CH466287A - Process for the preparation of 3-indolyl-lower aliphatic acids - Google Patents

Process for the preparation of 3-indolyl-lower aliphatic acids

Info

Publication number
CH466287A
CH466287A CH490368A CH490368A CH466287A CH 466287 A CH466287 A CH 466287A CH 490368 A CH490368 A CH 490368A CH 490368 A CH490368 A CH 490368A CH 466287 A CH466287 A CH 466287A
Authority
CH
Switzerland
Prior art keywords
indolyl
preparation
lower aliphatic
aliphatic acids
acids
Prior art date
Application number
CH490368A
Other languages
German (de)
Inventor
Gal George
Sletzinger Meyer
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH466287A publication Critical patent/CH466287A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH490368A 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids CH466287A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25564263A 1963-02-01 1963-02-01

Publications (1)

Publication Number Publication Date
CH466287A true CH466287A (en) 1968-12-15

Family

ID=22969254

Family Applications (16)

Application Number Title Priority Date Filing Date
CH490268A CH466286A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-aliphatic acids
CH236568A CH464203A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-aliphatic acids or their t-butyl esters
CH236468A CH466283A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-aliphatic acids
CH236668A CH457437A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH235868A CH457434A (en) 1963-02-01 1964-01-31 Process for the preparation of the t-butyl ester of 3-indole-lower aliphatic acids
CH236068A CH457435A (en) 1963-02-01 1964-01-31 Process for the preparation of esters of 3-indole-aliphatic acids
CH1674568A CH466289A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-alcyl-3-indolyl-aliphatic acids
CH490368A CH466287A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH1674468A CH466288A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH1674768A CH466290A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-indolyl-aliphatic acids
CH236168A CH464202A (en) 1963-02-01 1964-01-31 Process for the production of 3-indole-lower aliphatic acids
CH236268A CH557815A (en) 1963-02-01 1964-01-31 Alpha- 1-acyl-3-indolyl aliphatic acid derivs
CH236368A CH457436A (en) 1963-02-01 1964-01-31 Process for the preparation of esters of 3-indolyl-lower aliphatic acids
CH419468A CH466284A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH444166A CH466285A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-acetic acid or its esters
CH115364A CH489495A (en) 1963-02-01 1967-02-23 Process for the preparation of 3-indolyl-lower aliphatic acids

Family Applications Before (7)

Application Number Title Priority Date Filing Date
CH490268A CH466286A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-aliphatic acids
CH236568A CH464203A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-aliphatic acids or their t-butyl esters
CH236468A CH466283A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-aliphatic acids
CH236668A CH457437A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH235868A CH457434A (en) 1963-02-01 1964-01-31 Process for the preparation of the t-butyl ester of 3-indole-lower aliphatic acids
CH236068A CH457435A (en) 1963-02-01 1964-01-31 Process for the preparation of esters of 3-indole-aliphatic acids
CH1674568A CH466289A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-alcyl-3-indolyl-aliphatic acids

Family Applications After (8)

Application Number Title Priority Date Filing Date
CH1674468A CH466288A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH1674768A CH466290A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-indolyl-aliphatic acids
CH236168A CH464202A (en) 1963-02-01 1964-01-31 Process for the production of 3-indole-lower aliphatic acids
CH236268A CH557815A (en) 1963-02-01 1964-01-31 Alpha- 1-acyl-3-indolyl aliphatic acid derivs
CH236368A CH457436A (en) 1963-02-01 1964-01-31 Process for the preparation of esters of 3-indolyl-lower aliphatic acids
CH419468A CH466284A (en) 1963-02-01 1964-01-31 Process for the preparation of 3-indolyl-lower aliphatic acids
CH444166A CH466285A (en) 1963-02-01 1964-01-31 Process for the preparation of 1-acyl-3-indolyl-acetic acid or its esters
CH115364A CH489495A (en) 1963-02-01 1967-02-23 Process for the preparation of 3-indolyl-lower aliphatic acids

Country Status (11)

Country Link
AT (1) AT277992B (en)
BE (1) BE643268A (en)
BR (1) BR6456479D0 (en)
CH (16) CH466286A (en)
DE (16) DE1695492A1 (en)
DK (11) DK112238B (en)
FI (9) FI46955C (en)
FR (1) FR1559559A (en)
GB (13) GB1050730A (en)
NL (1) NL6400813A (en)
SE (12) SE317975B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163233B (en) * 1970-07-31 1973-07-28
EP0347776B2 (en) * 1988-06-21 2002-07-10 Vita Zahnfabrik H. Rauter GmbH & Co. KG Dispersed ceramic material
GB9518994D0 (en) * 1995-09-16 1995-11-15 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
DE1695488A1 (en) 1970-09-17
CH464202A (en) 1968-10-31
DK112447B (en) 1968-12-16
DE1793561A1 (en) 1972-01-20
FI47100B (en) 1973-05-31
DK112238B (en) 1968-11-25
SE307133B (en) 1968-12-23
DE1695485A1 (en) 1971-04-15
FI47096B (en) 1973-05-31
FR1559559A (en) 1969-03-14
DE1695486A1 (en) 1971-04-15
FI47101B (en) 1973-05-31
SE302130B (en) 1968-07-08
CH557815A (en) 1975-01-15
CH466285A (en) 1968-12-15
CH489495A (en) 1970-04-30
CH464203A (en) 1968-10-31
FI46955C (en) 1973-08-10
DE1770116A1 (en) 1971-10-14
NL6400813A (en) 1964-08-03
GB1050731A (en)
DK112446B (en) 1968-12-16
FI47101C (en) 1973-09-10
SE302463B (en) 1968-07-22
BR6456479D0 (en) 1973-09-20
DE1695493A1 (en) 1971-04-01
GB1050739A (en)
CH457434A (en) 1968-06-15
AT277992B (en) 1970-01-12
GB1050736A (en)
DE1695487A1 (en) 1970-10-01
FI46955B (en) 1973-05-02
FI47099B (en) 1973-05-31
DE1695491A1 (en) 1971-04-15
DK109334C (en) 1968-04-16
CH466289A (en) 1968-12-15
GB1050732A (en)
DE1695484A1 (en) 1971-04-15
SE302133B (en) 1968-07-08
DE1695492A1 (en) 1971-04-01
GB1050728A (en)
CH466288A (en) 1968-12-15
CH457437A (en) 1968-06-15
DK112239B (en) 1968-11-25
GB1050729A (en)
DE1695490A1 (en) 1971-04-15
DE1695489A1 (en) 1970-08-13
CH466290A (en) 1968-12-15
FI47096C (en) 1973-09-10
GB1050735A (en)
DK111751B (en) 1968-10-07
SE302131B (en) 1968-07-08
CH466286A (en) 1968-12-15
DE1470059B1 (en) 1970-01-29
FI47185B (en) 1973-07-02
DE1770134A1 (en) 1971-09-30
GB1050730A (en)
CH466283A (en) 1968-12-15
SE304995B (en) 1968-10-14
FI47185C (en) 1973-10-10
DK112313B (en) 1968-12-02
SE302132B (en) 1968-07-08
CH466284A (en) 1968-12-15
FI47097C (en) 1973-09-10
DK112314B (en) 1968-12-02
SE320069B (en) 1970-02-02
GB1050733A (en)
FI47099C (en) 1973-09-10
CH457436A (en) 1968-06-15
SE320666B (en) 1970-02-16
BE643268A (en) 1964-07-31
FI47097B (en) 1973-05-31
GB1050737A (en)
DE1770132A1 (en) 1971-09-30
GB1050740A (en)
FI47100C (en) 1973-09-10
SE307948B (en) 1969-01-27
DK109562C (en) 1968-05-13
GB1050738A (en)
FI47098C (en) 1973-09-10
CH457435A (en) 1968-06-15
FI47098B (en) 1973-05-31
SE320367B (en) 1970-02-09
DK109514C (en) 1968-05-06
SE317975B (en) 1969-12-01
GB1050734A (en)
DK113501B (en) 1969-03-31
DE1770802A1 (en) 1972-02-17

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