CN100523176C - 单核细胞起源的移植物接纳诱导性细胞及其制备和用途 - Google Patents

单核细胞起源的移植物接纳诱导性细胞及其制备和用途 Download PDF

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CN100523176C
CN100523176C CNB038215748A CN03821574A CN100523176C CN 100523176 C CN100523176 C CN 100523176C CN B038215748 A CNB038215748 A CN B038215748A CN 03821574 A CN03821574 A CN 03821574A CN 100523176 C CN100523176 C CN 100523176C
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cell
cells
taic
graft
inducibility
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CN1681918A (zh
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B·K·F·克雷默
F·费恩德里希
M·鲁恩克
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BLASTICON BIOTECHNOLOGISCHE FO
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
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    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB038215748A 2002-07-12 2003-07-11 单核细胞起源的移植物接纳诱导性细胞及其制备和用途 Expired - Fee Related CN100523176C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231655.4 2002-07-12
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung

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CN1681918A CN1681918A (zh) 2005-10-12
CN100523176C true CN100523176C (zh) 2009-08-05

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US (1) US20060286670A1 (enExample)
EP (2) EP1557462B1 (enExample)
JP (1) JP2005532803A (enExample)
CN (1) CN100523176C (enExample)
AT (2) ATE390480T1 (enExample)
AU (1) AU2003250939B2 (enExample)
BR (1) BR0312693A (enExample)
CA (1) CA2492383A1 (enExample)
DE (3) DE10231655A1 (enExample)
DK (2) DK1557462T3 (enExample)
ES (3) ES2304647T3 (enExample)
IL (3) IL166021A0 (enExample)
NO (1) NO20050719L (enExample)
PT (2) PT1557462E (enExample)
RU (1) RU2370535C2 (enExample)
SI (3) SI1492869T1 (enExample)
WO (1) WO2004007701A1 (enExample)
ZA (2) ZA200501054B (enExample)

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EP1644484B1 (en) * 2003-07-11 2008-09-17 Blasticon Biotechnologische Forschung GmbH Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
EP1928479B1 (en) * 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007043641A1 (ja) 2005-10-14 2007-04-19 Fukuoka University 膵島移植における移植膵島障害抑制剤
BRPI0617664B8 (pt) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
WO2007116962A1 (ja) 2006-04-07 2007-10-18 Osaka University 筋再生促進剤
CN101646459B (zh) 2007-01-23 2014-02-12 国立大学法人信州大学 慢性排斥反应抑制剂
JP5544290B2 (ja) 2008-06-05 2014-07-09 独立行政法人国立がん研究センター 神経浸潤抑制剤
ES2615861T3 (es) * 2008-10-30 2017-06-08 Yeda Research And Development Company Ltd. Células T de memoria central anti-terceros, métodos de producción de las mismas y uso de las mismas en trasplante y tratamiento de enfermedades
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
HUE060454T2 (hu) 2010-05-28 2023-03-28 Chugai Pharmaceutical Co Ltd Daganatellenes T-sejt-választ fokozó szer
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
JP5727665B2 (ja) * 2014-12-11 2015-06-03 テルモ株式会社 シート状細胞培養物の製造方法
JP5893786B2 (ja) * 2015-04-02 2016-03-23 テルモ株式会社 シート状細胞培養物の製造方法
KR102769850B1 (ko) * 2015-07-03 2025-02-20 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 조절 t 세포를 수득하는 방법 및 이의 용도
JP6903866B2 (ja) * 2016-01-27 2021-07-14 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP6140322B2 (ja) * 2016-02-24 2017-05-31 テルモ株式会社 シート状細胞培養物の製造方法
JP6490738B2 (ja) * 2017-04-28 2019-03-27 テルモ株式会社 シート状細胞培養物の製造方法
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
EP3698808B1 (en) 2017-10-20 2025-01-01 Hyogo College Of Medicine Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
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JP7002497B2 (ja) * 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP6872051B2 (ja) * 2020-02-05 2021-05-19 テルモ株式会社 シート状細胞培養物の製造方法

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DK1557462T3 (da) 2008-06-23
CA2492383A1 (en) 2004-01-22
IL166021A0 (en) 2006-01-15
AU2003250939B2 (en) 2008-05-22
RU2370535C2 (ru) 2009-10-20
SI1644484T1 (sl) 2009-02-28
ZA200501054B (en) 2005-08-30
HK1071586A1 (en) 2005-07-22
ATE390480T1 (de) 2008-04-15
DK1492869T3 (da) 2006-03-06
ES2252696T3 (es) 2006-05-16
IL172854A0 (en) 2006-06-11
ATE309331T1 (de) 2005-11-15
BR0312693A (pt) 2005-04-26
EP1557462A3 (en) 2006-02-01
CN1681918A (zh) 2005-10-12
US20060286670A1 (en) 2006-12-21
JP2005532803A (ja) 2005-11-04
DE60302231D1 (de) 2005-12-15
PT1644484E (pt) 2008-10-21
DE60302231T2 (de) 2006-07-20
RU2005103627A (ru) 2005-08-27
ES2310711T3 (es) 2009-01-16
SI1492869T1 (sl) 2006-04-30
WO2004007701A1 (en) 2004-01-22
EP1492869B1 (en) 2005-11-09
ES2304647T3 (es) 2008-10-16
DE60320009D1 (de) 2008-05-08
AU2003250939A1 (en) 2004-02-02
IL166021A (en) 2010-05-17
EP1557462A2 (en) 2005-07-27
DE10231655A1 (de) 2004-02-26
DE60320009T2 (de) 2009-05-20
EP1492869B9 (en) 2006-05-24
ZA200601074B (en) 2007-11-28
EP1557462B1 (en) 2008-03-26
PT1557462E (pt) 2008-06-18
NO20050719L (no) 2005-04-04
SI1557462T1 (sl) 2008-08-31
EP1492869A1 (en) 2005-01-05

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