CN104189043A - 新的水飞蓟提取物、制备方法和应用 - Google Patents

新的水飞蓟提取物、制备方法和应用 Download PDF

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Publication number
CN104189043A
CN104189043A CN201410378585.0A CN201410378585A CN104189043A CN 104189043 A CN104189043 A CN 104189043A CN 201410378585 A CN201410378585 A CN 201410378585A CN 104189043 A CN104189043 A CN 104189043A
Authority
CN
China
Prior art keywords
milk thistle
fruit extract
thistle fruit
release rate
silymarin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410378585.0A
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English (en)
Chinese (zh)
Inventor
A·纳戈尔
J·X·阿圭热
S·R·普尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euromed SA
Original Assignee
Euromed SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euromed SA filed Critical Euromed SA
Publication of CN104189043A publication Critical patent/CN104189043A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201410378585.0A 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用 Pending CN104189043A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102007063115.6 2007-12-23
DE102007063115 2007-12-23
DE102008039271A DE102008039271A1 (de) 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
DE102008039271.5 2008-08-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2008801254794A Division CN101925360A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用

Publications (1)

Publication Number Publication Date
CN104189043A true CN104189043A (zh) 2014-12-10

Family

ID=40690102

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410378585.0A Pending CN104189043A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用
CN2008801254794A Pending CN101925360A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2008801254794A Pending CN101925360A (zh) 2007-12-23 2008-12-23 新的水飞蓟提取物、制备方法和应用

Country Status (20)

Country Link
US (1) US20110027396A1 (https=)
EP (2) EP2222320B1 (https=)
JP (2) JP5442632B2 (https=)
KR (2) KR101607445B1 (https=)
CN (2) CN104189043A (https=)
AU (1) AU2008340922B2 (https=)
BR (1) BRPI0822069B8 (https=)
CA (2) CA2709947C (https=)
CY (1) CY1115081T1 (https=)
DE (1) DE102008039271A1 (https=)
DK (1) DK2222320T3 (https=)
ES (1) ES2438003T3 (https=)
HK (1) HK1203352A1 (https=)
HR (1) HRP20131165T1 (https=)
MX (1) MX2010006982A (https=)
PL (1) PL2222320T3 (https=)
PT (1) PT2222320E (https=)
RU (1) RU2489161C2 (https=)
SI (1) SI2222320T1 (https=)
WO (1) WO2009080006A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518090A (zh) * 2020-05-12 2020-08-11 沈阳药科大学 黄烷黄酮衍生物及其制备方法和用途

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JP5841048B2 (ja) * 2009-05-14 2016-01-06 エウロメッド・エセ・ア ウイルス性肝炎の治療のための非晶質シリビニン
CN102225085B (zh) * 2011-06-20 2012-09-05 黑龙江大学 一种从水飞蓟秸秆中提取水飞蓟总黄酮的方法
KR101316806B1 (ko) * 2011-08-02 2013-10-10 (주)이뮤노텍 글루타치온과 실리마린을 유효성분으로 함유하는 항산화 및 간보호용 조성물
KR101655396B1 (ko) * 2013-08-06 2016-09-08 에스케이바이오랜드 주식회사 수용성 밀크씨슬 추출물 및 이의 제조방법
JP2015113332A (ja) * 2013-12-16 2015-06-22 花王株式会社 生薬粉体
CN104744447B (zh) * 2013-12-31 2017-12-26 天士力制药集团股份有限公司 水飞蓟宾迷迭香酸酯及其制备方法和用途
CN104651037A (zh) * 2014-01-17 2015-05-27 吴长军 一种亚临界流体萃取水飞蓟籽仁中油脂和蛋白的方法
CN105622594B (zh) * 2016-03-17 2019-05-17 江苏中兴药业有限公司 一种高纯度水飞蓟素的制备方法
ES2706008B8 (es) * 2017-09-22 2021-07-12 Euromed S A Procedimiento para la preparacion de una composicion a partir del cardo mariano y composicion obtenida
KR102242002B1 (ko) 2019-02-21 2021-04-19 주식회사 노바케이메드 동충하초균사체로 고상발효된 홍삼 추출물을 유효성분으로 함유하는 지방간 질환 예방 또는 치료용 조성물
KR102669644B1 (ko) * 2023-06-27 2024-05-27 한국자연한방 주식회사 실리마린 생체이용률이 증대된 밀크씨슬 추출물을 포함하는 지방간 개선, 예방 또는 치료용 조성물

Citations (2)

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WO2003020291A1 (en) * 2001-08-30 2003-03-13 Ivax Corporation Increased solubility flavanolignan preparations
CN1438989A (zh) * 2000-05-26 2003-08-27 兰贝克赛实验室有限公司 新的无定形盐酸舍曲林

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DE1767666C3 (de) 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518090A (zh) * 2020-05-12 2020-08-11 沈阳药科大学 黄烷黄酮衍生物及其制备方法和用途

Also Published As

Publication number Publication date
WO2009080006A2 (de) 2009-07-02
EP2222320B1 (de) 2013-09-18
BRPI0822069B1 (pt) 2019-10-08
BRPI0822069A2 (pt) 2015-06-23
MX2010006982A (es) 2010-12-06
EP2222320A2 (de) 2010-09-01
ES2438003T3 (es) 2014-01-15
RU2489161C2 (ru) 2013-08-10
PL2222320T3 (pl) 2014-02-28
DE102008039271A1 (de) 2009-06-25
DK2222320T3 (da) 2013-12-16
KR20150038663A (ko) 2015-04-08
KR101607445B1 (ko) 2016-03-29
JP5442632B2 (ja) 2014-03-12
BRPI0822069B8 (pt) 2021-05-25
PT2222320E (pt) 2013-12-23
CY1115081T1 (el) 2016-12-14
JP2011507812A (ja) 2011-03-10
RU2010130855A (ru) 2012-01-27
SI2222320T1 (sl) 2014-01-31
HRP20131165T1 (hr) 2014-01-03
EP2567703A3 (de) 2013-03-20
US20110027396A1 (en) 2011-02-03
CA2922846A1 (en) 2009-07-02
KR101541938B1 (ko) 2015-08-04
AU2008340922B2 (en) 2012-07-19
KR20100126272A (ko) 2010-12-01
WO2009080006A3 (de) 2009-10-08
EP2567703A2 (de) 2013-03-13
HK1203352A1 (en) 2015-10-30
CN101925360A (zh) 2010-12-22
CA2709947C (en) 2016-05-17
CA2709947A1 (en) 2009-07-02
JP2014074051A (ja) 2014-04-24
AU2008340922A1 (en) 2009-07-02

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