JP2005532803A5 - - Google Patents
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- Publication number
- JP2005532803A5 JP2005532803A5 JP2004520603A JP2004520603A JP2005532803A5 JP 2005532803 A5 JP2005532803 A5 JP 2005532803A5 JP 2004520603 A JP2004520603 A JP 2004520603A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2005532803 A5 JP2005532803 A5 JP 2005532803A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- inducing
- medium
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 40
- 238000000034 method Methods 0.000 claims 23
- 230000001939 inductive effect Effects 0.000 claims 12
- 210000001616 monocyte Anatomy 0.000 claims 10
- 239000002609 medium Substances 0.000 claims 9
- 210000003289 regulatory T cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012894 fetal calf serum Substances 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10231655A DE10231655A1 (de) | 2002-07-12 | 2002-07-12 | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| PCT/EP2003/007551 WO2004007701A1 (en) | 2002-07-12 | 2003-07-11 | Transplant acceptance inducing cells of monocytic origin and their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532803A JP2005532803A (ja) | 2005-11-04 |
| JP2005532803A5 true JP2005532803A5 (enExample) | 2006-09-21 |
Family
ID=30009939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520603A Pending JP2005532803A (ja) | 2002-07-12 | 2003-07-11 | 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060286670A1 (enExample) |
| EP (2) | EP1557462B1 (enExample) |
| JP (1) | JP2005532803A (enExample) |
| CN (1) | CN100523176C (enExample) |
| AT (2) | ATE309331T1 (enExample) |
| AU (1) | AU2003250939B2 (enExample) |
| BR (1) | BR0312693A (enExample) |
| CA (1) | CA2492383A1 (enExample) |
| DE (3) | DE10231655A1 (enExample) |
| DK (2) | DK1492869T3 (enExample) |
| ES (3) | ES2252696T3 (enExample) |
| IL (3) | IL166021A0 (enExample) |
| NO (1) | NO20050719L (enExample) |
| PT (2) | PT1557462E (enExample) |
| RU (1) | RU2370535C2 (enExample) |
| SI (3) | SI1492869T1 (enExample) |
| WO (1) | WO2004007701A1 (enExample) |
| ZA (2) | ZA200501054B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10362002B4 (de) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adulte pluripotente Stammzellen |
| AU2004256154A1 (en) * | 2003-07-11 | 2005-01-20 | Blasticon Biotechnologische Forschung Gmbh | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations |
| EP2514315A3 (en) * | 2005-08-24 | 2012-11-07 | Yeda Research and Development Co. Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
| US8470316B2 (en) | 2005-10-14 | 2013-06-25 | Chugai Seiyaku Kabushiki Kaisha | Agents for suppressing damage to transplanted islets after islet transplantation |
| RU2450830C2 (ru) | 2005-10-21 | 2012-05-20 | Чугаи Сейяку Кабусики Кайся | Средства для лечения кардиопатии |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| MX2009007830A (es) | 2007-01-23 | 2009-10-07 | Univ Shinshu | Inhibidor de rechazo cronico. |
| TW201503898A (zh) | 2008-06-05 | 2015-02-01 | Chugai Pharmaceutical Co Ltd | 神經浸潤抑制劑 |
| WO2010049935A1 (en) * | 2008-10-30 | 2010-05-06 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| JP5436905B2 (ja) * | 2009-03-26 | 2014-03-05 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP5667357B2 (ja) * | 2009-11-30 | 2015-02-12 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| CN101812428A (zh) * | 2010-04-26 | 2010-08-25 | 西北农林科技大学 | 一种乳腺上皮细胞的组织块种植方法 |
| RS63800B1 (sr) | 2010-05-28 | 2022-12-30 | Chugai Pharmaceutical Co Ltd | Poboljšanje antitumorskog odgovora t ćelije |
| DE102011004335A1 (de) | 2011-02-17 | 2012-08-23 | Thomas Grammel | Verfahren zur Herstellung eines Vakzins |
| RU2508924C1 (ru) * | 2013-02-21 | 2014-03-10 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" | Способ профилактики и лечения отторжения почечного трансплантата |
| JP5727665B2 (ja) * | 2014-12-11 | 2015-06-03 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP5893786B2 (ja) * | 2015-04-02 | 2016-03-23 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| KR102769850B1 (ko) * | 2015-07-03 | 2025-02-20 | 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 | 조절 t 세포를 수득하는 방법 및 이의 용도 |
| JP6903866B2 (ja) * | 2016-01-27 | 2021-07-14 | 国立大学法人 熊本大学 | 血液由来単球の増殖誘導方法 |
| JP6140322B2 (ja) * | 2016-02-24 | 2017-05-31 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP6490738B2 (ja) * | 2017-04-28 | 2019-03-27 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| TWI822728B (zh) | 2018-01-31 | 2023-11-21 | 加藤元一 | 含有il-6抑制劑的哮喘治療劑 |
| JP6657452B2 (ja) * | 2019-02-27 | 2020-03-04 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| AU2020259884A1 (en) | 2019-04-17 | 2021-10-07 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
| JP7002497B2 (ja) * | 2019-06-20 | 2022-01-20 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP6872051B2 (ja) * | 2020-02-05 | 2021-05-19 | テルモ株式会社 | シート状細胞培養物の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766920A (en) * | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US9068164B1 (en) * | 1995-02-02 | 2015-06-30 | Tristem Trading (Cyprus) Limited | Method of preparing an undifferentiated cell |
| US7112440B2 (en) * | 1995-02-02 | 2006-09-26 | Ghazi Jaswinder Dhoot | Method of increasing the relative number of CD45 low cells in a cell population |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US7410773B2 (en) * | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| WO1996027392A1 (en) * | 1995-03-08 | 1996-09-12 | The Scripps Research Institute | Antigen presenting system and methods for activation of t-cells |
| AU7499498A (en) * | 1997-05-21 | 1998-12-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods and compositions for making dendritic cells from expanded populations ofmonocytes and for activating t cells |
| NL1017973C2 (nl) * | 2000-05-10 | 2002-11-08 | Tristem Trading Cyprus Ltd | Inrichting. |
| AU2002224851A1 (en) * | 2000-11-14 | 2002-05-27 | Universite Libre De Bruxelles | Generation and use of dendritic cells |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
-
2002
- 2002-07-12 DE DE10231655A patent/DE10231655A1/de not_active Ceased
-
2003
- 2003-07-11 BR BR0312693-5A patent/BR0312693A/pt not_active IP Right Cessation
- 2003-07-11 PT PT05009317T patent/PT1557462E/pt unknown
- 2003-07-11 ES ES03763823T patent/ES2252696T3/es not_active Expired - Lifetime
- 2003-07-11 DK DK03763823T patent/DK1492869T3/da active
- 2003-07-11 ES ES05009317T patent/ES2304647T3/es not_active Expired - Lifetime
- 2003-07-11 DE DE60320009T patent/DE60320009T2/de not_active Expired - Fee Related
- 2003-07-11 JP JP2004520603A patent/JP2005532803A/ja active Pending
- 2003-07-11 DE DE60302231T patent/DE60302231T2/de not_active Expired - Fee Related
- 2003-07-11 CN CNB038215748A patent/CN100523176C/zh not_active Expired - Fee Related
- 2003-07-11 DK DK05009317T patent/DK1557462T3/da active
- 2003-07-11 WO PCT/EP2003/007551 patent/WO2004007701A1/en not_active Ceased
- 2003-07-11 IL IL16602103A patent/IL166021A0/xx unknown
- 2003-07-11 AT AT03763823T patent/ATE309331T1/de not_active IP Right Cessation
- 2003-07-11 AU AU2003250939A patent/AU2003250939B2/en not_active Ceased
- 2003-07-11 CA CA002492383A patent/CA2492383A1/en not_active Abandoned
- 2003-07-11 US US10/520,931 patent/US20060286670A1/en not_active Abandoned
- 2003-07-11 EP EP05009317A patent/EP1557462B1/en not_active Expired - Lifetime
- 2003-07-11 SI SI200330146T patent/SI1492869T1/sl unknown
- 2003-07-11 SI SI200331240T patent/SI1557462T1/sl unknown
- 2003-07-11 EP EP03763823A patent/EP1492869B9/en not_active Expired - Lifetime
- 2003-07-11 AT AT05009317T patent/ATE390480T1/de not_active IP Right Cessation
- 2003-07-11 RU RU2005103627/13A patent/RU2370535C2/ru not_active IP Right Cessation
-
2004
- 2004-01-09 ES ES04701001T patent/ES2310711T3/es not_active Expired - Lifetime
- 2004-01-09 SI SI200430965T patent/SI1644484T1/sl unknown
- 2004-01-09 PT PT04701001T patent/PT1644484E/pt unknown
- 2004-12-28 IL IL166021A patent/IL166021A/en not_active IP Right Cessation
-
2005
- 2005-02-04 ZA ZA200501054A patent/ZA200501054B/xx unknown
- 2005-02-10 NO NO20050719A patent/NO20050719L/no not_active Application Discontinuation
- 2005-12-27 IL IL172854A patent/IL172854A0/en unknown
-
2006
- 2006-02-07 ZA ZA200601074A patent/ZA200601074B/en unknown
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