DE10231655A1 - Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung - Google Patents

Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung Download PDF

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Publication number
DE10231655A1
DE10231655A1 DE10231655A DE10231655A DE10231655A1 DE 10231655 A1 DE10231655 A1 DE 10231655A1 DE 10231655 A DE10231655 A DE 10231655A DE 10231655 A DE10231655 A DE 10231655A DE 10231655 A1 DE10231655 A1 DE 10231655A1
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Prior art keywords
cells
lew
taiz
monocytes
days
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Ceased
Application number
DE10231655A
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German (de)
English (en)
Inventor
Bernd Karl Friedrich Prof. Dr.med. Kremer
Maren Dr. Schulze
Fred Prof. Dr.med. Faendrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blasticon Biotechnologische Forschung GmbH
Original Assignee
Blasticon Biotechnologische Forschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blasticon Biotechnologische Forschung GmbH filed Critical Blasticon Biotechnologische Forschung GmbH
Priority to DE10231655A priority Critical patent/DE10231655A1/de
Priority to HK05104363.6A priority patent/HK1071586B/en
Priority to AT03763823T priority patent/ATE309331T1/de
Priority to IL16602103A priority patent/IL166021A0/xx
Priority to DE60302231T priority patent/DE60302231T2/de
Priority to CNB038215748A priority patent/CN100523176C/zh
Priority to DK05009317T priority patent/DK1557462T3/da
Priority to BR0312693-5A priority patent/BR0312693A/pt
Priority to PT05009317T priority patent/PT1557462E/pt
Priority to DE60320009T priority patent/DE60320009T2/de
Priority to AT05009317T priority patent/ATE390480T1/de
Priority to JP2004520603A priority patent/JP2005532803A/ja
Priority to SI200331240T priority patent/SI1557462T1/sl
Priority to CA002492383A priority patent/CA2492383A1/en
Priority to EP05009317A priority patent/EP1557462B1/en
Priority to US10/520,931 priority patent/US20060286670A1/en
Priority to SI200330146T priority patent/SI1492869T1/sl
Priority to DK03763823T priority patent/DK1492869T3/da
Priority to AU2003250939A priority patent/AU2003250939B2/en
Priority to PCT/EP2003/007551 priority patent/WO2004007701A1/en
Priority to ES03763823T priority patent/ES2252696T3/es
Priority to ES05009317T priority patent/ES2304647T3/es
Priority to EP03763823A priority patent/EP1492869B9/en
Priority to RU2005103627/13A priority patent/RU2370535C2/ru
Priority to PT04701001T priority patent/PT1644484E/pt
Priority to ES04701001T priority patent/ES2310711T3/es
Priority to SI200430965T priority patent/SI1644484T1/sl
Publication of DE10231655A1 publication Critical patent/DE10231655A1/de
Priority to IL166021A priority patent/IL166021A/en
Priority to ZA200501054A priority patent/ZA200501054B/xx
Priority to NO20050719A priority patent/NO20050719L/no
Priority to IL172854A priority patent/IL172854A0/en
Priority to ZA200601074A priority patent/ZA200601074B/en
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/17Monocytes; Macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/22Colony stimulating factors (G-CSF, GM-CSF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/24Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE10231655A 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung Ceased DE10231655A1 (de)

Priority Applications (32)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
US10/520,931 US20060286670A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
DK03763823T DK1492869T3 (da) 2002-07-12 2003-07-11 Transplantataccept-inducerende celler af monocytisk oprindelse, deres fremstilling og anvendelse
IL16602103A IL166021A0 (en) 2002-07-12 2003-07-11 Trabsolant acceptance inducing cells of monocytic origin and their preparation and use
DE60302231T DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
CNB038215748A CN100523176C (zh) 2002-07-12 2003-07-11 单核细胞起源的移植物接纳诱导性细胞及其制备和用途
DK05009317T DK1557462T3 (da) 2002-07-12 2003-07-11 Transplantataccept-inducerende celler af monocytisk oprindelse, deres fremstilling og anvendelse
BR0312693-5A BR0312693A (pt) 2002-07-12 2003-07-11 Células indutoras de aceitação de transplante de origem monocìtica e sua preparação e aplicação
PT05009317T PT1557462E (pt) 2002-07-12 2003-07-11 Células de indução da aceitação de um transplante de origem monocítica e a sua preparação e utilização
DE60320009T DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
AT05009317T ATE390480T1 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
JP2004520603A JP2005532803A (ja) 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用
SI200331240T SI1557462T1 (sl) 2002-07-12 2003-07-11 Celice monocitnega izvora, ki inducirajo sprejemljivost transplantata, kot tudi njihova priprava in uporaba
CA002492383A CA2492383A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
EP05009317A EP1557462B1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
HK05104363.6A HK1071586B (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
SI200330146T SI1492869T1 (sl) 2002-07-12 2003-07-11 Celice monocitnega izvora, ki inducirajo sprejemanje transplantata, in njihova priprava in uporaba
PCT/EP2003/007551 WO2004007701A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
AT03763823T ATE309331T1 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
AU2003250939A AU2003250939B2 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
ES03763823T ES2252696T3 (es) 2002-07-12 2003-07-11 Celulas inductoras de aceptacion de trasplantes de origen monocitico y su preparacion y uso.
ES05009317T ES2304647T3 (es) 2002-07-12 2003-07-11 Celulas inductoras de aceptacion de trasplantes de origen monocitico y su preparacion y uso.
EP03763823A EP1492869B9 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
RU2005103627/13A RU2370535C2 (ru) 2002-07-12 2003-07-11 Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела
PT04701001T PT1644484E (pt) 2002-07-12 2004-01-09 Células autólogas de indução de auto-tolerância de origem monocítica e sua utilização em preparações farmacêuticas
ES04701001T ES2310711T3 (es) 2002-07-12 2004-01-09 Celulas autologas inductoras de la auto-tolerancia de origen monocitico y su uso en preparaciones farmaceuticas.
SI200430965T SI1644484T1 (sl) 2002-07-12 2004-01-09 Avtologne samo-toleranco inducirajoče celice monocitnega izvora in njihova uporaba v farmacevtskihpripravah
IL166021A IL166021A (en) 2002-07-12 2004-12-28 Transplant acceptance inducing cells of monocytic origin and their preparation and use
ZA200501054A ZA200501054B (en) 2002-07-12 2005-02-04 Transplant acceptance inducing cells of monocytic origin and their preparation and use.
NO20050719A NO20050719L (no) 2002-07-12 2005-02-10 Transplantat akseptinduserende celler av monocytisk opprinnelse og deres fremstilling og anvendelse
IL172854A IL172854A0 (en) 2002-07-12 2005-12-27 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
ZA200601074A ZA200601074B (en) 2002-07-12 2006-02-07 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
DE10231655A1 true DE10231655A1 (de) 2004-02-26

Family

ID=30009939

Family Applications (3)

Application Number Title Priority Date Filing Date
DE10231655A Ceased DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
DE60302231T Expired - Fee Related DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
DE60320009T Expired - Fee Related DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE60302231T Expired - Fee Related DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
DE60320009T Expired - Fee Related DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung

Country Status (18)

Country Link
US (1) US20060286670A1 (enExample)
EP (2) EP1557462B1 (enExample)
JP (1) JP2005532803A (enExample)
CN (1) CN100523176C (enExample)
AT (2) ATE390480T1 (enExample)
AU (1) AU2003250939B2 (enExample)
BR (1) BR0312693A (enExample)
CA (1) CA2492383A1 (enExample)
DE (3) DE10231655A1 (enExample)
DK (2) DK1557462T3 (enExample)
ES (3) ES2304647T3 (enExample)
IL (3) IL166021A0 (enExample)
NO (1) NO20050719L (enExample)
PT (2) PT1557462E (enExample)
RU (1) RU2370535C2 (enExample)
SI (3) SI1492869T1 (enExample)
WO (1) WO2004007701A1 (enExample)
ZA (2) ZA200501054B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603809B2 (en) 2003-06-23 2013-12-10 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E. V. Isolated adult pluripotent stem cells and methods for isolating and cultivating thereof

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* Cited by examiner, † Cited by third party
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EP1644484B1 (en) * 2003-07-11 2008-09-17 Blasticon Biotechnologische Forschung GmbH Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
EP1928479B1 (en) * 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007043641A1 (ja) 2005-10-14 2007-04-19 Fukuoka University 膵島移植における移植膵島障害抑制剤
BRPI0617664B8 (pt) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
WO2007116962A1 (ja) 2006-04-07 2007-10-18 Osaka University 筋再生促進剤
CN101646459B (zh) 2007-01-23 2014-02-12 国立大学法人信州大学 慢性排斥反应抑制剂
JP5544290B2 (ja) 2008-06-05 2014-07-09 独立行政法人国立がん研究センター 神経浸潤抑制剤
ES2615861T3 (es) * 2008-10-30 2017-06-08 Yeda Research And Development Company Ltd. Células T de memoria central anti-terceros, métodos de producción de las mismas y uso de las mismas en trasplante y tratamiento de enfermedades
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
HUE060454T2 (hu) 2010-05-28 2023-03-28 Chugai Pharmaceutical Co Ltd Daganatellenes T-sejt-választ fokozó szer
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
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