SE302132B - Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect - Google Patents

Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect

Info

Publication number
SE302132B
SE302132B SE88867A SE88867A SE302132B SE 302132 B SE302132 B SE 302132B SE 88867 A SE88867 A SE 88867A SE 88867 A SE88867 A SE 88867A SE 302132 B SE302132 B SE 302132B
Authority
SE
Sweden
Prior art keywords
indolyl
alpha
derivatives
preparation
inflammatory effect
Prior art date
Application number
SE88867A
Other languages
Swedish (sv)
Inventor
G Gal
M Sletzinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE302132B publication Critical patent/SE302132B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE88867A 1963-02-01 1967-01-20 Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect SE302132B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
SE302132B true SE302132B (en) 1968-07-08

Family

ID=22969254

Family Applications (12)

Application Number Title Priority Date Filing Date
SE88967A SE317975B (en) 1963-02-01 1964-01-31
SE123764A SE307948B (en) 1963-02-01 1964-01-31
SE89267A SE302463B (en) 1963-02-01 1964-01-31
SE896/67A SE320666B (en) 1963-02-01 1967-01-20
SE890/67A SE307133B (en) 1963-02-01 1967-01-20
SE88667A SE302130B (en) 1963-02-01 1967-01-20 Methods of preparing derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect
SE89367A SE302133B (en) 1963-02-01 1967-01-20 Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect
SE891/67A SE304995B (en) 1963-02-01 1967-01-20
SE88867A SE302132B (en) 1963-02-01 1967-01-20 Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect
SE894/67A SE320367B (en) 1963-02-01 1967-01-20
SE895/67A SE320069B (en) 1963-02-01 1967-01-20
SE88767A SE302131B (en) 1963-02-01 1967-01-31

Family Applications Before (8)

Application Number Title Priority Date Filing Date
SE88967A SE317975B (en) 1963-02-01 1964-01-31
SE123764A SE307948B (en) 1963-02-01 1964-01-31
SE89267A SE302463B (en) 1963-02-01 1964-01-31
SE896/67A SE320666B (en) 1963-02-01 1967-01-20
SE890/67A SE307133B (en) 1963-02-01 1967-01-20
SE88667A SE302130B (en) 1963-02-01 1967-01-20 Methods of preparing derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect
SE89367A SE302133B (en) 1963-02-01 1967-01-20 Process for the preparation of derivatives of alpha- (3-indolyl) -acetic acids with anti-inflammatory effect
SE891/67A SE304995B (en) 1963-02-01 1967-01-20

Family Applications After (3)

Application Number Title Priority Date Filing Date
SE894/67A SE320367B (en) 1963-02-01 1967-01-20
SE895/67A SE320069B (en) 1963-02-01 1967-01-20
SE88767A SE302131B (en) 1963-02-01 1967-01-31

Country Status (11)

Country Link
AT (1) AT277992B (en)
BE (1) BE643268A (en)
BR (1) BR6456479D0 (en)
CH (16) CH466286A (en)
DE (16) DE1695492A1 (en)
DK (11) DK112238B (en)
FI (9) FI46955C (en)
FR (1) FR1559559A (en)
GB (13) GB1050730A (en)
NL (1) NL6400813A (en)
SE (12) SE317975B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (en) * 1970-07-31 1973-07-28
EP0347776B2 (en) * 1988-06-21 2002-07-10 Vita Zahnfabrik H. Rauter GmbH & Co. KG Dispersed ceramic material
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DE1695488A1 (en) 1970-09-17
CH464202A (en) 1968-10-31
DK112447B (en) 1968-12-16
DE1793561A1 (en) 1972-01-20
FI47100B (en) 1973-05-31
DK112238B (en) 1968-11-25
SE307133B (en) 1968-12-23
DE1695485A1 (en) 1971-04-15
FI47096B (en) 1973-05-31
FR1559559A (en) 1969-03-14
DE1695486A1 (en) 1971-04-15
FI47101B (en) 1973-05-31
SE302130B (en) 1968-07-08
CH557815A (en) 1975-01-15
CH466285A (en) 1968-12-15
CH489495A (en) 1970-04-30
CH464203A (en) 1968-10-31
FI46955C (en) 1973-08-10
DE1770116A1 (en) 1971-10-14
NL6400813A (en) 1964-08-03
GB1050731A (en)
DK112446B (en) 1968-12-16
FI47101C (en) 1973-09-10
SE302463B (en) 1968-07-22
BR6456479D0 (en) 1973-09-20
DE1695493A1 (en) 1971-04-01
GB1050739A (en)
CH457434A (en) 1968-06-15
AT277992B (en) 1970-01-12
GB1050736A (en)
DE1695487A1 (en) 1970-10-01
FI46955B (en) 1973-05-02
FI47099B (en) 1973-05-31
DE1695491A1 (en) 1971-04-15
DK109334C (en) 1968-04-16
CH466289A (en) 1968-12-15
GB1050732A (en)
DE1695484A1 (en) 1971-04-15
SE302133B (en) 1968-07-08
DE1695492A1 (en) 1971-04-01
GB1050728A (en)
CH466288A (en) 1968-12-15
CH457437A (en) 1968-06-15
DK112239B (en) 1968-11-25
GB1050729A (en)
CH466287A (en) 1968-12-15
DE1695490A1 (en) 1971-04-15
DE1695489A1 (en) 1970-08-13
CH466290A (en) 1968-12-15
FI47096C (en) 1973-09-10
GB1050735A (en)
DK111751B (en) 1968-10-07
SE302131B (en) 1968-07-08
CH466286A (en) 1968-12-15
DE1470059B1 (en) 1970-01-29
FI47185B (en) 1973-07-02
DE1770134A1 (en) 1971-09-30
GB1050730A (en)
CH466283A (en) 1968-12-15
SE304995B (en) 1968-10-14
FI47185C (en) 1973-10-10
DK112313B (en) 1968-12-02
CH466284A (en) 1968-12-15
FI47097C (en) 1973-09-10
DK112314B (en) 1968-12-02
SE320069B (en) 1970-02-02
GB1050733A (en)
FI47099C (en) 1973-09-10
CH457436A (en) 1968-06-15
SE320666B (en) 1970-02-16
BE643268A (en) 1964-07-31
FI47097B (en) 1973-05-31
GB1050737A (en)
DE1770132A1 (en) 1971-09-30
GB1050740A (en)
FI47100C (en) 1973-09-10
SE307948B (en) 1969-01-27
DK109562C (en) 1968-05-13
GB1050738A (en)
FI47098C (en) 1973-09-10
CH457435A (en) 1968-06-15
FI47098B (en) 1973-05-31
SE320367B (en) 1970-02-09
DK109514C (en) 1968-05-06
SE317975B (en) 1969-12-01
GB1050734A (en)
DK113501B (en) 1969-03-31
DE1770802A1 (en) 1972-02-17

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