DD201790A5 - Verfahren zur herstellung von 3-aryl-5-isothiazolen - Google Patents

Verfahren zur herstellung von 3-aryl-5-isothiazolen Download PDF

Info

Publication number
DD201790A5
DD201790A5 DD81233487A DD23348781A DD201790A5 DD 201790 A5 DD201790 A5 DD 201790A5 DD 81233487 A DD81233487 A DD 81233487A DD 23348781 A DD23348781 A DD 23348781A DD 201790 A5 DD201790 A5 DD 201790A5
Authority
DD
German Democratic Republic
Prior art keywords
acid
general formula
amino
ester
hydrogen
Prior art date
Application number
DD81233487A
Other languages
German (de)
English (en)
Inventor
James R Beck
Robert P Gajewski
Ronald E Hackler
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD201790A5 publication Critical patent/DD201790A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD81233487A 1980-09-22 1981-09-22 Verfahren zur herstellung von 3-aryl-5-isothiazolen DD201790A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (1)

Publication Number Publication Date
DD201790A5 true DD201790A5 (de) 1983-08-10

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81233487A DD201790A5 (de) 1980-09-22 1981-09-22 Verfahren zur herstellung von 3-aryl-5-isothiazolen

Country Status (22)

Country Link
US (1) US4346094A (cs)
EP (1) EP0048615B1 (cs)
JP (1) JPS5785379A (cs)
KR (1) KR830007597A (cs)
AR (1) AR229103A1 (cs)
AT (1) ATE7657T1 (cs)
AU (1) AU7551681A (cs)
CS (1) CS228536B2 (cs)
DD (1) DD201790A5 (cs)
DE (1) DE3163900D1 (cs)
DK (1) DK417981A (cs)
ES (1) ES8301225A1 (cs)
FI (1) FI812940L (cs)
GB (1) GB2084573B (cs)
GR (1) GR75046B (cs)
IL (1) IL63890A0 (cs)
NO (1) NO813208L (cs)
PL (1) PL130497B1 (cs)
PT (1) PT73711B (cs)
RO (1) RO82216A (cs)
YU (1) YU227181A (cs)
ZA (1) ZA816549B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
SG86971A1 (en) * 1990-11-30 2002-03-19 Teijin Ltd 2-arylthiazole derivatives and pharmaceutical composition thereof
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
EP1044002A4 (en) 1997-11-07 2003-05-02 Univ Johns Hopkins METHODS FOR THE TREATMENT OF HEART CONTRACTILITY
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
KR20040089607A (ko) 2002-02-06 2004-10-21 시바 스페셜티 케미칼스 홀딩 인크. 설포네이트 유도체 및 잠산으로서의 이의 용도
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. 2-フェニルピリジン誘導体
US7612108B2 (en) * 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
ES2355068T3 (es) 2005-10-07 2011-03-22 Astellas Pharma Inc. Derivado del ácido triarilcarboxílico.
PT1992361E (pt) 2006-02-24 2012-07-10 Astellas Pharma Inc Medicamento ou agente preventivo contra úlceras digestivas
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
WO2009143020A1 (en) * 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same
DK2404908T3 (da) 2009-02-27 2014-04-28 Teijin Pharma Ltd Fremgangsmåde til fremstilling af phenyl-substitueret heterocyclisk derivat gennem kobling under anvendelse af en overgangsmetalkatalysator
WO2010112408A1 (en) 2009-03-30 2010-10-07 Basf Se Uv-dose indicator films
CN103068807B (zh) 2010-08-27 2016-05-25 帝人制药株式会社 通过使用钯化合物的偶合法的苯基取代杂环衍生物的制备方法
CN103443072B (zh) 2011-01-28 2016-05-18 巴斯夫欧洲公司 包含肟磺酸酯作为热固化剂的可聚合组合物
SI2980085T1 (en) * 2013-03-29 2018-08-31 Teijin Pharma Limited Derivate pyrazole
US10487050B2 (en) 2014-08-29 2019-11-26 Basf Se Oxime sulfonate derivatives
BR112017023057B1 (pt) 2015-04-29 2023-03-28 Bsn Medical Gmbh Processo para preparação de no e processo cosmético
BR112017023170B1 (pt) 2015-04-29 2022-08-16 Bsn Medical Gmbh Dispositivo de banho medicinal e seu uso

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Also Published As

Publication number Publication date
RO82216A (ro) 1983-07-07
PL130497B1 (en) 1984-08-31
NO813208L (no) 1982-03-23
PL233103A1 (cs) 1982-12-20
GB2084573A (en) 1982-04-15
EP0048615B1 (en) 1984-05-30
CS228536B2 (en) 1984-05-14
JPS5785379A (en) 1982-05-28
FI812940A7 (fi) 1982-03-23
IL63890A0 (en) 1981-12-31
FI812940L (fi) 1982-03-23
DE3163900D1 (en) 1984-07-05
PT73711B (en) 1982-12-20
AR229103A1 (es) 1983-06-15
KR830007597A (ko) 1983-11-04
ATE7657T1 (de) 1984-06-15
US4346094A (en) 1982-08-24
GB2084573B (en) 1984-09-12
ES505678A0 (es) 1982-12-01
DK417981A (da) 1982-03-23
RO82216B (ro) 1983-06-30
ZA816549B (en) 1983-04-27
ES8301225A1 (es) 1982-12-01
PT73711A (en) 1981-10-01
YU227181A (en) 1983-10-31
EP0048615A1 (en) 1982-03-31
AU7551681A (en) 1982-04-01
GR75046B (cs) 1984-07-12

Similar Documents

Publication Publication Date Title
DD201790A5 (de) Verfahren zur herstellung von 3-aryl-5-isothiazolen
DE69207017T2 (de) Benzamide
DE69503769T2 (de) Isoxazoline verbindung zur hemmung tnf-freigabe
DD248588A5 (de) Verfahren zur herstellung von hydroxy-und alkoxypyrimidinen
DD218887A5 (de) Verfahren zur herstellung von 1,4-dihydropyridinen
DE19632549A1 (de) Arylalkanoylpyridazine
DE69222459T2 (de) Thiazolidindionderivate, ihre Herstellung und Anwendung
DD283402A5 (de) Verfahren zur herstellung von 2-substituierten adenosinderivaten
DE19830431A1 (de) Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren
DE2537070C2 (cs)
DE10259244A1 (de) N-(Indolethyl-)cycloamin-Verbindungen
DD209446A5 (de) Verfahren zur herstellung von neuen aromatischen verbindungen
DE10235639A1 (de) Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel
CH646972A5 (en) Process for the preparation of new 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
DD287495A5 (de) Verfahren zur herstellung herterozyclischer stickstoffverbindungen
DE3008904A1 (de) 1-mercaptoacyldihydropyrazol-5-carbonsaeure-derivate und ihre salze mit basen, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von hypertonie
DE1795822C2 (de) Thiazolylalkancarbonsäuren, Verfahren zu ihrer Herstellung und antiphlogistische Zubereitung
AT396362B (de) 5,5-dimethyl-3-phenylvinyl-1-aminoalkoxy-iminocyclohex-2-enderivate
DE3216843C2 (de) 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4255575A (en) 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives
DE69110217T2 (de) Derivate der Kaffeinsäure und sie enthaltende pharmazeutische Zusammensetzungen.
US4645771A (en) Tetrahydropyridine derivatives
DE102006029795A1 (de) Neue Harnstoff-Derivate und deren Verwendungen
DE2322561A1 (de) Trisubstituierte imidazole
DE602005005967T2 (de) Substituierte azetidinverbindungen als cyclooxigenase-1-cyclooxygenase-2-inhibitoren und deren herstellung und verwendung als medikament