DE19726167B4 - Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung - Google Patents
Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung Download PDFInfo
- Publication number
- DE19726167B4 DE19726167B4 DE19726167A DE19726167A DE19726167B4 DE 19726167 B4 DE19726167 B4 DE 19726167B4 DE 19726167 A DE19726167 A DE 19726167A DE 19726167 A DE19726167 A DE 19726167A DE 19726167 B4 DE19726167 B4 DE 19726167B4
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- Germany
- Prior art keywords
- insulin
- amino acid
- chain
- acid residues
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 189
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- -1 halogen cyanide Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 108010027338 isoleucylcysteine Proteins 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (35)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726167A DE19726167B4 (de) | 1997-06-20 | 1997-06-20 | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| PT98110889T PT885961E (pt) | 1997-06-20 | 1998-06-15 | Novos derivados da insulina com inicio de accao rapido |
| ES98110889T ES2232900T3 (es) | 1997-06-20 | 1998-06-15 | Nuevos derivados de insulina con una rapida iniciacion del efecto. |
| AT98110889T ATE283919T1 (de) | 1997-06-20 | 1998-06-15 | Neue insulinderivate mit schnellem wirkungseintritt |
| DE59812316T DE59812316D1 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
| EP98110889A EP0885961B1 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
| DK98110889T DK0885961T3 (da) | 1997-06-20 | 1998-06-15 | Hidtil ukendte insulinderivater med hurtig indtræden af virkning |
| DE200412000049 DE122004000049I2 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
| NZ330700A NZ330700A (en) | 1997-06-20 | 1998-06-17 | B27, B28, B29 (B chain) insulin derivatives having a rapid onset of action |
| SK836-98A SK285267B6 (sk) | 1997-06-20 | 1998-06-17 | Deriváty inzulínu s rýchlym začiatkom pôsobenia, spôsob ich prípravy a farmaceutický prostriedok s ich obsahom |
| RU98112109/14A RU2207874C9 (ru) | 1997-06-20 | 1998-06-18 | Производное инсулина или его физиологически приемлемая соль, предшественник производного инсулина, днк-последовательность, кодирующая предшественник, вектор экспрессии, содержащий упомянутую днк-последовательность, субстрат, трансформированный упомянутым вектором экспрессии, фармацевтическая композиция с понижающей, соответственно регулирующей уровень глюкозы в крови эффективностью |
| IDP980887A ID20462A (id) | 1997-06-20 | 1998-06-18 | Turunan insulin baru yang mempunyai permulaan kerja yang cepat |
| HU9801368A HU221176B1 (en) | 1997-06-20 | 1998-06-18 | New insulin derivatives with rapid action |
| UA98063193A UA65529C2 (uk) | 1997-06-20 | 1998-06-18 | Похідна інсуліну або її фізіологічно прийнятна сіль, попередник похідної інсуліну, днк-послідовність, що кодує попередник, вектор експресії, субстрат, трансформований вектором експресії, фармацевтична композиція |
| US09/099,307 US6221633B1 (en) | 1997-06-20 | 1998-06-18 | Insulin derivatives having a rapid onset of action |
| CA2235443A CA2235443C (en) | 1997-06-20 | 1998-06-18 | Novel insulin derivatives having a rapid onset of action |
| TR1998/01144A TR199801144A2 (xx) | 1997-06-20 | 1998-06-18 | H�zl� etki giri�li yeni ens�lin t�revleri. |
| ARP980102911A AR015899A1 (es) | 1997-06-20 | 1998-06-18 | Derivado de insulina o sales compatibles de los mismos, procedimiento para su preparacion, secuencias de adn, vector de expresion, celula hospedante incapaz de conducir a la regeneracion de un animal o planta, composicion farmaceutica, solucion inyectable con actividad de insulina y utilizacion de d |
| CZ19981934A CZ295964B6 (cs) | 1997-06-20 | 1998-06-18 | Nové deriváty inzulinu s rychlým začátkem působení, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
| NO19982860A NO321720B1 (no) | 1997-06-20 | 1998-06-19 | Insulinderivater og forloperproteiner, fremgangsmate for fremstilling inkludert DNA-sekvenser, ekspresjonsbaerer og vertsceller, samt deres anvendelse spesielt i farmasoytiske preparater for behandling av diabetes. |
| JP17237998A JP3676573B2 (ja) | 1997-06-20 | 1998-06-19 | 迅速な作用発現を示す新規インスリン誘導体 |
| IL125006A IL125006A (en) | 1997-06-20 | 1998-06-19 | Insulin derivatives with rapid onset of action |
| KR1019980023037A KR100546225B1 (ko) | 1997-06-20 | 1998-06-19 | 신속한 작용개시를 나타내는 인슐린 유도체 |
| ZA985363A ZA985363B (en) | 1997-06-20 | 1998-06-19 | Novel insulin derivatives having a rapid onset of action |
| AU73064/98A AU740344C (en) | 1997-06-20 | 1998-06-19 | Novel insulin derivatives having a rapid onset of action |
| CNB981149502A CN1195777C (zh) | 1997-06-20 | 1998-06-19 | 新的速效胰岛素衍生物 |
| PL326936A PL196626B1 (pl) | 1997-06-20 | 1998-06-20 | Nowe pochodne insuliny, sposób ich wytwarzania, prekursory pochodnych insuliny, sekwencje DNA kodujące te prekursory, wektory ekspresyjne, komórka gospodarza, środek farmaceutyczny, roztwór o aktywności insulinowej i zastosowanie nowych pochodnych insuliny |
| BRPI9803708A BRPI9803708B8 (pt) | 1997-06-20 | 1998-06-22 | derivados de insulina de rápido início de ação, processo para a sua preparação, bem como precursor, preparação farmacêutica, solução injetável e uso |
| TW087109743A TW562806B (en) | 1997-06-20 | 1998-07-10 | Novel insulin derivatives having a rapid onset of action |
| HK99101746.7A HK1016616B (en) | 1997-06-20 | 1999-04-21 | Novel insulin derivatives having a rapid onset of action |
| NL300170C NL300170I2 (nl) | 1997-06-20 | 2005-01-27 | Nieuwe insulinederivaten met snel begin van werking. |
| LU91138C LU91138I2 (fr) | 1997-06-20 | 2005-02-02 | Glulisine d'insuline et ses dérivés pharmaceutiquement acceptables. |
| FR05C0009C FR05C0009I2 (fr) | 1997-06-20 | 2005-03-21 | Nouveaux dérivés de l'insuline avec déclenchement d'action rapide |
| CY200500004C CY2005004I2 (el) | 1997-06-20 | 2005-03-28 | Νεα παραγωγα ινσουλινης με ταχεια εναρξη δρασεως |
| NO2006014C NO2006014I1 (no) | 1997-06-20 | 2006-10-26 | Insulin glulisin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726167A DE19726167B4 (de) | 1997-06-20 | 1997-06-20 | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19726167A1 DE19726167A1 (de) | 1999-01-28 |
| DE19726167B4 true DE19726167B4 (de) | 2008-01-24 |
Family
ID=7833099
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19726167A Expired - Lifetime DE19726167B4 (de) | 1997-06-20 | 1997-06-20 | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| DE200412000049 Active DE122004000049I2 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
| DE59812316T Expired - Lifetime DE59812316D1 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE200412000049 Active DE122004000049I2 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
| DE59812316T Expired - Lifetime DE59812316D1 (de) | 1997-06-20 | 1998-06-15 | Neue Insulinderivate mit schnellem Wirkungseintritt |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6221633B1 (enExample) |
| EP (1) | EP0885961B1 (enExample) |
| JP (1) | JP3676573B2 (enExample) |
| KR (1) | KR100546225B1 (enExample) |
| CN (1) | CN1195777C (enExample) |
| AR (1) | AR015899A1 (enExample) |
| AT (1) | ATE283919T1 (enExample) |
| AU (1) | AU740344C (enExample) |
| BR (1) | BRPI9803708B8 (enExample) |
| CA (1) | CA2235443C (enExample) |
| CY (1) | CY2005004I2 (enExample) |
| CZ (1) | CZ295964B6 (enExample) |
| DE (3) | DE19726167B4 (enExample) |
| DK (1) | DK0885961T3 (enExample) |
| ES (1) | ES2232900T3 (enExample) |
| FR (1) | FR05C0009I2 (enExample) |
| HU (1) | HU221176B1 (enExample) |
| ID (1) | ID20462A (enExample) |
| IL (1) | IL125006A (enExample) |
| LU (1) | LU91138I2 (enExample) |
| NL (1) | NL300170I2 (enExample) |
| NO (2) | NO321720B1 (enExample) |
| NZ (1) | NZ330700A (enExample) |
| PL (1) | PL196626B1 (enExample) |
| PT (1) | PT885961E (enExample) |
| RU (1) | RU2207874C9 (enExample) |
| SK (1) | SK285267B6 (enExample) |
| TR (1) | TR199801144A2 (enExample) |
| TW (1) | TW562806B (enExample) |
| UA (1) | UA65529C2 (enExample) |
| ZA (1) | ZA985363B (enExample) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19947456A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| US8623379B2 (en) | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| AU2002252199B2 (en) | 2001-03-08 | 2008-01-03 | Emory University | MVA expressing modified HIV envelope, GAG, and POL genes |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| HUP0401318A3 (en) * | 2001-08-22 | 2008-03-28 | Sanofi Aventis Deutschland | Combined preparations containing 2,3,4,5-tetrahydro-benzo[b]thiepine-1,1-dioxide derivatives and other active substances, and the use thereof |
| CN1635900A (zh) * | 2001-08-28 | 2005-07-06 | 伊莱利利公司 | Glp－1和基础胰岛素的预混合物 |
| US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
| US6884812B2 (en) | 2001-08-31 | 2005-04-26 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals |
| IL160556A0 (en) | 2001-08-31 | 2004-07-25 | Aventis Pharma Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators |
| US7179788B2 (en) * | 2001-10-19 | 2007-02-20 | Eli Lilly And Company | Biphasic mixtures of GLP-1 and insulin |
| US20050250676A1 (en) * | 2001-11-19 | 2005-11-10 | Aventis Pharma Deutschland Gmbh | Method of activating insulin receptor substrate-2 to stimulate insulin production |
| AU2002346491A1 (en) * | 2001-12-19 | 2003-07-09 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| US7078404B2 (en) * | 2002-04-11 | 2006-07-18 | Sanofi-Aventis Deutschland Gmbh | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use |
| US7223796B2 (en) * | 2002-04-11 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use |
| ATE496064T1 (de) * | 2002-05-07 | 2011-02-15 | Novo Nordisk As | Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten |
| US7049341B2 (en) * | 2002-06-07 | 2006-05-23 | Aventis Pharma Deutschland Gmbh | N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use |
| US7262220B2 (en) * | 2002-07-11 | 2007-08-28 | Sanofi-Aventis Deutschland Gmbh | Urea- and urethane-substituted acylureas, process for their preparation and their use |
| DE10231370B4 (de) * | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| AU2003249937A1 (en) * | 2002-07-12 | 2004-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclically substituted benzoylureas, method for their production and their use as medicaments |
| US20040157922A1 (en) * | 2002-10-04 | 2004-08-12 | Aventis Pharma Deutschland Gmbh | Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments |
| US7208504B2 (en) * | 2002-10-12 | 2007-04-24 | Sanofi-Aventis Deutschland Gmbh | Bicyclic inhibitors of hormone sensitive lipase |
| DE10250297A1 (de) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung |
| US7193035B2 (en) * | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| US20040138099A1 (en) * | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
| DE10258007B4 (de) * | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258008B4 (de) * | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| US20040242583A1 (en) * | 2003-01-20 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use |
| US7179941B2 (en) * | 2003-01-23 | 2007-02-20 | Sanofi-Aventis Deutschland Gmbh | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7196114B2 (en) * | 2003-02-17 | 2007-03-27 | Sanofi-Aventis Deutschland Gmbh | Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use |
| DE10308355A1 (de) * | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US7173151B2 (en) * | 2003-02-27 | 2007-02-06 | Sanofi-Aventisdeutschand Gmbh | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals |
| DE10308352A1 (de) * | 2003-02-27 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2219635A1 (de) * | 1971-04-30 | 1972-11-09 | EH Lilly and Co., Indianapolis, Ind. (V.St.A.) | Insulinprodukt |
| EP0375437A2 (en) * | 1988-12-23 | 1990-06-27 | Novo Nordisk A/S | Human insulin analogues |
| WO1990007522A1 (en) * | 1988-12-23 | 1990-07-12 | Novo Nordisk A/S | Human insulin analogues |
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