RO82216B - Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului - Google Patents

Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului

Info

Publication number
RO82216B
RO82216B RO105346A RO10534681A RO82216B RO 82216 B RO82216 B RO 82216B RO 105346 A RO105346 A RO 105346A RO 10534681 A RO10534681 A RO 10534681A RO 82216 B RO82216 B RO 82216B
Authority
RO
Romania
Prior art keywords
carbon atoms
general formula
aryl
hydrogen
preparation
Prior art date
Application number
RO105346A
Other languages
English (en)
Other versions
RO82216A (ro
Inventor
James Richard Beck
Robert Peter Gajewski
Ronald Ervin Hackler
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO82216B publication Critical patent/RO82216B/ro
Publication of RO82216A publication Critical patent/RO82216A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului cu formula generala I: (vezi formula) în care R reprezinta hidrogen, halogen, o grupa amino, hidroxi sai alchilamino cu 1...4 atomi de carbon Ar reprezinta fenil, piridil, tienil sau: (vezi formula) în care R1, R2 si R3 reprezinta hidrogen, halogen, grupe haloalchil cu 1...4 atomi de carbon, alcoxi cu 1...4 atomi de carbon, alchil cu 1...4 atomi de carbon, sau R1 si R2 si R3 luati împreuna reprezinta un radical alchilendioxi cu 1...4 atomi de carbon cu exceptia cazului în care R reprezinta hidrogen sau brom, si Ar reprezinta fenil, constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R si Ar au semnificatiile de mai sus si Qreprezinta un radical ales dintre (vezi formula) în care R4 si R5 sunt identici sau diferiti si reprezinta hidrogen sau alchil cu 1...3 atomi de carbon si R6 reprezinta alchil cu 1...4 atomi de carbon se hidrolizeaza în prezenta unui hidroxid de met al alcalin, în mediu apos, la o temperatura cuprinsa între 0 si 110 degree C, iar acidul cu formula generala I poate fi, eventual, transformat, prin metode în sine cunoscute, într-o sare sau ester acceptabile farmaceutic.
RO81105346A 1980-09-22 1981-09-21 Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului RO82216A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (2)

Publication Number Publication Date
RO82216B true RO82216B (ro) 1983-06-30
RO82216A RO82216A (ro) 1983-07-07

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
RO81105346A RO82216A (ro) 1980-09-22 1981-09-21 Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului

Country Status (22)

Country Link
US (1) US4346094A (ro)
EP (1) EP0048615B1 (ro)
JP (1) JPS5785379A (ro)
KR (1) KR830007597A (ro)
AR (1) AR229103A1 (ro)
AT (1) ATE7657T1 (ro)
AU (1) AU7551681A (ro)
CS (1) CS228536B2 (ro)
DD (1) DD201790A5 (ro)
DE (1) DE3163900D1 (ro)
DK (1) DK417981A (ro)
ES (1) ES8301225A1 (ro)
FI (1) FI812940A7 (ro)
GB (1) GB2084573B (ro)
GR (1) GR75046B (ro)
IL (1) IL63890A0 (ro)
NO (1) NO813208L (ro)
PL (1) PL130497B1 (ro)
PT (1) PT73711B (ro)
RO (1) RO82216A (ro)
YU (1) YU227181A (ro)
ZA (1) ZA816549B (ro)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
ATE142494T1 (de) * 1990-11-30 1996-09-15 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
AU1520699A (en) 1997-11-07 1999-05-31 Johns Hopkins University, The Methods for treatment of disorders of cardiac contractility
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
KR20040089607A (ko) 2002-02-06 2004-10-21 시바 스페셜티 케미칼스 홀딩 인크. 설포네이트 유도체 및 잠산으로서의 이의 용도
US7820700B2 (en) * 2004-08-27 2010-10-26 Astellas Pharma Inc. 2-phenylpyridine derivative
WO2006022375A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルチオフェン誘導体
WO2007043457A1 (ja) 2005-10-07 2007-04-19 Astellas Pharma Inc. トリアリールカルボン酸誘導体
MX2008010646A (es) 2006-02-24 2008-10-14 Astellas Pharma Inc Agente para tratar o prevenir ulcera digestiva.
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
CA2725047A1 (en) * 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same
US8952174B2 (en) 2009-02-27 2015-02-10 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
JP2012522084A (ja) 2009-03-30 2012-09-20 ビーエーエスエフ ソシエタス・ヨーロピア Ｕｖ線量インジケータフィルム
AU2011294204B2 (en) 2010-08-27 2015-07-23 Teijin Limited Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
JP5955339B2 (ja) 2011-01-28 2016-07-20 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 熱硬化剤としてオキシムスルホネートを含む重合性組成物
NZ712680A (en) * 2013-03-29 2020-02-28 Teijin Pharma Ltd Pyrazole derivative
KR20170048422A (ko) 2014-08-29 2017-05-08 바스프 에스이 옥심 술포네이트 유도체
AU2016256577B2 (en) 2015-04-29 2019-04-04 Bsn Medical Gmbh Medical bathing device
US20180116920A1 (en) 2015-04-29 2018-05-03 Bsn Medical Gmbh Multi-step process for no production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Also Published As

Publication number Publication date
YU227181A (en) 1983-10-31
NO813208L (no) 1982-03-23
KR830007597A (ko) 1983-11-04
DK417981A (da) 1982-03-23
JPS5785379A (en) 1982-05-28
PL130497B1 (en) 1984-08-31
DE3163900D1 (en) 1984-07-05
RO82216A (ro) 1983-07-07
ZA816549B (en) 1983-04-27
US4346094A (en) 1982-08-24
IL63890A0 (en) 1981-12-31
PL233103A1 (ro) 1982-12-20
AU7551681A (en) 1982-04-01
FI812940L (fi) 1982-03-23
ES505678A0 (es) 1982-12-01
GR75046B (ro) 1984-07-12
ES8301225A1 (es) 1982-12-01
PT73711B (en) 1982-12-20
EP0048615A1 (en) 1982-03-31
EP0048615B1 (en) 1984-05-30
PT73711A (en) 1981-10-01
DD201790A5 (de) 1983-08-10
FI812940A7 (fi) 1982-03-23
GB2084573B (en) 1984-09-12
ATE7657T1 (de) 1984-06-15
GB2084573A (en) 1982-04-15
CS228536B2 (en) 1984-05-14
AR229103A1 (es) 1983-06-15

Similar Documents

Publication Publication Date Title
RO82216B (ro) Procedeu pentru prepararea unor derivati ai 3-aril-5-izotiazolului
RO70660B (ro) Procedeu pentru prepararea unor derivati de 3-arilo0i-3-fenilpropilamina
ES2000910A6 (es) Procedimiento para preparar piridina-2,3-dicarboxilatos sustituidos y disustituidos
RO70264B (ro) Procedeu pentru prepararea unor derivati ai acidului 1-alchil-5-aroilpirol-2-acetic
RO82962B (ro) Procedeu pentru prepararea unor derivati de cefalosporina
RO83311B (ro) Procedeu de preparare a unor saruri de monoester de acid fosforic
RO86851B (ro) Procedeu pentru prepararea unor derivati de piperazin-2-ona
RO86258B (ro) Procedeu pentru obtinerea unor derivati mono-, di- si tri-substituiti de flavan
ZA847673B (en) Quinazoline and isoquiniline derivatives
AU579116B2 (en) Use of quinoline derivatives for the protection of cultivated plants
RO84586B (ro) Procedeu pentru prepararea unor derivati de piranona
PL281367A1 (en) Method of obtaining novel purine derivatives
RO85556B (ro) Procedeu pentru prepararea unor derivati de aminoacizi
RO85812B (ro) Procedeu pentru prepararea de derivati de azolilpentena
RO83707B (ro) Procedeu pentru prepararea esterilor clormetilici ai unor derivati ai acidului penicilanic
GB1397647A (en) Thiophene derivatives
RO81506B (ro) Procedeu pentru prepararea derivati de acizi 1, 3, 4-tiadiazol-2-carboxilici
RO83468B (ro) Procedeu de obtinere a derivatilor de 5, 6, 7, 7a-tetrahidro-4h-tieno(3, 2-c)-piridin-2-onei
FI822133A0 (fi) Nya 1-benzyl-3,4-dihydro-isokinolinderivat
RO85268B (ro) Procedeu pentru prepararea unor derivati de 1, 2, 4-oxa-diazina
ES8301931A1 (es) Un procedimiento para la preparacion de nuevos imidazoles.
RO81937B (ro) Procedeu pentru prepararea unor derivati ai acidului 7 beta - aminotiazolil -acetamido-3-cefem-4-carboxilic
RO85820B (ro) Procedeu pentru prepararea unor derivati de metil-chinoxalin-1, 4-dioxid
RO86840B (ro) Procedeu de preparare a unor esteri ai acidului fenoxifenoxipropioni cu proprietati erbicide
RO67533B (ro) Procedeu pentru prepararea unor derivati de 3-triaziniltiometilcefalosporina