DD267739A5 - Verfahren zur Herstellung eines zu Hefe heterologen Poly-Peptids - Google Patents
Verfahren zur Herstellung eines zu Hefe heterologen Poly-Peptids Download PDFInfo
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- DD267739A5 DD267739A5 DD31325586A DD31325586A DD267739A5 DD 267739 A5 DD267739 A5 DD 267739A5 DD 31325586 A DD31325586 A DD 31325586A DD 31325586 A DD31325586 A DD 31325586A DD 267739 A5 DD267739 A5 DD 267739A5
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- German Democratic Republic
- Prior art keywords
- dna
- yeast
- promoter
- hybrid
- fragment
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Alcoholic Beverages (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Graft Or Block Polymers (AREA)
- Enzymes And Modification Thereof (AREA)
- Led Devices (AREA)
- Gyroscopes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858521496A GB8521496D0 (en) | 1985-08-29 | 1985-08-29 | Repressible yeast promoters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD267739A5 true DD267739A5 (de) | 1989-05-10 |
Family
ID=10584428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| DD29389486A DD254212A5 (de) | 1985-08-29 | 1986-08-27 | Verfahren zur herstellung eines hefehybrivectors, der einen oder mehrere DNS-inserts enthalt |
| DD31325586A DD267739A5 (de) | 1985-08-29 | 1986-08-27 | Verfahren zur Herstellung eines zu Hefe heterologen Poly-Peptids |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD29389486A DD254212A5 (de) | 1985-08-29 | 1986-08-27 | Verfahren zur herstellung eines hefehybrivectors, der einen oder mehrere DNS-inserts enthalt |
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| Country | Link |
|---|---|
| US (1) | US5436136A (ja) |
| EP (1) | EP0213593B1 (ja) |
| JP (1) | JPH07110233B2 (ja) |
| AT (1) | ATE62510T1 (ja) |
| AU (1) | AU599329B2 (ja) |
| CA (1) | CA1318616C (ja) |
| DD (2) | DD254212A5 (ja) |
| DE (1) | DE3678647D1 (ja) |
| DK (1) | DK175093B1 (ja) |
| ES (3) | ES2001618A6 (ja) |
| FI (1) | FI91280C (ja) |
| GB (1) | GB8521496D0 (ja) |
| GR (1) | GR862209B (ja) |
| HU (1) | HU211207B (ja) |
| IE (1) | IE58844B1 (ja) |
| IL (1) | IL79837A (ja) |
| NO (1) | NO175871C (ja) |
| NZ (1) | NZ217388A (ja) |
| PH (1) | PH24715A (ja) |
| PT (1) | PT83273B (ja) |
| SU (1) | SU1630616A3 (ja) |
| ZA (1) | ZA866535B (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987003008A1 (en) * | 1985-11-13 | 1987-05-21 | International Genetic Engineering, Inc. | Shortened phosphoglycerate kinase promoter |
| GB8530631D0 (en) | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
| MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
| GB8620926D0 (en) * | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| GB8907110D0 (en) * | 1988-05-04 | 1989-05-10 | Ciba Geigy Ag | Improvements in the production of polypeptides |
| NO177065C (no) * | 1988-09-26 | 1995-07-12 | Labofina Sa | Framgangsmåte for framstilling av enzymatisk aktivt humant lysozym |
| JPH06500470A (ja) * | 1990-09-04 | 1994-01-20 | メルク エンド カンパニー インコーポレーテッド | メチロトローフ酵母細胞におけるインスリン様成長因子の産生 |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| DE69232666T2 (de) * | 1991-04-01 | 2003-03-20 | Merck & Co., Inc. | Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung |
| US5674728A (en) * | 1993-11-03 | 1997-10-07 | Novartis Corporation | Aspergillus niger vacuolar aspartyl protease |
| JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
| DE69731960T2 (de) * | 1996-09-24 | 2005-12-15 | Cadus Pharmaceutical Corp. | Verfahren und zusammensetzungen für die identifizierung von receptor effectoren |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| US6890730B1 (en) | 1999-12-10 | 2005-05-10 | The Salk Institute | Sequence and method for increasing protein expression in cellular expression systems |
| US8008459B2 (en) * | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| EP2571991A1 (en) | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
| CA3180326A1 (en) | 2020-04-20 | 2021-10-28 | Vestaron Corporation | Proteolytically stable u1-agatoxin-ta1b variant polypeptides for pest control |
| CN116096236A (zh) | 2020-05-01 | 2023-05-09 | 韦斯塔隆公司 | 杀昆虫组合 |
| IL307293A (en) | 2021-04-01 | 2023-11-01 | Vestaron Corp | AV3 mutant polypeptides for pest control |
| WO2023122805A1 (en) | 2021-12-20 | 2023-06-29 | Vestaron Corporation | Sorbitol driven selection pressure method |
| WO2023225555A1 (en) | 2022-05-18 | 2023-11-23 | Vestaron Corporation | Pesticidal actx peptide variants |
| WO2023245100A1 (en) | 2022-06-17 | 2023-12-21 | Vestaron Corporation | Antimicrobial ncr13 variant peptides |
| WO2024026406A2 (en) | 2022-07-29 | 2024-02-01 | Vestaron Corporation | Next Generation ACTX Peptides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2125047B (en) * | 1982-08-09 | 1986-02-19 | Ciba Geigy Ag | Yeast hybrid vectors and their use for the production of polypeptides |
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| US4876197A (en) * | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| DE3485810T2 (de) * | 1983-05-27 | 1992-12-10 | Texas A & M University Syst | Verfahren zur herstellung eines rekombinanten baculovirus-expressionsvektors. |
| GB8314961D0 (en) * | 1983-05-31 | 1983-07-06 | Kingsman A J | Dna sequence |
| EP0143081B1 (en) * | 1983-11-21 | 1989-08-23 | Ciba-Geigy Ag | Synthesis of tissue plasminogen activator(tpa) by yeast |
| EP0164566A3 (de) * | 1984-05-11 | 1986-10-29 | LGA Gastechnik GmbH | Sicherheitseinrichtung für Flüssiggastanks |
| ATE102250T1 (de) * | 1984-05-11 | 1994-03-15 | Chiron Corp | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
| US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
-
1985
- 1985-08-29 GB GB858521496A patent/GB8521496D0/en active Pending
-
1986
- 1986-08-25 IL IL79837A patent/IL79837A/xx not_active IP Right Cessation
- 1986-08-25 FI FI863430A patent/FI91280C/fi not_active IP Right Cessation
- 1986-08-26 DE DE8686111820T patent/DE3678647D1/de not_active Expired - Lifetime
- 1986-08-26 AT AT86111820T patent/ATE62510T1/de not_active IP Right Cessation
- 1986-08-26 EP EP86111820A patent/EP0213593B1/en not_active Expired - Lifetime
- 1986-08-27 CA CA000516879A patent/CA1318616C/en not_active Expired - Lifetime
- 1986-08-27 DD DD29389486A patent/DD254212A5/de not_active IP Right Cessation
- 1986-08-27 DD DD31325586A patent/DD267739A5/de unknown
- 1986-08-27 GR GR862209A patent/GR862209B/el unknown
- 1986-08-28 PH PH34192A patent/PH24715A/en unknown
- 1986-08-28 HU HU863720A patent/HU211207B/hu unknown
- 1986-08-28 PT PT83273A patent/PT83273B/pt unknown
- 1986-08-28 NZ NZ217388A patent/NZ217388A/xx unknown
- 1986-08-28 DK DK198604096A patent/DK175093B1/da not_active IP Right Cessation
- 1986-08-28 IE IE230786A patent/IE58844B1/en not_active IP Right Cessation
- 1986-08-28 SU SU864028035A patent/SU1630616A3/ru active
- 1986-08-28 AU AU62032/86A patent/AU599329B2/en not_active Expired
- 1986-08-28 NO NO863458A patent/NO175871C/no not_active IP Right Cessation
- 1986-08-28 ZA ZA866535A patent/ZA866535B/xx unknown
- 1986-08-29 ES ES8601490A patent/ES2001618A6/es not_active Expired
- 1986-08-29 JP JP61201924A patent/JPH07110233B2/ja not_active Expired - Lifetime
-
1988
- 1988-03-16 ES ES8800794A patent/ES2006382A6/es not_active Expired
- 1988-03-16 ES ES8800795A patent/ES2006383A6/es not_active Expired
-
1991
- 1991-12-20 US US07/811,898 patent/US5436136A/en not_active Expired - Lifetime
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