FI47098C - Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect. - Google Patents

Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect.

Info

Publication number
FI47098C
FI47098C FI257170A FI257170A FI47098C FI 47098 C FI47098 C FI 47098C FI 257170 A FI257170 A FI 257170A FI 257170 A FI257170 A FI 257170A FI 47098 C FI47098 C FI 47098C
Authority
FI
Finland
Prior art keywords
indolylacetaldehyde
antipyretic
chlorobenzoyl
inflammatory
methoxy
Prior art date
Application number
FI257170A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI47098B (en
Inventor
George Gal
Sletzinger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of FI47098B publication Critical patent/FI47098B/fi
Publication of FI47098C publication Critical patent/FI47098C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI257170A 1963-02-01 1970-09-21 Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect. FI47098C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (2)

Publication Number Publication Date
FI47098B FI47098B (en) 1973-05-31
FI47098C true FI47098C (en) 1973-09-10

Family

ID=22969254

Family Applications (9)

Application Number Title Priority Date Filing Date
FI16964A FI46955C (en) 1963-02-01 1964-01-29 Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower alkyl-5-lower alkoxy-3-indolylacetic acid
FI257170A FI47098C (en) 1963-02-01 1970-09-21 Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect.
FI257570A FI47101C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids.
FI702570A FI47097C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically effective 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid.
FI257370A FI47185C (en) 1963-02-01 1970-09-21 Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-indole-3-ethanol with anti-inflammatory and antipyretic action.
FI256870A FI47096C (en) 1963-02-01 1970-09-21 Process for the preparation of tert-butyl ester of therapeutically active alpha- (3-indolyl) lower aliphatic acids.
FI257470A FI47100C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower-alkyl-5-lower-alkoxy-3-indolyl-acetic acid.
FI257270A FI47099C (en) 1963-02-01 1970-09-21 A process for preparing 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid having anti-inflammatory, antipyretic and analgesic activity.
FI257070A FI47097B (en) 1963-02-01 1970-09-21

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI16964A FI46955C (en) 1963-02-01 1964-01-29 Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower alkyl-5-lower alkoxy-3-indolylacetic acid

Family Applications After (7)

Application Number Title Priority Date Filing Date
FI257570A FI47101C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids.
FI702570A FI47097C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically effective 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid.
FI257370A FI47185C (en) 1963-02-01 1970-09-21 Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-indole-3-ethanol with anti-inflammatory and antipyretic action.
FI256870A FI47096C (en) 1963-02-01 1970-09-21 Process for the preparation of tert-butyl ester of therapeutically active alpha- (3-indolyl) lower aliphatic acids.
FI257470A FI47100C (en) 1963-02-01 1970-09-21 Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower-alkyl-5-lower-alkoxy-3-indolyl-acetic acid.
FI257270A FI47099C (en) 1963-02-01 1970-09-21 A process for preparing 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid having anti-inflammatory, antipyretic and analgesic activity.
FI257070A FI47097B (en) 1963-02-01 1970-09-21

Country Status (11)

Country Link
AT (1) AT277992B (en)
BE (1) BE643268A (en)
BR (1) BR6456479D0 (en)
CH (16) CH466286A (en)
DE (16) DE1695492A1 (en)
DK (11) DK112238B (en)
FI (9) FI46955C (en)
FR (1) FR1559559A (en)
GB (13) GB1050730A (en)
NL (1) NL6400813A (en)
SE (12) SE317975B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (en) * 1970-07-31 1973-07-28
EP0347776B2 (en) * 1988-06-21 2002-07-10 Vita Zahnfabrik H. Rauter GmbH & Co. KG Dispersed ceramic material
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DE1695488A1 (en) 1970-09-17
CH464202A (en) 1968-10-31
DK112447B (en) 1968-12-16
DE1793561A1 (en) 1972-01-20
FI47100B (en) 1973-05-31
DK112238B (en) 1968-11-25
SE307133B (en) 1968-12-23
DE1695485A1 (en) 1971-04-15
FI47096B (en) 1973-05-31
FR1559559A (en) 1969-03-14
DE1695486A1 (en) 1971-04-15
FI47101B (en) 1973-05-31
SE302130B (en) 1968-07-08
CH557815A (en) 1975-01-15
CH466285A (en) 1968-12-15
CH489495A (en) 1970-04-30
CH464203A (en) 1968-10-31
FI46955C (en) 1973-08-10
DE1770116A1 (en) 1971-10-14
NL6400813A (en) 1964-08-03
GB1050731A (en)
DK112446B (en) 1968-12-16
FI47101C (en) 1973-09-10
SE302463B (en) 1968-07-22
BR6456479D0 (en) 1973-09-20
DE1695493A1 (en) 1971-04-01
GB1050739A (en)
CH457434A (en) 1968-06-15
AT277992B (en) 1970-01-12
GB1050736A (en)
DE1695487A1 (en) 1970-10-01
FI46955B (en) 1973-05-02
FI47099B (en) 1973-05-31
DE1695491A1 (en) 1971-04-15
DK109334C (en) 1968-04-16
CH466289A (en) 1968-12-15
GB1050732A (en)
DE1695484A1 (en) 1971-04-15
SE302133B (en) 1968-07-08
DE1695492A1 (en) 1971-04-01
GB1050728A (en)
CH466288A (en) 1968-12-15
CH457437A (en) 1968-06-15
DK112239B (en) 1968-11-25
GB1050729A (en)
CH466287A (en) 1968-12-15
DE1695490A1 (en) 1971-04-15
DE1695489A1 (en) 1970-08-13
CH466290A (en) 1968-12-15
FI47096C (en) 1973-09-10
GB1050735A (en)
DK111751B (en) 1968-10-07
SE302131B (en) 1968-07-08
CH466286A (en) 1968-12-15
DE1470059B1 (en) 1970-01-29
FI47185B (en) 1973-07-02
DE1770134A1 (en) 1971-09-30
GB1050730A (en)
CH466283A (en) 1968-12-15
SE304995B (en) 1968-10-14
FI47185C (en) 1973-10-10
DK112313B (en) 1968-12-02
SE302132B (en) 1968-07-08
CH466284A (en) 1968-12-15
FI47097C (en) 1973-09-10
DK112314B (en) 1968-12-02
SE320069B (en) 1970-02-02
GB1050733A (en)
FI47099C (en) 1973-09-10
CH457436A (en) 1968-06-15
SE320666B (en) 1970-02-16
BE643268A (en) 1964-07-31
FI47097B (en) 1973-05-31
GB1050737A (en)
DE1770132A1 (en) 1971-09-30
GB1050740A (en)
FI47100C (en) 1973-09-10
SE307948B (en) 1969-01-27
DK109562C (en) 1968-05-13
GB1050738A (en)
CH457435A (en) 1968-06-15
FI47098B (en) 1973-05-31
SE320367B (en) 1970-02-09
DK109514C (en) 1968-05-06
SE317975B (en) 1969-12-01
GB1050734A (en)
DK113501B (en) 1969-03-31
DE1770802A1 (en) 1972-02-17

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