BR0206841A - Modificação cristalina de um depsipeptìdeo cìclico com melhor eficácia - Google Patents

Modificação cristalina de um depsipeptìdeo cìclico com melhor eficácia

Info

Publication number
BR0206841A
BR0206841A BR0206841-9A BRPI0206841A BR0206841A BR 0206841 A BR0206841 A BR 0206841A BR PI0206841 A BRPI0206841 A BR PI0206841A BR 0206841 A BR0206841 A BR 0206841A
Authority
BR
Brazil
Prior art keywords
crystalline modification
cyclic depsipeptide
better efficacy
cyclic
depsipeptide
Prior art date
Application number
BR0206841-9A
Other languages
English (en)
Inventor
Jochen Kalbe
Michael Traeubel
Achim Harder
Georg Von Samson-Himmelstjerna
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR0206841A publication Critical patent/BR0206841A/pt
Publication of BRPI0206841B1 publication Critical patent/BRPI0206841B1/pt
Publication of BRPI0206841B8 publication Critical patent/BRPI0206841B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MODIFICAçãO CRISTALINA DE UM DEPSIPEPTìDEO CìCLICO COM MELHOR EFICáCIA". A invenção refere-se à aplicação da modificação cristalina (I) do depsipeptídeo cíclico da fórmula (I) para a preparação de medicamentos, especialmente para o combate de endoparasitas.
BRPI0206841-9 2001-02-01 2002-01-21 aplicação de depsipeptídeo cíclico BRPI0206841B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10104362.7 2001-02-01
DE10104362A DE10104362A1 (de) 2001-02-01 2001-02-01 Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit
PCT/EP2002/000541 WO2002066048A1 (de) 2001-02-01 2002-01-21 Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit

Publications (3)

Publication Number Publication Date
BR0206841A true BR0206841A (pt) 2004-02-25
BRPI0206841B1 BRPI0206841B1 (pt) 2018-02-14
BRPI0206841B8 BRPI0206841B8 (pt) 2021-05-25

Family

ID=7672376

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0206841-9 BRPI0206841B8 (pt) 2001-02-01 2002-01-21 aplicação de depsipeptídeo cíclico

Country Status (28)

Country Link
US (1) US20040115483A1 (pt)
EP (1) EP1357932B1 (pt)
JP (1) JP2004525111A (pt)
KR (2) KR20090041451A (pt)
CN (1) CN1278735C (pt)
AT (1) ATE284703T1 (pt)
AU (1) AU2002226415B2 (pt)
BR (1) BRPI0206841B8 (pt)
CA (1) CA2436832C (pt)
CR (1) CR7039A (pt)
CZ (1) CZ299564B6 (pt)
DE (2) DE10104362A1 (pt)
EE (1) EE05490B1 (pt)
ES (1) ES2233805T3 (pt)
HK (1) HK1075013A1 (pt)
HR (1) HRP20030635A2 (pt)
HU (1) HU229229B1 (pt)
IL (2) IL157026A0 (pt)
MX (1) MXPA03006866A (pt)
NO (1) NO331289B1 (pt)
NZ (1) NZ527230A (pt)
PL (1) PL213106B1 (pt)
PT (1) PT1357932E (pt)
RU (1) RU2300390C2 (pt)
SK (1) SK286280B6 (pt)
UA (1) UA74623C2 (pt)
WO (1) WO2002066048A1 (pt)
ZA (1) ZA200305864B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080003546A1 (en) * 2006-06-29 2008-01-03 Dunbar Kimberly L Animated digital charted yarncraft instruction
SI3298027T1 (sl) 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health USA Inc. Antihelmintične depsipeptidne spojine
WO2017116702A1 (en) 2015-12-28 2017-07-06 Merial, Inc. Anthelmintic depsipeptide compounds
CN110167921A (zh) 2016-11-16 2019-08-23 勃林格殷格翰动物保健美国公司 驱蠕虫缩肽化合物
CN114195732A (zh) * 2022-01-04 2022-03-18 丽珠集团福州福兴医药有限公司 一种艾默德斯的单晶型iii及其制备方法
CN114262303A (zh) * 2022-01-04 2022-04-01 丽珠集团福州福兴医药有限公司 一种艾默德斯的单晶型ii及其制备方法
CN114989110A (zh) * 2022-07-13 2022-09-02 丽珠集团福州福兴医药有限公司 单晶型ⅳ的艾默德斯及其制备方法
CN115010680A (zh) * 2022-07-13 2022-09-06 丽珠集团福州福兴医药有限公司 单晶型i的艾默德斯及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2096907A (en) * 1981-04-22 1982-10-27 Exxon Research Engineering Co Distillation column with steam stripping
CA2132199C (en) * 1992-03-17 2000-01-18 Hitoshi Nishiyama Depsipeptide derivative, production thereof and use thereof
DE4317458A1 (de) * 1992-06-11 1993-12-16 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung
DE4400464A1 (de) * 1994-01-11 1995-07-13 Bayer Ag Endoparasitizide Mittel
JP3985050B2 (ja) * 1995-06-30 2007-10-03 アステラス製薬株式会社 デプシペプチド誘導体その製造法およびその新規中間体
CZ295705B6 (cs) * 1995-09-22 2005-10-12 Bayer Aktiengesellschaft Cyklodepsipeptidové deriváty sloučeniny PF1022 a farmaceutický prostředek s jejich obsahem
NZ504812A (en) * 1997-11-10 2002-08-28 Fujisawa Pharmaceutical Co A crystal of a phenyl-morpholino substituted depsipeptide derivative
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
DE10031044A1 (de) * 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere

Also Published As

Publication number Publication date
MXPA03006866A (es) 2004-05-31
PT1357932E (pt) 2005-04-29
IL157026A (en) 2010-11-30
HRP20030635A2 (en) 2005-10-31
EP1357932A1 (de) 2003-11-05
EP1357932B1 (de) 2004-12-15
JP2004525111A (ja) 2004-08-19
KR20030081378A (ko) 2003-10-17
EE200300365A (et) 2003-10-15
ES2233805T3 (es) 2005-06-16
CZ20032063A3 (cs) 2003-11-12
PL213106B1 (pl) 2013-01-31
UA74623C2 (en) 2006-01-16
CA2436832A1 (en) 2002-08-29
EE05490B1 (et) 2011-12-15
CN1278735C (zh) 2006-10-11
NO331289B1 (no) 2011-11-21
BRPI0206841B8 (pt) 2021-05-25
DE50201777D1 (de) 2005-01-20
HK1075013A1 (en) 2005-12-02
SK9882003A3 (en) 2003-12-02
SK286280B6 (sk) 2008-06-06
CA2436832C (en) 2013-06-11
RU2300390C2 (ru) 2007-06-10
CR7039A (es) 2004-06-08
CZ299564B6 (cs) 2008-09-03
NO20033413D0 (no) 2003-07-30
NO20033413L (no) 2003-09-26
IL157026A0 (en) 2004-02-08
KR20090041451A (ko) 2009-04-28
AU2002226415B2 (en) 2007-03-22
HUP0302880A2 (hu) 2003-12-29
BRPI0206841B1 (pt) 2018-02-14
ATE284703T1 (de) 2005-01-15
WO2002066048A8 (de) 2003-11-20
RU2003126589A (ru) 2005-02-27
ZA200305864B (en) 2004-08-27
NZ527230A (en) 2005-04-29
WO2002066048A1 (de) 2002-08-29
PL362389A1 (en) 2004-11-02
CN1592631A (zh) 2005-03-09
HUP0302880A3 (en) 2005-05-30
US20040115483A1 (en) 2004-06-17
DE10104362A1 (de) 2002-08-08
HU229229B1 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
BR0212386A (pt) Composto, formulação farmacêutica, e, uso de um composto
BR0112030A (pt) Novos compostos que possuem atividade antibacteriana, antifúngica ou antitumor
BR0207583A (pt) Derivados de poliamida possuindo atividade antibacteriana, antifungo ou antitumor
SE0302760D0 (sv) New compounds
SE0201544D0 (sv) Novel compounds and thier use
ATE303149T1 (de) Orale pharmazeutische zusammensetzung aus cefpodoxim-proxetil
BR0209127A (pt) compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
NO20065836L (no) Linezolidkrystallform
BR0116217A (pt) Quinolonas antimicrobianas, composição farmacêutica, bem como aplicação farmacêutica das referidas quinolonas
BR0306870A (pt) Composição farmacêutica oral, e, método para preparar a mesma
BR0210028A (pt) Agentes antibacterianos
BRPI0418181A (pt) emprego de 2-aminotetralinas substituìdas para prevenção do tratamento de morbus parkinson
BR0211972A (pt) Composição oftálmica
BR0113590A (pt) 7-oxo-piridopirimidinas
ES2186550A1 (es) Nuevos derivados de oxazolidinonas como antibacterianos.
BR0101230A (pt) Processo para a preparação de11-amino-3-cloro-6,11-diidro-5-5-dioxo-6-metil-dibenzo[c,f][1,2]tiazepina e aplicação para a sìntese detianeptina
BR0212353A (pt) Composto, composição farmacêutica, e, uso de um composto
BRPI0406824A (pt) Indolonaoxazoldinonas antiibacterianas, intermediários para seu preparo e composições farmacêuticas que as contêm
BR0206841A (pt) Modificação cristalina de um depsipeptìdeo cìclico com melhor eficácia
HUP0500439A2 (hu) Propofol vízoldható előgyógyszerét tartalmazó vizes alapú gyógyászati készítmények
WO2002062322A3 (en) Glycine betaine and its use as anti-hemorrhagic agent
MXPA05006889A (es) Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.
BR0114395A (pt) Composição farmacêutica para administração por suprimento via oral
SE9904128D0 (sv) Novel compounds
CY1106964T1 (el) Φαρμακα που περιεχουν ν,ν’-διυποκατεστημενες ενωσεις πιπεραζινης και η χρησιμοποιηση τους

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BAYER ANIMAL HEALTH GMBH (DE)

Free format text: TRANSFERIDO DE: BAYER AKTIENGESELLSCHAFT

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/01/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 21/01/2022