DE10231655A1 - Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung - Google Patents

Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung Download PDF

Info

Publication number
DE10231655A1
DE10231655A1 DE10231655A DE10231655A DE10231655A1 DE 10231655 A1 DE10231655 A1 DE 10231655A1 DE 10231655 A DE10231655 A DE 10231655A DE 10231655 A DE10231655 A DE 10231655A DE 10231655 A1 DE10231655 A1 DE 10231655A1
Authority
DE
Germany
Prior art keywords
cells
lew
taiz
monocytes
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10231655A
Other languages
German (de)
English (en)
Inventor
Bernd Karl Friedrich Prof. Dr.med. Kremer
Maren Dr. Schulze
Fred Prof. Dr.med. Faendrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blasticon Biotechnologische Forschung GmbH
Original Assignee
Blasticon Biotechnologische Forschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blasticon Biotechnologische Forschung GmbH filed Critical Blasticon Biotechnologische Forschung GmbH
Priority to DE10231655A priority Critical patent/DE10231655A1/de
Priority to CNB038215748A priority patent/CN100523176C/zh
Priority to PCT/EP2003/007551 priority patent/WO2004007701A1/en
Priority to DE60320009T priority patent/DE60320009T2/de
Priority to SI200331240T priority patent/SI1557462T1/sl
Priority to IL16602103A priority patent/IL166021A0/xx
Priority to US10/520,931 priority patent/US20060286670A1/en
Priority to DK05009317T priority patent/DK1557462T3/da
Priority to CA002492383A priority patent/CA2492383A1/en
Priority to HK05104363.6A priority patent/HK1071586B/en
Priority to ES05009317T priority patent/ES2304647T3/es
Priority to DE60302231T priority patent/DE60302231T2/de
Priority to DK03763823T priority patent/DK1492869T3/da
Priority to AU2003250939A priority patent/AU2003250939B2/en
Priority to AT03763823T priority patent/ATE309331T1/de
Priority to SI200330146T priority patent/SI1492869T1/sl
Priority to EP03763823A priority patent/EP1492869B9/en
Priority to RU2005103627/13A priority patent/RU2370535C2/ru
Priority to JP2004520603A priority patent/JP2005532803A/ja
Priority to AT05009317T priority patent/ATE390480T1/de
Priority to PT05009317T priority patent/PT1557462E/pt
Priority to BR0312693-5A priority patent/BR0312693A/pt
Priority to ES03763823T priority patent/ES2252696T3/es
Priority to EP05009317A priority patent/EP1557462B1/en
Priority to PT04701001T priority patent/PT1644484E/pt
Priority to SI200430965T priority patent/SI1644484T1/sl
Priority to ES04701001T priority patent/ES2310711T3/es
Publication of DE10231655A1 publication Critical patent/DE10231655A1/de
Priority to IL166021A priority patent/IL166021A/en
Priority to ZA200501054A priority patent/ZA200501054B/xx
Priority to NO20050719A priority patent/NO20050719L/no
Priority to IL172854A priority patent/IL172854A0/en
Priority to ZA200601074A priority patent/ZA200601074B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE10231655A 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung Ceased DE10231655A1 (de)

Priority Applications (32)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
SI200330146T SI1492869T1 (sl) 2002-07-12 2003-07-11 Celice monocitnega izvora, ki inducirajo sprejemanje transplantata, in njihova priprava in uporaba
RU2005103627/13A RU2370535C2 (ru) 2002-07-12 2003-07-11 Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела
DE60320009T DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
SI200331240T SI1557462T1 (sl) 2002-07-12 2003-07-11 Celice monocitnega izvora, ki inducirajo sprejemljivost transplantata, kot tudi njihova priprava in uporaba
IL16602103A IL166021A0 (en) 2002-07-12 2003-07-11 Trabsolant acceptance inducing cells of monocytic origin and their preparation and use
US10/520,931 US20060286670A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
DK05009317T DK1557462T3 (da) 2002-07-12 2003-07-11 Transplantataccept-inducerende celler af monocytisk oprindelse, deres fremstilling og anvendelse
CA002492383A CA2492383A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
HK05104363.6A HK1071586B (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
ES05009317T ES2304647T3 (es) 2002-07-12 2003-07-11 Celulas inductoras de aceptacion de trasplantes de origen monocitico y su preparacion y uso.
DE60302231T DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
DK03763823T DK1492869T3 (da) 2002-07-12 2003-07-11 Transplantataccept-inducerende celler af monocytisk oprindelse, deres fremstilling og anvendelse
AU2003250939A AU2003250939B2 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
AT03763823T ATE309331T1 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
CNB038215748A CN100523176C (zh) 2002-07-12 2003-07-11 单核细胞起源的移植物接纳诱导性细胞及其制备和用途
EP03763823A EP1492869B9 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
AT05009317T ATE390480T1 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
PCT/EP2003/007551 WO2004007701A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
JP2004520603A JP2005532803A (ja) 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用
PT05009317T PT1557462E (pt) 2002-07-12 2003-07-11 Células de indução da aceitação de um transplante de origem monocítica e a sua preparação e utilização
BR0312693-5A BR0312693A (pt) 2002-07-12 2003-07-11 Células indutoras de aceitação de transplante de origem monocìtica e sua preparação e aplicação
ES03763823T ES2252696T3 (es) 2002-07-12 2003-07-11 Celulas inductoras de aceptacion de trasplantes de origen monocitico y su preparacion y uso.
EP05009317A EP1557462B1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use
PT04701001T PT1644484E (pt) 2002-07-12 2004-01-09 Células autólogas de indução de auto-tolerância de origem monocítica e sua utilização em preparações farmacêuticas
SI200430965T SI1644484T1 (sl) 2002-07-12 2004-01-09 Avtologne samo-toleranco inducirajoče celice monocitnega izvora in njihova uporaba v farmacevtskihpripravah
ES04701001T ES2310711T3 (es) 2002-07-12 2004-01-09 Celulas autologas inductoras de la auto-tolerancia de origen monocitico y su uso en preparaciones farmaceuticas.
IL166021A IL166021A (en) 2002-07-12 2004-12-28 Transplant acceptance inducing cells of monocytic origin and their preparation and use
ZA200501054A ZA200501054B (en) 2002-07-12 2005-02-04 Transplant acceptance inducing cells of monocytic origin and their preparation and use.
NO20050719A NO20050719L (no) 2002-07-12 2005-02-10 Transplantat akseptinduserende celler av monocytisk opprinnelse og deres fremstilling og anvendelse
IL172854A IL172854A0 (en) 2002-07-12 2005-12-27 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
ZA200601074A ZA200601074B (en) 2002-07-12 2006-02-07 Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
DE10231655A1 true DE10231655A1 (de) 2004-02-26

Family

ID=30009939

Family Applications (3)

Application Number Title Priority Date Filing Date
DE10231655A Ceased DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
DE60320009T Expired - Fee Related DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
DE60302231T Expired - Fee Related DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE60320009T Expired - Fee Related DE60320009T2 (de) 2002-07-12 2003-07-11 Transplantat-Akzeptanz-induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
DE60302231T Expired - Fee Related DE60302231T2 (de) 2002-07-12 2003-07-11 Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung

Country Status (18)

Country Link
US (1) US20060286670A1 (enExample)
EP (2) EP1557462B1 (enExample)
JP (1) JP2005532803A (enExample)
CN (1) CN100523176C (enExample)
AT (2) ATE309331T1 (enExample)
AU (1) AU2003250939B2 (enExample)
BR (1) BR0312693A (enExample)
CA (1) CA2492383A1 (enExample)
DE (3) DE10231655A1 (enExample)
DK (2) DK1492869T3 (enExample)
ES (3) ES2252696T3 (enExample)
IL (3) IL166021A0 (enExample)
NO (1) NO20050719L (enExample)
PT (2) PT1557462E (enExample)
RU (1) RU2370535C2 (enExample)
SI (3) SI1492869T1 (enExample)
WO (1) WO2004007701A1 (enExample)
ZA (2) ZA200501054B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603809B2 (en) 2003-06-23 2013-12-10 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E. V. Isolated adult pluripotent stem cells and methods for isolating and cultivating thereof

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004256154A1 (en) * 2003-07-11 2005-01-20 Blasticon Biotechnologische Forschung Gmbh Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
EP2514315A3 (en) * 2005-08-24 2012-11-07 Yeda Research and Development Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
US8470316B2 (en) 2005-10-14 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
RU2450830C2 (ru) 2005-10-21 2012-05-20 Чугаи Сейяку Кабусики Кайся Средства для лечения кардиопатии
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
MX2009007830A (es) 2007-01-23 2009-10-07 Univ Shinshu Inhibidor de rechazo cronico.
TW201503898A (zh) 2008-06-05 2015-02-01 Chugai Pharmaceutical Co Ltd 神經浸潤抑制劑
WO2010049935A1 (en) * 2008-10-30 2010-05-06 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
RS63800B1 (sr) 2010-05-28 2022-12-30 Chugai Pharmaceutical Co Ltd Poboljšanje antitumorskog odgovora t ćelije
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
JP5727665B2 (ja) * 2014-12-11 2015-06-03 テルモ株式会社 シート状細胞培養物の製造方法
JP5893786B2 (ja) * 2015-04-02 2016-03-23 テルモ株式会社 シート状細胞培養物の製造方法
KR102769850B1 (ko) * 2015-07-03 2025-02-20 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 조절 t 세포를 수득하는 방법 및 이의 용도
JP6903866B2 (ja) * 2016-01-27 2021-07-14 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP6140322B2 (ja) * 2016-02-24 2017-05-31 テルモ株式会社 シート状細胞培養物の製造方法
JP6490738B2 (ja) * 2017-04-28 2019-03-27 テルモ株式会社 シート状細胞培養物の製造方法
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
WO2019078344A1 (ja) 2017-10-20 2019-04-25 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
TWI822728B (zh) 2018-01-31 2023-11-21 加藤元一 含有il-6抑制劑的哮喘治療劑
JP6657452B2 (ja) * 2019-02-27 2020-03-04 テルモ株式会社 シート状細胞培養物の製造方法
AU2020259884A1 (en) 2019-04-17 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination
JP7002497B2 (ja) * 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP6872051B2 (ja) * 2020-02-05 2021-05-19 テルモ株式会社 シート状細胞培養物の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
US9068164B1 (en) * 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
WO1996027392A1 (en) * 1995-03-08 1996-09-12 The Scripps Research Institute Antigen presenting system and methods for activation of t-cells
AU7499498A (en) * 1997-05-21 1998-12-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and compositions for making dendritic cells from expanded populations ofmonocytes and for activating t cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
AU2002224851A1 (en) * 2000-11-14 2002-05-27 Universite Libre De Bruxelles Generation and use of dendritic cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603809B2 (en) 2003-06-23 2013-12-10 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E. V. Isolated adult pluripotent stem cells and methods for isolating and cultivating thereof
US9206393B2 (en) 2003-06-23 2015-12-08 Fraunhofer Gesellschaft Zur Forderung De Angewandten Forschung E.V. Isolated adult pluripotent stem cells and methods for isolating and cultivating thereof

Also Published As

Publication number Publication date
EP1492869B9 (en) 2006-05-24
EP1557462A2 (en) 2005-07-27
PT1644484E (pt) 2008-10-21
DE60302231T2 (de) 2006-07-20
WO2004007701A1 (en) 2004-01-22
SI1644484T1 (sl) 2009-02-28
ZA200501054B (en) 2005-08-30
AU2003250939B2 (en) 2008-05-22
PT1557462E (pt) 2008-06-18
EP1557462A3 (en) 2006-02-01
CN100523176C (zh) 2009-08-05
RU2005103627A (ru) 2005-08-27
DK1492869T3 (da) 2006-03-06
DK1557462T3 (da) 2008-06-23
EP1492869A1 (en) 2005-01-05
AU2003250939A1 (en) 2004-02-02
DE60320009D1 (de) 2008-05-08
DE60302231D1 (de) 2005-12-15
EP1492869B1 (en) 2005-11-09
CN1681918A (zh) 2005-10-12
HK1071586A1 (en) 2005-07-22
SI1557462T1 (sl) 2008-08-31
ES2310711T3 (es) 2009-01-16
ZA200601074B (en) 2007-11-28
EP1557462B1 (en) 2008-03-26
IL172854A0 (en) 2006-06-11
ES2304647T3 (es) 2008-10-16
CA2492383A1 (en) 2004-01-22
RU2370535C2 (ru) 2009-10-20
NO20050719L (no) 2005-04-04
DE60320009T2 (de) 2009-05-20
ATE390480T1 (de) 2008-04-15
ATE309331T1 (de) 2005-11-15
IL166021A (en) 2010-05-17
SI1492869T1 (sl) 2006-04-30
JP2005532803A (ja) 2005-11-04
BR0312693A (pt) 2005-04-26
IL166021A0 (en) 2006-01-15
US20060286670A1 (en) 2006-12-21
ES2252696T3 (es) 2006-05-16

Similar Documents

Publication Publication Date Title
DE60302231T2 (de) Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
DE69929681T2 (de) Mesenchymale stammzellen für die prävention und behandlung von immunantworten bei transplantationen
DE60026561T2 (de) Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen
DE69832402T2 (de) Erzeugung von hämatopoietischen zellen aus multipotenten neuronalen stammzellen
DE69715611T2 (de) Verwendung eines rapamycinderivates zur behandlung von gefäss erkrankungen und xenotransplantationen
KR101578591B1 (ko) 간엽줄기세포 및 면역조절 t 세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
DE69431107T2 (de) Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen
DE69131331T2 (de) Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
DE19833476A1 (de) Genetisch modifizierte CD34-Negative, adhärent wachsende Stammzellen und deren Verwendung in der Gentherapie
DE19813759C1 (de) Verfahren zur Induktion einer durch NK-Zellen vermittelten Immunantwort
WO2014069655A1 (ja) 免疫寛容誘導剤
Fujiki et al. Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4+ CD25+ FoxP3+ T regulatory cells
WO2002040640A2 (en) Methods of using cd8+/tcr- facilitating cells (fc) for the engraftment of purified hematopoietic stem cells (hsc)
DE69835591T2 (de) Induktoren für immuntoleranz
DE69012105T2 (de) Proliferation von cd4-lymfocyten.
EP1370641B1 (de) Verwendung von stammzellen und cd6-depletierten stammzellen zur toleranzinduktion gegenüber allogenen transplantaten und/oder zur leukämiebehandlung
US20040228845A1 (en) Methods of using CD8+/TCR- facilitating cells (FC) for the engraftment of purified hematopoietic stem cells (HSC)
DE69532557T2 (de) Zubereitung enthaltend Glykane übereinstimmend mit Transferrin Glykaner als aktives Prinzip für die Induktion der Immuntoleranz gegen Antigene
KR101694554B1 (ko) 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물
US20070148141A1 (en) Method of using hepatic progenitors in treating liver dysfunction
DE69431184T2 (de) Ein thymus-fremdtransplantat
DE60106748T2 (de) Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark
DE69816812T2 (de) Non myeloablative therapie für toleranzinduktion
Hess et al. Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease.
Vanclée et al. Murine dendritic cells that are resistant to maturation are unable to induce tolerance to allogeneic stem cells

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8131 Rejection