DE10104362A1 - Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit - Google Patents
Kristallmodifikation eines cyclischen Depsipeptids mit besserer WirksamkeitInfo
- Publication number
- DE10104362A1 DE10104362A1 DE10104362A DE10104362A DE10104362A1 DE 10104362 A1 DE10104362 A1 DE 10104362A1 DE 10104362 A DE10104362 A DE 10104362A DE 10104362 A DE10104362 A DE 10104362A DE 10104362 A1 DE10104362 A1 DE 10104362A1
- Authority
- DE
- Germany
- Prior art keywords
- spp
- modification
- crystal modification
- substances
- depsipeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- AHGNXJYQZLZKFZ-UHFFFAOYSA-N benzimidazol-1-yl carbamate Chemical compound C1=CC=C2N(OC(=O)N)C=NC2=C1 AHGNXJYQZLZKFZ-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
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- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
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- 230000034994 death Effects 0.000 description 1
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- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 230000036576 dermal application Effects 0.000 description 1
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- 230000009189 diving Effects 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000002706 dry binder Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 244000088681 endo Species 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960005282 febantel Drugs 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
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- 239000002563 ionic surfactant Substances 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
- 229940043349 potassium metabisulfite Drugs 0.000 description 1
- 235000010263 potassium metabisulphite Nutrition 0.000 description 1
- 229960002957 praziquantel Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
- 229960005134 pyrantel Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000004544 spot-on Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10104362A DE10104362A1 (de) | 2001-02-01 | 2001-02-01 | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
| KR1020097006790A KR20090041451A (ko) | 2001-02-01 | 2002-01-21 | 강도가 개선된 사이클릭 뎁시펩타이드의 결정 변형체 |
| PL362389A PL213106B1 (pl) | 2001-02-01 | 2002-01-21 | Zastosowanie depsypeptydu |
| PCT/EP2002/000541 WO2002066048A1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
| CA2436832A CA2436832C (en) | 2001-02-01 | 2002-01-21 | Crystal form of a cyclic depsipeptide having improved activity |
| AT02716073T ATE284703T1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
| MXPA03006866A MXPA03006866A (es) | 2001-02-01 | 2002-01-21 | Modificacion cristalina de depsipeptido ciclico con actividad mejorada. |
| HU0302880A HU229229B1 (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| UA2003088108A UA74623C2 (en) | 2001-02-01 | 2002-01-21 | Composition containing crystal modification of cyclic depsipeptide and method for combating endoparasites in animals |
| AU2002226415A AU2002226415B2 (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| PT02716073T PT1357932E (pt) | 2001-02-01 | 2002-01-21 | Modificacao cristalina de um depsipeptido ciclico com eficacia melhorada |
| CZ20032063A CZ299564B6 (cs) | 2001-02-01 | 2002-01-21 | Krystalová modifikace cyklického depsipeptidu se zlepšeným úcinkem |
| HR20030635A HRP20030635A2 (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| ES02716073T ES2233805T3 (es) | 2001-02-01 | 2002-01-21 | Modifcacion cristalina de un depsipetido ciclico con avtividad mejorada. |
| IL15702602A IL157026A0 (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| BRPI0206841-9 BRPI0206841B8 (pt) | 2001-02-01 | 2002-01-21 | aplicação de depsipeptídeo cíclico |
| CNB028044843A CN1278735C (zh) | 2001-02-01 | 2002-01-21 | 具有改进活性的环缩酚肽的晶型 |
| RU2003126589/15A RU2300390C2 (ru) | 2001-02-01 | 2002-01-21 | Кристаллическая модификация циклического депсипептида с улучшенной активностью |
| SI200230082T SI1357932T1 (enExample) | 2001-02-01 | 2002-01-21 | |
| NZ527230A NZ527230A (en) | 2001-02-01 | 2002-01-21 | Crystal form of a cyclic depsipeptide having improved activity |
| DE50201777T DE50201777D1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
| SK988-2003A SK286280B6 (sk) | 2001-02-01 | 2002-01-21 | Použitie depsipeptidu na výrobu liekov |
| JP2002565606A JP2004525111A (ja) | 2001-02-01 | 2002-01-21 | 改良された強度を有する環式デプシペプチドの結晶変態 |
| US10/470,853 US20040115483A1 (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| EP02716073A EP1357932B1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
| KR10-2003-7009110A KR20030081378A (ko) | 2001-02-01 | 2002-01-21 | 강도가 개선된 사이클릭 뎁시펩타이드의 결정 변형체 |
| HK05107422.8A HK1075013B (en) | 2001-02-01 | 2002-01-21 | Crystal modification of a cyclic depsipeptide having improved strength |
| EEP200300365A EE05490B1 (et) | 2001-02-01 | 2002-01-21 | Parendatud toimega tsklilise depsipeptiidi kristallivorm |
| IL157026A IL157026A (en) | 2001-02-01 | 2003-07-21 | Use of Cyclic Depseptide with Improved Strength for the Preparation of a Pharmaceutical Preparation for the Treatment of Pathogenic Endoprosites |
| CR7039A CR7039A (es) | 2001-02-01 | 2003-07-30 | Modificacion cristalina de un depsipeptido ciclico con actividad mejorada |
| NO20033413A NO331289B1 (no) | 2001-02-01 | 2003-07-30 | Anvendelse av krystallmodifisert syklisk depsipeptid for a kontrollere patogene endoparasitter |
| ZA200305864A ZA200305864B (en) | 2001-02-01 | 2003-07-30 | Crystal modification of a cyclic depsipeptide having improved strength. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10104362A DE10104362A1 (de) | 2001-02-01 | 2001-02-01 | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10104362A1 true DE10104362A1 (de) | 2002-08-08 |
Family
ID=7672376
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10104362A Withdrawn DE10104362A1 (de) | 2001-02-01 | 2001-02-01 | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
| DE50201777T Expired - Lifetime DE50201777D1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50201777T Expired - Lifetime DE50201777D1 (de) | 2001-02-01 | 2002-01-21 | Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040115483A1 (enExample) |
| EP (1) | EP1357932B1 (enExample) |
| JP (1) | JP2004525111A (enExample) |
| KR (2) | KR20030081378A (enExample) |
| CN (1) | CN1278735C (enExample) |
| AT (1) | ATE284703T1 (enExample) |
| AU (1) | AU2002226415B2 (enExample) |
| BR (1) | BRPI0206841B8 (enExample) |
| CA (1) | CA2436832C (enExample) |
| CR (1) | CR7039A (enExample) |
| CZ (1) | CZ299564B6 (enExample) |
| DE (2) | DE10104362A1 (enExample) |
| EE (1) | EE05490B1 (enExample) |
| ES (1) | ES2233805T3 (enExample) |
| HR (1) | HRP20030635A2 (enExample) |
| HU (1) | HU229229B1 (enExample) |
| IL (2) | IL157026A0 (enExample) |
| MX (1) | MXPA03006866A (enExample) |
| NO (1) | NO331289B1 (enExample) |
| NZ (1) | NZ527230A (enExample) |
| PL (1) | PL213106B1 (enExample) |
| PT (1) | PT1357932E (enExample) |
| RU (1) | RU2300390C2 (enExample) |
| SK (1) | SK286280B6 (enExample) |
| UA (1) | UA74623C2 (enExample) |
| WO (1) | WO2002066048A1 (enExample) |
| ZA (1) | ZA200305864B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080003546A1 (en) * | 2006-06-29 | 2008-01-03 | Dunbar Kimberly L | Animated digital charted yarncraft instruction |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| CN114262303A (zh) * | 2022-01-04 | 2022-04-01 | 丽珠集团福州福兴医药有限公司 | 一种艾默德斯的单晶型ii及其制备方法 |
| CN114195732A (zh) * | 2022-01-04 | 2022-03-18 | 丽珠集团福州福兴医药有限公司 | 一种艾默德斯的单晶型iii及其制备方法 |
| CN115010680A (zh) * | 2022-07-13 | 2022-09-06 | 丽珠集团福州福兴医药有限公司 | 单晶型i的艾默德斯及其制备方法 |
| CN114989110A (zh) * | 2022-07-13 | 2022-09-02 | 丽珠集团福州福兴医药有限公司 | 单晶型ⅳ的艾默德斯及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2096907A (en) * | 1981-04-22 | 1982-10-27 | Exxon Research Engineering Co | Distillation column with steam stripping |
| DK0634408T3 (da) * | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
| DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| EP0872481B1 (en) * | 1995-06-30 | 2009-03-18 | Astellas Pharma Inc. | Depsipeptide derivative, process for production thereof, and novel intermediate therefor |
| DE69634961T2 (de) * | 1995-09-22 | 2006-04-20 | Bayer Ag | Neue zyklische depsipeptid pf1022 derivate |
| KR100551651B1 (ko) * | 1997-11-10 | 2006-02-13 | 아스텔라스세이야쿠 가부시키가이샤 | 뎁시펩티드 유도체의 신규 결정 및 그의 제조 방법 |
| DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE10031044A1 (de) * | 2000-06-26 | 2002-01-03 | Bayer Ag | Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere |
-
2001
- 2001-02-01 DE DE10104362A patent/DE10104362A1/de not_active Withdrawn
-
2002
- 2002-01-21 AT AT02716073T patent/ATE284703T1/de active
- 2002-01-21 CA CA2436832A patent/CA2436832C/en not_active Expired - Lifetime
- 2002-01-21 BR BRPI0206841-9 patent/BRPI0206841B8/pt not_active IP Right Cessation
- 2002-01-21 HR HR20030635A patent/HRP20030635A2/hr not_active Application Discontinuation
- 2002-01-21 HU HU0302880A patent/HU229229B1/hu unknown
- 2002-01-21 EE EEP200300365A patent/EE05490B1/xx unknown
- 2002-01-21 IL IL15702602A patent/IL157026A0/xx unknown
- 2002-01-21 PT PT02716073T patent/PT1357932E/pt unknown
- 2002-01-21 CZ CZ20032063A patent/CZ299564B6/cs not_active IP Right Cessation
- 2002-01-21 PL PL362389A patent/PL213106B1/pl unknown
- 2002-01-21 JP JP2002565606A patent/JP2004525111A/ja active Pending
- 2002-01-21 KR KR10-2003-7009110A patent/KR20030081378A/ko not_active Ceased
- 2002-01-21 UA UA2003088108A patent/UA74623C2/uk unknown
- 2002-01-21 EP EP02716073A patent/EP1357932B1/de not_active Expired - Lifetime
- 2002-01-21 ES ES02716073T patent/ES2233805T3/es not_active Expired - Lifetime
- 2002-01-21 KR KR1020097006790A patent/KR20090041451A/ko not_active Ceased
- 2002-01-21 DE DE50201777T patent/DE50201777D1/de not_active Expired - Lifetime
- 2002-01-21 AU AU2002226415A patent/AU2002226415B2/en not_active Expired
- 2002-01-21 SK SK988-2003A patent/SK286280B6/sk not_active IP Right Cessation
- 2002-01-21 RU RU2003126589/15A patent/RU2300390C2/ru active
- 2002-01-21 CN CNB028044843A patent/CN1278735C/zh not_active Expired - Lifetime
- 2002-01-21 MX MXPA03006866A patent/MXPA03006866A/es active IP Right Grant
- 2002-01-21 NZ NZ527230A patent/NZ527230A/xx not_active IP Right Cessation
- 2002-01-21 WO PCT/EP2002/000541 patent/WO2002066048A1/de not_active Ceased
- 2002-01-21 US US10/470,853 patent/US20040115483A1/en not_active Abandoned
-
2003
- 2003-07-21 IL IL157026A patent/IL157026A/en unknown
- 2003-07-30 ZA ZA200305864A patent/ZA200305864B/en unknown
- 2003-07-30 CR CR7039A patent/CR7039A/es unknown
- 2003-07-30 NO NO20033413A patent/NO331289B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| 8127 | New person/name/address of the applicant |
Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE |
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| 8139 | Disposal/non-payment of the annual fee |