JP4575599B2 - 非水溶性の非晶質または部分的に非晶質の放出制御基材を製造する方法 - Google Patents

非水溶性の非晶質または部分的に非晶質の放出制御基材を製造する方法 Download PDF

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JP4575599B2
JP4575599B2 JP2000613406A JP2000613406A JP4575599B2 JP 4575599 B2 JP4575599 B2 JP 4575599B2 JP 2000613406 A JP2000613406 A JP 2000613406A JP 2000613406 A JP2000613406 A JP 2000613406A JP 4575599 B2 JP4575599 B2 JP 4575599B2
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dosage form
active agent
release
base
starch
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JP2002542276A5 (https=
JP2002542276A (ja
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ライン、フーベルト
シュテフェンス、クラウス−ユルゲン
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ユーロ−セルティック エス． ア．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000613406A 1999-04-22 2000-04-20 非水溶性の非晶質または部分的に非晶質の放出制御基材を製造する方法 Expired - Fee Related JP4575599B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19918325.2 1999-04-22
DE19918325A DE19918325A1 (de) 1999-04-22 1999-04-22 Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
PCT/EP2000/003612 WO2000064415A1 (de) 1999-04-22 2000-04-20 Verfahren zur herstellung einer wasserunlöslichen amorphen oder teilamorphen retardmatrix

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007098734A Division JP5022086B2 (ja) 1999-04-22 2007-04-04 医薬の剤形の使用方法

Publications (3)

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JP2002542276A JP2002542276A (ja) 2002-12-10
JP2002542276A5 JP2002542276A5 (https=) 2006-10-05
JP4575599B2 true JP4575599B2 (ja) 2010-11-04

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JP2000613406A Expired - Fee Related JP4575599B2 (ja) 1999-04-22 2000-04-20 非水溶性の非晶質または部分的に非晶質の放出制御基材を製造する方法
JP2007098734A Expired - Lifetime JP5022086B2 (ja) 1999-04-22 2007-04-04 医薬の剤形の使用方法

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JP2007098734A Expired - Lifetime JP5022086B2 (ja) 1999-04-22 2007-04-04 医薬の剤形の使用方法

Country Status (18)

Country Link
US (1) US8557286B1 (https=)
EP (2) EP1839651A1 (https=)
JP (2) JP4575599B2 (https=)
KR (1) KR100511113B1 (https=)
CN (1) CN1214783C (https=)
AT (1) ATE356617T1 (https=)
AU (1) AU763609B2 (https=)
BR (1) BR0009927B1 (https=)
CA (1) CA2372025C (https=)
CY (1) CY1106478T1 (https=)
DE (3) DE19918325A1 (https=)
DK (1) DK1171101T3 (https=)
ES (1) ES2284495T3 (https=)
HU (1) HU227001B1 (https=)
IL (1) IL145755A0 (https=)
PT (1) PT1171101E (https=)
RU (1) RU2208436C2 (https=)
WO (1) WO2000064415A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007211019A (ja) * 1999-04-22 2007-08-23 Euro-Celtique Sa 医薬の剤形またはその前駆物質の製造方法、医薬の剤形、及び医薬の剤形の使用方法

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US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
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EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
WO2003028698A2 (de) * 2001-09-26 2003-04-10 Steffens Klaus-Juergen Verfahren und vorrichtung zur herstellung von granulaten umfassend mindestens einen pharmazeutischen wirkstoff
HUE032656T2 (en) 2002-04-05 2017-10-30 Euro Celtique Sa Pharmaceutical composition containing oxicodone and naloxone
EP1479381A1 (en) * 2003-05-19 2004-11-24 Euro-Celtique S.A. Pharmaceutical dosage form comprising a solid solution
EP1604667A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US8367105B2 (en) 2004-11-10 2013-02-05 Teva Pharmaceutical Industries, Ltd. Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
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SG174286A1 (en) 2009-03-10 2011-10-28 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
DE102011011889B4 (de) 2011-02-21 2015-11-05 Leistritz Extrusionstechnik Gmbh Vorrichtung und Verfahren zur kontinuierlichen Herstellung von biplan geschnittenen Formkörpern enthaltend wenigstens einen Füllstoff
DE102011015370A1 (de) * 2011-03-29 2012-10-04 Emodys Gmbh Matrix für eine orale Darreichungsform, Verfahren zu deren Herstellung sowie Verwendung derselben
AU2012357848C1 (en) * 2011-12-21 2018-07-19 Bayer Pharma Aktiengesellschaft Preparations containing amorphous emodepside
JP2016525138A (ja) 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
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AU4554200A (en) 2000-11-10
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US8557286B1 (en) 2013-10-15
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CN1347315A (zh) 2002-05-01
CA2372025C (en) 2007-09-25
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PT1171101E (pt) 2007-06-08
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HUP0200843A3 (en) 2003-04-28
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