FI47185C - Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-indoli-3-etanolin v almistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja anlgeet tinen vaikutus. - Google Patents

Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-indoli-3-etanolin v almistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja anlgeet tinen vaikutus.

Info

Publication number
FI47185C
FI47185C FI257370A FI257370A FI47185C FI 47185 C FI47185 C FI 47185C FI 257370 A FI257370 A FI 257370A FI 257370 A FI257370 A FI 257370A FI 47185 C FI47185 C FI 47185C
Authority
FI
Finland
Prior art keywords
chlorobenzoyl
indole
inflammatory
methoxy
ethanol
Prior art date
Application number
FI257370A
Other languages
English (en)
Swedish (sv)
Other versions
FI47185B (fi
Inventor
George Gal
Sletzinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of FI47185B publication Critical patent/FI47185B/fi
Publication of FI47185C publication Critical patent/FI47185C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI257370A 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-indoli-3-etanolin v almistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja anlgeet tinen vaikutus. FI47185C (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (2)

Publication Number Publication Date
FI47185B FI47185B (fi) 1973-07-02
FI47185C true FI47185C (fi) 1973-10-10

Family

ID=22969254

Family Applications (9)

Application Number Title Priority Date Filing Date
FI16964A FI46955C (fi) 1963-02-01 1964-01-29 Menetelmä terapeuttisesti vaikuttavan 1-p-klooribentsoyyli-2-alempi-al kyyli-5-alempi-alkoksi-3-indolyyli-etikkahapon valmistamiseksi
FI702570A FI47097C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavan 1-p-klooribentsoyyli-2-metyyli-5 -metoksi-3-indolyylietikkahapon valmistamiseksi.
FI257570A FI47101C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien alfa-(3-indolyyli)-alempien-ali faattisten happojen valmistamiseksi.
FI257070A FI47097B (fi) 1963-02-01 1970-09-21
FI257270A FI47099C (fi) 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-3-indolyylietikkaha pon valmistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja an algeettinen vaikutus.
FI257170A FI47098C (fi) 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-3-indolyyliasetalde hydin valmistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja analgeettinen vaikutus.
FI257370A FI47185C (fi) 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-indoli-3-etanolin v almistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja anlgeet tinen vaikutus.
FI257470A FI47100C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien 1-p-klooribentsoyyli-2-alempi-a lkyyli-5-alempi-alkoksi-3-indolyyli-etikkahapon valmistamiseksi.
FI256870A FI47096C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien alfa-(3-indolyyli)-alempien-ali faattisten happojen tert.-butyyliesterin valmistamiseksi.

Family Applications Before (6)

Application Number Title Priority Date Filing Date
FI16964A FI46955C (fi) 1963-02-01 1964-01-29 Menetelmä terapeuttisesti vaikuttavan 1-p-klooribentsoyyli-2-alempi-al kyyli-5-alempi-alkoksi-3-indolyyli-etikkahapon valmistamiseksi
FI702570A FI47097C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavan 1-p-klooribentsoyyli-2-metyyli-5 -metoksi-3-indolyylietikkahapon valmistamiseksi.
FI257570A FI47101C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien alfa-(3-indolyyli)-alempien-ali faattisten happojen valmistamiseksi.
FI257070A FI47097B (fi) 1963-02-01 1970-09-21
FI257270A FI47099C (fi) 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-3-indolyylietikkaha pon valmistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja an algeettinen vaikutus.
FI257170A FI47098C (fi) 1963-02-01 1970-09-21 Menetelmä 1-p-klooribentsoyyli-2-metyyli-5-metoksi-3-indolyyliasetalde hydin valmistamiseksi, jolla on tulehdusta estävä, antipyreettinen ja analgeettinen vaikutus.

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI257470A FI47100C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien 1-p-klooribentsoyyli-2-alempi-a lkyyli-5-alempi-alkoksi-3-indolyyli-etikkahapon valmistamiseksi.
FI256870A FI47096C (fi) 1963-02-01 1970-09-21 Menetelmä terapeuttisesti vaikuttavien alfa-(3-indolyyli)-alempien-ali faattisten happojen tert.-butyyliesterin valmistamiseksi.

Country Status (11)

Country Link
AT (1) AT277992B (fi)
BE (1) BE643268A (fi)
BR (1) BR6456479D0 (fi)
CH (16) CH457435A (fi)
DE (16) DE1695492A1 (fi)
DK (11) DK109334C (fi)
FI (9) FI46955C (fi)
FR (1) FR1559559A (fi)
GB (13) GB1050738A (fi)
NL (1) NL6400813A (fi)
SE (12) SE302463B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (fi) * 1970-07-31 1973-07-28
DE58902127D1 (de) * 1988-06-21 1992-10-01 Rauter Vita Zahnfabrik Dispergierte keramikmasse.
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DK113501B (da) 1969-03-31
FI47099C (fi) 1973-09-10
DE1695487A1 (de) 1970-10-01
FI47101B (fi) 1973-05-31
CH466283A (de) 1968-12-15
FI47097B (fi) 1973-05-31
DK109514C (da) 1968-05-06
FI47101C (fi) 1973-09-10
DE1770134A1 (de) 1971-09-30
CH466288A (de) 1968-12-15
SE317975B (fi) 1969-12-01
FI47100C (fi) 1973-09-10
GB1050733A (fi)
DE1770116A1 (de) 1971-10-14
GB1050735A (fi)
GB1050728A (fi)
FI46955B (fi) 1973-05-02
SE302463B (fi) 1968-07-22
SE320666B (fi) 1970-02-16
GB1050740A (fi)
SE304995B (fi) 1968-10-14
DE1470059B1 (de) 1970-01-29
DK109334C (da) 1968-04-16
FI47096B (fi) 1973-05-31
FR1559559A (fi) 1969-03-14
SE302131B (fi) 1968-07-08
FI47098C (fi) 1973-09-10
CH457436A (de) 1968-06-15
CH457437A (de) 1968-06-15
DK112447B (da) 1968-12-16
CH457434A (de) 1968-06-15
DE1695488A1 (de) 1970-09-17
CH557815A (de) 1975-01-15
BR6456479D0 (pt) 1973-09-20
NL6400813A (fi) 1964-08-03
SE320069B (fi) 1970-02-02
DE1770802A1 (de) 1972-02-17
DK112239B (da) 1968-11-25
SE307948B (fi) 1969-01-27
SE320367B (fi) 1970-02-09
CH466286A (de) 1968-12-15
CH457435A (de) 1968-06-15
SE302133B (sv) 1968-07-08
FI47099B (fi) 1973-05-31
FI47100B (fi) 1973-05-31
AT277992B (de) 1970-01-12
DK112446B (da) 1968-12-16
DK112238B (da) 1968-11-25
GB1050739A (fi)
GB1050729A (fi)
GB1050731A (fi)
FI47096C (fi) 1973-09-10
CH464202A (de) 1968-10-31
CH466289A (de) 1968-12-15
CH466284A (de) 1968-12-15
DK111751B (da) 1968-10-07
DE1695490A1 (de) 1971-04-15
DE1695493A1 (de) 1971-04-01
DK109562C (da) 1968-05-13
CH466287A (de) 1968-12-15
DK112314B (da) 1968-12-02
DE1695491A1 (de) 1971-04-15
SE307133B (fi) 1968-12-23
DE1793561A1 (de) 1972-01-20
DE1695492A1 (de) 1971-04-01
FI47097C (fi) 1973-09-10
DE1695484A1 (de) 1971-04-15
GB1050737A (fi)
GB1050734A (fi)
GB1050736A (fi)
CH464203A (de) 1968-10-31
GB1050730A (fi)
CH466285A (de) 1968-12-15
DK112313B (da) 1968-12-02
CH466290A (de) 1968-12-15
FI47185B (fi) 1973-07-02
DE1695489A1 (de) 1970-08-13
CH489495A (de) 1970-04-30
BE643268A (fi) 1964-07-31
GB1050738A (fi)
DE1695485A1 (de) 1971-04-15
SE302130B (sv) 1968-07-08
FI46955C (fi) 1973-08-10
DE1695486A1 (de) 1971-04-15
DE1770132A1 (de) 1971-09-30
FI47098B (fi) 1973-05-31
GB1050732A (fi)
SE302132B (sv) 1968-07-08

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