DE1695487A1 - Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren - Google Patents

Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren

Info

Publication number
DE1695487A1
DE1695487A1 DE19641695487 DE1695487A DE1695487A1 DE 1695487 A1 DE1695487 A1 DE 1695487A1 DE 19641695487 DE19641695487 DE 19641695487 DE 1695487 A DE1695487 A DE 1695487A DE 1695487 A1 DE1695487 A1 DE 1695487A1
Authority
DE
Germany
Prior art keywords
indolyl
preparation
dar
acetic acids
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19641695487
Other languages
English (en)
Inventor
Gal George
Meyer Sletzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1695487A1 publication Critical patent/DE1695487A1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (2)

  1. Belögexemplar
    »Darf nicht geändert werden
    Si 416
    25* 3epte«bber »967
    P at e_ η t a η g ρ r ü c h e
    Ι» Verfahren sur Herstellung von Indolyl-CJj-esaigsäuir^n dar allgeeeintn Porroel
    SO-R,
    (R1 * gegebenenfalls substituiertes Phenyl; H2 * Wasserstoff, niedriges Alkyl; R^ « nleärlaas Alkoxy, Diaik^iaiaiE.öi \.,nd itlsen, daduroh g-ek^nnreisteet, dar § ss,ri eine »llge»ein«n Forael
    »Ε,
    009840/2U1 - 11 -
    BAD
    (R* ■· Alkyl; R1, R2 uacl Rc feate«n ui.% obigen
    «it einer wässrigen Esterase b«i pH 5 HS.« 9 und gewünschten falls die erfcalierv* üävrti in «in S&ls ftthrt·
  2. 2. Verf«hi*en naeh Änspyueh 1, daoxurch g«k*?nesi5im&t % däa» man die Este^aet in eteer
    einsetzt.
    009840/2U1 -M-
    BAD ORI0/NAL
DE19641695487 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren Pending DE1695487A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
DE1695487A1 true DE1695487A1 (de) 1970-10-01

Family

ID=22969254

Family Applications (16)

Application Number Title Priority Date Filing Date
DE19641695492 Pending DE1695492A1 (de) 1963-02-01 1964-01-14 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641793561 Pending DE1793561A1 (de) 1963-02-01 1964-01-24 Hydrazonverbindungen und Verfahren zu deren Herstellung
DE19641770132 Pending DE1770132A1 (de) 1963-02-01 1964-01-24 Indol-Verbindungen und Verfahren zu ihrer Herstellung
DE19641695487 Pending DE1695487A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren
DE19641695489 Pending DE1695489A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeurealkylestern
DE19641470059D Pending DE1470059B1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von substituierten Indolyl-(3)-essigsaeureverbindungen undihren Salzen
DE19641770116 Pending DE1770116A1 (de) 1963-02-01 1964-01-24 Substituierte Indolyl-(3)-acetaldehyde und Verfahren zu ihrer Herstellung
DE19641770802 Pending DE1770802A1 (de) 1963-02-01 1964-01-24 Indolyl-(3)-acetonitrile und Verfahren zu ihrer Herstellung
DE19641695486 Pending DE1695486A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeurealkylestern
DE19641695485 Pending DE1695485A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren
DE19641695493 Pending DE1695493A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641695484 Pending DE1695484A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641695491 Pending DE1695491A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von [1-p-Chlorbenzoyl-2-methyl-5-methoxyindolyl-(3)]-essigsaeure und ihren Salzen
DE19641770134 Pending DE1770134A1 (de) 1963-02-01 1964-01-24 ss-[Indolyl(3)]-aethanole und Verfahren zu ihrer Herstellung
DE19641695488 Pending DE1695488A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren
DE19641695490 Pending DE1695490A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE19641695492 Pending DE1695492A1 (de) 1963-02-01 1964-01-14 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641793561 Pending DE1793561A1 (de) 1963-02-01 1964-01-24 Hydrazonverbindungen und Verfahren zu deren Herstellung
DE19641770132 Pending DE1770132A1 (de) 1963-02-01 1964-01-24 Indol-Verbindungen und Verfahren zu ihrer Herstellung

Family Applications After (12)

Application Number Title Priority Date Filing Date
DE19641695489 Pending DE1695489A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeurealkylestern
DE19641470059D Pending DE1470059B1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von substituierten Indolyl-(3)-essigsaeureverbindungen undihren Salzen
DE19641770116 Pending DE1770116A1 (de) 1963-02-01 1964-01-24 Substituierte Indolyl-(3)-acetaldehyde und Verfahren zu ihrer Herstellung
DE19641770802 Pending DE1770802A1 (de) 1963-02-01 1964-01-24 Indolyl-(3)-acetonitrile und Verfahren zu ihrer Herstellung
DE19641695486 Pending DE1695486A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeurealkylestern
DE19641695485 Pending DE1695485A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren
DE19641695493 Pending DE1695493A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641695484 Pending DE1695484A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeureverbindungen
DE19641695491 Pending DE1695491A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von [1-p-Chlorbenzoyl-2-methyl-5-methoxyindolyl-(3)]-essigsaeure und ihren Salzen
DE19641770134 Pending DE1770134A1 (de) 1963-02-01 1964-01-24 ss-[Indolyl(3)]-aethanole und Verfahren zu ihrer Herstellung
DE19641695488 Pending DE1695488A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren
DE19641695490 Pending DE1695490A1 (de) 1963-02-01 1964-01-24 Verfahren zur Herstellung von Indolyl-(3)-essigsaeuren

Country Status (11)

Country Link
AT (1) AT277992B (de)
BE (1) BE643268A (de)
BR (1) BR6456479D0 (de)
CH (16) CH466285A (de)
DE (16) DE1695492A1 (de)
DK (11) DK112238B (de)
FI (9) FI46955C (de)
FR (1) FR1559559A (de)
GB (13) GB1050733A (de)
NL (1) NL6400813A (de)
SE (12) SE302463B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (de) * 1970-07-31 1973-07-28
DE58902127D1 (de) * 1988-06-21 1992-10-01 Rauter Vita Zahnfabrik Dispergierte keramikmasse.
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DE1695485A1 (de) 1971-04-15
GB1050731A (de)
SE302133B (sv) 1968-07-08
FI47096C (fi) 1973-09-10
DK109562C (da) 1968-05-13
FI47101C (fi) 1973-09-10
FI47100C (fi) 1973-09-10
DK112446B (da) 1968-12-16
FI47097C (fi) 1973-09-10
DE1770802A1 (de) 1972-02-17
DK112314B (da) 1968-12-02
DE1695489A1 (de) 1970-08-13
DK111751B (da) 1968-10-07
DE1695484A1 (de) 1971-04-15
CH457434A (de) 1968-06-15
SE307948B (de) 1969-01-27
DK112447B (da) 1968-12-16
CH466290A (de) 1968-12-15
SE320367B (de) 1970-02-09
SE317975B (de) 1969-12-01
SE304995B (de) 1968-10-14
FI47101B (de) 1973-05-31
SE320069B (de) 1970-02-02
SE302463B (de) 1968-07-22
GB1050735A (de)
GB1050738A (de)
DE1695492A1 (de) 1971-04-01
DE1695486A1 (de) 1971-04-15
NL6400813A (de) 1964-08-03
GB1050736A (de)
DE1695493A1 (de) 1971-04-01
FI46955C (fi) 1973-08-10
FI47096B (de) 1973-05-31
FR1559559A (de) 1969-03-14
SE302131B (de) 1968-07-08
GB1050729A (de)
BR6456479D0 (pt) 1973-09-20
CH457437A (de) 1968-06-15
AT277992B (de) 1970-01-12
DK112239B (da) 1968-11-25
CH466283A (de) 1968-12-15
DK109334C (da) 1968-04-16
CH466288A (de) 1968-12-15
FI47098C (fi) 1973-09-10
FI47098B (de) 1973-05-31
FI47185C (fi) 1973-10-10
CH557815A (de) 1975-01-15
GB1050740A (de)
FI47100B (de) 1973-05-31
CH457435A (de) 1968-06-15
DE1695488A1 (de) 1970-09-17
CH466287A (de) 1968-12-15
DE1770132A1 (de) 1971-09-30
SE302132B (sv) 1968-07-08
SE307133B (de) 1968-12-23
CH466285A (de) 1968-12-15
CH464203A (de) 1968-10-31
DE1695491A1 (de) 1971-04-15
SE320666B (de) 1970-02-16
FI47185B (de) 1973-07-02
DK109514C (da) 1968-05-06
BE643268A (de) 1964-07-31
DE1793561A1 (de) 1972-01-20
GB1050730A (de)
CH457436A (de) 1968-06-15
CH466284A (de) 1968-12-15
GB1050733A (de)
DE1695490A1 (de) 1971-04-15
SE302130B (sv) 1968-07-08
GB1050739A (de)
DE1770134A1 (de) 1971-09-30
FI47099B (de) 1973-05-31
GB1050732A (de)
FI47097B (de) 1973-05-31
DE1470059B1 (de) 1970-01-29
FI47099C (fi) 1973-09-10
FI46955B (de) 1973-05-02
CH489495A (de) 1970-04-30
DK113501B (da) 1969-03-31
CH466286A (de) 1968-12-15
DK112313B (da) 1968-12-02
GB1050734A (de)
CH464202A (de) 1968-10-31
GB1050728A (de)
DE1770116A1 (de) 1971-10-14
CH466289A (de) 1968-12-15
GB1050737A (de)
DK112238B (da) 1968-11-25

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