DK113501B - Process for the preparation of α- (3-indolyl) -acetic acid compounds. - Google Patents

Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Info

Publication number
DK113501B
DK113501B DK598365A DK598365A DK113501B DK 113501 B DK113501 B DK 113501B DK 598365 A DK598365 A DK 598365A DK 598365 A DK598365 A DK 598365A DK 113501 B DK113501 B DK 113501B
Authority
DK
Denmark
Prior art keywords
indolyl
preparation
acetic acid
acid compounds
compounds
Prior art date
Application number
DK598365A
Other languages
Danish (da)
Inventor
G Gal
M Sletzinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK113501B publication Critical patent/DK113501B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK598365A 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds. DK113501B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
DK113501B true DK113501B (en) 1969-03-31

Family

ID=22969254

Family Applications (11)

Application Number Title Priority Date Filing Date
DK48964A DK112238B (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598265A DK109562C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598765A DK109334C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598565A DK109514C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598965A DK112314B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598665A DK112239B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598365A DK113501B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598865A DK112313B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598465A DK111751B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93366A DK112447B (en) 1963-02-01 1966-02-23 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93266A DK112446B (en) 1963-02-01 1966-02-23 Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Family Applications Before (6)

Application Number Title Priority Date Filing Date
DK48964A DK112238B (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598265A DK109562C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598765A DK109334C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598565A DK109514C (en) 1963-02-01 1964-01-31 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598965A DK112314B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598665A DK112239B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK598865A DK112313B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598465A DK111751B (en) 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93366A DK112447B (en) 1963-02-01 1966-02-23 Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93266A DK112446B (en) 1963-02-01 1966-02-23 Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Country Status (11)

Country Link
AT (1) AT277992B (en)
BE (1) BE643268A (en)
BR (1) BR6456479D0 (en)
CH (16) CH457435A (en)
DE (16) DE1695492A1 (en)
DK (11) DK112238B (en)
FI (9) FI46955C (en)
FR (1) FR1559559A (en)
GB (13) GB1050738A (en)
NL (1) NL6400813A (en)
SE (12) SE302463B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (en) * 1970-07-31 1973-07-28
WO1989012436A1 (en) * 1988-06-21 1989-12-28 Vita Zahnfabrik H. Rauter Gmbh & Co. Kg Disperse ceramic mass
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DK109562C (en) 1968-05-13
DK112239B (en) 1968-11-25
DK112313B (en) 1968-12-02
FI47096C (en) 1973-09-10
FI47097B (en) 1973-05-31
SE302463B (en) 1968-07-22
DE1770134A1 (en) 1971-09-30
CH466288A (en) 1968-12-15
AT277992B (en) 1970-01-12
DE1770802A1 (en) 1972-02-17
GB1050728A (en)
CH464202A (en) 1968-10-31
GB1050732A (en)
GB1050734A (en)
SE317975B (en) 1969-12-01
DE1695487A1 (en) 1970-10-01
DE1770132A1 (en) 1971-09-30
CH464203A (en) 1968-10-31
CH557815A (en) 1975-01-15
GB1050733A (en)
CH466290A (en) 1968-12-15
SE320666B (en) 1970-02-16
GB1050729A (en)
FI47097C (en) 1973-09-10
GB1050731A (en)
SE320069B (en) 1970-02-02
FI46955B (en) 1973-05-02
FI47100C (en) 1973-09-10
DE1695484A1 (en) 1971-04-15
DE1695493A1 (en) 1971-04-01
GB1050736A (en)
SE307948B (en) 1969-01-27
SE302132B (en) 1968-07-08
SE304995B (en) 1968-10-14
CH466286A (en) 1968-12-15
FI47185B (en) 1973-07-02
FI47096B (en) 1973-05-31
FR1559559A (en) 1969-03-14
DE1695492A1 (en) 1971-04-01
DK112446B (en) 1968-12-16
NL6400813A (en) 1964-08-03
GB1050738A (en)
SE320367B (en) 1970-02-09
BE643268A (en) 1964-07-31
CH466289A (en) 1968-12-15
FI47185C (en) 1973-10-10
DE1695489A1 (en) 1970-08-13
GB1050730A (en)
DE1470059B1 (en) 1970-01-29
SE307133B (en) 1968-12-23
SE302133B (en) 1968-07-08
FI47099B (en) 1973-05-31
SE302131B (en) 1968-07-08
SE302130B (en) 1968-07-08
DK112314B (en) 1968-12-02
CH457434A (en) 1968-06-15
FI47101C (en) 1973-09-10
DE1695488A1 (en) 1970-09-17
DE1770116A1 (en) 1971-10-14
DE1695485A1 (en) 1971-04-15
FI46955C (en) 1973-08-10
DK109514C (en) 1968-05-06
CH457435A (en) 1968-06-15
DE1695491A1 (en) 1971-04-15
GB1050739A (en)
CH489495A (en) 1970-04-30
DK112447B (en) 1968-12-16
GB1050740A (en)
CH466285A (en) 1968-12-15
DE1695486A1 (en) 1971-04-15
CH466284A (en) 1968-12-15
CH457436A (en) 1968-06-15
DE1793561A1 (en) 1972-01-20
DK111751B (en) 1968-10-07
CH466287A (en) 1968-12-15
CH457437A (en) 1968-06-15
CH466283A (en) 1968-12-15
DK109334C (en) 1968-04-16
BR6456479D0 (en) 1973-09-20
FI47101B (en) 1973-05-31
FI47098B (en) 1973-05-31
DK112238B (en) 1968-11-25
DE1695490A1 (en) 1971-04-15
FI47099C (en) 1973-09-10
FI47098C (en) 1973-09-10
FI47100B (en) 1973-05-31
GB1050737A (en)
GB1050735A (en)

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