DD263980A5 - Verfahren zur herstellung von neuen diphenyl-propylamin-derivaten - Google Patents

Verfahren zur herstellung von neuen diphenyl-propylamin-derivaten Download PDF

Info

Publication number
DD263980A5
DD263980A5 DD87304844A DD30484487A DD263980A5 DD 263980 A5 DD263980 A5 DD 263980A5 DD 87304844 A DD87304844 A DD 87304844A DD 30484487 A DD30484487 A DD 30484487A DD 263980 A5 DD263980 A5 DD 263980A5
Authority
DD
German Democratic Republic
Prior art keywords
diphenyl
general formula
azahexane
hydrogen
group
Prior art date
Application number
DD87304844A
Other languages
German (de)
English (en)
Inventor
Dezsoe Korbonits
Pal Kiss
Laszlo Szekeres
Gyula Papp
Gabor Kovacs
Andrea Santa
Sandor Virag
Eva Udvari
Imre Bata
Katalin Marmarost
Laszlo Tardos
Peter Koermoeczy
Vera Gergely
Zoltan Vargai
Original Assignee
��������@��@����������@��@��@����������@���������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ��������@��@����������@��@��@����������@���������k�� filed Critical ��������@��@����������@��@��@����������@���������k��
Publication of DD263980A5 publication Critical patent/DD263980A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
DD87304844A 1986-07-11 1987-07-10 Verfahren zur herstellung von neuen diphenyl-propylamin-derivaten DD263980A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862873A HU200591B (en) 1986-07-11 1986-07-11 Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds

Publications (1)

Publication Number Publication Date
DD263980A5 true DD263980A5 (de) 1989-01-18

Family

ID=55982790

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87304844A DD263980A5 (de) 1986-07-11 1987-07-10 Verfahren zur herstellung von neuen diphenyl-propylamin-derivaten

Country Status (28)

Country Link
US (1) US4988730A (xx)
EP (1) EP0253327B1 (xx)
JP (1) JP2637737B2 (xx)
KR (1) KR910000864B1 (xx)
CN (1) CN1019571B (xx)
AT (1) ATE75722T1 (xx)
AU (1) AU599117B2 (xx)
CA (1) CA1335104C (xx)
CS (1) CS271343B2 (xx)
DD (1) DD263980A5 (xx)
DE (1) DE3778770D1 (xx)
DK (1) DK360187A (xx)
ES (1) ES2032778T3 (xx)
FI (1) FI95128C (xx)
GR (1) GR3004518T3 (xx)
HR (1) HRP930508A2 (xx)
HU (1) HU200591B (xx)
IE (1) IE60028B1 (xx)
IL (1) IL83044A (xx)
NO (1) NO167658C (xx)
NZ (1) NZ221036A (xx)
PH (1) PH24514A (xx)
PL (1) PL150887B1 (xx)
PT (1) PT85304B (xx)
SI (1) SI8711299A8 (xx)
SU (2) SU1597096A3 (xx)
YU (1) YU46559B (xx)
ZA (1) ZA874812B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
GB8823203D0 (en) * 1988-10-04 1988-11-09 Pfizer Ltd Therapeutic agents
JPH04329415A (ja) * 1991-04-30 1992-11-18 Fujitsu Ltd カード型入出力インタフェース装置及びシステム
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
KR100251995B1 (ko) * 1991-08-23 2000-06-01 젠센 제임스 유. 칼슘 수용체 활성 분자
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5198548A (en) * 1992-01-30 1993-03-30 Warner-Lambert Company Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
ATE267009T1 (de) * 1993-02-23 2004-06-15 Brigham & Womens Hospital Calciumrezeptoraktive moleküle
US5492933A (en) * 1993-10-08 1996-02-20 Sepracor, Inc. Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof
EP1275635A1 (en) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
ATE352537T1 (de) 1996-05-01 2007-02-15 Nps Pharma Inc Verbindungen, die auf anorganische ionen- rezeptoren wirken
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
US6124507A (en) 1997-12-10 2000-09-26 Union Carbide Chemicals & Plastics Technology Corporation Electron donors
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH462189A (de) 1961-08-10 1968-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von substituierten Propylaminderivaten
DE1171930B (de) * 1961-08-10 1964-06-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von koronardilatent wirksamen substituierten Propylaminderivaten
GB1032650A (en) * 1962-05-24 1966-06-15 Chinoin Gyogyszer Es Vegyeszet Improvements in or relating to diphenyl-propylamine derivatives
DD122967A1 (de) * 1975-07-10 1976-11-12 Lothar Luecke Hylamin-derivate

Also Published As

Publication number Publication date
IE871866L (en) 1988-01-11
CS511987A2 (en) 1989-08-14
HU200591B (en) 1990-07-28
SU1597096A3 (ru) 1990-09-30
AU599117B2 (en) 1990-07-12
NO167658B (no) 1991-08-19
EP0253327A3 (en) 1988-11-30
NO872880D0 (no) 1987-07-10
KR880001573A (ko) 1988-04-25
YU46559B (sh) 1993-11-16
FI95128C (fi) 1995-12-27
AU7552687A (en) 1988-01-14
PL266759A1 (en) 1988-09-01
NO872880L (no) 1988-01-12
NZ221036A (en) 1990-05-28
PH24514A (en) 1990-07-18
PT85304B (pt) 1990-03-30
IL83044A0 (en) 1987-12-31
GR3004518T3 (xx) 1993-04-28
CS271343B2 (en) 1990-09-12
EP0253327B1 (de) 1992-05-06
DK360187A (da) 1988-01-12
CA1335104C (en) 1995-04-04
PT85304A (en) 1987-08-01
PL150887B1 (en) 1990-07-31
HRP930508A2 (en) 1995-02-28
ATE75722T1 (de) 1992-05-15
SI8711299A8 (en) 1996-08-31
JPS6372657A (ja) 1988-04-02
IE60028B1 (en) 1994-05-18
FI873069A0 (fi) 1987-07-10
HUT46651A (en) 1988-11-28
SU1588740A1 (ru) 1990-08-30
NO167658C (no) 1991-11-27
KR910000864B1 (ko) 1991-02-11
CN87104753A (zh) 1988-06-15
DE3778770D1 (de) 1992-06-11
JP2637737B2 (ja) 1997-08-06
FI95128B (fi) 1995-09-15
ZA874812B (en) 1988-10-26
YU129987A (en) 1988-06-30
DK360187D0 (da) 1987-07-10
ES2032778T3 (es) 1993-03-01
EP0253327A2 (de) 1988-01-20
CN1019571B (zh) 1992-12-23
US4988730A (en) 1991-01-29
IL83044A (en) 1991-09-16
FI873069A (fi) 1988-01-12

Similar Documents

Publication Publication Date Title
DD263980A5 (de) Verfahren zur herstellung von neuen diphenyl-propylamin-derivaten
DE1643262C3 (de) i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2615406A1 (de) Beta-adrenergische rezeptoren-blocker
DE3114239C2 (de) N↑4↑-Carbamoylpiperazinpropanolderivate, Verfahren zu ihrer Herstellung und pharmazeutisches Mittel
DE3309596A1 (de) 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel
DE2037852A1 (de) Neue Piperazindenvate und Ver fahren zu ihrer Herstellung
CH372667A (de) Verfahren zur Herstellung von 3-Aryl-3-pyrrolidinolen
DE1445904A1 (de) Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen
EP0105210B1 (de) Isochinolinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen und ihre Verwendung
CH640227A5 (de) Aminoalkoxyphenyl-derivate.
EP0284914B1 (de) Benzofuranderivate und diese enthaltende therapeutische Mittel
DE1620016C3 (de) 3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung
EP0027928B1 (de) Piperidinderivate von 4,5-Dialkyl-3-hydroxy-pyrrol-2-carbonsäureestern, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2619617C2 (xx)
DE3727736A1 (de) Neue benzofuranderivate und diese enthaltende therapeutische mittel
EP0778274A1 (de) Amidinohydrazone vom Benzo(b)furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0030688B1 (de) Piperidinderivate von 3-Hydroxy-thiophen-2-carbonsäureestern, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0152556A1 (de) Aminopropanolderivate von substituierten 2-Hydroxy-propiophenonen, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
DE2403809C2 (de) 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate
DE1793799C2 (de) 1 -Phenoxy^-hydroxyO-alkylaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DD153682A1 (de) Verfahren zur herstellung neuer alkanolamine
DE4000213A1 (de) O-hydroxy-ss-(1-naphthyl)-propiophenonderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE1543369C3 (de) l-Aryloxy-2-aminoalkane und pharmazeutische Präparate auf deren Basis
DE1543673C3 (de) Basisch substituierte Benzofuranderivate und deren pharmazeutisch verträgliche Säureadditionssalze sowie Verfahren zu deren Herstellung und Arzneimittel mit einem Gehalt dieser Verbindungen
AT243792B (de) Verfahren zur Herstellung von neuen 4-Imidazolidon-Verbindungen

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee