DE19612967A1 - Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren - Google Patents

Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren

Info

Publication number
DE19612967A1
DE19612967A1 DE19612967A DE19612967A DE19612967A1 DE 19612967 A1 DE19612967 A1 DE 19612967A1 DE 19612967 A DE19612967 A DE 19612967A DE 19612967 A DE19612967 A DE 19612967A DE 19612967 A1 DE19612967 A1 DE 19612967A1
Authority
DE
Germany
Prior art keywords
cells
influenza viruses
influenza
virus
viruses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19612967A
Other languages
German (de)
English (en)
Inventor
Albrecht Dr Groener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines GmbH
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7790127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19612967(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE19612967A priority Critical patent/DE19612967A1/de
Priority to DK97915628.8T priority patent/DK0891420T4/da
Priority to ES97915628T priority patent/ES2236799T5/es
Priority to PT05075182T priority patent/PT1526172E/pt
Priority to DE69732407.9T priority patent/DE69732407T3/de
Priority to DK05075182.5T priority patent/DK1526172T3/da
Priority to ES05075182T priority patent/ES2367081T3/es
Priority to ES09011476T priority patent/ES2435726T3/es
Priority to AT05075182T priority patent/ATE513905T1/de
Priority to DE122007000082C priority patent/DE122007000082I1/de
Priority to CA002250078A priority patent/CA2250078C/en
Priority to EP05075182A priority patent/EP1526172B1/en
Priority to AT97915628T priority patent/ATE288479T1/de
Priority to JP53509097A priority patent/JP4447054B2/ja
Priority to PCT/IB1997/000404 priority patent/WO1997037001A1/en
Priority to EP09011476.0A priority patent/EP2172543B1/en
Priority to EP97915628.8A priority patent/EP0891420B2/en
Priority to PT97915628T priority patent/PT891420E/pt
Publication of DE19612967A1 publication Critical patent/DE19612967A1/de
Priority to US10/245,037 priority patent/US20030119183A1/en
Priority to HK05109564.2A priority patent/HK1075467B/en
Priority to JP2006189769A priority patent/JP2006296437A/ja
Priority to US11/592,336 priority patent/US20070117131A1/en
Priority to NL300307C priority patent/NL300307I1/nl
Priority to LU91381C priority patent/LU91381I2/fr
Priority to JP2008169656A priority patent/JP2008245659A/ja
Priority to JP2010198362A priority patent/JP5264843B2/ja
Priority to HK10108428.3A priority patent/HK1142093B/en
Priority to JP2011157202A priority patent/JP2011212020A/ja
Priority to JP2013039239A priority patent/JP2013116124A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE19612967A 1996-04-01 1996-04-01 Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren Withdrawn DE19612967A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE19612967A DE19612967A1 (de) 1996-04-01 1996-04-01 Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
EP97915628.8A EP0891420B2 (en) 1996-04-01 1997-04-01 Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
PCT/IB1997/000404 WO1997037001A1 (en) 1996-04-01 1997-04-01 Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
EP09011476.0A EP2172543B1 (en) 1996-04-01 1997-04-01 Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
PT05075182T PT1526172E (pt) 1996-04-01 1997-04-01 Processo para a replicação de vírus influenza em cultura celular e os vírus influenza que podem ser obtidos pelo processo
DE69732407.9T DE69732407T3 (de) 1996-04-01 1997-04-01 Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren
DK05075182.5T DK1526172T3 (da) 1996-04-01 1997-04-01 Fremgangsmåde til replikation af influenzavira i cellekultur og ved fremgangsmåden opnåelige influenzavira
ES05075182T ES2367081T3 (es) 1996-04-01 1997-04-01 Procedimiento para la replicación de virus de la gripe en cultivo celular y los virus de la gripe que pueden obtenerse por el procedimiento.
ES09011476T ES2435726T3 (es) 1996-04-01 1997-04-01 Procedimiento para la replicación de virus de la gripe en cultivo celular y los virus de la gripe que pueden obtenerse por el procedimiento
AT05075182T ATE513905T1 (de) 1996-04-01 1997-04-01 Verfahren für die replikation von influenza in zellkultur, und die bei diesem verfahren hergestellten influenza viren
DE122007000082C DE122007000082I1 (de) 1996-04-01 1997-04-01 Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren
ES97915628T ES2236799T5 (es) 1996-04-01 1997-04-01 Procedimientos de replicación de virus de influenza en cultivo celular y virus de influenza obtenibles por el procedimiento
EP05075182A EP1526172B1 (en) 1996-04-01 1997-04-01 Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
AT97915628T ATE288479T1 (de) 1996-04-01 1997-04-01 Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren
JP53509097A JP4447054B2 (ja) 1996-04-01 1997-04-01 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス
DK97915628.8T DK0891420T4 (da) 1996-04-01 1997-04-01 Fremgangsmåde til replikation af influenzavirus i cellekultur samt de ved fremgangsmåden opnåelige influenzavirus
PT97915628T PT891420E (pt) 1996-04-01 1997-04-01 Processos para a replicacao dos virus influenza numa cultura celular e os virus influenza que se podem obter atraves do processo
CA002250078A CA2250078C (en) 1996-04-01 1997-04-01 Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
US10/245,037 US20030119183A1 (en) 1996-04-01 2002-09-16 Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
HK05109564.2A HK1075467B (en) 1996-04-01 2005-10-27 Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
JP2006189769A JP2006296437A (ja) 1996-04-01 2006-07-10 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス
US11/592,336 US20070117131A1 (en) 1996-04-01 2006-11-03 Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
NL300307C NL300307I1 (nl) 1996-04-01 2007-11-28 Werkwijzen voor de replicatie van influenzavirussen in celkweek en de influenzavirussen die verkrijgbaar zijn met behulp van de werkwijze
LU91381C LU91381I2 (fr) 1996-04-01 2007-11-30 OPTAFLU-Définition du produit: Vaccin grippal préparé à partir du virus de la grippe dans une culture celluluaire ou les cellules sont cultivées à unetempérature comprise entre 30°C et 36°C pour la r éplication des virus
JP2008169656A JP2008245659A (ja) 1996-04-01 2008-06-27 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス
JP2010198362A JP5264843B2 (ja) 1996-04-01 2010-09-03 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス
HK10108428.3A HK1142093B (en) 1996-04-01 2010-09-06 Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
JP2011157202A JP2011212020A (ja) 1996-04-01 2011-07-15 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス
JP2013039239A JP2013116124A (ja) 1996-04-01 2013-02-28 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19612967A DE19612967A1 (de) 1996-04-01 1996-04-01 Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren

Publications (1)

Publication Number Publication Date
DE19612967A1 true DE19612967A1 (de) 1997-10-02

Family

ID=7790127

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19612967A Withdrawn DE19612967A1 (de) 1996-04-01 1996-04-01 Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE69732407.9T Expired - Lifetime DE69732407T3 (de) 1996-04-01 1997-04-01 Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren
DE122007000082C Pending DE122007000082I1 (de) 1996-04-01 1997-04-01 Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69732407.9T Expired - Lifetime DE69732407T3 (de) 1996-04-01 1997-04-01 Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren
DE122007000082C Pending DE122007000082I1 (de) 1996-04-01 1997-04-01 Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren

Country Status (12)

Country Link
US (2) US20030119183A1 (https=)
EP (3) EP1526172B1 (https=)
JP (6) JP4447054B2 (https=)
AT (2) ATE288479T1 (https=)
CA (1) CA2250078C (https=)
DE (3) DE19612967A1 (https=)
DK (2) DK1526172T3 (https=)
ES (3) ES2367081T3 (https=)
LU (1) LU91381I2 (https=)
NL (1) NL300307I1 (https=)
PT (2) PT891420E (https=)
WO (1) WO1997037001A1 (https=)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
EP1027426A4 (en) * 1997-10-31 2006-04-19 Merck & Co Inc METHOD FOR IMPROVED MIXING OF A VARICELLA INFECTED CELL CULTURE IN ROLL BOTTLES
JP2001521736A (ja) * 1997-10-31 2001-11-13 メルク エンド カムパニー インコーポレーテッド 回転瓶内の混合増進方法
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
KR100797547B1 (ko) 2000-03-03 2008-01-24 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 무혈청 배양 및 부유 배양에서 사용할 수 있는 세포 및상기 세포를 사용하여 백신용 바이러스를 제조하는 방법
DE10144906B4 (de) * 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
AU2002346424A1 (en) * 2001-11-19 2003-06-10 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
US20060019375A1 (en) * 2002-09-16 2006-01-26 Josef Seidl Device for culturing cells, particularly human or animal cells
ES2295465T3 (es) 2002-09-16 2008-04-16 Pan-Biotech Gmbh Procedimiento para el cultivo de celulas, en especial de celulas humanas o de animales.
CA2503774C (en) 2003-06-20 2007-09-25 Microbix Biosystems Inc. Improvements in virus production
JP5600375B2 (ja) 2004-03-09 2014-10-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド インフルエンザウイルスワクチン
JP2007537760A (ja) * 2004-05-20 2007-12-27 アイディー バイオメディカル コーポレイション インフルエンザワクチンを製造するためのプロセス
EP2848692B1 (en) 2004-05-21 2017-08-16 Novartis Vaccines and Diagnostics, Inc. Alphavirus vectors for influenza virus vaccines
ATE489965T1 (de) * 2004-09-09 2010-12-15 Novartis Vaccines & Diagnostic Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen
US7510719B2 (en) 2004-12-08 2009-03-31 Medimmune, Llc Methods of producing influenza vaccine compositions
DK2368975T3 (en) 2004-12-23 2015-01-05 Medimmune Llc Non-tumorigenic MDCK cell line for the propagation of viruses
FR2884255B1 (fr) 2005-04-11 2010-11-05 Vivalis Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe
ES2525518T3 (es) 2005-11-01 2014-12-26 Novartis Vaccines And Diagnostics Gmbh Vacunas virales derivadas de células con niveles reducidos de ADN celular residual
US11707520B2 (en) 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
NZ568211A (en) 2005-11-04 2011-11-25 Novartis Vaccines & Diagnostic Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
JP2009514844A (ja) 2005-11-04 2009-04-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル スプリットインフルエンザワクチン用のアジュバントとしての遊離水相界面活性剤を含むエマルション
NZ594482A (en) 2005-11-04 2012-11-30 Novartis Vaccines & Diagnostic Influenza vaccines with reduced amount of oil-in-water emulsion as adjuvant
CN102755645A (zh) 2005-11-04 2012-10-31 诺华疫苗和诊断有限公司 佐剂配制的包含细胞因子诱导剂的流感疫苗
CA2628152C (en) 2005-11-04 2016-02-02 Novartis Vaccines And Diagnostics S.R.L. Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
PL2478916T3 (pl) 2006-01-27 2020-11-16 Seqirus UK Limited Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy
CN101448523A (zh) 2006-03-24 2009-06-03 诺华疫苗和诊断有限两合公司 无需冷藏储存流感疫苗
CA2647985C (en) 2006-03-31 2014-12-30 Warf-Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
US7883844B2 (en) 2006-05-11 2011-02-08 Juridical Foundation The Chemosero-Therapeutic Research Institute Method for propagating influenza virus
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
EP4585610A3 (en) 2006-09-11 2025-09-24 Seqirus UK Limited Making influenza virus vaccines without using eggs
EP2615167A1 (en) 2006-09-15 2013-07-17 MedImmune, LLC Method for eliminating DNA contaminants from viral preparations
PT2121011E (pt) 2006-12-06 2014-07-31 Novartis Ag Vacinas compreendendo um antigénio a partir de quatro estirpes do vírus da gripe
CN101688186A (zh) 2007-05-04 2010-03-31 巴克斯特国际公司 用于病毒增殖的两阶段温度分布
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
KR20100045437A (ko) 2007-06-27 2010-05-03 노파르티스 아게 첨가물이 적은 인플루엔자 백신
JP5518041B2 (ja) 2008-03-18 2014-06-11 ノバルティス アーゲー インフルエンザウイルスワクチン抗原の調製における改良
EP2344634A4 (en) 2008-09-24 2012-08-29 Medimmune Llc METHODS OF CELL CULTURE, AND PROPAGATION AND PURIFICATION OF VIRUSES
EA201171032A1 (ru) 2009-02-10 2012-02-28 Новартис Аг Схемы лечения с помощью вакцины против гриппа, связанного с пандемическими штаммами
CA2752041A1 (en) 2009-02-10 2010-08-19 Novartis Ag Influenza vaccines with increased amounts of h3 antigen
EP3173097A3 (en) 2009-02-10 2017-07-12 Seqirus UK Limited Influenza vaccines with reduced amounts of squalene
USH2283H1 (en) 2009-04-27 2013-09-03 Novartis Ag Vaccines for protecting against influenza
EA021009B1 (ru) 2009-05-21 2015-03-31 Новартис Аг ОБРАТНАЯ ГЕНЕТИКА С ИСПОЛЬЗОВАНИЕМ НЕЭНДОГЕННЫХ ПРОМОТОРОВ pol I
WO2010144797A2 (en) 2009-06-12 2010-12-16 Vaccine Technologies, Incorporated Influenza vaccines with enhanced immunogenicity and uses thereof
CN104862335A (zh) 2009-07-31 2015-08-26 诺华股份有限公司 反向遗传系统
US20120237536A1 (en) 2009-09-10 2012-09-20 Novartis Combination vaccines against respiratory tract diseases
CA2778332A1 (en) 2009-10-20 2011-04-28 Novartis Ag Improved reverse genetics methods for virus rescue
EP2493912B1 (en) 2009-10-26 2020-07-29 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
EP2531592A1 (en) 2010-02-04 2012-12-12 Vivalis Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US20130203151A1 (en) 2010-04-26 2013-08-08 Scott Balsitis Production of alphavirus replicon particles in packaging cells
CN103025350A (zh) 2010-05-21 2013-04-03 诺华有限公司 流感病毒的重配方法
CA2801151A1 (en) 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens with lyophilization
WO2011151723A2 (en) 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens without lyophilization
WO2012023044A1 (en) 2010-08-20 2012-02-23 Novartis Ag Soluble needle arrays for delivery of influenza vaccines
WO2012051211A2 (en) 2010-10-11 2012-04-19 Novartis Ag Antigen delivery platforms
WO2012103361A1 (en) 2011-01-26 2012-08-02 Novartis Ag Rsv immunization regimen
CA2829774C (en) 2011-03-14 2019-09-24 National Research Council Of Canada Method of viral production in cells
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
RU2014118727A (ru) 2011-10-11 2015-11-20 Новартис Аг Рекомбинантные самореплицирующиеся полицистронные молекулы рнк
US20140348863A1 (en) 2011-10-12 2014-11-27 Alessia Bianchi Cmv antigens and uses thereof
EP2768528A1 (en) 2011-10-20 2014-08-27 Novartis AG Adjuvanted influenza b virus vaccines for pediatric priming
CN103608453B (zh) 2012-03-02 2018-07-24 思齐乐 流感病毒重配
EP2822585B1 (en) 2012-03-06 2017-05-17 Janssen Vaccines & Prevention B.V. Improved vaccination against influenza
EP2855701A1 (en) 2012-06-04 2015-04-08 Novartis AG Improved safety testing
GB201218195D0 (en) 2012-10-10 2012-11-21 Istituto Zooprofilattico Sperimentale Delle Venezie Composition
KR20150110494A (ko) 2012-12-03 2015-10-02 노파르티스 아게 재배열 인플루엔자 a 바이러스
SG11201507454XA (en) 2013-03-13 2015-10-29 Novartis Ag Influenza b virus reassortment
SG11201509265SA (en) 2013-05-10 2015-12-30 Novartis Ag Avoiding narcolepsy risk in influenza vaccines
DE202013005100U1 (de) 2013-06-05 2013-08-26 Novartis Ag Influenza Virus Reassortierung
DE202013005130U1 (de) 2013-06-05 2013-09-10 Novartis Ag Influenza Virus Reassortierung
CN105722976A (zh) 2013-06-06 2016-06-29 诺华股份有限公司 流感病毒重配
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
US11013795B2 (en) 2015-06-26 2021-05-25 Seqirus UK Limited Antigenically matched influenza vaccines
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
KR102790570B1 (ko) 2015-07-07 2025-04-04 세퀴러스 유케이 리미티드 인플루엔자 효능 검정
US11197925B2 (en) 2016-02-19 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
KR20200117981A (ko) 2017-11-03 2020-10-14 다케다 백신즈 인코포레이티드 지카 백신 및 면역원성 조성물, 그리고 이를 이용하는 방법들
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
EP3914295A2 (en) 2019-01-23 2021-12-01 Yoshihiro Kawaoka Mutations that confer genetic stability to additional genes in influenza viruses
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
CN114929269A (zh) 2019-05-01 2022-08-19 威斯康星校友研究基金会(Warf) 用于疫苗开发的改进的流感病毒复制
BR112021019845A2 (pt) 2019-05-08 2022-02-15 Takeda Vaccines Inc Composições de vírus inativado e formulações de vacina contra zika
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
EP4061930A1 (en) 2019-11-18 2022-09-28 Seqirus Pty Ltd Method for producing reassortant influenza viruses
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたｎａを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
KR102444684B1 (ko) * 2020-04-29 2022-09-16 에스케이바이오사이언스(주) 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법
EP4476329A1 (en) 2022-02-09 2024-12-18 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1278075B (de) * 1964-06-22 1968-09-19 Norden Lab Inc Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen
US4064232A (en) * 1974-01-14 1977-12-20 Sandoz Ltd. Process for isolating the immunogenic components of influenza viruses
US4500513A (en) * 1979-05-15 1985-02-19 Miles Laboratories, Inc. Influenza vaccine production in liquid cell culture
USRE33164E (en) * 1979-05-15 1990-02-13 Mobay Corporation Influenza vaccine production in liquid cell culture
CA1122527A (en) * 1979-05-15 1982-04-27 Karen K. Brown Influenza vaccine production in liquid cell culture
US5013663A (en) * 1983-06-15 1991-05-07 American Home Products Corporation Canine corona virus vaccine
US4783411A (en) * 1984-10-22 1988-11-08 Janis Gabliks Influenza-A virus vaccine from fish cell cultures
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
US5753489A (en) * 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
US5756341A (en) * 1994-11-10 1998-05-26 Immuno Ag Method for controlling the infectivity of viruses
US5646033A (en) * 1994-11-30 1997-07-08 Dyncorp African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US6514502B1 (en) * 1999-01-26 2003-02-04 Schering-Plough Veterinary Corporation Propagation of bovine cononavirus in chinese hamster ovary cells

Also Published As

Publication number Publication date
EP0891420B1 (en) 2005-02-02
JP2006296437A (ja) 2006-11-02
CA2250078C (en) 2009-06-23
ATE288479T1 (de) 2005-02-15
US20070117131A1 (en) 2007-05-24
DK0891420T3 (da) 2005-04-25
PT891420E (pt) 2005-06-30
WO1997037001A1 (en) 1997-10-09
JP4447054B2 (ja) 2010-04-07
DE122007000082I1 (de) 2009-01-02
US20030119183A1 (en) 2003-06-26
EP2172543A1 (en) 2010-04-07
ES2435726T3 (es) 2013-12-23
JP2010275321A (ja) 2010-12-09
LU91381I2 (fr) 2008-01-30
DE69732407T3 (de) 2014-07-10
PT1526172E (pt) 2011-09-01
EP0891420B2 (en) 2013-11-20
JP2008245659A (ja) 2008-10-16
HK1142093A1 (en) 2010-11-26
HK1075467A1 (en) 2005-12-16
ES2236799T5 (es) 2014-01-23
NL300307I1 (nl) 2008-02-01
ATE513905T1 (de) 2011-07-15
EP1526172A1 (en) 2005-04-27
JP2011212020A (ja) 2011-10-27
EP0891420A1 (en) 1999-01-20
DK0891420T4 (da) 2014-01-20
DE69732407D1 (de) 2005-03-10
ES2367081T3 (es) 2011-10-28
JP5264843B2 (ja) 2013-08-14
ES2236799T3 (es) 2005-07-16
JP2000507825A (ja) 2000-06-27
EP2172543B1 (en) 2013-08-21
EP1526172B1 (en) 2011-06-22
JP2013116124A (ja) 2013-06-13
DK1526172T3 (da) 2011-10-03
DE69732407T2 (de) 2006-01-19
CA2250078A1 (en) 1997-10-09

Similar Documents

Publication Publication Date Title
DE69732407T2 (de) Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren
DE19612966B4 (de) MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
DE10144906B4 (de) Verfahren zur großtechnischen Herstellung von Impfstoffen
EP1427817B1 (de) Vermehrung von viren in zellkultur
DE3486292T2 (de) Tierärztliche Impfstoffe.
DE68919449T2 (de) Herstellung von IBDV in kontinuierlichen Zellinien.
DE69923470T2 (de) Kombinationsimpfstoff gegen hav und masernvirus und verfahren zu seiner produktion
DE2713371C2 (https=)
CH617588A5 (https=)
EP0019218B1 (de) Influenzavirus-Vaccine, Verfahren zu ihrer Herstellung und Verfahren zur Vermehrung von Influenzaviren
DE69216732T2 (de) Impfstoff gegen den Geflügelanämieerreger
CH504532A (de) Verfahren zur Züchtung pathogener Viren, Zellstamm zur Ausführung des Verfahrens und Anwendung des Verfahrens
DE60222296T2 (de) Impfstoff von umhüllten viren und verfahren zu seiner herstellung
CH616959A5 (https=)
DE19655440B4 (de) Verfahren zur Herstellung eines Influenzaimpfstoffs
DE3413960A1 (de) Verfahren zur gewinnung von zellkulturen
DD144359A1 (de) Verfahren zur herstellung von immunpraeparaten gegen geschwulstkrankheiten
HK1142093B (en) Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
DE3500744A1 (de) Verfahren zur herstellung eines impfstoffes gegen herpes-viren
HK1075467B (en) Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process

Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: CHIRON BEHRING GMBH & CO., 35039 MARBURG, DE

8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS GMBH & CO. K, DE

8172 Supplementary division/partition in:

Ref document number: 19655440

Country of ref document: DE

Kind code of ref document: P

Q171 Divided out to:

Ref document number: 19655440

Country of ref document: DE

Kind code of ref document: P

8125 Change of the main classification

Ipc: A61K 39/145 AFI20051017BHDE

R016 Response to examination communication
R082 Change of representative

Representative=s name: UEXKUELL & STOLBERG, 22607 HAMBURG, DE

Representative=s name: UEXKUELL & STOLBERG, DE

R081 Change of applicant/patentee

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS GMBH, DE

Free format text: FORMER OWNER: NOVARTIS VACCINES AND DIAGNOSTICS GMBH & CO. KG, 35041 MARBURG, DE

Effective date: 20111209

R082 Change of representative

Representative=s name: UEXKUELL & STOLBERG, DE

Effective date: 20111209

Representative=s name: UEXKUELL & STOLBERG PARTNERSCHAFT VON PATENT- , DE

Effective date: 20111209

R016 Response to examination communication
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee