DD206556A5 - Verfahren zur herstellung von tetrahydro-5,6,7,7a-thieno(3,2-c)pyridinon-2-derivaten - Google Patents
Verfahren zur herstellung von tetrahydro-5,6,7,7a-thieno(3,2-c)pyridinon-2-derivaten Download PDFInfo
- Publication number
- DD206556A5 DD206556A5 DD82241198A DD24119882A DD206556A5 DD 206556 A5 DD206556 A5 DD 206556A5 DD 82241198 A DD82241198 A DD 82241198A DD 24119882 A DD24119882 A DD 24119882A DD 206556 A5 DD206556 A5 DD 206556A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- formula
- derivatives
- compound
- hydrochloric acid
- item
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960004279 formaldehyde Drugs 0.000 claims abstract 2
- 235000019256 formaldehyde Nutrition 0.000 claims abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- 101000588924 Anthopleura elegantissima Delta-actitoxin-Ael1a Proteins 0.000 claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- -1 nitro, carboxy Chemical group 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 239000012429 reaction media Substances 0.000 claims description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- KFOPKOFKGJJEBW-ZSSYTAEJSA-N methyl 2-[(1s,7r,8s,9s,10r,13r,14s,17r)-1,7-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]acetate Chemical compound C([C@H]1O)C2=CC(=O)C[C@H](O)[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC(=O)OC)[C@@]1(C)CC2 KFOPKOFKGJJEBW-ZSSYTAEJSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 230000002744 anti-aggregatory effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8113067A FR2508459A1 (fr) | 1981-06-30 | 1981-06-30 | Procede de preparation de derives de la tetrahydro-5,6,7,7a 4h thieno (3,2-c) pyridinone-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD206556A5 true DD206556A5 (de) | 1984-02-01 |
Family
ID=9260134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD82241198A DD206556A5 (de) | 1981-06-30 | 1982-06-29 | Verfahren zur herstellung von tetrahydro-5,6,7,7a-thieno(3,2-c)pyridinon-2-derivaten |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4458074A (cs) |
| EP (1) | EP0069001B1 (cs) |
| JP (1) | JPS5810583A (cs) |
| KR (1) | KR840000556A (cs) |
| AR (1) | AR231448A1 (cs) |
| AT (1) | ATE12772T1 (cs) |
| AU (1) | AU548640B2 (cs) |
| CA (1) | CA1187880A (cs) |
| CS (1) | CS236483B2 (cs) |
| DD (1) | DD206556A5 (cs) |
| DE (1) | DE3263114D1 (cs) |
| DK (1) | DK153488C (cs) |
| ES (1) | ES8305372A1 (cs) |
| FI (1) | FI71738C (cs) |
| FR (1) | FR2508459A1 (cs) |
| GR (1) | GR77202B (cs) |
| HU (1) | HU186944B (cs) |
| IE (1) | IE52993B1 (cs) |
| IL (1) | IL65985A0 (cs) |
| NO (1) | NO157654C (cs) |
| NZ (1) | NZ200857A (cs) |
| PT (1) | PT75157B (cs) |
| SU (1) | SU1274624A3 (cs) |
| YU (1) | YU143082A (cs) |
| ZA (1) | ZA824619B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2495156A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique |
| JP2523045Y2 (ja) * | 1989-01-07 | 1997-01-22 | アスモ株式会社 | メタリングポンプ |
| FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
| AU3192700A (en) | 1999-03-17 | 2000-10-04 | Daiichi Pharmaceutical Co., Ltd. | Medicinal compositions |
| SG11201709722TA (en) | 2015-06-08 | 2017-12-28 | Ihi Corp | Reactor |
| JP6819199B2 (ja) | 2016-10-13 | 2021-01-27 | 株式会社Ihi | 圧力容器 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR53950E (fr) * | 1945-02-02 | 1947-01-13 | Edouard Bataille Sa | Appareil pour traitement ou séparation de matières diverses |
| FR2319642A2 (fr) * | 1975-07-30 | 1977-02-25 | Parcor | Nouveau procede de preparation de derives de la thienopyridine |
| US4127580A (en) * | 1975-02-07 | 1978-11-28 | Parcor | Process for the preparation of thieno-pyridine derivatives |
| FR2495158A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Nouveau procede de preparation de derives de la tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinone-2 |
-
1981
- 1981-06-30 FR FR8113067A patent/FR2508459A1/fr active Granted
-
1982
- 1982-06-01 IE IE1315/82A patent/IE52993B1/en not_active IP Right Cessation
- 1982-06-04 NZ NZ200857A patent/NZ200857A/en unknown
- 1982-06-06 IL IL65985A patent/IL65985A0/xx not_active IP Right Cessation
- 1982-06-08 AR AR289631A patent/AR231448A1/es active
- 1982-06-09 ES ES514102A patent/ES8305372A1/es not_active Expired
- 1982-06-09 GR GR68379A patent/GR77202B/el unknown
- 1982-06-10 AU AU84754/82A patent/AU548640B2/en not_active Ceased
- 1982-06-21 DE DE8282401131T patent/DE3263114D1/de not_active Expired
- 1982-06-21 AT AT82401131T patent/ATE12772T1/de not_active IP Right Cessation
- 1982-06-21 EP EP82401131A patent/EP0069001B1/fr not_active Expired
- 1982-06-23 SU SU823455996A patent/SU1274624A3/ru active
- 1982-06-29 NO NO822229A patent/NO157654C/no unknown
- 1982-06-29 FI FI822319A patent/FI71738C/fi not_active IP Right Cessation
- 1982-06-29 HU HU822109A patent/HU186944B/hu not_active IP Right Cessation
- 1982-06-29 DK DK291882A patent/DK153488C/da active
- 1982-06-29 ZA ZA824619A patent/ZA824619B/xx unknown
- 1982-06-29 US US06/393,381 patent/US4458074A/en not_active Expired - Fee Related
- 1982-06-29 CS CS824902A patent/CS236483B2/cs unknown
- 1982-06-29 PT PT75157A patent/PT75157B/pt not_active IP Right Cessation
- 1982-06-29 CA CA000406277A patent/CA1187880A/en not_active Expired
- 1982-06-29 DD DD82241198A patent/DD206556A5/de not_active IP Right Cessation
- 1982-06-30 KR KR1019820002917A patent/KR840000556A/ko not_active Abandoned
- 1982-06-30 YU YU01430/82A patent/YU143082A/xx unknown
- 1982-06-30 JP JP57113842A patent/JPS5810583A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DD206556A5 (de) | Verfahren zur herstellung von tetrahydro-5,6,7,7a-thieno(3,2-c)pyridinon-2-derivaten | |
| CH659464A5 (de) | Verfahren zur herstellung von 1,8-dihydroxy-10-acyl-9-anthronen. | |
| DE936747C (de) | Verfahren zur Herstellung von neuen Pyrimidinderivaten und deren Salzen | |
| DE960279C (de) | Verfahren zur Herstellung von Bis-[imidazyl-(2)]-disulfid und dessen Abkoemmlingen | |
| DE2246376A1 (de) | Verfahren zur herstellung von cyanacetylcarbamaten | |
| DE19501377B4 (de) | Verfahren zur Herstellung von trans-1,4,5,8-Tetranitro-1,4,5,8-tetraazadecalin (TNAD) | |
| CH407096A (de) | Verfahren zur Herstellung von aromatischen Diisothiocyanaten | |
| DE2321332C2 (de) | Verfahren zur Herstellung von 2-Nitro-5-chlor-benzolsulfonsäurechlorid oder von 2-Nitro-5-chlor-benzolsulfonsäure | |
| DE945237C (de) | Verfahren zur Herstellung von Pyrrolinonen | |
| AT204552B (de) | Verfahren zur Herstellung von neuen, heterocyclischen Bis-sulfonamiden | |
| AT240374B (de) | Verfahren zur Herstellung von β-Lactamen | |
| DE3303704A1 (de) | 2,4-dichlor-5-thiazolcarboxaldehyd und ein verfahren zu seiner herstellung | |
| DE1670677C (de) | Verfahren zur Herstellung von 3,1-Benzothiazinen | |
| AT218526B (de) | Verfahren zur Herstellung von neuen Phenthiazinderivaten | |
| AT205030B (de) | Verfahren zur Herstellung von neuen 5-Hydroxy-7-methyl-s-triazol-(4,3-c)-pyrimidinen | |
| DE544886C (de) | Verfahren zur Darstellung von Substitutionsprodukten von aromatischen Kohlenwasserstoffen | |
| DE1445648C (de) | Homopiperazindenvate | |
| DE1768130C3 (de) | lsocyan-diphenyl(-thio)-äther sowie Verfahren zu ihrer Herstellung und deren Verwendung zur Bekämpfung von Akariden | |
| AT250356B (de) | Verfahren zur Herstellung von Pyridinderivaten | |
| DE2032628C (cs) | ||
| DE1058519B (de) | Verfahren zur Herstellung von Pyrazolo-[3, 4-d]-v-triazinen | |
| DE3135728A1 (de) | Verfahren zur herstellung von apovincaminsaeureestern | |
| DE1033671B (de) | Verfahren zur Herstellung von Diazomethan | |
| CH365730A (de) | Verfahren zur Herstellung neuer Triazine | |
| CH297665A (de) | Verfahren zur Herstellung eines neuen Pyridin-3,5-dicarbonsäure-Derivates. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |