ES2233805T3 - Modifcacion cristalina de un depsipetido ciclico con avtividad mejorada. - Google Patents
Modifcacion cristalina de un depsipetido ciclico con avtividad mejorada.Info
- Publication number
- ES2233805T3 ES2233805T3 ES02716073T ES02716073T ES2233805T3 ES 2233805 T3 ES2233805 T3 ES 2233805T3 ES 02716073 T ES02716073 T ES 02716073T ES 02716073 T ES02716073 T ES 02716073T ES 2233805 T3 ES2233805 T3 ES 2233805T3
- Authority
- ES
- Spain
- Prior art keywords
- spp
- modification
- animals
- cyclic
- depsipetide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000011230 binding agent Substances 0.000 description 1
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- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
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- 235000013330 chicken meat Nutrition 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
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- 239000002706 dry binder Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
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- 210000004907 gland Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
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- 239000002563 ionic surfactant Substances 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
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- 235000013372 meat Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
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- 229920005615 natural polymer Polymers 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
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- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
- 229940043349 potassium metabisulfite Drugs 0.000 description 1
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- 229960002957 praziquantel Drugs 0.000 description 1
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- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
- 229960005134 pyrantel Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 238000003307 slaughter Methods 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
- 239000004544 spot-on Substances 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10104362 | 2001-02-01 | ||
| DE10104362A DE10104362A1 (de) | 2001-02-01 | 2001-02-01 | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2233805T3 true ES2233805T3 (es) | 2005-06-16 |
Family
ID=7672376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02716073T Expired - Lifetime ES2233805T3 (es) | 2001-02-01 | 2002-01-21 | Modifcacion cristalina de un depsipetido ciclico con avtividad mejorada. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040115483A1 (enExample) |
| EP (1) | EP1357932B1 (enExample) |
| JP (1) | JP2004525111A (enExample) |
| KR (2) | KR20030081378A (enExample) |
| CN (1) | CN1278735C (enExample) |
| AT (1) | ATE284703T1 (enExample) |
| AU (1) | AU2002226415B2 (enExample) |
| BR (1) | BRPI0206841B8 (enExample) |
| CA (1) | CA2436832C (enExample) |
| CR (1) | CR7039A (enExample) |
| CZ (1) | CZ299564B6 (enExample) |
| DE (2) | DE10104362A1 (enExample) |
| EE (1) | EE05490B1 (enExample) |
| ES (1) | ES2233805T3 (enExample) |
| HR (1) | HRP20030635A2 (enExample) |
| HU (1) | HU229229B1 (enExample) |
| IL (2) | IL157026A0 (enExample) |
| MX (1) | MXPA03006866A (enExample) |
| NO (1) | NO331289B1 (enExample) |
| NZ (1) | NZ527230A (enExample) |
| PL (1) | PL213106B1 (enExample) |
| PT (1) | PT1357932E (enExample) |
| RU (1) | RU2300390C2 (enExample) |
| SK (1) | SK286280B6 (enExample) |
| UA (1) | UA74623C2 (enExample) |
| WO (1) | WO2002066048A1 (enExample) |
| ZA (1) | ZA200305864B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080003546A1 (en) * | 2006-06-29 | 2008-01-03 | Dunbar Kimberly L | Animated digital charted yarncraft instruction |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| CN114262303A (zh) * | 2022-01-04 | 2022-04-01 | 丽珠集团福州福兴医药有限公司 | 一种艾默德斯的单晶型ii及其制备方法 |
| CN114195732A (zh) * | 2022-01-04 | 2022-03-18 | 丽珠集团福州福兴医药有限公司 | 一种艾默德斯的单晶型iii及其制备方法 |
| CN115010680A (zh) * | 2022-07-13 | 2022-09-06 | 丽珠集团福州福兴医药有限公司 | 单晶型i的艾默德斯及其制备方法 |
| CN114989110A (zh) * | 2022-07-13 | 2022-09-02 | 丽珠集团福州福兴医药有限公司 | 单晶型ⅳ的艾默德斯及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2096907A (en) * | 1981-04-22 | 1982-10-27 | Exxon Research Engineering Co | Distillation column with steam stripping |
| DK0634408T3 (da) * | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
| DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
| DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| EP0872481B1 (en) * | 1995-06-30 | 2009-03-18 | Astellas Pharma Inc. | Depsipeptide derivative, process for production thereof, and novel intermediate therefor |
| DE69634961T2 (de) * | 1995-09-22 | 2006-04-20 | Bayer Ag | Neue zyklische depsipeptid pf1022 derivate |
| KR100551651B1 (ko) * | 1997-11-10 | 2006-02-13 | 아스텔라스세이야쿠 가부시키가이샤 | 뎁시펩티드 유도체의 신규 결정 및 그의 제조 방법 |
| DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE10031044A1 (de) * | 2000-06-26 | 2002-01-03 | Bayer Ag | Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere |
-
2001
- 2001-02-01 DE DE10104362A patent/DE10104362A1/de not_active Withdrawn
-
2002
- 2002-01-21 AT AT02716073T patent/ATE284703T1/de active
- 2002-01-21 CA CA2436832A patent/CA2436832C/en not_active Expired - Lifetime
- 2002-01-21 BR BRPI0206841-9 patent/BRPI0206841B8/pt not_active IP Right Cessation
- 2002-01-21 HR HR20030635A patent/HRP20030635A2/hr not_active Application Discontinuation
- 2002-01-21 HU HU0302880A patent/HU229229B1/hu unknown
- 2002-01-21 EE EEP200300365A patent/EE05490B1/xx unknown
- 2002-01-21 IL IL15702602A patent/IL157026A0/xx unknown
- 2002-01-21 PT PT02716073T patent/PT1357932E/pt unknown
- 2002-01-21 CZ CZ20032063A patent/CZ299564B6/cs not_active IP Right Cessation
- 2002-01-21 PL PL362389A patent/PL213106B1/pl unknown
- 2002-01-21 JP JP2002565606A patent/JP2004525111A/ja active Pending
- 2002-01-21 KR KR10-2003-7009110A patent/KR20030081378A/ko not_active Ceased
- 2002-01-21 UA UA2003088108A patent/UA74623C2/uk unknown
- 2002-01-21 EP EP02716073A patent/EP1357932B1/de not_active Expired - Lifetime
- 2002-01-21 ES ES02716073T patent/ES2233805T3/es not_active Expired - Lifetime
- 2002-01-21 KR KR1020097006790A patent/KR20090041451A/ko not_active Ceased
- 2002-01-21 DE DE50201777T patent/DE50201777D1/de not_active Expired - Lifetime
- 2002-01-21 AU AU2002226415A patent/AU2002226415B2/en not_active Expired
- 2002-01-21 SK SK988-2003A patent/SK286280B6/sk not_active IP Right Cessation
- 2002-01-21 RU RU2003126589/15A patent/RU2300390C2/ru active
- 2002-01-21 CN CNB028044843A patent/CN1278735C/zh not_active Expired - Lifetime
- 2002-01-21 MX MXPA03006866A patent/MXPA03006866A/es active IP Right Grant
- 2002-01-21 NZ NZ527230A patent/NZ527230A/xx not_active IP Right Cessation
- 2002-01-21 WO PCT/EP2002/000541 patent/WO2002066048A1/de not_active Ceased
- 2002-01-21 US US10/470,853 patent/US20040115483A1/en not_active Abandoned
-
2003
- 2003-07-21 IL IL157026A patent/IL157026A/en unknown
- 2003-07-30 ZA ZA200305864A patent/ZA200305864B/en unknown
- 2003-07-30 CR CR7039A patent/CR7039A/es unknown
- 2003-07-30 NO NO20033413A patent/NO331289B1/no not_active IP Right Cessation
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