (1) ES2284495T3 (https=)
HU (1) HU227001B1 (https=)
IL (1) IL145755A0 (https=)
PT (1) PT1171101E (https=)
RU (1) RU2208436C2 (https=)
WO (1) WO2000064415A1 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100930A1 (en) * 2003-05-19 2004-11-25 Euro-Celtique S.A. Pharmaceutical dosage form comprising a solid solution
EP1961421A1 (en) 2004-06-08 2008-08-27 Euro-Celtique S.A. Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)
EP2255808A2 (en) 2004-06-08 2010-12-01 Euro-Celtique S.A. Opioids for the treatment of the restlessness of the lower limbs
DE102011015370A1 (de) * 2011-03-29 2012-10-04 Emodys Gmbh Matrix für eine orale Darreichungsform, Verfahren zu deren Herstellung sowie Verwendung derselben
US8673355B2 (en) 1997-12-22 2014-03-18 Purdue Pharma L.P. Opioid agonist/antagonist combinations
US8822487B2 (en) 1997-12-22 2014-09-02 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US8846090B2 (en) 2002-04-05 2014-09-30 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US8969369B2 (en) 2001-05-11 2015-03-03 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US10258235B2 (en) 2005-02-28 2019-04-16 Purdue Pharma L.P. Method and device for the assessment of bowel function

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
WO2003028698A2 (de) * 2001-09-26 2003-04-10 Steffens Klaus-Juergen Verfahren und vorrichtung zur herstellung von granulaten umfassend mindestens einen pharmazeutischen wirkstoff
US8367105B2 (en) 2004-11-10 2013-02-05 Teva Pharmaceutical Industries, Ltd. Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
DE102007028869A1 (de) 2007-06-22 2008-12-24 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
SG174286A1 (en) 2009-03-10 2011-10-28 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
DE102011011889B4 (de) 2011-02-21 2015-11-05 Leistritz Extrusionstechnik Gmbh Vorrichtung und Verfahren zur kontinuierlichen Herstellung von biplan geschnittenen Formkörpern enthaltend wenigstens einen Füllstoff
AU2012357848C1 (en) * 2011-12-21 2018-07-19 Bayer Pharma Aktiengesellschaft Preparations containing amorphous emodepside
JP2016525138A (ja) 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
ES2938608T3 (es) 2017-09-20 2023-04-13 Tillotts Pharma Ag Método para preparar una forma farmacéutica sólida que comprende anticuerpos mediante granulación en húmedo, extrusión y esferonización

Family Cites Families (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
US3065143A (en) 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
US4132753A (en) 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US3830934A (en) 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
US3652589A (en) 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3714350A (en) 1969-03-10 1973-01-30 Mobil Oil Corp Phosphoryl and thiophosphoryl pyrones as insecticides
US3880991A (en) 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US4344431A (en) 1969-03-24 1982-08-17 University Of Delaware Polymeric article for dispensing drugs
GB1405088A (en) 1971-06-03 1975-09-03 Mundipharma Ag Slow release formulation
FR2183546B1 (https=) 1972-05-10 1975-06-20 Servier Lab
US3965256A (en) 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
DE2360796B2 (de) 1973-12-06 1977-06-02 Edelfettwerke Werner Schlüter, 2000 Hamburg; Glyco Iberica S.A., Gava, Barcelona (Spanien) Vti: Hegel, K.Th., Dr.; Dickel, K., Dipl.-Ing.; Pat.-Anwälte, 2000 Hamburg und 8000 München Arzneimittel mit verzoegerter abgabe des wirkstoffs im darm
US3974157A (en) 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
DE2426811A1 (de) 1974-06-04 1976-01-08 Klinge Co Chem Pharm Fab Verfahren zur herstellung von retard-tabletten
DE2426812A1 (de) 1974-06-04 1976-01-02 Klinge Co Chem Pharm Fab Verfahren zur herstellung von granulaten
DE2439538C3 (de) 1974-08-17 1980-07-17 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe
US4076798A (en) 1975-05-29 1978-02-28 American Cyanamid Company High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition
DE2549740A1 (de) 1975-11-17 1977-05-18 Sandoz Ag Neue galenische formen und verfahren zu deren herstellung
US4406883A (en) 1976-07-23 1983-09-27 Merrell Dow Pharmaceuticals Inc. Controlled release suppositories consisting essentially of a linear polymer particularly, polyvinyl pyrrolidones
GB1593261A (en) 1976-07-23 1981-07-15 Inveresk Res Int Controlled release suppository
US4173417A (en) 1977-04-15 1979-11-06 Hpm Corporation Extrusion apparatus and method
US4366172A (en) 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
US4230687A (en) 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
EP0008083A1 (de) 1978-08-15 1980-02-20 Ciba-Geigy Ag Verfahren zur Herstellung von Granulaten schwerschmelzbarer Zusatzstoffe für Kunststoffe, insbesondere von Pigmenten, durch thermische Rollgranulierung und die so erhaltenen Granulate
CH637014A5 (de) 1978-09-29 1983-07-15 Sandoz Ag Verfahren zur herstellung von suppositorien.
DE2923279C2 (de) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4259314A (en) 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS56140915A (en) 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
DE3024416C2 (de) 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
JPS57171428A (en) 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
DE3124983A1 (de) 1981-06-25 1983-01-20 Meditest Inst Fuer Medizinisch Arzneiformen zur oralen verabreichung
US4374082A (en) 1981-08-18 1983-02-15 Richard Hochschild Method for making a pharmaceutical and/or nutritional dosage form
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4987136A (en) 1982-03-16 1991-01-22 The Rockefeller University Method for controlling gastrointestinal dysmotility
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4421736A (en) 1982-05-20 1983-12-20 Merrel Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
US4443428A (en) 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
ZA836627B (en) 1982-10-08 1984-05-30 Verex Lab Constant release rate solid oral dosage formulation of pharmaceutical compounds having a high degree of water solubility
BG46154A3 (bg) 1983-02-18 1989-10-16 Warner-Lambert Company Llc Метод за получаване на капсули
US4882167A (en) 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
JPS6013838A (ja) 1983-07-04 1985-01-24 Mitsui Petrochem Ind Ltd ポリプロピレン組成物
US4917899A (en) 1983-12-22 1990-04-17 Elan Corporation Plc Controlled absorption diltiazem formulation
EP0147780A3 (en) 1984-01-03 1987-03-11 Merck & Co. Inc. Drug delivery device
EP0152379A3 (de) 1984-02-15 1986-10-29 Ciba-Geigy Ag Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
GB8405112D0 (en) 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
US4649042A (en) 1984-05-31 1987-03-10 Eli Lilly And Company Rumen delivery device
CH671337A5 (https=) 1984-06-19 1989-08-31 Ceskoslovenska Akademie Ved
US4629621A (en) 1984-07-23 1986-12-16 Zetachron, Inc. Erodible matrix for sustained release bioactive composition
US4894234A (en) 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for antiarrhythmics
EP0189861A3 (en) 1985-01-26 1988-02-17 Showa Denko Kabushiki Kaisha Percutaneous absorption accelerator for ionic water-soluble medicine
US4772475A (en) 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
US4720384A (en) 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
JPS61293911A (ja) 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
DE3524003A1 (de) 1985-07-04 1987-01-08 Heumann Ludwig & Co Gmbh Arzneimittelgranulat mit verzoegerter wirkstofffreisetzung und verfahren zu seiner herstellung
GB8521350D0 (en) 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
EP0223431B1 (en) 1985-11-08 1992-04-29 Imperial Chemical Industries Plc Apparatus and method for forming pellets
US4882156A (en) 1985-12-20 1989-11-21 Warner Lambert Co. Confectionery delivery system for expectorants
US4882159A (en) 1985-12-20 1989-11-21 Warner Lambert Co. Confectionery delivery system for appetite suppressants
US4882152A (en) 1985-12-20 1989-11-21 Yang Robert K Confectionery delivery system for laxatives, vitamins and antacids
US4882155A (en) 1985-12-20 1989-11-21 Warner Lambert Co. Confectionery delivery system for antiarrhythmics
US4778676A (en) 1985-12-20 1988-10-18 Warner-Lambert Company Confectionery delivery system for actives
US4882151A (en) 1985-12-20 1989-11-21 Warner Lambert Co. Confectionery delivery system for antihistimines
US4882157A (en) 1985-12-20 1989-11-21 Yang Robert K Confectionery delivery system for anti-cholesterolemics
US4882153A (en) 1985-12-20 1989-11-21 Warner Lambert Co. Confectionery delivery system for antitussives
US4879108A (en) 1985-12-20 1989-11-07 Warner-Lambert Company Confectionery delivery system for antipyretics
JP2521504B2 (ja) 1985-12-27 1996-08-07 昭和電工株式会社 酵素の造粒法
DE3602360A1 (de) 1986-01-27 1987-07-30 Krupp Polysius Ag Seitenkratzer fuer schuettguthalde
DE3602370A1 (de) 1986-01-27 1987-08-06 Chrubasik Sigrun Verwendung von analgetica durch inhalation
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
GB2186485B (en) 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
US4994227A (en) 1986-03-10 1991-02-19 American Cyanamid Company Method for the preparation of sustained released bolus formulation
DE3610878A1 (de) 1986-04-01 1987-10-08 Boehringer Ingelheim Kg Formlinge aus pellets
DE3612211A1 (de) 1986-04-11 1987-10-15 Basf Ag Kontinuierliches verfahren zum tablettieren
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
US4820523A (en) 1986-04-15 1989-04-11 Warner-Lambert Company Pharmaceutical composition
GB8613689D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
ES2058111T3 (es) 1986-06-10 1994-11-01 Euro Celtique Sa Composicion de liberacion controlada de dihidrocodeina.
USRE33093E (en) 1986-06-16 1989-10-17 Johnson & Johnson Consumer Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
DE3623193A1 (de) 1986-07-10 1988-01-14 Gruenenthal Gmbh Neue verbindungen, diese enthaltende arzneimittel und verfahren zu deren herstellung
JPH0816066B2 (ja) 1986-07-18 1996-02-21 エーザイ株式会社 持続性薬効製剤
US4970075A (en) 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4760094A (en) 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
GB8626098D0 (en) 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
IE873172L (en) 1986-12-29 1988-06-29 Harvard College Continuous process for producing a comestible tablet
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
ZA882783B (en) 1987-06-10 1988-10-20 Warner-Lambert Company Process for preparing a pharmaceutical composition
DE3721721C1 (de) 1987-07-01 1988-06-09 Hoechst Ag Verfahren zur Umhuellung von Granulaten
GB8717168D0 (en) 1987-07-21 1987-08-26 Roussel Lab Ltd Controlled-release device
FR2618329B1 (fr) 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
US5049394A (en) 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
US4959208A (en) 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
SE463450B (sv) 1987-12-11 1990-11-26 Nemo Ivarson Anordning foer blandning, knaadning och extrudering av produkter framstaellda av vaetska och pulver
EP0327295A3 (en) 1988-02-01 1989-09-06 F.H. FAULDING & CO. LTD. Tetracycline dosage form
US4842761A (en) 1988-03-23 1989-06-27 International Flavors & Fragrances, Inc. Compositions and methods for controlled release of fragrance-bearing substances
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
US5472710A (en) 1988-04-16 1995-12-05 Schwarz Pharma Ag Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
DE3812799A1 (de) 1988-04-16 1989-10-26 Sanol Arznei Schwarz Gmbh Oral zu verabreichende pharmazeutische zubereitung mit kontrollierter wirkstofffreisetzung und verfahren zu deren herstellung
JP2681373B2 (ja) 1988-07-18 1997-11-26 塩野義製薬株式会社 徐放性製剤の製造法
DE3827061C1 (https=) 1988-08-10 1990-02-15 Deutsche Gelatine-Fabriken Stoess & Co Gmbh, 6930 Eberbach, De
US4925675A (en) 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
ES2058546T3 (es) 1988-09-30 1994-11-01 Rhone Poulenc Rorer Ltd Formulaciones farmaceuticas granulares.
US5178868A (en) 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
NZ231281A (en) 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
IL92343A0 (en) 1988-12-20 1990-07-26 Gist Brocades Nv Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them
EP0376331A3 (en) 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
CA2007055A1 (en) 1989-01-06 1990-07-06 Garth Boehm Theophylline dosage form
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5196203A (en) 1989-01-06 1993-03-23 F. H. Faulding & Co. Limited Theophylline dosage form
US5013306A (en) 1989-01-18 1991-05-07 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5165952A (en) 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
FR2642420B1 (fr) 1989-01-27 1991-09-06 Valpan Sa Labo Pharma Nouvelle forme galenique a liberation programmee contenant une association de sels ferreux, d'acide succinique et d'acide ascorbique
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5126145A (en) 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5229148A (en) 1989-04-19 1993-07-20 Wm. Wrigley Jr. Company Method of combining active ingredients with polyvinyl acetates
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US4967486A (en) 1989-06-19 1990-11-06 Glatt Gmbh Microwave assisted fluidized bed processor
DK161743C (da) 1989-07-03 1992-02-17 Niro Atomizer As Fremgangsmaade og apparat til agglomerering af et pulverformigt materiale
DE415693T1 (de) 1989-08-28 1991-10-17 Arizona Technology Development Corp., Tucson, Ariz. Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit.
EP0418596A3 (en) 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
IL96311A (en) 1989-12-01 1995-05-26 Abbott Lab Medications with delayed release
DE4000571C1 (https=) 1990-01-10 1991-06-06 Herbert 7853 Steinen De Huettlin
US5296266A (en) 1990-02-22 1994-03-22 Seiko Epson Corporation Method of preparing microcapsule
KR0168849B1 (ko) 1990-04-12 1999-01-15 요시또시 가즈오 피목 조성물 및 그의 제조방법
IE65045B1 (en) 1990-04-28 1995-10-04 Takeda Chemical Industries Ltd Granulated preparations and method of producing the same
GB9012316D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
EP0491953B1 (en) 1990-06-25 1997-04-23 Towa Chemical Industry Co., Ltd. Molasses-containing maltitol crystal and production thereof
US5183690A (en) 1990-06-25 1993-02-02 The United States Of America, As Represented By The Secretary Of Agriculture Starch encapsulation of biologically active agents by a continuous process
HU208495B (en) 1990-06-27 1993-11-29 Alkaloida Vegyeszeti Gyar Process for producing retarde pharmaceutical compositions
FR2663818B1 (fr) 1990-06-29 1993-07-09 Rhone Poulenc Nutrition Animale Procede de preparation de granules de principes actifs par extrusion.
GB2246514B (en) 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
US5035509A (en) 1990-08-13 1991-07-30 Hpm Corporation Multi-channel extrusion screw with a zig-zag undercut barrier
DK0472502T3 (da) 1990-08-24 1995-10-09 Spirig Ag Fremgangsmåde til fremstilling af pellets
JP2875611B2 (ja) 1990-08-29 1999-03-31 エーザイ株式会社 ケイ酸カルシウム含有外用剤
US5102668A (en) 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
DE4031881C2 (de) 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
GB2248842A (en) 1990-10-16 1992-04-22 American Cyanamid Co Film-forming polymer compositions
US5271934A (en) 1990-10-22 1993-12-21 Revlon Consumer Products Corporation Encapsulated antiperspirant salts and deodorant/antiperspirants
FR2670398B1 (fr) 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5240400A (en) 1990-12-17 1993-08-31 Fuji Paudal Kabushiki Kaisha Screw-type extrusion granulating apparatus, especially for producing very fine granules
JPH0622669B2 (ja) 1990-12-17 1994-03-30 不二パウダル株式会社 前押出式スクリュー型押出し造粒機
AU1589492A (en) * 1991-03-01 1992-10-06 Warner-Lambert Company Starch-based controlled release compositions
US5403593A (en) 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
US5273758A (en) 1991-03-18 1993-12-28 Sandoz Ltd. Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms
US5132142A (en) 1991-03-19 1992-07-21 Glatt Gmbh Apparatus and method for producing pellets by layering power onto particles
IT1245891B (it) 1991-04-12 1994-10-25 Alfa Wassermann Spa Formulazioni farmaceutiche a rilascio controllato per uso orale gastroresistenti contenenti acidi biliari e loro sali.
KR0182801B1 (ko) 1991-04-16 1999-05-01 아만 히데아키 고체 분산체의 제조방법
US5380535A (en) 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
SG48815A1 (en) 1991-06-28 1998-05-18 Univ Brown Res Found Capsule extrusion systems
IT1251153B (it) 1991-08-06 1995-05-04 Vectorpharma Int Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica
DE4127665A1 (de) 1991-08-22 1993-02-25 Beiersdorf Ag Galenische matrix
US5340581A (en) 1991-08-23 1994-08-23 Gillette Canada, Inc. Sustained-release matrices for dental application
AU657351B2 (en) 1991-09-06 1995-03-09 Mcneilab, Inc. Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
GB9121204D0 (en) 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5162117A (en) 1991-11-22 1992-11-10 Schering Corporation Controlled release flutamide composition
DE4138513A1 (de) 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
ATE140620T1 (de) 1991-12-05 1996-08-15 Mallinckrodt Veterinary Inc Glasartige kohlenhydratenmatrize zur verabreichung von heilmitteln mit verzögerter wirkstoffabgabe
GB2281204A (en) 1993-07-27 1995-03-01 Euro Celtique Sa Sustained release morphine compositions
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
GB2284760B (en) 1993-11-23 1998-06-24 Euro Celtique Sa A method of preparing pharmaceutical compositions by melt pelletisation
US5167964A (en) 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
US5262172A (en) 1992-06-19 1993-11-16 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing buffered bile acids
US5234697A (en) 1992-06-22 1993-08-10 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing salts of bile acids
US5429825A (en) 1992-06-26 1995-07-04 Mcneil-Ppc, Inc. Rotomelt granulation
US5350584A (en) 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
DE69332291T2 (de) 1992-10-16 2003-07-31 Nippon Shinyaku Co., Ltd. Verfahren zur herstellung von wachsmatrizes
DE4236752A1 (de) 1992-10-30 1994-05-05 Asta Medica Ag Kombinationspräparat aus Flupirtin und Morphin zur Behandlung von Schmerzen und zur Vermeidung der Morphin-Abhängigkeit
MX9400016A (es) 1993-01-04 1994-08-31 Eastman Kodak Co Copolimeros de bloque epoxidizados.
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
IT1265074B1 (it) 1993-05-18 1996-10-30 Istituto Biochimico Italiano Composizione farmaceutica a lento rilascio contenente come sostanza attiva un acido biliare
IL109944A (en) 1993-07-01 1998-12-06 Euro Celtique Sa Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
DE4329794C2 (de) 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
WO1995013794A1 (en) * 1993-11-18 1995-05-26 Nippon Shinyaku Co., Ltd. Process for producing stable medicinal composition, and pharmaceutical preparation
US5476528A (en) 1993-12-20 1995-12-19 Tennessee Valley Authority System for improving material release profiles
JP3224931B2 (ja) 1994-01-12 2001-11-05 株式会社日本製鋼所 二軸混練押出機
US5395626A (en) 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
DE4418837A1 (de) 1994-05-30 1995-12-07 Bayer Ag Thermisches Granulierverfahren
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
DE19729273C2 (de) * 1997-07-09 2000-08-17 Aventis Res & Tech Gmbh & Co Thermoplastische Mischung auf 1,4-alpha-D-Polyglucanbasis, Verfahren zu deren Herstellung und Verwendung
WO1999034780A1 (de) * 1998-01-12 1999-07-15 Bühler AG Verfahren und vorrichtung zum verkapseln von wirkstoffen
DE19852826A1 (de) * 1998-11-17 2000-05-18 Aventis Res & Tech Gmbh & Co Poly(alpha-1,4-D-Glucan)
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
JP5257315B2 (ja) 2009-09-29 2013-08-07 住友大阪セメント株式会社 無機系アンカーの上向き施工方法

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8822487B2 (en) 1997-12-22 2014-09-02 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US9474750B2 (en) 1997-12-22 2016-10-25 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US9205082B2 (en) 1997-12-22 2015-12-08 Purdue Pharma L.P. Opioid agonist/antagonist combinations
US8936808B1 (en) 1997-12-22 2015-01-20 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US8932630B1 (en) 1997-12-22 2015-01-13 Purdue Pharma L.P Opioid agonist/antagonist combinations
US8673355B2 (en) 1997-12-22 2014-03-18 Purdue Pharma L.P. Opioid agonist/antagonist combinations
US9161937B2 (en) 2001-05-11 2015-10-20 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9283216B2 (en) 2001-05-11 2016-03-15 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9511066B2 (en) 2001-05-11 2016-12-06 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9480685B2 (en) 2001-05-11 2016-11-01 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9358230B1 (en) 2001-05-11 2016-06-07 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US8969369B2 (en) 2001-05-11 2015-03-03 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9056051B2 (en) 2001-05-11 2015-06-16 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9084729B2 (en) 2001-05-11 2015-07-21 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9345701B1 (en) 2001-05-11 2016-05-24 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9168252B2 (en) 2001-05-11 2015-10-27 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9283221B2 (en) 2001-05-11 2016-03-15 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US8846090B2 (en) 2002-04-05 2014-09-30 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US8846091B2 (en) 2002-04-05 2014-09-30 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US9555000B2 (en) 2002-04-05 2017-01-31 Purdue Pharma L.P. Pharmaceutical preparation containing oxycodone and naloxone
US9655855B2 (en) 2002-04-05 2017-05-23 Purdue Pharma L.P. Matrix for sustained, invariant and independent release of active compounds
US9907793B2 (en) 2002-04-05 2018-03-06 Purdue Pharma L.P. Pharmaceutical preparation containing oxycodone and naloxone
US10420762B2 (en) 2002-04-05 2019-09-24 Purdue Pharma L.P. Pharmaceutical preparation containing oxycodone and naloxone
WO2004100930A1 (en) * 2003-05-19 2004-11-25 Euro-Celtique S.A. Pharmaceutical dosage form comprising a solid solution
EP2255808A2 (en) 2004-06-08 2010-12-01 Euro-Celtique S.A. Opioids for the treatment of the restlessness of the lower limbs
EP1961421A1 (en) 2004-06-08 2008-08-27 Euro-Celtique S.A. Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)
US8518925B2 (en) 2004-06-08 2013-08-27 Euro-Celtique S.A. Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)
US10258235B2 (en) 2005-02-28 2019-04-16 Purdue Pharma L.P. Method and device for the assessment of bowel function
DE102011015370A1 (de) * 2011-03-29 2012-10-04 Emodys Gmbh Matrix für eine orale Darreichungsform, Verfahren zu deren Herstellung sowie Verwendung derselben

Also Published As

Publication number Publication date
DK1171101T3 (da) 2007-07-16
HUP0200843A2 (hu) 2002-07-29
EP1171101B1 (de) 2007-03-14
WO2000064415A1 (de) 2000-11-02
JP4575599B2 (ja) 2010-11-04
DE20022720U1 (de) 2002-02-28
AU4554200A (en) 2000-11-10
CY1106478T1 (el) 2012-01-25
EP1171101A1 (de) 2002-01-16
BR0009927A (pt) 2002-01-08
ES2284495T3 (es) 2007-11-16
AU763609B2 (en) 2003-07-31
US8557286B1 (en) 2013-10-15
DE50014164D1 (de) 2007-04-26
CN1347315A (zh) 2002-05-01
CA2372025C (en) 2007-09-25
RU2001128233A (ru) 2004-02-27
PT1171101E (pt) 2007-06-08
KR20010112440A (ko) 2001-12-20
JP5022086B2 (ja) 2012-09-12
IL145755A0 (en) 2002-07-25
CA2372025A1 (en) 2000-11-02
HUP0200843A3 (en) 2003-04-28
KR100511113B1 (ko) 2005-08-31
CN1214783C (zh) 2005-08-17
HU227001B1 (en) 2010-04-28
ATE356617T1 (de) 2007-04-15
JP2007211019A (ja) 2007-08-23
BR0009927B1 (pt) 2011-12-27
RU2208436C2 (ru) 2003-07-20
EP1839651A1 (de) 2007-10-03
JP2002542276A (ja) 2002-12-10

Similar Documents

Publication Publication Date Title
EP1171101B1 (de) Verfahren zur herstellung einer wasserunlöslichen amorphen retardmatrix
DE69432186T2 (de) Verfahren zur herstellung stabiler arzneimittel
DE68907835T3 (de) Direkt verpressbare Füllstoffe zur verzögerten Freisetzung.
DE69326163T2 (de) Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen
EP0756480B1 (de) Retard-matrixpellets und verfahren zu ihrer herstellung
DE69915718T2 (de) Fliessfähige, direktverpressbare Stärke als Bindemittel, Sprengmittel und Füllstoff für Presstabletten und Hartgelatinkapseln
EP1162953B1 (de) Mechanisch stabile pharmazeutische darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive substanzen
DE3877764T2 (de) Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.
DE60027608T2 (de) Mesalazine enthaltende pharmazeutische Zusammensetzungen mit gesteuerter Freisetzung
DE3587274T2 (de) Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend.
DE60110192T2 (de) Verfahren und System zur gleichmäßigen Arzneistoffabgabe
DE69403463T2 (de) Verfahren zur herstellung von wirkstoff enthaltenden teilchen durch extrusion und lyophilisation
DE69530421T2 (de) Stärkeacetatpräparat mit modifizierbaren eigenschaften, verfahren für seine herstellung und verwendung
DD159966A5 (de) Verfahren zur herstellung von arzneimitteln mit retardierter wirkstoff-freisetzung
DE10046541A1 (de) Mechanisch stabile darreichungsformen, enthaltend Ubichinone
DE10026699A1 (de) Formulierung auf Heparin-, Glycosaminoglycan- oder Heparinoidbasis und Verwendung der Formulierung sowie der Formulierungsgrundlage
EP0596203A1 (de) Wirkstoffe und wasserlösliche Polymeren enthaltende Zubereitungen in Form fester Teilchen
DE60019550T2 (de) Dämpfwachsperlen zur herstellung von festen formgegenständen
WO2001000175A1 (de) Mechanisch stabile pharmazeutische darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive substanzen
DE4021678A1 (de) Verfahren zur herstellung klein dimensionierter formkoerper mit hohem etofibrat-gehalt und kontrollierter wirkstoff-freisetzung, deren verwendung und daraus bestehende oral verabreichbare applikationsformen
DE4127522A1 (de) Neue masse mit einem hydrophilen polymer und einem davon verschiedenen hydrophilen material
EP3943071B1 (de) Zusammensetzung, enthaltend natürliche lipophile verbindungen, verwendung der zusammensetzung und verfahren zur herstellung der zusammensetzung
EP1220656A2 (de) Formkörper mit einer amphiphilen äusseren phase und einer lipophilen inneren phase
DE60112117T2 (de) Warmgeformte feste arzneizusammensetzung zur gesteuerten wirkstoffabgabe von perindopril
DE19901040A1 (de) Arzneiformen mit gesteuerter Freisetzung, enthaltend gut wasserlösliche Wirkstoffe

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8130 Withdrawal