YU46559B - Postupak za dobivanje novih derivata difenilpropilamina - Google Patents
Postupak za dobivanje novih derivata difenilpropilaminaInfo
- Publication number
- YU46559B YU46559B YU129987A YU129987A YU46559B YU 46559 B YU46559 B YU 46559B YU 129987 A YU129987 A YU 129987A YU 129987 A YU129987 A YU 129987A YU 46559 B YU46559 B YU 46559B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- denotes
- denotes hydrogen
- hydrogen
- preparation
- benzyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
Abstract
POSTUPAK ZA DOBIVANJE NOVIH DERIVATA DIFENILPROPILAMINA, opšte formule I: gde R1 je vodonik ili metil grupa, R2 je vodonik, metil ili n-decil grupa, Z je fenil grupa supstituisana sa R3, R4 i R5, gde R3 je vodonik, fluor, hlor ili brom ili nitro, C1-12alkil, C1-4alkoksi, fenoksi ili benziloksi grupa, R4 i R5 predstavljaju vodonik, hlor ili hidroksi, alkoksi, benziloksi grupu, ili R4 i R5 zajedno grade metilendioksi grupu ili Z može biti 4-metoksinafdtil ili 4-etoksinaftil grupa, i R6 je vodonik ili fluor, uz ograničenje da svaki od R1, R2, R3, R4, R5 i R6, be nigz ustivremeno biti vodonik kada R2 je metil, kao i njihovih fiziološki prihvatljivih adicionih soli, naznačen time, što se defenilpropilaminski derivat opšte formule II gde je A je vodonik, i R6 je kao što je definisano napred podvrgava reduktivnoj kondenzacionoj reakciji sa ketonom opšte formule II gde je R2 i Z su kao što je definisano napred, u jednom stupnju ili, ako se želi, u dva stupnja, u organskom rastvaraču ili sredini bez rastvarača na temperaturi od 20-90В°C pod pritiskom od 100 do 1 000 000 Pa i ako se želi jedinjenje opšte formule I, gde je R1 je vodonik i R2, R3, R4, R5, R6 i Z su kao što je definisano napred se prevodi u tercijerni amin metilovanjem na azotu i ako se želi tako dobiveno jedinjenje opšte formule I se prevodi u adicionu so kiseline sa neorganskom ili organskom kiselinom.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI8711299A SI8711299A8 (en) | 1986-07-11 | 1987-07-10 | Process for preparing new diphenylpropylamine derivatives |
HR930508A HRP930508A2 (en) | 1986-07-11 | 1993-03-24 | Difenilpropilamina process for the preparation of the novel enylpropylamine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU862873A HU200591B (en) | 1986-07-11 | 1986-07-11 | Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
YU129987A YU129987A (en) | 1988-06-30 |
YU46559B true YU46559B (sh) | 1993-11-16 |
Family
ID=55982790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU129987A YU46559B (sh) | 1986-07-11 | 1987-07-10 | Postupak za dobivanje novih derivata difenilpropilamina |
Country Status (28)
Country | Link |
---|---|
US (1) | US4988730A (sh) |
EP (1) | EP0253327B1 (sh) |
JP (1) | JP2637737B2 (sh) |
KR (1) | KR910000864B1 (sh) |
CN (1) | CN1019571B (sh) |
AT (1) | ATE75722T1 (sh) |
AU (1) | AU599117B2 (sh) |
CA (1) | CA1335104C (sh) |
CS (1) | CS271343B2 (sh) |
DD (1) | DD263980A5 (sh) |
DE (1) | DE3778770D1 (sh) |
DK (1) | DK360187A (sh) |
ES (1) | ES2032778T3 (sh) |
FI (1) | FI95128C (sh) |
GR (1) | GR3004518T3 (sh) |
HR (1) | HRP930508A2 (sh) |
HU (1) | HU200591B (sh) |
IE (1) | IE60028B1 (sh) |
IL (1) | IL83044A (sh) |
NO (1) | NO167658C (sh) |
NZ (1) | NZ221036A (sh) |
PH (1) | PH24514A (sh) |
PL (1) | PL150887B1 (sh) |
PT (1) | PT85304B (sh) |
SI (1) | SI8711299A8 (sh) |
SU (2) | SU1597096A3 (sh) |
YU (1) | YU46559B (sh) |
ZA (1) | ZA874812B (sh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1205124B (it) * | 1987-06-05 | 1989-03-15 | Simens Soteta Italiana Medicin | Composto attivo nella terapia carciovascolare |
GB8823203D0 (en) * | 1988-10-04 | 1988-11-09 | Pfizer Ltd | Therapeutic agents |
JPH04329415A (ja) * | 1991-04-30 | 1992-11-18 | Fujitsu Ltd | カード型入出力インタフェース装置及びシステム |
US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6011068A (en) * | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5688938A (en) * | 1991-08-23 | 1997-11-18 | The Brigham & Women's Hospital, Inc. | Calcium receptor-active molecules |
US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5763569A (en) * | 1991-08-23 | 1998-06-09 | The Brigham And Women's Hospital, Inc | Calcium receptor-active molecules |
JP2728564B2 (ja) * | 1991-08-23 | 1998-03-18 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | カルシウム受容体活性化分子 |
US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5858684A (en) * | 1991-08-23 | 1999-01-12 | The Brigham And Women's Hospital, Inc. | Method of screening calcium receptor-active molecules |
US5198548A (en) * | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
ATE267009T1 (de) * | 1993-02-23 | 2004-06-15 | Brigham & Womens Hospital | Calciumrezeptoraktive moleküle |
US5962314A (en) * | 1993-02-23 | 1999-10-05 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5492933A (en) * | 1993-10-08 | 1996-02-20 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof |
KR100293621B1 (ko) | 1994-10-21 | 2001-11-26 | 젠센, 제임스 유. | 칼슘수용체-활성화합물 |
ES2201300T3 (es) * | 1996-05-01 | 2004-03-16 | Nps Pharmaceuticals, Inc. | Compuestos activos frente a receptores de iones inorganicos. |
SE9701144D0 (sv) * | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
US6124507A (en) * | 1997-12-10 | 2000-09-26 | Union Carbide Chemicals & Plastics Technology Corporation | Electron donors |
EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
FR2902789A1 (fr) * | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1171930B (de) * | 1961-08-10 | 1964-06-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von koronardilatent wirksamen substituierten Propylaminderivaten |
CH462189A (de) * | 1961-08-10 | 1968-09-15 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von substituierten Propylaminderivaten |
GB1032650A (en) * | 1962-05-24 | 1966-06-15 | Chinoin Gyogyszer Es Vegyeszet | Improvements in or relating to diphenyl-propylamine derivatives |
DD122967A1 (de) * | 1975-07-10 | 1976-11-12 | Lothar Luecke | Hylamin-derivate |
-
1986
- 1986-07-11 HU HU862873A patent/HU200591B/hu not_active IP Right Cessation
-
1987
- 1987-07-01 IL IL83044A patent/IL83044A/xx unknown
- 1987-07-02 ZA ZA874812A patent/ZA874812B/xx unknown
- 1987-07-06 CS CS875119A patent/CS271343B2/cs unknown
- 1987-07-07 PH PH35508A patent/PH24514A/en unknown
- 1987-07-10 IE IE186687A patent/IE60028B1/en not_active IP Right Cessation
- 1987-07-10 EP EP87109989A patent/EP0253327B1/de not_active Expired - Lifetime
- 1987-07-10 PL PL1987266759A patent/PL150887B1/pl unknown
- 1987-07-10 SI SI8711299A patent/SI8711299A8/sl unknown
- 1987-07-10 NZ NZ221036A patent/NZ221036A/xx unknown
- 1987-07-10 JP JP62172731A patent/JP2637737B2/ja not_active Expired - Lifetime
- 1987-07-10 YU YU129987A patent/YU46559B/sh unknown
- 1987-07-10 DE DE8787109989T patent/DE3778770D1/de not_active Expired - Fee Related
- 1987-07-10 SU SU874202957A patent/SU1597096A3/ru active
- 1987-07-10 PT PT85304A patent/PT85304B/pt not_active IP Right Cessation
- 1987-07-10 CA CA000541775A patent/CA1335104C/en not_active Expired - Fee Related
- 1987-07-10 FI FI873069A patent/FI95128C/fi not_active IP Right Cessation
- 1987-07-10 ES ES198787109989T patent/ES2032778T3/es not_active Expired - Lifetime
- 1987-07-10 NO NO872880A patent/NO167658C/no unknown
- 1987-07-10 DK DK360187A patent/DK360187A/da not_active Application Discontinuation
- 1987-07-10 DD DD87304844A patent/DD263980A5/de not_active IP Right Cessation
- 1987-07-10 AU AU75526/87A patent/AU599117B2/en not_active Ceased
- 1987-07-10 AT AT87109989T patent/ATE75722T1/de not_active IP Right Cessation
- 1987-07-11 KR KR1019870007467A patent/KR910000864B1/ko not_active IP Right Cessation
- 1987-07-11 CN CN87104753A patent/CN1019571B/zh not_active Expired
-
1988
- 1988-01-25 SU SU884355073A patent/SU1588740A1/ru active
-
1989
- 1989-07-21 US US07/385,539 patent/US4988730A/en not_active Expired - Fee Related
-
1992
- 1992-05-07 GR GR920400801T patent/GR3004518T3/el unknown
-
1993
- 1993-03-24 HR HR930508A patent/HRP930508A2/hr not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU46559B (sh) | Postupak za dobivanje novih derivata difenilpropilamina | |
DK164937C (da) | Analogifremgangsmaade til fremstilling af 1-alkyl-2-aminotetralinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt 1-alkyl-2-aminotetralinderivater til anvendelse som udgangsmateriale i fremgangsmaaden | |
ES520226A0 (es) | Procedimiento para la preparacion de derivados de cefem. | |
ES2077199T3 (es) | Nuevas piperacinas 1,4-disustituidas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
SE8406538D0 (sv) | Novel derivatives of purine | |
MX9201014A (es) | Composicion farmaceutica para disminuir el nivel de colesterol en plasma. | |
DK178883D0 (da) | 2-(2'-hydroxy-3'-(1,1-dimethylpropylamino)-propoxy)-beta-phenylpropiophenon, syreadditionssalte deraf, fremgangsmade til fremstilling deraf samt farmaceutiske praeparater med indhold deraf | |
PT100415A (pt) | Novas morfolinas de accao farmaceutica, e processo para a sua preparacao | |
ES523426A0 (es) | Un metodo para preparar nuevos derivados de guanina | |
PT82847B (pt) | Processo para a preparacao de composicoes farmaceuticas contendo 4-amino-2-(imidazolodina-2-ona-1-il)-pirimidina-5-carboxil-(n-(3-trifluormetil-fenil)-amidas) | |
DK222588D0 (da) | 5-quinoxalyl-imidazolidin-2,4-dioner, deres fremstilling og anvendelse som laegemidler | |
FI880384A0 (fi) | Nya imidazo- och triazolotiadiaziner, foerfarande foer deras framstaellning, dessa innehaollande laekemedel och deras anvaendning, samt naogra vid framstaellningen av naemnda foereningar bildade mellanprodukter. | |
FI820172L (fi) | Basiskt substituerade antranilsyror deras framstaellningsfoerfarande och anvaendning | |
DE3778858D1 (de) | 17-benzylspartein-derivate enthaltende positiv inotrop wirksame pharmazeutische zubereitungen. | |
ES2072462T3 (es) | Nuevas sales del acido 2-(2,6-dicloroanilino)fenilacetico, procedimiento para su elaboracion y uso de las mismas en preparados farmaceuticos de uso topico. | |
FI841611A (fi) | 1,3-bis(dimetylamino)-2-propyl-4- klorofenoxiacetat, foerfarande foer framstaellning av detta och denna foerening innehaollande laekemedelspreparat. |