DE102008039271A1 - Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung - Google Patents

Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung Download PDF

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Publication number
DE102008039271A1
DE102008039271A1 DE102008039271A DE102008039271A DE102008039271A1 DE 102008039271 A1 DE102008039271 A1 DE 102008039271A1 DE 102008039271 A DE102008039271 A DE 102008039271A DE 102008039271 A DE102008039271 A DE 102008039271A DE 102008039271 A1 DE102008039271 A1 DE 102008039271A1
Authority
DE
Germany
Prior art keywords
liver
milk thistle
fruit extract
necessary
thistle fruit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102008039271A
Other languages
German (de)
English (en)
Inventor
Astrid Dr. Nagell
Jaime Xiol Aguirre
Santiago Rull Prous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus GmbH
Original Assignee
Euromed SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euromed SA filed Critical Euromed SA
Priority to DE102008039271A priority Critical patent/DE102008039271A1/de
Priority to HRP20131165AT priority patent/HRP20131165T1/hr
Priority to CA2709947A priority patent/CA2709947C/en
Priority to ES08865199.7T priority patent/ES2438003T3/es
Priority to JP2010538335A priority patent/JP5442632B2/ja
Priority to CA2922846A priority patent/CA2922846A1/en
Priority to KR1020107015846A priority patent/KR101541938B1/ko
Priority to MX2010006982A priority patent/MX2010006982A/es
Priority to EP12195762A priority patent/EP2567703A3/de
Priority to AU2008340922A priority patent/AU2008340922B2/en
Priority to PCT/DE2008/002117 priority patent/WO2009080006A2/de
Priority to SI200831118T priority patent/SI2222320T1/sl
Priority to PT88651997T priority patent/PT2222320E/pt
Priority to CN2008801254794A priority patent/CN101925360A/zh
Priority to RU2010130855/15A priority patent/RU2489161C2/ru
Priority to US12/810,178 priority patent/US20110027396A1/en
Priority to PL08865199T priority patent/PL2222320T3/pl
Priority to DK08865199.7T priority patent/DK2222320T3/da
Priority to KR1020157006607A priority patent/KR101607445B1/ko
Priority to CN201410378585.0A priority patent/CN104189043A/zh
Priority to EP08865199.7A priority patent/EP2222320B1/de
Priority to BRPI0822069A priority patent/BRPI0822069B8/pt
Publication of DE102008039271A1 publication Critical patent/DE102008039271A1/de
Priority to HK15103460.8A priority patent/HK1203352A1/xx
Priority to CY20131101145T priority patent/CY1115081T1/el
Priority to JP2013260758A priority patent/JP2014074051A/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE102008039271A 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung Withdrawn DE102008039271A1 (de)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DE102008039271A DE102008039271A1 (de) 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
EP08865199.7A EP2222320B1 (de) 2007-12-23 2008-12-23 Neuer mariendistelextrakt, verfahren zur herstellung und verwendung
CN2008801254794A CN101925360A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用
ES08865199.7T ES2438003T3 (es) 2007-12-23 2008-12-23 Nuevo extracto de cardo lechero, método para su preparación y empleo
JP2010538335A JP5442632B2 (ja) 2007-12-23 2008-12-23 新規ミルクシスル抽出物、調製方法、および使用
CA2922846A CA2922846A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use
KR1020107015846A KR101541938B1 (ko) 2007-12-23 2008-12-23 신규한 밀크씨슬 추출물, 제조방법 및 용도
MX2010006982A MX2010006982A (es) 2007-12-23 2008-12-23 Extracto de cardo de leche novedoso, metodo de preparacion y uso.
EP12195762A EP2567703A3 (de) 2007-12-23 2008-12-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
AU2008340922A AU2008340922B2 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for the production, and use
PCT/DE2008/002117 WO2009080006A2 (de) 2007-12-23 2008-12-23 Neuer mariendistelextrakt, verfahren zur herstellung und verwendung
SI200831118T SI2222320T1 (sl) 2007-12-23 2008-12-23 Novi izvleček pegastega badlja, postopek za pripravo in uporaba
PT88651997T PT2222320E (pt) 2007-12-23 2008-12-23 Novo extracto de cardo de leite, método de preparação e uso
HRP20131165AT HRP20131165T1 (hr) 2007-12-23 2008-12-23 Novi ekstrakt iz mlijeka äśiäśka, postupak za proizvodnju, i uporaba
RU2010130855/15A RU2489161C2 (ru) 2007-12-23 2008-12-23 Новый экстракт чертополоха молочного, способ его получения и применение
CN201410378585.0A CN104189043A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用
PL08865199T PL2222320T3 (pl) 2007-12-23 2008-12-23 Nowy wyciąg z ostropestu plamistego, sposób przygotowania i zastosowanie
DK08865199.7T DK2222320T3 (da) 2007-12-23 2008-12-23 Hidtil ukendt ekstrakt af marietidsel, fremgangsmåde til fremstilling samt anvendelse deraf
KR1020157006607A KR101607445B1 (ko) 2007-12-23 2008-12-23 신규한 밀크씨슬 추출물, 제조방법 및 용도
US12/810,178 US20110027396A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for the production, and use
CA2709947A CA2709947C (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use
BRPI0822069A BRPI0822069B8 (pt) 2007-12-23 2008-12-23 método para preparação de um extrato de fruta de cardo leiteiro
HK15103460.8A HK1203352A1 (en) 2007-12-23 2011-01-26 Novel milk thistle extract, method for the production, and use
CY20131101145T CY1115081T1 (el) 2007-12-23 2013-12-13 Νεο εκχυλισμα απο γαϊδουραγκαθο, μεθοδος για την παρασκευη και η χρηση του
JP2013260758A JP2014074051A (ja) 2007-12-23 2013-12-18 新規ミルクシスル抽出物、調製方法、および使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007063115.6 2007-12-23
DE102007063115 2007-12-23
DE102008039271A DE102008039271A1 (de) 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
DE102008039271A1 true DE102008039271A1 (de) 2009-06-25

Family

ID=40690102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102008039271A Withdrawn DE102008039271A1 (de) 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung

Country Status (20)

Country Link
US (1) US20110027396A1 (https=)
EP (2) EP2222320B1 (https=)
JP (2) JP5442632B2 (https=)
KR (2) KR101607445B1 (https=)
CN (2) CN101925360A (https=)
AU (1) AU2008340922B2 (https=)
BR (1) BRPI0822069B8 (https=)
CA (2) CA2709947C (https=)
CY (1) CY1115081T1 (https=)
DE (1) DE102008039271A1 (https=)
DK (1) DK2222320T3 (https=)
ES (1) ES2438003T3 (https=)
HK (1) HK1203352A1 (https=)
HR (1) HRP20131165T1 (https=)
MX (1) MX2010006982A (https=)
PL (1) PL2222320T3 (https=)
PT (1) PT2222320E (https=)
RU (1) RU2489161C2 (https=)
SI (1) SI2222320T1 (https=)
WO (1) WO2009080006A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019058179A1 (en) * 2017-09-22 2019-03-28 Euromed Sa ENHANCED SOLUBILITY OF CHARDON-MARY EXTRACT

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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JP5841048B2 (ja) * 2009-05-14 2016-01-06 エウロメッド・エセ・ア ウイルス性肝炎の治療のための非晶質シリビニン
CN102225085B (zh) * 2011-06-20 2012-09-05 黑龙江大学 一种从水飞蓟秸秆中提取水飞蓟总黄酮的方法
KR101316806B1 (ko) * 2011-08-02 2013-10-10 (주)이뮤노텍 글루타치온과 실리마린을 유효성분으로 함유하는 항산화 및 간보호용 조성물
KR101655396B1 (ko) * 2013-08-06 2016-09-08 에스케이바이오랜드 주식회사 수용성 밀크씨슬 추출물 및 이의 제조방법
JP2015113332A (ja) * 2013-12-16 2015-06-22 花王株式会社 生薬粉体
CN104744447B (zh) * 2013-12-31 2017-12-26 天士力制药集团股份有限公司 水飞蓟宾迷迭香酸酯及其制备方法和用途
CN104651037A (zh) * 2014-01-17 2015-05-27 吴长军 一种亚临界流体萃取水飞蓟籽仁中油脂和蛋白的方法
CN105622594B (zh) * 2016-03-17 2019-05-17 江苏中兴药业有限公司 一种高纯度水飞蓟素的制备方法
KR102242002B1 (ko) 2019-02-21 2021-04-19 주식회사 노바케이메드 동충하초균사체로 고상발효된 홍삼 추출물을 유효성분으로 함유하는 지방간 질환 예방 또는 치료용 조성물
CN111518090B (zh) * 2020-05-12 2021-08-10 沈阳药科大学 黄烷黄酮衍生物及其制备方法和用途
KR102669644B1 (ko) * 2023-06-27 2024-05-27 한국자연한방 주식회사 실리마린 생체이용률이 증대된 밀크씨슬 추출물을 포함하는 지방간 개선, 예방 또는 치료용 조성물

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DE1923982A1 (de) 1969-05-10 1970-11-19 Knapsack Ag Verfahren zur Herstellung von flammwidrigen Polyurethanhartschaeumen
DE1767666A1 (de) 1968-06-01 1971-09-23 Madaus & Co Dr Arzneimittel mit stabilisierender Wirkung auf den Cytometabolismus
DE2020407A1 (de) 1970-04-27 1971-11-11 Bernhard Dr Janiak Technisches Verfahren zur Isolierung von Silimarin
DE2914330A1 (de) 1979-04-09 1980-10-30 Madaus & Co Dr Verfahren zur gewinnung von silymarin aus pflanzen
EP0422497B1 (en) 1989-10-09 1996-03-06 IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them
EP0722918B1 (en) 1995-01-20 1999-05-12 Murata Manufacturing Co., Ltd. Piezoelectric ceramic composition
US5906991A (en) 1995-01-18 1999-05-25 Dr. Madaus Gmbh & Co Process for the manufacture of flavanolignan preparations with improved release and absorbability, compositions obtainable thereby and their use for the preparation of pharmaceuticals
EP1021198B1 (de) 1997-10-08 2002-02-27 Willmar Schwabe GmbH & Co. Flavonolignan-zubereitungen, insbesondere silymarin-zubereitungen

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FR2181188A5 (en) * 1972-04-20 1973-11-30 Dott Inverni Della Beffa Polyhydroxyphenylchromones - by solvent extn of non-defatted fruit of Silybum marianum
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DE3225688A1 (de) * 1982-07-09 1984-01-12 Suschnik Matthias Dr Verfahren zur gewinnung von silymarin aus silybum marianum
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DE1767666A1 (de) 1968-06-01 1971-09-23 Madaus & Co Dr Arzneimittel mit stabilisierender Wirkung auf den Cytometabolismus
DE1923982A1 (de) 1969-05-10 1970-11-19 Knapsack Ag Verfahren zur Herstellung von flammwidrigen Polyurethanhartschaeumen
DE2020407A1 (de) 1970-04-27 1971-11-11 Bernhard Dr Janiak Technisches Verfahren zur Isolierung von Silimarin
DE2914330A1 (de) 1979-04-09 1980-10-30 Madaus & Co Dr Verfahren zur gewinnung von silymarin aus pflanzen
EP0422497B1 (en) 1989-10-09 1996-03-06 IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them
US5906991A (en) 1995-01-18 1999-05-25 Dr. Madaus Gmbh & Co Process for the manufacture of flavanolignan preparations with improved release and absorbability, compositions obtainable thereby and their use for the preparation of pharmaceuticals
EP0722918B1 (en) 1995-01-20 1999-05-12 Murata Manufacturing Co., Ltd. Piezoelectric ceramic composition
EP1021198B1 (de) 1997-10-08 2002-02-27 Willmar Schwabe GmbH & Co. Flavonolignan-zubereitungen, insbesondere silymarin-zubereitungen

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Pelter A., Hänsel R., Tetrahedron Letters, 25, (1968)
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Pharmacopoea Europaea (Ph. Eur.), europäisches Arzneibuch 2007

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019058179A1 (en) * 2017-09-22 2019-03-28 Euromed Sa ENHANCED SOLUBILITY OF CHARDON-MARY EXTRACT
AU2018336098B2 (en) * 2017-09-22 2023-09-07 Euromed, S.A. Enhanced solubility of milk thistle extract
US11819528B2 (en) * 2017-09-22 2023-11-21 Euromed, S.A. Enhanced solubility of milk thistle extract

Also Published As

Publication number Publication date
EP2567703A3 (de) 2013-03-20
CA2922846A1 (en) 2009-07-02
EP2222320B1 (de) 2013-09-18
PL2222320T3 (pl) 2014-02-28
JP2014074051A (ja) 2014-04-24
AU2008340922B2 (en) 2012-07-19
CN104189043A (zh) 2014-12-10
MX2010006982A (es) 2010-12-06
KR20150038663A (ko) 2015-04-08
JP5442632B2 (ja) 2014-03-12
BRPI0822069B8 (pt) 2021-05-25
KR20100126272A (ko) 2010-12-01
CN101925360A (zh) 2010-12-22
EP2567703A2 (de) 2013-03-13
PT2222320E (pt) 2013-12-23
WO2009080006A2 (de) 2009-07-02
KR101541938B1 (ko) 2015-08-04
HRP20131165T1 (hr) 2014-01-03
BRPI0822069B1 (pt) 2019-10-08
JP2011507812A (ja) 2011-03-10
RU2010130855A (ru) 2012-01-27
RU2489161C2 (ru) 2013-08-10
US20110027396A1 (en) 2011-02-03
EP2222320A2 (de) 2010-09-01
SI2222320T1 (sl) 2014-01-31
HK1203352A1 (en) 2015-10-30
WO2009080006A3 (de) 2009-10-08
AU2008340922A1 (en) 2009-07-02
KR101607445B1 (ko) 2016-03-29
CA2709947C (en) 2016-05-17
BRPI0822069A2 (pt) 2015-06-23
DK2222320T3 (da) 2013-12-16
CY1115081T1 (el) 2016-12-14
CA2709947A1 (en) 2009-07-02
ES2438003T3 (es) 2014-01-15

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