DE1965304A1 - Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung - Google Patents

Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung

Info

Publication number
DE1965304A1
DE1965304A1 DE19691965304 DE1965304A DE1965304A1 DE 1965304 A1 DE1965304 A1 DE 1965304A1 DE 19691965304 DE19691965304 DE 19691965304 DE 1965304 A DE1965304 A DE 1965304A DE 1965304 A1 DE1965304 A1 DE 1965304A1
Authority
DE
Germany
Prior art keywords
group
compound
general formula
aryl
chr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691965304
Other languages
German (de)
English (en)
Inventor
Kei Arima
Kazuo Kariyone
Masanobu Kohsaka
Heiichi Sakai
Gakuzo Tamura
Hisatoyo Yazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE1965304A1 publication Critical patent/DE1965304A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19691965304 1968-12-30 1969-12-29 Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung Pending DE1965304A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8369 1968-12-30
JP44050780A JPS4843755B1 (enrdf_load_html_response) 1969-06-26 1969-06-26

Publications (1)

Publication Number Publication Date
DE1965304A1 true DE1965304A1 (de) 1970-07-23

Family

ID=26332993

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691965304 Pending DE1965304A1 (de) 1968-12-30 1969-12-29 Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung

Country Status (5)

Country Link
AT (1) AT299449B (enrdf_load_html_response)
BE (1) BE743875A (enrdf_load_html_response)
DE (1) DE1965304A1 (enrdf_load_html_response)
FR (1) FR2027356A1 (enrdf_load_html_response)
NL (1) NL6919607A (enrdf_load_html_response)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
AU757510C (en) 1998-08-27 2003-09-11 Medimmune Limited Pyrrolobenzodiazepines
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
ES2398975T3 (es) 2004-03-01 2013-03-25 Spirogen Sàrl Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
EP1723152B1 (en) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
NZ602933A (en) 2010-04-15 2014-09-26 Seattle Genetics Inc Pyrrolobenzodiazepines used to treat proliferative diseases
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
CN103987718A (zh) 2011-09-20 2014-08-13 斯皮罗根有限公司 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
JP6166728B2 (ja) 2011-10-14 2017-07-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピンの製造に有用な合成方法及び中間体
AU2012322613B2 (en) 2011-10-14 2016-04-21 Medimmune Limited Pyrrolobenzodiazepines and targeted conjugates
ES2945932T3 (es) 2011-10-14 2023-07-10 Seagen Inc Pirrolobenzodiazepinas y conjugados dirigidos
BR112014008981A2 (pt) 2011-10-14 2017-05-02 Spirogen Sàrl pirrolobenzodiazepinas
EA028457B1 (ru) 2011-10-14 2017-11-30 Медимьюн Лимитед Пирролобензодиазепины
SMT201900017T1 (it) 2012-10-12 2019-02-28 Medimmune Ltd Coniugati pirrolobenzodiazepina-anticorpo
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
PT2766048E (pt) 2012-10-12 2015-02-25 Spirogen Sarl Pirrolobenzodiazepinas e conjugados das mesmas
KR20150083994A (ko) 2012-10-12 2015-07-21 스피로즌 살 피롤로벤조디아제핀 및 그의 컨주게이트
DK2906251T3 (da) 2012-10-12 2017-11-20 Adc Therapeutics Sa Pyrrolobenzodiazepin-anti-CD22-antistofkonjugater
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
DK2906253T3 (en) 2012-10-12 2018-10-22 Adc Therapeutics Sa Pyrrolobenzodiazepine anti-PSMA antibody conjugates
ES2660029T3 (es) 2012-10-12 2018-03-20 Medimmune Limited Conjugados de anticuerpo-pirrolobenzodiazepinas
TR201808051T4 (tr) 2012-10-12 2018-06-21 Adc Therapeutics Sa Pirrolobenzodiazepin antikor konjugatları.
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
BR112017011111A2 (pt) 2014-11-25 2017-12-26 Adc Therapeutics Sa conjugados de pirrolobenzodiazepina-anticorpo
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
DK3544636T3 (da) 2017-02-08 2021-05-10 Adc Therapeutics Sa Pyrrolobenzodiazepin-antistof-konjugater
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
US20200129637A1 (en) 2017-04-20 2020-04-30 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
WO2018229222A1 (en) 2017-06-14 2018-12-20 Adc Therapeutics Sa Dosage regimes for the administration of an anti-cd19 adc
KR102270107B1 (ko) 2017-08-18 2021-06-30 메디뮨 리미티드 피롤로벤조디아제핀 컨쥬게이트
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
ES2967878T3 (es) 2019-03-15 2024-05-06 Medimmune Ltd Dímeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento del cáncer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361742A (en) * 1964-12-07 1968-01-02 Hoffmann La Roche 5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides

Also Published As

Publication number Publication date
NL6919607A (enrdf_load_html_response) 1970-07-02
BE743875A (enrdf_load_html_response) 1970-05-28
FR2027356A1 (en) 1970-09-25
AT299449B (de) 1972-05-15
FR2027356B1 (enrdf_load_html_response) 1974-01-11

Similar Documents

Publication Publication Date Title
DE1965304A1 (de) Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung
DE2347682C2 (de) Rapamycin, Verfahren zu seiner Herstellung und pharmazeutisches Mittel
DE3887820T2 (de) Antibiotika, Benanomicine A und B und Dexylosylbenanomicin B, ihre Herstellung und Verwendung.
DE2634499A1 (de) Neue tylosinderivate und verfahren zu ihrer herstellung
DE2743654C3 (enrdf_load_html_response)
DE2816608A1 (de) Antibiotisches n-acetyl-dehydro- thienamycin
DE69322235T2 (de) Thiomarinol-Derivate und Verfahren zu ihrer Herstellung
DE69204734T2 (de) Antibakterielle Verbindung.
DE2150593C2 (de) Neues Antibiotikum Ws-4545(Bicyclomycin), Verfahren zu dessen Herstellung und dieses enthaltende pharmazeutische Zubereitung
DE3048421C2 (de) Antibiotische Substanz, Verfahren zu deren Herstellung und antimykotisches Mittel, welches diese enthält
DE3782169T2 (de) Verfahren zur herstellung von antibiotica 10381b.
DE68924991T2 (de) 2-Pyranon-Derivat und Verfahren zu dessen Herstellung.
DE2833689C2 (enrdf_load_html_response)
CH634853A5 (de) Schwefelhaltige metabolite, ihre herstellung und verwendung in arznei- und futtermitteln.
US3692777A (en) 5h-pyrrolo {8 2,1-c{9 {8 1,4{9 {0 benzodiazepin-5-ones
DE2332065C2 (de) Verfahren zur Herstellung von Cephalosporinen sowie deren N-Alkoxycarbonyl- oder N-Arylcarbamoylderivaten
AT364455B (de) Verfahren zur herstellung von neuen phosphonsaeuren
DE69206858T2 (de) Verbindung UCA1064-B
CH531564A (de) Verfahren zur Herstellung neuer Hexahydropyrrolobenzodiazepinone
DE1667923C3 (de) Neue Antibiotika, Verfahren zu ihrer Herstellung sowie pharmazeutische Zubereitung, die diese Antibiotika enthält
AT206582B (de) Verfahren zur biosynthetischen Herstellung des neuen O-Diazoacetyl-1-serins
DE926271C (de) Verfahren zur Gewinnung eines neuen Antibiotikums
DE4211056C1 (en) Spiran heterocyclic deriv. for controlling fungi and bacteria uncontrollable - prepd. by fermenting Sorangium e.g. Polyangium cellulosum in medium contg. carbon and nitrogen sources and mineral salts in adsorber resin, and eluting
DE1492035C3 (de) Josamycin und dessen pharmakologisch verträgliche Säureadditionssalze und Verfahren zur Herstellung dieses Antibiotikums
DE2916155A1 (de) Verbindung dc-11, verfahren zu ihrer herstellung, pharmazeutische zubereitung und mikroorganismenstamm zur durchfuehrung des herstellungsverfahrens