JP2005532803A - 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 - Google Patents

単球由来の移植片受容誘導細胞ならびにその調製およびその使用 Download PDF

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JP2005532803A
JP2005532803A JP2004520603A JP2004520603A JP2005532803A JP 2005532803 A JP2005532803 A JP 2005532803A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2005532803 A JP2005532803 A JP 2005532803A
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cells
taic
cell
lymphocytes
monocytes
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JP2005532803A5 (enExample
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ベルント カール フリードリヒ クレーマー，
フレッド フェンドリヒ，
マーレン ルーンケ，
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ブラスティコン ビオテクノロギッシュ フォーシュング ゲーエムベーハー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004520603A 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 Pending JP2005532803A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
PCT/EP2003/007551 WO2004007701A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use

Publications (2)

Publication Number Publication Date
JP2005532803A true JP2005532803A (ja) 2005-11-04
JP2005532803A5 JP2005532803A5 (enExample) 2006-09-21

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JP2004520603A Pending JP2005532803A (ja) 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用

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Country Link
US (1) US20060286670A1 (enExample)
EP (2) EP1557462B1 (enExample)
JP (1) JP2005532803A (enExample)
CN (1) CN100523176C (enExample)
AT (2) ATE309331T1 (enExample)
AU (1) AU2003250939B2 (enExample)
BR (1) BR0312693A (enExample)
CA (1) CA2492383A1 (enExample)
DE (3) DE10231655A1 (enExample)
DK (2) DK1492869T3 (enExample)
ES (3) ES2252696T3 (enExample)
IL (3) IL166021A0 (enExample)
NO (1) NO20050719L (enExample)
PT (2) PT1557462E (enExample)
RU (1) RU2370535C2 (enExample)
SI (3) SI1492869T1 (enExample)
WO (1) WO2004007701A1 (enExample)
ZA (2) ZA200501054B (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010226991A (ja) * 2009-03-26 2010-10-14 Terumo Corp シート状細胞培養物の製造方法
JP2011110368A (ja) * 2009-11-30 2011-06-09 Terumo Corp シート状細胞培養物の製造方法
JP2015057071A (ja) * 2014-12-11 2015-03-26 テルモ株式会社 シート状細胞培養物の製造方法
JP2015133981A (ja) * 2015-04-02 2015-07-27 テルモ株式会社 シート状細胞培養物の製造方法
JP2016136960A (ja) * 2016-02-24 2016-08-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2017131136A (ja) * 2016-01-27 2017-08-03 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP2017136089A (ja) * 2017-04-28 2017-08-10 テルモ株式会社 シート状細胞培養物の製造方法
JP2019107013A (ja) * 2019-02-27 2019-07-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2019193645A (ja) * 2019-06-20 2019-11-07 テルモ株式会社 シート状細胞培養物の製造方法
JP2020078320A (ja) * 2020-02-05 2020-05-28 テルモ株式会社 シート状細胞培養物の製造方法

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DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
AU2004256154A1 (en) * 2003-07-11 2005-01-20 Blasticon Biotechnologische Forschung Gmbh Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
EP2514315A3 (en) * 2005-08-24 2012-11-07 Yeda Research and Development Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
US8470316B2 (en) 2005-10-14 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Agents for suppressing damage to transplanted islets after islet transplantation
RU2450830C2 (ru) 2005-10-21 2012-05-20 Чугаи Сейяку Кабусики Кайся Средства для лечения кардиопатии
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
MX2009007830A (es) 2007-01-23 2009-10-07 Univ Shinshu Inhibidor de rechazo cronico.
TW201503898A (zh) 2008-06-05 2015-02-01 Chugai Pharmaceutical Co Ltd 神經浸潤抑制劑
WO2010049935A1 (en) * 2008-10-30 2010-05-06 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
RS63800B1 (sr) 2010-05-28 2022-12-30 Chugai Pharmaceutical Co Ltd Poboljšanje antitumorskog odgovora t ćelije
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
KR102769850B1 (ko) * 2015-07-03 2025-02-20 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 조절 t 세포를 수득하는 방법 및 이의 용도
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
WO2019078344A1 (ja) 2017-10-20 2019-04-25 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
TWI822728B (zh) 2018-01-31 2023-11-21 加藤元一 含有il-6抑制劑的哮喘治療劑
AU2020259884A1 (en) 2019-04-17 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination

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US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
US9068164B1 (en) * 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
WO1996027392A1 (en) * 1995-03-08 1996-09-12 The Scripps Research Institute Antigen presenting system and methods for activation of t-cells
AU7499498A (en) * 1997-05-21 1998-12-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and compositions for making dendritic cells from expanded populations ofmonocytes and for activating t cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
AU2002224851A1 (en) * 2000-11-14 2002-05-27 Universite Libre De Bruxelles Generation and use of dendritic cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010226991A (ja) * 2009-03-26 2010-10-14 Terumo Corp シート状細胞培養物の製造方法
JP2011110368A (ja) * 2009-11-30 2011-06-09 Terumo Corp シート状細胞培養物の製造方法
JP2015057071A (ja) * 2014-12-11 2015-03-26 テルモ株式会社 シート状細胞培養物の製造方法
JP2015133981A (ja) * 2015-04-02 2015-07-27 テルモ株式会社 シート状細胞培養物の製造方法
JP2017131136A (ja) * 2016-01-27 2017-08-03 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP2016136960A (ja) * 2016-02-24 2016-08-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2017136089A (ja) * 2017-04-28 2017-08-10 テルモ株式会社 シート状細胞培養物の製造方法
JP2019107013A (ja) * 2019-02-27 2019-07-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2019193645A (ja) * 2019-06-20 2019-11-07 テルモ株式会社 シート状細胞培養物の製造方法
JP7002497B2 (ja) 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP2020078320A (ja) * 2020-02-05 2020-05-28 テルモ株式会社 シート状細胞培養物の製造方法
JP2021106609A (ja) * 2020-02-05 2021-07-29 テルモ株式会社 シート状細胞培養物の製造方法
JP7074908B2 (ja) 2020-02-05 2022-05-24 テルモ株式会社 シート状細胞培養物の製造方法
JP2022106986A (ja) * 2020-02-05 2022-07-20 テルモ株式会社 シート状細胞培養物の製造方法
JP7486544B2 (ja) 2020-02-05 2024-05-17 テルモ株式会社 シート状細胞培養物の製造方法

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EP1492869B9 (en) 2006-05-24
EP1557462A2 (en) 2005-07-27
PT1644484E (pt) 2008-10-21
DE60302231T2 (de) 2006-07-20
WO2004007701A1 (en) 2004-01-22
SI1644484T1 (sl) 2009-02-28
ZA200501054B (en) 2005-08-30
AU2003250939B2 (en) 2008-05-22
PT1557462E (pt) 2008-06-18
EP1557462A3 (en) 2006-02-01
CN100523176C (zh) 2009-08-05
RU2005103627A (ru) 2005-08-27
DK1492869T3 (da) 2006-03-06
DE10231655A1 (de) 2004-02-26
DK1557462T3 (da) 2008-06-23
EP1492869A1 (en) 2005-01-05
AU2003250939A1 (en) 2004-02-02
DE60320009D1 (de) 2008-05-08
DE60302231D1 (de) 2005-12-15
EP1492869B1 (en) 2005-11-09
CN1681918A (zh) 2005-10-12
HK1071586A1 (en) 2005-07-22
SI1557462T1 (sl) 2008-08-31
ES2310711T3 (es) 2009-01-16
ZA200601074B (en) 2007-11-28
EP1557462B1 (en) 2008-03-26
IL172854A0 (en) 2006-06-11
ES2304647T3 (es) 2008-10-16
CA2492383A1 (en) 2004-01-22
RU2370535C2 (ru) 2009-10-20
NO20050719L (no) 2005-04-04
DE60320009T2 (de) 2009-05-20
ATE390480T1 (de) 2008-04-15
ATE309331T1 (de) 2005-11-15
IL166021A (en) 2010-05-17
SI1492869T1 (sl) 2006-04-30
BR0312693A (pt) 2005-04-26
IL166021A0 (en) 2006-01-15
US20060286670A1 (en) 2006-12-21
ES2252696T3 (es) 2006-05-16

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