DE3751081T2 - [Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung. - Google Patents

[Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung.

Info

Publication number
DE3751081T2
DE3751081T2 DE3751081T DE3751081T DE3751081T2 DE 3751081 T2 DE3751081 T2 DE 3751081T2 DE 3751081 T DE3751081 T DE 3751081T DE 3751081 T DE3751081 T DE 3751081T DE 3751081 T2 DE3751081 T2 DE 3751081T2
Authority
DE
Germany
Prior art keywords
motilin
leu
production
dna molecules
coding dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751081T
Other languages
English (en)
Other versions
DE3751081D1 (de
Inventor
Shinkichi Honda
Tatsunari Nishi
Seiga Itoh
Moriyuki Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3751081D1 publication Critical patent/DE3751081D1/de
Publication of DE3751081T2 publication Critical patent/DE3751081T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/63—Motilins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
DE3751081T 1986-09-12 1987-09-11 [Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung. Expired - Fee Related DE3751081T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61215088A JP2862870B2 (ja) 1986-09-12 1986-09-12 新規ペプチド
JP5192104A JP2634132B2 (ja) 1986-09-12 1993-08-03 新規ペプチド

Publications (2)

Publication Number Publication Date
DE3751081D1 DE3751081D1 (de) 1995-03-30
DE3751081T2 true DE3751081T2 (de) 1995-10-19

Family

ID=26507110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751081T Expired - Fee Related DE3751081T2 (de) 1986-09-12 1987-09-11 [Leu 13] Motilin, dessen kodierende DNS-Moleküle und Verfahren zu dessen Herstellung.

Country Status (4)

Country Link
EP (1) EP0259891B1 (de)
JP (2) JP2862870B2 (de)
CA (1) CA1339464C (de)
DE (1) DE3751081T2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2575022B2 (ja) * 1987-05-07 1997-01-22 株式会社 三和化学研究所 ヒトモチリン前駆体、該前駆体含有クローン化ｄｎａ、その調製法並びに該クローン化ｄｎａが組込まれたプラスミド
JP2753274B2 (ja) * 1988-08-24 1998-05-18 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
US5459049A (en) * 1989-01-06 1995-10-17 Sanwa Kagaku Kenkyushko Co., Ltd. Motilin-like polypeptide and use thereof
JPH0722517B2 (ja) * 1989-08-24 1995-03-15 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
JPH0742319B2 (ja) * 1989-01-06 1995-05-10 株式会社三和化学研究所 モチリン様活性を有するポリペプチド及びその用途
EP0378078A1 (de) * 1989-01-06 1990-07-18 Sanwa Kagaku Kenkyusho Co., Ltd. Dem Motilin ähnliches Polypeptid und seine Verwendung
ES2063406T3 (es) * 1990-06-26 1995-01-01 Sanwa Kagaku Kenkyusho Co Procedimiento para la preparacion de analogos de polipeptido intestinal vasoactivo.
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
JPH0740926B2 (ja) * 1990-10-09 1995-05-10 エム・ディ・リサーチ株式会社 形質転換体およびペプチド前駆体タンパク質の製造方法
EP0638089B2 (de) † 1992-04-15 2008-03-05 The Johns Hopkins University Synthese von verschiedenen und nützlichen oligonukleotidsammlungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5239670A (en) * 1975-09-22 1977-03-28 Eisai Co Ltd Process for synthesizing motilin
DE2544348C3 (de) * 1975-10-03 1979-12-13 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen L-Leucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
WO1986007383A1 (en) * 1985-06-04 1986-12-18 Biotechnology Research Partners, Ltd. Autoantigen vaccines

Also Published As

Publication number Publication date
CA1339464C (en) 1997-09-16
JP2862870B2 (ja) 1999-03-03
EP0259891B1 (de) 1995-02-22
EP0259891A3 (en) 1989-08-09
JPS6371195A (ja) 1988-03-31
EP0259891A2 (de) 1988-03-16
JPH0690759A (ja) 1994-04-05
DE3751081D1 (de) 1995-03-30
JP2634132B2 (ja) 1997-07-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee