DK113501B - Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser. - Google Patents

Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser.

Info

Publication number
DK113501B
DK113501B DK598365A DK598365A DK113501B DK 113501 B DK113501 B DK 113501B DK 598365 A DK598365 A DK 598365A DK 598365 A DK598365 A DK 598365A DK 113501 B DK113501 B DK 113501B
Authority
DK
Denmark
Prior art keywords
indolyl
preparation
acetic acid
acid compounds
compounds
Prior art date
Application number
DK598365A
Other languages
English (en)
Inventor
G Gal
M Sletzinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK113501B publication Critical patent/DK113501B/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK598365A 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser. DK113501B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
DK113501B true DK113501B (da) 1969-03-31

Family

ID=22969254

Family Applications (11)

Application Number Title Priority Date Filing Date
DK48964A DK112238B (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser.
DK598765A DK109334C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598565A DK109514C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling afα-(3-indolyl)-eddikesyreforbindelser.
DK598265A DK109562C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598665A DK112239B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598465A DK111751B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598965A DK112314B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598865A DK112313B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598365A DK113501B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser.
DK93366A DK112447B (da) 1963-02-01 1966-02-23 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK93266A DK112446B (da) 1963-02-01 1966-02-23 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.

Family Applications Before (8)

Application Number Title Priority Date Filing Date
DK48964A DK112238B (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyre-forbindelser.
DK598765A DK109334C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598565A DK109514C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling afα-(3-indolyl)-eddikesyreforbindelser.
DK598265A DK109562C (da) 1963-02-01 1964-01-31 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598665A DK112239B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598465A DK111751B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598965A DK112314B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK598865A DK112313B (da) 1963-02-01 1965-11-22 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK93366A DK112447B (da) 1963-02-01 1966-02-23 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK93266A DK112446B (da) 1963-02-01 1966-02-23 Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.

Country Status (11)

Country Link
AT (1) AT277992B (da)
BE (1) BE643268A (da)
BR (1) BR6456479D0 (da)
CH (16) CH557815A (da)
DE (16) DE1695492A1 (da)
DK (11) DK112238B (da)
FI (9) FI46955C (da)
FR (1) FR1559559A (da)
GB (13) GB1050732A (da)
NL (1) NL6400813A (da)
SE (12) SE302463B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (da) * 1970-07-31 1973-07-28
WO1989012436A1 (fr) * 1988-06-21 1989-12-28 Vita Zahnfabrik H. Rauter Gmbh & Co. Kg Masse ceramique dispersee
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
CH489495A (de) 1970-04-30
FI47100B (da) 1973-05-31
GB1050734A (da)
AT277992B (de) 1970-01-12
DK112238B (da) 1968-11-25
CH466283A (de) 1968-12-15
GB1050729A (da)
SE307948B (da) 1969-01-27
DE1695491A1 (de) 1971-04-15
CH466289A (de) 1968-12-15
DK112313B (da) 1968-12-02
DE1695484A1 (de) 1971-04-15
CH557815A (de) 1975-01-15
CH457436A (de) 1968-06-15
SE320367B (da) 1970-02-09
FI47098C (fi) 1973-09-10
BR6456479D0 (pt) 1973-09-20
DE1695492A1 (de) 1971-04-01
BE643268A (da) 1964-07-31
GB1050736A (da)
DK111751B (da) 1968-10-07
GB1050731A (da)
CH464203A (de) 1968-10-31
FI47101B (da) 1973-05-31
SE320666B (da) 1970-02-16
DE1770802A1 (de) 1972-02-17
GB1050739A (da)
CH466290A (de) 1968-12-15
FI47096C (fi) 1973-09-10
DE1695485A1 (de) 1971-04-15
GB1050732A (da)
GB1050733A (da)
DE1695487A1 (de) 1970-10-01
NL6400813A (da) 1964-08-03
DE1695486A1 (de) 1971-04-15
SE302132B (sv) 1968-07-08
CH457435A (de) 1968-06-15
FI47099B (da) 1973-05-31
CH466288A (de) 1968-12-15
DE1695490A1 (de) 1971-04-15
FI47096B (da) 1973-05-31
FR1559559A (da) 1969-03-14
DK109334C (da) 1968-04-16
CH457437A (de) 1968-06-15
DK112314B (da) 1968-12-02
CH466285A (de) 1968-12-15
FI47100C (fi) 1973-09-10
DK112239B (da) 1968-11-25
GB1050737A (da)
CH457434A (de) 1968-06-15
FI46955C (fi) 1973-08-10
DE1695489A1 (de) 1970-08-13
SE304995B (da) 1968-10-14
FI47099C (fi) 1973-09-10
GB1050740A (da)
DE1793561A1 (de) 1972-01-20
DE1770134A1 (de) 1971-09-30
CH466286A (de) 1968-12-15
FI47101C (fi) 1973-09-10
FI47185C (fi) 1973-10-10
FI47098B (da) 1973-05-31
SE302133B (sv) 1968-07-08
FI47097C (fi) 1973-09-10
FI47097B (da) 1973-05-31
SE302131B (da) 1968-07-08
DE1770116A1 (de) 1971-10-14
DE1695488A1 (de) 1970-09-17
DK112446B (da) 1968-12-16
SE307133B (da) 1968-12-23
SE302463B (da) 1968-07-22
SE320069B (da) 1970-02-02
GB1050728A (da)
GB1050730A (da)
DK109562C (da) 1968-05-13
DE1695493A1 (de) 1971-04-01
CH464202A (de) 1968-10-31
CH466284A (de) 1968-12-15
GB1050735A (da)
FI46955B (da) 1973-05-02
DK109514C (da) 1968-05-06
SE302130B (sv) 1968-07-08
GB1050738A (da)
DE1470059B1 (de) 1970-01-29
SE317975B (da) 1969-12-01
DK112447B (da) 1968-12-16
CH466287A (de) 1968-12-15
DE1770132A1 (de) 1971-09-30
FI47185B (da) 1973-07-02

Similar Documents

Publication Publication Date Title
DK117068B (da) Fremgangsmåde til fremstilling af N-1-aroylindolyleddikesyreforbindelser.
DK120639B (da) Fremgangsmåde til fremstilling af benzimidazolforbindelser.
DK120898B (da) Fremgangsmåde til fremstilling af indolyleddikesyreforbindelser.
DK124264B (da) Analogifremgangsmåde til fremstilling af mitosanforbindelser.
DK127726B (da) Analogifremgangsmåde til fremstilling af 1-halogenbenzoylaminomethyl-2-phenyl-cyclopropan-forbindelser.
DK111113B (da) Fremgangsmåde til fremstilling af 3-methylflavon-8-carboxylsyre.
DK124334B (da) Fremgangsmåde til fremstilling af derivater af 7-aminocephalosporansyre.
DK120075B (da) Analogifremgangsmåde til fremstilling af N-aromatisk substituerede syreamider.
DK113858B (da) Fremgangsmåde til fremstilling af benzimidazolforbindelser.
DK113859B (da) Fremgangsmåde til fremstilling af hydroksamsyrer.
DK120637B (da) Fremgangsmåde til fremstilling af α-(3-indolyl)-alkan- eller - alkensyrer.
DK109334C (da) Fremgangsmåde til fremstilling af α-(3-indolyl)-eddikesyreforbindelser.
DK116127B (da) Fremgangsmåde til rensning af alkylestere af α-(0,0-dimethyldithiophosphoryl)-α-phenyleddikesyre.
DK105592C (da) Fremgangsmåde til fremstilling af substituerede 5-fluor-pyrimidiner.
DK121022B (da) Analogifremgangsmåde til fremstilling af γ -resorcylsyreanilider.
DK123764B (da) Analogifremgangsmåde til fremstilling af syreamider.
DK136644B (da) Fremgangsmåde til fremstilling af 1-p-chlorbenzoyl-2-methyl-3-indolyl-eddikesyre-forbindelser.
DK107548C (da) Fremgangsmåde til fremstilling af carboxylsyrenitriler.
DK120542B (da) Fremgangsmåde til fremstilling af α-(2-methyl-3-indolyl)-eddikesyrer.
DK113149B (da) Fremgangsmåde til fremstilling af sulfamylanthranilsyrer.
DK114980B (da) Fremgangsmåde til fremstilling af sulfamylanthranilsyreamider.
DK111957B (da) Fremgangsmåde til fremstilling af adamantylderivater af αhydroxy-carboxylsyrer.
DK114126B (da) Fremgangsmåde til fremstilling af substituereded benzamider.
DK123021B (da) Analogifremgangsmåde til fremstilling af syreadditionssalte af 2-aminoadamantan.
DK127724B (da) Fremgangsmåde til fremstilling af trans-40-aminomethylcyclohexan-1-carboxylsyre.