JPS5785379A - 3-aryl-5-isothiazole derivative - Google Patents

3-aryl-5-isothiazole derivative

Info

Publication number
JPS5785379A
JPS5785379A JP56150483A JP15048381A JPS5785379A JP S5785379 A JPS5785379 A JP S5785379A JP 56150483 A JP56150483 A JP 56150483A JP 15048381 A JP15048381 A JP 15048381A JP S5785379 A JPS5785379 A JP S5785379A
Authority
JP
Japan
Prior art keywords
aryl
isothiazole derivative
isothiazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56150483A
Other languages
English (en)
Inventor
Aaru Betsuku Jieemuzu
Pii Gajiefusukii Robaato
Ii Hatsukuraa Ronarudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5785379A publication Critical patent/JPS5785379A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP56150483A 1980-09-22 1981-09-22 3-aryl-5-isothiazole derivative Pending JPS5785379A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (1)

Publication Number Publication Date
JPS5785379A true JPS5785379A (en) 1982-05-28

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56150483A Pending JPS5785379A (en) 1980-09-22 1981-09-22 3-aryl-5-isothiazole derivative

Country Status (22)

Country Link
US (1) US4346094A (ja)
EP (1) EP0048615B1 (ja)
JP (1) JPS5785379A (ja)
KR (1) KR830007597A (ja)
AR (1) AR229103A1 (ja)
AT (1) ATE7657T1 (ja)
AU (1) AU7551681A (ja)
CS (1) CS228536B2 (ja)
DD (1) DD201790A5 (ja)
DE (1) DE3163900D1 (ja)
DK (1) DK417981A (ja)
ES (1) ES8301225A1 (ja)
FI (1) FI812940L (ja)
GB (1) GB2084573B (ja)
GR (1) GR75046B (ja)
IL (1) IL63890A0 (ja)
NO (1) NO813208L (ja)
PL (1) PL130497B1 (ja)
PT (1) PT73711B (ja)
RO (1) RO82216A (ja)
YU (1) YU227181A (ja)
ZA (1) ZA816549B (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
US7612108B2 (en) 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
US7816558B2 (en) 2005-10-07 2010-10-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
KR20110120896A (ko) 2009-02-27 2011-11-04 데이진 화-마 가부시키가이샤 천이 금속 촉매를 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법
US8067446B2 (en) 2006-02-24 2011-11-29 Astellas Pharma Inc. Methods for treating an ulcer of the small intestine and stomach
WO2012026565A1 (ja) 2010-08-27 2012-03-01 帝人ファーマ株式会社 パラジウム化合物を用いたカップリング法によるフェニル置換複素環誘導体の製造法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
ATE142494T1 (de) * 1990-11-30 1996-09-15 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
WO1999024038A1 (en) 1997-11-07 1999-05-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
CN100475798C (zh) 2002-02-06 2009-04-08 西巴特殊化学品控股有限公司 磺酸衍生物及其作为潜酸的用途
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
WO2010112408A1 (en) 2009-03-30 2010-10-07 Basf Se Uv-dose indicator films
KR101897842B1 (ko) 2011-01-28 2018-09-12 바스프 에스이 열 경화제로서 옥심 술포네이트를 포함하는 중합성 조성물
EP2980085B1 (en) 2013-03-29 2018-03-14 Teijin Pharma Limited Pyrazole derivative
CN106604912A (zh) 2014-08-29 2017-04-26 巴斯夫欧洲公司 肟磺酸酯衍生物
WO2016174043A1 (de) 2015-04-29 2016-11-03 Bsn Medical Gmbh Mehrstufiges verfahren zur no-herstellung
BR112017023170B1 (pt) 2015-04-29 2022-08-16 Bsn Medical Gmbh Dispositivo de banho medicinal e seu uso

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
US7612108B2 (en) 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
US7820700B2 (en) 2004-08-27 2010-10-26 Astellas Pharma Inc. 2-phenylpyridine derivative
JP4894517B2 (ja) * 2004-08-27 2012-03-14 アステラス製薬株式会社 ２−フェニルピリジン誘導体
US7816558B2 (en) 2005-10-07 2010-10-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
US8067446B2 (en) 2006-02-24 2011-11-29 Astellas Pharma Inc. Methods for treating an ulcer of the small intestine and stomach
US8426453B2 (en) 2006-02-24 2013-04-23 Astellas Pharma Inc. Treatment of a stomach or small intestine ulcer with 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
KR20110120896A (ko) 2009-02-27 2011-11-04 데이진 화-마 가부시키가이샤 천이 금속 촉매를 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법
EP2754658A1 (en) 2009-02-27 2014-07-16 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
WO2012026565A1 (ja) 2010-08-27 2012-03-01 帝人ファーマ株式会社 パラジウム化合物を用いたカップリング法によるフェニル置換複素環誘導体の製造法

Also Published As

Publication number Publication date
US4346094A (en) 1982-08-24
ZA816549B (en) 1983-04-27
EP0048615B1 (en) 1984-05-30
IL63890A0 (en) 1981-12-31
AR229103A1 (es) 1983-06-15
RO82216A (ro) 1983-07-07
PT73711B (en) 1982-12-20
PT73711A (en) 1981-10-01
ATE7657T1 (de) 1984-06-15
EP0048615A1 (en) 1982-03-31
GB2084573B (en) 1984-09-12
CS228536B2 (en) 1984-05-14
ES505678A0 (es) 1982-12-01
DE3163900D1 (en) 1984-07-05
ES8301225A1 (es) 1982-12-01
KR830007597A (ko) 1983-11-04
PL130497B1 (en) 1984-08-31
GB2084573A (en) 1982-04-15
GR75046B (ja) 1984-07-12
RO82216B (ro) 1983-06-30
DK417981A (da) 1982-03-23
NO813208L (no) 1982-03-23
FI812940L (fi) 1982-03-23
PL233103A1 (ja) 1982-12-20
AU7551681A (en) 1982-04-01
DD201790A5 (de) 1983-08-10
YU227181A (en) 1983-10-31

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